ID U3JR39_FICAL Unreviewed; 929 AA.
AC U3JR39;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=DHX36 {ECO:0000313|Ensembl:ENSFALP00000005243.2};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000005243.2, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000005243.2, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000005243.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR AlphaFoldDB; U3JR39; -.
DR STRING; 59894.ENSFALP00000005243; -.
DR Ensembl; ENSFALT00000005268.2; ENSFALP00000005243.2; ENSFALG00000005045.2.
DR eggNOG; KOG0920; Eukaryota.
DR GeneTree; ENSGT00940000156903; -.
DR HOGENOM; CLU_001832_1_4_1; -.
DR OrthoDB; 1095660at2759; -.
DR Proteomes; UP000016665; Chromosome 9.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd17981; DEXHc_DHX36; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934:SF237; ATP-DEPENDENT DNA_RNA HELICASE DHX36; 1.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 138..308
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 398..568
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 33..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..77
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 929 AA; 106182 MW; 8F87460BB786E711 CRC64;
MGRCEDRTRD SEGWRAVVRM DERREEQIVQ LLNAVQTKND KEQEAMSWWS GDEEGSAPEQ
PPKAKPDAEK APVRQRPTCE KTSLDLDVEY LCEKTEQDAD LDEQLKEDLM KKRSDPRYIE
MQRFREKLPS YKMREELVKL INTHRVTVIS GETGCGKTTQ VTQFILDDHI ERGLGSTCRI
VCTQPRRISA ISVAERVAAE RAEACGNGRS TGYQIRLQSR LPRKQGSILY CTTGIVLQWL
QSDKHLSSIS HVVLDEIHER NLQSDVLMSI IKDLLNVRLD LKVILMSATL NAEKFSEYFD
HCPMIHIPGF TFPVVEYLLE DVIEKLRYTP EKTDRRLHWR KGFMQGRVSR PEKEEKEEIY
REQWPAYLRQ LQGRYSAGTI DALEMMDDDK VDLDLVAALI RHIVLEEEDG AILVFLPGWD
NISTLHEILM SQVMFKSDRF IIIPLHSLMP TVNQTQVFKK TPPGVRKIVI ATNIAETSIT
IDDVVFVIDG GKIKETHFDT QNNISTMAAE WVSKANAKQR KGRAGRVQPG HCYHLYNGLR
ASLLDDYQLP EILRTPLEEL CLQIKILKLG GIAYFLSKLM DPPSRDAVTL AINHLMELNA
LDRQEELTPL GVHLARLPVE PHIGKMILFG ALFCCLDPVL TIAASLSFKD PFVIPLGKEK
IADARRKELS KNSKSDHLTV VNAFTGWEEA RSCGFRNEKD YCWEYFLSSN TMQMLHNMKG
QFAEHLLAAG FVNSRNPKDP KSNTNSGNEK LLKAVICAGL YPKVAKIRPS FSKKRKMVKV
CTKTDGSVNI HPKSVNVEET EFHYNWLVYH LKMRTSSIYL YDCTEVSPYC LLFFGGDISI
QKDKDQDTIA VDEWIVFQSP EKIANLVKKL RQELDDLLQE KIERPRPVDW AAVRSRDTAL
LSAIIDLITT QENAAARNFA PRFQGERCS
//
