ID U4L921_PYROM Unreviewed; 1644 AA.
AC U4L921;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00012494};
DE EC=2.7.7.48 {ECO:0000256|ARBA:ARBA00012494};
GN ORFNames=PCON_09614 {ECO:0000313|EMBL:CCX10021.1};
OS Pyronema omphalodes (strain CBS 100304) (Pyronema confluens).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Pezizomycetes;
OC Pezizales; Pyronemataceae; Pyronema.
OX NCBI_TaxID=1076935 {ECO:0000313|EMBL:CCX10021.1};
RN [1] {ECO:0000313|EMBL:CCX10021.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS100304 {ECO:0000313|EMBL:CCX10021.1};
RC TISSUE=Vegetative mycelium {ECO:0000313|EMBL:CCX10021.1};
RX PubMed=24068976; DOI=10.1371/journal.pgen.1003820;
RA Traeger S., Altegoer F., Freitag M., Gabaldon T., Kempken F., Kumar A.,
RA Marcet-Houben M., Poggeler S., Stajich J.E., Nowrousian M.;
RT "The genome and development-dependent transcriptomes of Pyronema confluens:
RT a window into fungal evolution.";
RL PLoS Genet. 9:E1003820-E1003820(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.48; Evidence={ECO:0000256|ARBA:ARBA00024517};
CC -!- SIMILARITY: Belongs to the RdRP family.
CC {ECO:0000256|ARBA:ARBA00005762}.
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DR EMBL; HF935502; CCX10021.1; -; Genomic_DNA.
DR STRING; 1076935.U4L921; -.
DR eggNOG; KOG0988; Eukaryota.
DR OMA; HTTHTEN; -.
DR OrthoDB; 5477883at2759; -.
DR Proteomes; UP000018144; Unassembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProt.
DR CDD; cd00590; RRM_SF; 1.
DR InterPro; IPR007855; RNA-dep_RNA_pol_euk-typ.
DR PANTHER; PTHR23079; RNA-DEPENDENT RNA POLYMERASE; 1.
DR PANTHER; PTHR23079:SF55; RNA-DIRECTED RNA POLYMERASE; 1.
DR Pfam; PF05183; RdRP; 1.
PE 3: Inferred from homology;
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022484,
KW ECO:0000313|EMBL:CCX10021.1}; RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484,
KW ECO:0000313|EMBL:CCX10021.1}; Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT REGION 1..272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 288..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 501..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1559..1590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..187
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..320
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 505..519
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1567..1583
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1644 AA; 185559 MW; C4D554B5DF12EF89 CRC64;
MTVPSSQNSG PTRSGYGGRG GRGGRGGRGG GGGHRGGRGN GYGNRTPATD LEFVLPPRPA
PTGPPSKIQR TISVPNPGPR SGPVPQSNPS LRPSASAPLA MDRKPSPVPG PRPAPTGSLA
QIKRLSLVSS PGPGSGPGVT LSERPSAAAP TGPPAKNKRP SPVPSPGPTS GPRAESTIPP
RPSASAPPAM EKKPSSGLGS RQGSISGSDS GGSRRGTPAN EQRATVNGQQ GIANGQQGAV
NDQQGKRRAK QFAEALQKGG FEPDTPHTQE AGGRALQLVQ RAIRDMARGE TMGSVPTGSR
SKDGINTSAS QPQMAQKQQE PQMVPEAIGG WTRERKPKIA PYRGLKDEEY KKYHEVPVHV
GPGLKNESVM DIFISLQKYG PIESIRLLTN NTGSFIGKAI VIFKSVRYPF WQEEEGIEFG
FGKVAVRWNR PTKTPYVPSK INRSKLHVGK MEFNVRSLEF GFMVKPEEFM VMYSSEPHIT
NIIWEVNLFK RRIEITYTMK KTQEQPKVAD SDPDQAKNPS QDDTSKFMIE IPFSHLKGLL
TPADEDPDAD IRTFVVPLPN PPKCFRQLID WSKTMNEIGQ MVWNIQDTWA RQTDVEYDMK
ARMEEPVSLR HKKPIIDLGR WTTYRLEFKL KTPEKKAEFK AMMSALKEYN IQAQPLTNFN
VNRENFALTT VWDFLDTDPS FGDYNLSYPV RYQLESCISH GFINEHNITQ QFLEELRRLP
ERTSVILLET VAEAKKRMYD PMEIFNLPRD RRLAMGRALP EFCVYMQRAT VTPTGIHFHT
PSVEISNRVI RQYNYCSNRF IRISFSDEEH IGRLRPSDRI TSNELYNRIW RTLANGIVIG
DRKFEFLAFG NSQLREHGAY FFASDGKITC DTIREWMGDF SDIPYIAKYA ARLGQCFSTT
KPFKLKKYTP ERIDDVERNG YRFTDGVGKI SPLLATLITQ TMQKNRPTDS YQSCCFQFRL
GGCKGVLVSW PDLPKYKLQI RNTQIKFWSE HAELEIIRCS QFSAASLNRQ LIIVLSNLGA
PDQYFRDRLR NVLTDYNEAI HKPSKALEIL TKYVDPNYMT LRIADLVRGG FMKSQEPFVI
SVLHLWRAWT MKYLKEKAKI VLEHGAFLLG CTDETQTLRG WYEDDKEDDL AQIFCQIWDH
HSKPPGPRII TGRCVVARNP SLHPGDVRIV EAIDVPALHH LIDVVVFPQT GDRDVPNMLS
GGDLDGDDYV VIWDEELVKP GVVKNEPPAN YTSNDARKAD GPVTITDVMK FFIDYLKNDR
LGSIANAHLA HADHQEDGVK SSICLELAQL HSDAVDFPKS GVKASMTKKH RVQEWPHFME
KPEEEGQRIS DKILGQLYQM VERVEFVPQY NLEPNEAIMT AFNLTEKEMQ WAKDIKTSYD
KDMRRIMSQH SINTEFEVWS TFVMSHSGGN DYKFHETIGE HSATLMDRYR EMILNSCGDR
AQELPRKVAA LYVYTQNHIE EGKKYLLNLR VETTPKLKGK ELNSNWSKME LAVMPLMSCP
WLFADILIYI SKGQLNVQKD YELGKPPVFQ NWRDDEDDVE RITIEDLAKL GKDMGGLVVT
EETDDEDEEE KKRKAKGKAV DVGSFDDDDD DEDIEVVQLV DVSVPPPQKK RNEHMGFNAA
GNDVDYQAIE EKLKEMEFKW EDLE
//
