ID U4UY31_DENPD Unreviewed; 885 AA.
AC U4UY31;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=D910_12497 {ECO:0000313|EMBL:ERL95230.1};
OS Dendroctonus ponderosae (Mountain pine beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Curculionidae; Scolytinae; Dendroctonus.
OX NCBI_TaxID=77166 {ECO:0000313|EMBL:ERL95230.1, ECO:0000313|Proteomes:UP000030742};
RN [1] {ECO:0000313|EMBL:ERL95230.1, ECO:0000313|Proteomes:UP000030742}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA Birol I., Jones S.J., Bohlmann J.;
RT "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT a major forest pest.";
RL Genome Biol. 14:R27-R27(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR EMBL; KB632411; ERL95230.1; -; Genomic_DNA.
DR AlphaFoldDB; U4UY31; -.
DR STRING; 77166.U4UY31; -.
DR Proteomes; UP000030742; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd17974; DEXHc_DHX16; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF83; PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000030742}.
FT DOMAIN 260..424
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 449..622
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 117..144
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 7..30
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 885 AA; 102506 MW; A5C565359C9B624E CRC64;
MSKAKKSRKR YESDSESSID SEEEARRKDL RERDEFAERL KKKDEEKTRN IVHASDRRAY
EEAAKRLQLQ NAEREKIIPK LRVESRRKYL EKRKEDKLLE LEADIVDDEY LFEEQILTER
ERKEREHKKE LLKLAQEHEK ARELERVQRY HMPRDLGKDS TSDYIEVDEL EKVPQSEQKK
WEKDQMASAV FKFGAKDAVK RDEYELLLED QIDFIQALQM PGIKDKMKRE PELSEFEKKK
LTIAETKKSL PIFPFRDDLI QAVREHQVLI IEGETGSGKT TQIPQYLHEA GFTENEKKIG
CTQPRRVAAM SVAARVAQEM DVKLGNEVGY AIRFEDCTSE RTVIKYMTDG TLHREFLSEP
DLQSYSVMII DEAHERTLHT DILFGLVKDI ARFRPDLKLL ISSATLDAQK FSEFFDEAPI
FRIPGRRFPV DIYYTKAPEA DYVDACVISV LQIHVTQPLG DVLVFLTGQD EIETCQELLQ
DRLRRLGSKV RELIILPVYA NLPSDMQAKI FEATPRGARK VVLATNIAET SLTIDNIIYV
IDPGFAKQNY FNSKTGMESL MVVPISKASA NQRAGRAGRV AAGKCFRLYT AWSYKHELEE
NTVPEIQRIN LGNAVLMLKA LGINDLIHFD FLDPPPHETL VLALEQLYAL GALNHHGELT
RLGRRMAEFP VDPMMAKMLL AAEKYKCAEE IVSITAMLSV NGAIFYRPKD KIIHADTARK
NFYHPGGDHL TLLNVYNQWR DTDYSLQWCY ENFIQSMKRA RDVREQLVGL MQRVEIEMVS
SISETTDIRK AITAGYFYHI ARLSKAGNYK TTVTVHPNSS LFEELPRWVL YHELVFTSKE
FMRQVIEIES KWLLEVAPHY YKPKELEDST NKKLPKTVGR SERTD
//
