ID W5P591_SHEEP Unreviewed; 4819 AA.
AC W5P591;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=[histone H3]-lysine(4) N-methyltransferase {ECO:0000256|ARBA:ARBA00023620};
DE EC=2.1.1.364 {ECO:0000256|ARBA:ARBA00023620};
GN Name=KMT2C {ECO:0000313|Ensembl:ENSOARP00000005594.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000005594.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000005594.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000005594.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000005594.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) +
CC N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:60264, Rhea:RHEA-COMP:15543, Rhea:RHEA-COMP:15547,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.364;
CC Evidence={ECO:0000256|ARBA:ARBA00024515};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60265;
CC Evidence={ECO:0000256|ARBA:ARBA00024515};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AMGL01089997; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01089998; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01089999; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01090000; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01090001; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR SMR; W5P591; -.
DR STRING; 9940.ENSOARP00000005594; -.
DR PaxDb; 9940-ENSOARP00000005594; -.
DR Ensembl; ENSOART00000005681.1; ENSOARP00000005594.1; ENSOARG00000005193.1.
DR eggNOG; KOG4443; Eukaryota.
DR HOGENOM; CLU_000065_3_0_1; -.
DR OMA; MYCKHLE; -.
DR Proteomes; UP000002356; Chromosome 4.
DR Bgee; ENSOARG00000005193; Expressed in leukocyte and 55 other cell types or tissues.
DR GO; GO:0044666; C:MLL3/4 complex; IEA:InterPro.
DR GO; GO:0140999; F:histone H3K4 trimethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd15696; ePHD1_KMT2C; 1.
DR CDD; cd22026; HMG-box_KMT2C; 1.
DR CDD; cd15509; PHD1_KMT2C_like; 1.
DR CDD; cd15594; PHD2_KMT2C; 1.
DR CDD; cd15511; PHD3_KMT2C; 1.
DR CDD; cd15596; PHD4_KMT2C; 1.
DR CDD; cd15513; PHD5_KMT2C_like; 1.
DR CDD; cd19171; SET_KMT2C_2D; 1.
DR Gene3D; 3.30.160.360; -; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 7.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR003889; FYrich_C.
DR InterPro; IPR003888; FYrich_N.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR041967; KMT2C_ePHD1.
DR InterPro; IPR047004; KMT2C_PHD2.
DR InterPro; IPR047003; KMT2C_PHD4.
DR InterPro; IPR037877; PHD3_KMT2C.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45888:SF1; HISTONE-LYSINE N-METHYLTRANSFERASE 2C; 1.
DR PANTHER; PTHR45888; HL01030P-RELATED; 1.
DR Pfam; PF05965; FYRC; 1.
DR Pfam; PF05964; FYRN; 1.
DR Pfam; PF00628; PHD; 4.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF13771; zf-HC5HC2H; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00542; FYRC; 1.
DR SMART; SM00541; FYRN; 1.
DR SMART; SM00398; HMG; 1.
DR SMART; SM00249; PHD; 8.
DR SMART; SM00508; PostSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 6.
DR SUPFAM; SSF47095; HMG-box; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51805; EPHD; 2.
DR PROSITE; PS51543; FYRC; 1.
DR PROSITE; PS51542; FYRN; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS50016; ZF_PHD_2; 6.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 158..262
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 272..322
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 275..320
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 319..369
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 395..451
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 879..932
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 929..979
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 1006..1061
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 4315..4418
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 4679..4795
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 4803..4819
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT REGION 14..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 93..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 681..727
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 750..783
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 807..834
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1137..1246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1328..1350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1384..1411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1532..1560
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1636..2375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2497..2671
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2705..2802
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2855..2882
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3135..3171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3198..3334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3361..3828
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3885..3925
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3941..3960
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4170..4194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..31
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 764..781
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1147..1194
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1396..1411
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1534..1560
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1636..1655
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1657..1684
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1685..1753
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1793..1824
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1892..1911
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1962..1985
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2008..2057
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2082..2107
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2257..2303
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2313..2327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2338..2352
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2359..2375
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2553..2576
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2592..2612
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2613..2636
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2705..2734
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2740..2757
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2764..2778
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3148..3166
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3212..3240
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3256..3280
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3316..3334
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3399..3439
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3465..3479
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3487..3509
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3545..3573
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3606..3628
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3715..3729
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3730..3758
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3759..3794
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3795..3813
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3814..3828
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4819 AA; 525829 MW; A3AABDC00C10AE49 CRC64;
VGVLSLTEKG SGVKAEIKEQ SAEEDAEAEV DSSKQPVPAL QRSVSEESAS SLVSVGVEAK
ISEQLCAFCY CGEKSSLGQG DLKQFRVTPG FILPWKNQPS NKKDGDDNSN GTCEKTQNSA
PRKQRGQRKE RPQQSVVACV SVSTQTASDD QPGKLWDELS LVGLPDAIDV QALFDPTGTC
WAHHRCVEWS LGVCQMEEPL LVNVDRAVVS GSTERCAFCK HLGATIKCCE EKCTQMYHYP
CAAGAGTFQD LSHFFLLCPE HIDQAPERSK EDANCAVCDS PGDLLDQFFC TTCGQHYHGM
CLDIAVTPLK RAGWQCPECK VCQNCKQSGE DSKMLVCDTC DKGYHTFCLQ PVMKSVPTNG
WRCKNCRICV ECGTRSSSQW HHNCLVCDSC YQQQENLCPF CGKCYHPELQ KDMLHCNMCK
RWVHLECDKP ADHEPDPQLR EEYICLYCKH VAAEMDPLQP GEEVEMAELP ADYNNEMEVE
GPEDHMLHAE IIYFKDISGD PTNVLFTAVH IHPGEQQRSN PPESCDMRGL LVSESSQDKV
DPESENQISR EVDGEAVEMC PKVACTCDRP SEDSMEVTQR ADALPPQLVV LQEEVQSVEE
PNVVASPEES RPPEVTIESV ILPLETLVSP DGESTSLCST EHLAVEREQR ENPEPSAFMD
LEAAPAVESQ VKDGLCQEGR SVKLSSETES SSSSAADTSK AHVSSSPALS SDLPSHDMLH
SYPSTPNASV ANILPTTYIS VTPKIGMGKP AITKRKFSPG RPRSRQGAWS THNTVSPPSW
SPDISEGREI FKPRQLPGSA IWSIKVGRGS GFPGKRRPRG AGLSGRGGRG RSKLKSGMGA
VVLPGVSAAD ISSNKDEEEN SMHNTVVLFS SSDKFTLHQD MCVVCGSFGQ GAEGRLLACS
QCGQCYHPYC VSIKITKVVL SKGWRCLECT VCEACGKATD PGRLLLCDDC DISYHTYCLD
PPLQTVPKGG WKCKWCVWCR HCGATSAGPR GEWQNNYTQC APCASLSACP VCHRNYREED
LILQCRQCDR WMHAVCQNFS TEEEVENVAD IGFDCSLCRP YMPTSNVPSS DCCESSLVAQ
IVTKAKELDP PKTYTQDGVC LTESGMTQLQ SLTVTVPRRK RSKPKLKLKI INQNSVAVLQ
TPPDIQSEHS RDGEMDDSRE GELMDCDGKS ESSPEREAVD DETKGVEGTE GVKKRKRKPY
RPGIGGFMVR QRSRTGQGKT KRSVIRKDSS GSISEQLPSR DDGWSEQLPD TLVDESISVN
ENTEKIKKRY RKRKNKLEEI FPAYLQEAFF GKDLLDTTRQ NKLSLDNLSE DTAQLSYKTN
TSTTFLDPSV DPLLSSSSAP AKPGAHGAAD DPLADISEVL NTDDDILGII SDDLAKSVDH
SAGIDVGPVA DDPSSLPQPS VGQSSRPLSE EQLDGILSPE LDKMVTDGAI LSKLYKIPEL
GGKDVEDLFT AVLSPAAPPP PPVPQPPPPP APQLLPVHSQ DVFSRMPLMN GLIGPSPHLP
HNALPPGSGL GTFSAVAQSP YADTRDKNPA FNPLAGDPTN SWAASAPTVE GESDTMSNAQ
RSTLKWEKEE ALGEMATVAP VLYTNINFPN LKEEFPDWTT RVKQIAKLWR KASSQERAPY
VQKARDNRAA LRINKVQMSN DSMKRQQQQD SIDPCSRIDS DLFKDPLKQR ESEHEQEWKF
RQQMRQKSKQ QAKIEATQKL EQVKSEQQQQ QQQQQQQLGS QPAMGQSGSD TPSSGIQSPL
TPQAGSGSLS PAQSFHKDLF PKPLPSTPAP APSDDVFVKK PQAPPPPPAP SRLSLQESLS
QAQPSQPPSP QVFAPGSSNS RPPSPMDPYA KMVGTPRPPP GGHSFPRRNA ALAESCGPLP
SASRLPQMGE AAANRPSPVR EVCAAGSDPY AKPPDTPRPV LTEPFPKPLG LPRSPALSDQ
TSQGPLAPGT SDHFPKPSPR ADAFQRQRIP DPYARPLLTP APLDGGPGPF KAPMQPPPPS
QDPYGPVSQA PRRLSIDPYE RPTLTPRPVD SFSHNQSSDP YSQPPLTPHP AMNESFSHPS
RAFSQPGPIS RPTSQDPYSQ PPGTPRPVVD SYSQPPGTSR SNPDPYSQPP GTPRPTTMDP
YSQQPPTPRP SAQADLFATS AASQRHPDPY AHPPGTPRPG MSVPYSQTPA APRPRISEGF
SRSSTRPALM PNQDPFLQAH NRGAALPGPL VRPPDACSQT PRPPGPGLSD AFSRVSPSAP
RDPYDQPPMT PRPQPDAFGT SQVAHDVADQ PRPGSEGSFG APSNTPMTPQ GQQFSSVSQL
PGPVPTSGVT DTQSTVNMSQ ADTEKLRQRQ KLREIILQQQ QQKKMASRQE KGTQDPGAVP
HPGPPGPPPH WQPEGVGQAF ARPPPPYPGS IRSPMAPPLG PRYTVFPKEA RGVYPPDVSS
MGMRPHGFRF GFPGGGHGTL SGQERFLVPP QQMQGSGVPP QLRRSLSVDM PRPLNNSPMN
NPGGLPAHFP AQSLPVQQHN ILGQAFIELR HRAPDGRPRL PFPAAPGNII EAPSHPRHGS
FIPRPDFPGP RHPDPMRRPS QGLPHQLPVH PNLEQVPPSQ QEQSHAVHSS ATVMRSLSHP
LGGEFSEAPL SASVPAETTS ENLQITTQSS DGLEEKLDSD DPSVKELDVK DLEGVEVKDL
DDEDLENLNL DTEDGKGDEL DTLGNLEAND PNLDDLLRSG EFDIIAYTDP ELDLEDKKNM
FNEELDLSVP IDDKLDNKCV SVEPEKKEQD NKSVVPSDKP SAWKKSTVSS EIKTEVLSPN
SKGEAKCESE KSEDGKDTAD PSCPPASAPL DRSDGDKAPV QPCDADLLEE RTTQEATGSN
ASAAHGAIQL PAEDAATPCS MPGPTPVLSS LLANEKPDPA DMRPLASPAP TLPASPSGHV
SSLPPPLMTP PGHVLDNTLN SNVAVVPRLN HAFPQGVQVN PGFIQGQPPV NHSFGTGKPA
SQPVPLTSQP GTSGMSGAQQ LMIPQTLAQQ SRERPLLLEE QPLLLQDLLD QERQEQQQQR
QMQAMIRQRS EPFFPNIDFD AITDPIMKAK MVALKGINKV MAQNNMGMPP MVMNRFPFMG
QSVAGAQSGD GQTLLPQAAA QDGSITHQIS RPNPPNFGPG FVNDSQRKQY EEWLQETQQL
LQMQQKYLEE QIGAHRKSKK ALSAKQRTAK KAGREFPEED AEQLKHVTEQ QSMVQKQLEQ
IRKQQKEHAE LIEDYRIKQQ QQQQCAMAPP PTVLPGVQPQ PPPPPAMSQP SFPMVPPQLQ
HPAVMPGHSS PARMPSVPGW QPPSAPPHLP LNPPRIQPPV AQLPIKTCTP APGAVSNANP
QSGPPPRVEF DDNNPFSESF QERERKERLR EQQERQRIQL MQEVDRQRAL QQRLELEQHG
LMGSELSSRP PAPQLSFFGS DLPRDFVPPP RPLPPSPQHQ MGQAVQPQGM QQAPLSSPPA
PGFLQTNERR QTGPSSFVPE SPSVPGGGPS FHPVKQVHGG LPGPGFQLSP PPALPAAPPA
ASSSLPGGQD PAVTQGQSYP GSAQSLIQLY SDIIPEEKGK KKRTRKKKKD EDMESAKAPS
TPHSDITAPP TPNLPETTST PAVPMPSDPP PLAGSEAAEP TGPSPPGTAA GPLCAEPEAQ
LPGRNFAQGT PDQQTYAESE TEKLSVEIPA TTQEAKLETP EPEQGPGRGG PEAEQLAGDQ
AEEQATAATA CPAHSPPRPA GAPANKGDSG NELLKHLLKN KRHLPLNQKP EGGFCSEDDS
TKDSKLVERQ NPAEVQTLGA QVQGGLGCGN NQLPKTDGGS ETKKQRSKRT QRTGEKAAPR
SKKRKKEDEE RQALYSTSDT FTHLKQQNNL SNPPTPPASL PPTPPPMACQ KMANGFATTE
ELAGKAGVLV SHEVTKSLGS KGFQLPFRPQ DDLLARAVAQ GPETVDVPAS LPTPPHNNQE
ELRVQEHGGE RDSPDSFVPS SSPESVVGME VSRYPDLSLV KEEPPEPVPS PIIPILPSNA
SRGLESRRND IKTEPGTLFF TSPFGSSPNG PRSGLISVAI TLHPAAAENI SSVVAAFSDL
LHVRIPNSYE VSNAPDVPSV GLVSSHRVNP GLEYRQRVFL RGPPPGSARP PRLASSFHLK
QPSTPLPPAS NGLCGYKDAG RGVSARAALR PQWCCHCKVV ILGSGVRKSA RDLAFVNQGS
RDGPGRVERD IVFCSNNCFI LYSSTAQAKT SESKESAPSL PQSPVRELPP KAPHQYNNNI
SSLDVRCLPQ LQERASPPAS PPISFPPAFE AAKVEAKPDE LKVTVKLKPR LRTVHGGFED
CRPIPKKWRG MKWRKWSIHI VVPKGAFQPP CEEEIDEFLK KLGTSLKPDP VPKDYRKCCF
CHEEGDGLTD GPARLLNLDL DLWVHLNCAL WSTEVYETQA GALINVELAL RRGLQMKCVF
CHRGCHRFRC TNIYHFTCAI KAQCMFFKDK TMLCPMHKPK GLHEQELSYF AVFRRVYVQR
DEVRQIASIV QRGEREHTFR VGSLVFHAIG QMPAFHSPTA LFPVGYEASR LYWSTRYANR
RCRYLCSIEE QDGRPVFLIR VVEQGHEDLV LSDTSPKDVG VWDKILEPVA CVRKKSEMLQ
LFPAYLKGED LFGLTVSAVA RIAESLPGVG ACENYTFRYG RNPLMELPLA VNPTGCARSE
PKMSAHAKRF VLRPHTLNST STSKSFQSTV TGELSAPYSK QFVHSKSSQY RKMKTEWKSN
VYLARSRIQG LGLYAARDIE KHTMVIEYIG TIIRNEVANR KEKLYESQNR GVYMFRMDSD
HVIDATLTGG PARYINHSCA PNCVAEVVAF RAGHKIIISS SRRIQKGEEL CYDYKFDFED
DQHKIPCHCG AVNCRKWMN
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