ID W6KG67_9TRYP Unreviewed; 932 AA.
AC W6KG67;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=GSEM1_T00000551001 {ECO:0000313|EMBL:CCW59972.1};
OS Phytomonas sp. EM1.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Phytomonas.
OX NCBI_TaxID=479712 {ECO:0000313|EMBL:CCW59972.1, ECO:0000313|Proteomes:UP000027080};
RN [1] {ECO:0000313|EMBL:CCW59972.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EM1 {ECO:0000313|EMBL:CCW59972.1};
RA Genoscope - CEA;
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CCW59972.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EM1 {ECO:0000313|EMBL:CCW59972.1};
RX PubMed=24516393; DOI=10.1371/journal.pgen.1004007;
RA Porcel B.M., Denoeud F., Opperdoes F., Noel B., Madoui M.A.,
RA Hammarton T.C., Field M.C., Da Silva C., Couloux A., Poulain J.,
RA Katinka M., Jabbari K., Aury J.M., Campbell D.A., Cintron R., Dickens N.J.,
RA Docampo R., Sturm N.R., Koumandou V.L., Fabre S., Flegontov P., Lukes J.,
RA Michaeli S., Mottram J.C., Szoor B., Zilberstein D., Bringaud F.,
RA Wincker P., Dollet M.;
RT "The Streamlined Genome of Phytomonas spp. Relative to Human Pathogenic
RT Kinetoplastids Reveals a Parasite Tailored for Plants.";
RL PLoS Genet. 10:e1004007-e1004007(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR EMBL; HF955061; CCW59972.1; -; Genomic_DNA.
DR AlphaFoldDB; W6KG67; -.
DR EnsemblProtists; CCW59972; CCW59972; GSEM1_T00000551001.
DR OrthoDB; 167906at2759; -.
DR Proteomes; UP000027080; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd17917; DEXHc_RHA-like; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF136; ATP-DEPENDENT RNA HELICASE DHX35-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000027080}.
FT DOMAIN 188..389
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 403..588
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 227..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..246
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 247..261
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 932 AA; 103782 MW; DF89C54CFC84AB40 CRC64;
MDRDAIKKAQ QASRTAFLKK QSKLQSKTSS AVLEERIKDI EQGVVPQSLV EADFLLKRAE
QVRAAQGLLQ TATHRHEMAD NTAIQSTKDL PSLSGDTVFG DRLGISEDVL PPYTRDVKDG
AGSDAVGSGF VAMDSETIER RVKAHEYVPE KSIDEIERDR VASLQQRHEL LQAQRRSLPI
YGVRAELLQL IKDNQVVVLV GETGSGKSTQ LLQYLYEEGF HLLSRTERRS TEAVSRPDPE
NSAKEDRGDE DEAEDDDEGD ELRLICTQPR RIAAMSVAER VAQEVGCSCG SVVGYRVRFD
DRSSSLTRIL FVTDGMMLNE FTKDPNLESV AAIMIDEAHE RSLSTDILLG LLRDVVRRNP
HIRVIVASAT INAEKFSNFF NKAPILNVKG RTFAVDVFYV DVPITDYVSE SAQTALSLHL
TKPLPGDILI FLPGQDAIES CAEILRQNLA ESQGTMRPLL ILPIYSAMPP KEQARIYTPT
PPGARKVVIA TNIAETSITI DGIVYVVDCG LCKQDYYNAR AMVEELRVVP TSQASAQQRA
GRAGRTQRGE CFRLYTPYTF RNELLEETTP EILRASMSAV VLQLKAIGVD NLLQFDFVDP
PSTESLERAL DQLYLLGAMK ADGRLTVTGR RMSEFPLEPP LSKALLRACG LRCGRHMAMA
AAMLSIDSIF LTSRDPQERQ LVESAKGELF AFGNGDVAGY VRVMEEWLRA GPQAGEFCRV
HGIHPRSLLR ARDVLDQILK IYDRIGLDLK EDDSNERHPT TLAAPEARGA TEGLYPSGRM
INTEALTKAL LSGFFFNVAK MGLDKRTYTI VRPIHTGGSS YGASLDDDAC TTEIHPNSFL
FRSGMKALPN KGLAAMMQSK ETSNGADVDL RIPQVLRERP SLVVFTQLRR TTKRYMMHLT
AIESVDMILE MSPLNYFTRE ELETKMRKRL RE
//
