ID W9Y9R1_9EURO Unreviewed; 1193 AA.
AC W9Y9R1;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=A1O1_06345 {ECO:0000313|EMBL:EXJ85976.1};
OS Capronia coronata CBS 617.96.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Capronia.
OX NCBI_TaxID=1182541 {ECO:0000313|EMBL:EXJ85976.1, ECO:0000313|Proteomes:UP000019484};
RN [1] {ECO:0000313|EMBL:EXJ85976.1, ECO:0000313|Proteomes:UP000019484}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 617.96 {ECO:0000313|EMBL:EXJ85976.1,
RC ECO:0000313|Proteomes:UP000019484};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Capronia coronata CBS 617.96.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EXJ85976.1}.
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DR EMBL; AMWN01000005; EXJ85976.1; -; Genomic_DNA.
DR RefSeq; XP_007725414.1; XM_007727224.1.
DR AlphaFoldDB; W9Y9R1; -.
DR STRING; 1182541.W9Y9R1; -.
DR GeneID; 19161213; -.
DR eggNOG; KOG0334; Eukaryota.
DR HOGENOM; CLU_003041_0_3_1; -.
DR OrthoDB; 5477821at2759; -.
DR Proteomes; UP000019484; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd17953; DEADc_DDX46; 1.
DR CDD; cd22474; KH-I_PRP5_like; 1.
DR CDD; cd18787; SF2_C_DEAD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR PANTHER; PTHR47959:SF13; ATP-DEPENDENT RNA HELICASE RHLE; 1.
DR PANTHER; PTHR47959; ATP-DEPENDENT RNA HELICASE RHLE-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51195; Q_MOTIF; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000019484}.
FT DOMAIN 555..583
FT /note="DEAD-box RNA helicase Q"
FT /evidence="ECO:0000259|PROSITE:PS51195"
FT DOMAIN 586..764
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 791..941
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 76..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 335..434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 446..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 952..1035
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 555..583
FT /note="Q motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00552"
FT COMPBIAS 76..147
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..208
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..258
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 335..349
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..385
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 446..463
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 965..988
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1193 AA; 131221 MW; 5AB8B8954C3A4F6E CRC64;
MREVVGRMTE VIGGSTPDHG VLMYVAATVS PSLWINAYTL SAQRRYRDRR DRDRDGYRRR
DRSIDRRYDS RRDDDYHYSR RDRSRDRRRS RDRDDRRRSK DRDTRSKRDD SRDKDRRPRD
ESTESRKRKR ENSRARDTRR DSGGISREVS SKKTLQSYGA HHHLQTSKPR TPTHQTAEEQ
KAARLAKLEQ WKKKQAEEQA RKQKELEASG GARSILNEID RKAELSPAVS SPQSPAANIS
TTTAPEPTAP SSNSYSGKFD PKAIVKKAQH GPASAKVLGG DVPAPVLTNG HSSPKDQPNP
ATNGSSTAKA LKAKGNLGKF GLGSKAATET DLSKSALAFE DDEGTKKTLL KLPDMQLETN
GDSRAVNPDE VDGEDDVDMQ DEGTEEEAMA AARAAAEQRS RAERGEDTAM TDASAAVSTT
DATDAQAEEE DVDPLDAFMQ DLQPQQNTKS FGQKSNAKSR QQEPEALFSD DDVDFTAIDD
DNPDNILSLA NATAKKKKKD IPAVNHSKIN YEPFRRNFYS EPIEMAEMTE EEVAVLRMEL
DNIKVRGVNV PKPVQKWAQC GLGVQVQEVI QRLGYEAPTS IQAQAIPAIM SGRDVIGVAK
TGSGKTIAFL LPVFRHIKDQ RPLDPLDGPI GLILSPTREL ATQIHKECKP FLKALGLRAV
CAYGGAPIKD QIADLKRGAE IVVCTPGRMI DLLAANGGRV TNLKRVTYVV LDEADRMFDM
GFEPQVMKIL SNIRPDRQTV LFSATFPRQM EALARKTLNK PIEIIVGGRS VVAPEITQIV
EVRDESTKFV RLLELLGKLY EDDKNEDDRA LIFVDRQESA DSLLRDLMKR GYPCMSIHGG
KDQIDRDSTI ADFKAGVIPI LIATSVAARG LDVKQLKLVV NYDAPNHLED YVHRAGRTGR
AGNTGTAVTF LTEEQDRYAV DIAKALRQSG QPVPESVQKL VDTFMEKVKA GKEKAAGSGF
GGKGLERLDQ ERDAAKARER KTFKTGDEVE EEEEKEDSKD VKVGDDLFAK AASSVKASDA
PAPSSSLPGV PKGIDLDGKI TVHRTEREAP SSGPASQMDK VAAAVGAINQ KLSKAGIMRS
GVPIDNKGPD AGAFHATLEI NDFPQKARWA VTNRTNVAKI LESTGTSITT KGSFYPAGKE
PGPGENPKLY ILVEGDTEVV VRDAMRELMR LLKEGTMSAA ESTERTGGRY SVV
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