KEGG   Vulpes vulpes (red fox): 112926217
Entry
112926217         CDS       T05911                                 
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
vvp  Vulpes vulpes (red fox)
Pathway
vvp00562  Inositol phosphate metabolism
vvp01100  Metabolic pathways
vvp01521  EGFR tyrosine kinase inhibitor resistance
vvp01522  Endocrine resistance
vvp01524  Platinum drug resistance
vvp04012  ErbB signaling pathway
vvp04014  Ras signaling pathway
vvp04015  Rap1 signaling pathway
vvp04024  cAMP signaling pathway
vvp04062  Chemokine signaling pathway
vvp04066  HIF-1 signaling pathway
vvp04068  FoxO signaling pathway
vvp04070  Phosphatidylinositol signaling system
vvp04071  Sphingolipid signaling pathway
vvp04072  Phospholipase D signaling pathway
vvp04140  Autophagy - animal
vvp04150  mTOR signaling pathway
vvp04151  PI3K-Akt signaling pathway
vvp04152  AMPK signaling pathway
vvp04210  Apoptosis
vvp04211  Longevity regulating pathway
vvp04213  Longevity regulating pathway - multiple species
vvp04218  Cellular senescence
vvp04360  Axon guidance
vvp04370  VEGF signaling pathway
vvp04380  Osteoclast differentiation
vvp04510  Focal adhesion
vvp04550  Signaling pathways regulating pluripotency of stem cells
vvp04611  Platelet activation
vvp04613  Neutrophil extracellular trap formation
vvp04620  Toll-like receptor signaling pathway
vvp04625  C-type lectin receptor signaling pathway
vvp04630  JAK-STAT signaling pathway
vvp04650  Natural killer cell mediated cytotoxicity
vvp04660  T cell receptor signaling pathway
vvp04662  B cell receptor signaling pathway
vvp04664  Fc epsilon RI signaling pathway
vvp04666  Fc gamma R-mediated phagocytosis
vvp04668  TNF signaling pathway
vvp04670  Leukocyte transendothelial migration
vvp04722  Neurotrophin signaling pathway
vvp04725  Cholinergic synapse
vvp04750  Inflammatory mediator regulation of TRP channels
vvp04810  Regulation of actin cytoskeleton
vvp04910  Insulin signaling pathway
vvp04914  Progesterone-mediated oocyte maturation
vvp04915  Estrogen signaling pathway
vvp04917  Prolactin signaling pathway
vvp04919  Thyroid hormone signaling pathway
vvp04923  Regulation of lipolysis in adipocytes
vvp04926  Relaxin signaling pathway
vvp04929  GnRH secretion
vvp04930  Type II diabetes mellitus
vvp04931  Insulin resistance
vvp04932  Non-alcoholic fatty liver disease
vvp04933  AGE-RAGE signaling pathway in diabetic complications
vvp04935  Growth hormone synthesis, secretion and action
vvp04960  Aldosterone-regulated sodium reabsorption
vvp04973  Carbohydrate digestion and absorption
vvp05010  Alzheimer disease
vvp05017  Spinocerebellar ataxia
vvp05020  Prion disease
vvp05100  Bacterial invasion of epithelial cells
vvp05132  Salmonella infection
vvp05135  Yersinia infection
vvp05142  Chagas disease
vvp05146  Amoebiasis
vvp05160  Hepatitis C
vvp05161  Hepatitis B
vvp05162  Measles
vvp05163  Human cytomegalovirus infection
vvp05164  Influenza A
vvp05165  Human papillomavirus infection
vvp05166  Human T-cell leukemia virus 1 infection
vvp05167  Kaposi sarcoma-associated herpesvirus infection
vvp05168  Herpes simplex virus 1 infection
vvp05169  Epstein-Barr virus infection
vvp05170  Human immunodeficiency virus 1 infection
vvp05171  Coronavirus disease - COVID-19
vvp05200  Pathways in cancer
vvp05203  Viral carcinogenesis
vvp05205  Proteoglycans in cancer
vvp05206  MicroRNAs in cancer
vvp05207  Chemical carcinogenesis - receptor activation
vvp05208  Chemical carcinogenesis - reactive oxygen species
vvp05210  Colorectal cancer
vvp05211  Renal cell carcinoma
vvp05212  Pancreatic cancer
vvp05213  Endometrial cancer
vvp05214  Glioma
vvp05215  Prostate cancer
vvp05218  Melanoma
vvp05220  Chronic myeloid leukemia
vvp05221  Acute myeloid leukemia
vvp05222  Small cell lung cancer
vvp05223  Non-small cell lung cancer
vvp05224  Breast cancer
vvp05225  Hepatocellular carcinoma
vvp05226  Gastric cancer
vvp05230  Central carbon metabolism in cancer
vvp05231  Choline metabolism in cancer
vvp05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
vvp05415  Diabetic cardiomyopathy
vvp05417  Lipid and atherosclerosis
vvp05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:vvp00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    112926217 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    112926217 (PIK3CA)
   04014 Ras signaling pathway
    112926217 (PIK3CA)
   04015 Rap1 signaling pathway
    112926217 (PIK3CA)
   04370 VEGF signaling pathway
    112926217 (PIK3CA)
   04630 JAK-STAT signaling pathway
    112926217 (PIK3CA)
   04668 TNF signaling pathway
    112926217 (PIK3CA)
   04066 HIF-1 signaling pathway
    112926217 (PIK3CA)
   04068 FoxO signaling pathway
    112926217 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    112926217 (PIK3CA)
   04072 Phospholipase D signaling pathway
    112926217 (PIK3CA)
   04071 Sphingolipid signaling pathway
    112926217 (PIK3CA)
   04024 cAMP signaling pathway
    112926217 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    112926217 (PIK3CA)
   04152 AMPK signaling pathway
    112926217 (PIK3CA)
   04150 mTOR signaling pathway
    112926217 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    112926217 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    112926217 (PIK3CA)
   04218 Cellular senescence
    112926217 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    112926217 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    112926217 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    112926217 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    112926217 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    112926217 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    112926217 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    112926217 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    112926217 (PIK3CA)
   04660 T cell receptor signaling pathway
    112926217 (PIK3CA)
   04662 B cell receptor signaling pathway
    112926217 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    112926217 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    112926217 (PIK3CA)
   04670 Leukocyte transendothelial migration
    112926217 (PIK3CA)
   04062 Chemokine signaling pathway
    112926217 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    112926217 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    112926217 (PIK3CA)
   04929 GnRH secretion
    112926217 (PIK3CA)
   04915 Estrogen signaling pathway
    112926217 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    112926217 (PIK3CA)
   04917 Prolactin signaling pathway
    112926217 (PIK3CA)
   04926 Relaxin signaling pathway
    112926217 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    112926217 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    112926217 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    112926217 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    112926217 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    112926217 (PIK3CA)
   04722 Neurotrophin signaling pathway
    112926217 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    112926217 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    112926217 (PIK3CA)
   04380 Osteoclast differentiation
    112926217 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    112926217 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    112926217 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    112926217 (PIK3CA)
   05206 MicroRNAs in cancer
    112926217 (PIK3CA)
   05205 Proteoglycans in cancer
    112926217 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    112926217 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    112926217 (PIK3CA)
   05203 Viral carcinogenesis
    112926217 (PIK3CA)
   05230 Central carbon metabolism in cancer
    112926217 (PIK3CA)
   05231 Choline metabolism in cancer
    112926217 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    112926217 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    112926217 (PIK3CA)
   05212 Pancreatic cancer
    112926217 (PIK3CA)
   05225 Hepatocellular carcinoma
    112926217 (PIK3CA)
   05226 Gastric cancer
    112926217 (PIK3CA)
   05214 Glioma
    112926217 (PIK3CA)
   05221 Acute myeloid leukemia
    112926217 (PIK3CA)
   05220 Chronic myeloid leukemia
    112926217 (PIK3CA)
   05218 Melanoma
    112926217 (PIK3CA)
   05211 Renal cell carcinoma
    112926217 (PIK3CA)
   05215 Prostate cancer
    112926217 (PIK3CA)
   05213 Endometrial cancer
    112926217 (PIK3CA)
   05224 Breast cancer
    112926217 (PIK3CA)
   05222 Small cell lung cancer
    112926217 (PIK3CA)
   05223 Non-small cell lung cancer
    112926217 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    112926217 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    112926217 (PIK3CA)
   05161 Hepatitis B
    112926217 (PIK3CA)
   05160 Hepatitis C
    112926217 (PIK3CA)
   05171 Coronavirus disease - COVID-19
    112926217 (PIK3CA)
   05164 Influenza A
    112926217 (PIK3CA)
   05162 Measles
    112926217 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    112926217 (PIK3CA)
   05163 Human cytomegalovirus infection
    112926217 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    112926217 (PIK3CA)
   05169 Epstein-Barr virus infection
    112926217 (PIK3CA)
   05165 Human papillomavirus infection
    112926217 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    112926217 (PIK3CA)
   05135 Yersinia infection
    112926217 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    112926217 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    112926217 (PIK3CA)
   05142 Chagas disease
    112926217 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    112926217 (PIK3CA)
   05017 Spinocerebellar ataxia
    112926217 (PIK3CA)
   05020 Prion disease
    112926217 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    112926217 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    112926217 (PIK3CA)
   05415 Diabetic cardiomyopathy
    112926217 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    112926217 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    112926217 (PIK3CA)
   04931 Insulin resistance
    112926217 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    112926217 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    112926217 (PIK3CA)
   01524 Platinum drug resistance
    112926217 (PIK3CA)
   01522 Endocrine resistance
    112926217 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:vvp04131]
    112926217 (PIK3CA)
Enzymes [BR:vvp01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     112926217 (PIK3CA)
Membrane trafficking [BR:vvp04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    112926217 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 112926217
NCBI-ProteinID: XP_025862981
UniProt: A0A3Q7T430
Position
Unknown
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRQYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgacgttagaatgcctccgtgaggct
acattaataactataaagcatgaattatttaaagaagcaagaaagtaccctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctttttcaaccctttttaaaa
gtaattgagccagtaggcaaccgagaagaaaagatcctcaatcgagaaattggttttgct
attggcatgccagtgtgtgaatttgatatggttaaagatccagaagtacaggacttccga
agaaatattctgaatgtttgtaaagaagctgtggatcttcgggatcttaattcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcaccagaactgccaaagcac
atatataataaattagataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaaccatgactgtgttccagaacaagta
attgctgaagcaatcagaaaaaaaactagaagtatgttgctatcatctgaacaactaaaa
ctctgtgttttagaatatcagggcaagtatattttaaaagtatgtggatgtgatgaatac
ttccttgaaaaatatcctctaagtcagtataagtacataagaagctgtataatgcttgga
aggatgcccaatttgatgttgatggctaaagaaagcctttactcccaattgccaatggac
tgtttcacaatgccatcttattccagacgcatctccacagctacaccatatatgaatgga
gaaacatctacaaaatctctctgggttataaatagcgcactcagaataaaaatcctttgt
gcaacctatgtaaatgtaaatattcgagacattgacaagatttatgttcgaacaggtatc
tatcatggaggagaacccttatgtgataatgttaacactcaaagagtaccttgttctaat
cccaggtggaatgaatggctaaattacgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgttctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcctggggaaatataaacttgtttgattacacagatactctagtatctggaaaa
atggctctgaatctttggccagtacctcatggattagaagatttgctgaaccctattggt
gttactgggtcaaatccaaataaagaaactccatgcttagagttggagtttgactggttc
agcagtgtggtaaagttcccagatatgtcagtgattgaagagcatgccaactggtcagtg
tctcgggaagcaggatttagttattcccatgcaggactgagtaacagactggctagagac
aacgaattaagagaaaatgataaagaacagctccgagcaatttgtacccgagatcctctc
tctgaaatcactgagcaagagaaagattttctgtggagccacagacaatattgtgtaact
atccctgaaattctacccaaactgcttctgtccgttaaatggaattctagagatgaagta
gctcagatgtactgcttagtaaaagattggcctccaatcaaacctgaacaggctatggag
cttctggactgtaattacccagatcctatggttcgaggttttgctgttcggtgcttggaa
aaatacttaacagatgacaagctttctcagtacctaattcagctagtacaggtcctaaaa
tacgaacaatatttggataacctgcttgtgagatttttactcaagaaagcattgactaat
caaaggattgggcattttttcttttggcacttaaaatctgagatgcacaataaaacggtt
agtcagaggtttggcctgcttttggagtcctattgccgtgcttgtgggatgtatttgaag
cacctaaataggcaagttgaggctatggaaaagctcattaacttaactgacattctcaaa
caagagaagaaggatgaaacacaaaaggtacagatgaagtttttagttgagcaaatgcgg
cgaccagatttcatggatgctctacaaggttttctatctcctctaaatcctgctcatcaa
ctaggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactctttcagaacaatgagatcatc
tttaaaaatggggatgatttacgacaagatatgctaacacttcaaataattcgcattatg
gaaaatatctggcaaaatcaaggtcttgatcttcgaatgttaccttatggttgtctgtca
atcggtgactgtgtgggacttattgaggtggtgcgaaattctcacactattatgcagatt
cagtgcaaaggtggcctgaaaggtgcactgcagttcaacagccacacactacaccagtgg
ctcaaagacaagaacaaaggagaaatatatgatgcagccattgacctgttcacacgttca
tgtgctggatattgtgttgctaccttcattttgggaattggagatcgtcacaatagtaac
atcatggttaaagatgatggacaactgtttcatatagattttggacactttttggaccat
aagaagaaaaaatttggttataaacgggaacgtgtgccatttgttttgacacaagatttc
ttaatagtgattagtaaaggagcccaggaatgcacaaaaacaagagaatttgagaggttt
caggagatgtgttacaaggcttatctagctattcggcagcatgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgatattgca
tacattcgaaagaccctagctttagataaaactgaacaagaggctttggaatatttcatg
aaacagatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
accattaagcagcatgctttgaactga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (105)   
   KEGG PATHWAY (105)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (8)   
   Pfam (8)   
All databases (129)   

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