KEGG ORTHOLOGY: K02620

ORTHOLOGY: K02620

Entry

K02620                      KO

Symbol

TCF7, TCF-1

Name

transcription factor 7

Pathway

map04310

Wnt signaling pathway

map04390

Hippo signaling pathway

map04519

Cadherin signaling

map04520

Adherens junction

map04550

Signaling pathways regulating pluripotency of stem cells

map04916

Melanogenesis

map04934

Cushing syndrome

map04936

Alcoholic liver disease

map05132

Salmonella infection

map05165

Human papillomavirus infection

map05167

Kaposi sarcoma-associated herpesvirus infection

map05200

Pathways in cancer

map05210

Colorectal cancer

map05213

Endometrial cancer

map05215

Prostate cancer

map05216

Thyroid cancer

map05217

Basal cell carcinoma

map05221

Acute myeloid leukemia

map05224

Breast cancer

map05225

Hepatocellular carcinoma

map05226

Gastric cancer

map05412

Arrhythmogenic right ventricular cardiomyopathy

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K02620  TCF7, TCF-1; transcription factor 7
   04390 Hippo signaling pathway
    K02620  TCF7, TCF-1; transcription factor 7
  09133 Signaling molecules and interaction
   04519 Cadherin signaling
    K02620  TCF7, TCF-1; transcription factor 7
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K02620  TCF7, TCF-1; transcription factor 7
   04550 Signaling pathways regulating pluripotency of stem cells
    K02620  TCF7, TCF-1; transcription factor 7
09150 Organismal Systems
  09152 Endocrine system
   04916 Melanogenesis
    K02620  TCF7, TCF-1; transcription factor 7
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K02620  TCF7, TCF-1; transcription factor 7
  09162 Cancer: specific types
   05210 Colorectal cancer
    K02620  TCF7, TCF-1; transcription factor 7
   05225 Hepatocellular carcinoma
    K02620  TCF7, TCF-1; transcription factor 7
   05226 Gastric cancer
    K02620  TCF7, TCF-1; transcription factor 7
   05216 Thyroid cancer
    K02620  TCF7, TCF-1; transcription factor 7
   05221 Acute myeloid leukemia
    K02620  TCF7, TCF-1; transcription factor 7
   05217 Basal cell carcinoma
    K02620  TCF7, TCF-1; transcription factor 7
   05215 Prostate cancer
    K02620  TCF7, TCF-1; transcription factor 7
   05213 Endometrial cancer
    K02620  TCF7, TCF-1; transcription factor 7
   05224 Breast cancer
    K02620  TCF7, TCF-1; transcription factor 7
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    K02620  TCF7, TCF-1; transcription factor 7
   05165 Human papillomavirus infection
    K02620  TCF7, TCF-1; transcription factor 7
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K02620  TCF7, TCF-1; transcription factor 7
  09166 Cardiovascular disease
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K02620  TCF7, TCF-1; transcription factor 7
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K02620  TCF7, TCF-1; transcription factor 7
   04934 Cushing syndrome
    K02620  TCF7, TCF-1; transcription factor 7
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K02620  TCF7, TCF-1; transcription factor 7
Transcription factors [BR:ko03000]
Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   HMG TCF-1
    K02620  TCF7, TCF-1; transcription factor 7

Genes

HSA:	6932(TCF7)

PTR:	745839(TCF7)

PPS:	100980839(TCF7)

GGO:	101149731(TCF7)

PON:	100461234(TCF7)

PPYG:

129036888(TCF7)

NLE:	100595737(TCF7)

HMH:	116471505(TCF7)

SSYN:

129457838(TCF7)

MCC:	710234(TCF7)

MCF:	102142248(TCF7)

MTHB:

126955989

MNI:	105467144(TCF7)

CSAB:

103244543(TCF7)

CATY:

105599768(TCF7)

PANU:

101024089(TCF7)

TGE:	112626303(TCF7)

MLEU:

105531321(TCF7)

RRO:	104659811(TCF7)

RBB:	108529562(TCF7)

TFN:	117065864(TCF7)

PTEH:

111529175(TCF7)

CANG:

105518212(TCF7)

CJC:	100399154(TCF7)

SBQ:	101029076(TCF7)

CIMI:

108307147(TCF7)

ANAN:

105708982(TCF7)

CSYR:

103268315(TCF7)

MMUR:

105869975(TCF7)

LCAT:

123637773(TCF7)

ERUF:

138393034(TCF7)

PCOQ:

105816027(TCF7)

OGA:	100947392(TCF7)

MMU:	21414(Tcf7)

MCAL:

110304948(Tcf7)

MPAH:

110332085(Tcf7)

RNO:	363595(Tcf7)

MCOC:

116077224(Tcf7)

ANU:	117710774(Tcf7)

ASYL:

127695303(Tcf7)

MMIU:

308425880(TCF7)

MUN:	110549622(Tcf7)

CGE:	100757390(Tcf7)

MAUA:

101823261(Tcf7)

PROB:

127219310(Tcf7)

PLEU:

114683055(Tcf7)

PMAV:

102905415(Tcf7)

MORG:

121456269(Tcf7)

MFOT:

126510979

AAMP:

119812304(Tcf7)

CNL:	130877513(Tcf7)

NGI:	103729786(Tcf7)

HGL:	101707882(Tcf7)

CPOC:

100712802(Tcf7)

CCAN:

109689465(Tcf7)

DORD:

105996789(Tcf7)

DSP:	122115432(Tcf7)

DMER:

138807914(Tcf7)

PLOP:

125342174(Tcf7)

NCAR:

124986637

SVUL:

306663695(TCF7)

MMMA:

107148128(Tcf7)

ITI:	101967509(Tcf7)

SCIL:

308641560(TCF7)

MAVE:

308264856(TCF7)

OCU:

100339216

OPI:	101526730(TCF7)

OCZ:	121150630(TCF7)

TUP:	102484318(TCF7)

GVR:	103592399(TCF7)

CFA:	481506(TCF7)

CLUD:

112650538(TCF7)

VVP:	112917059(TCF7)

VLG:	121495797(TCF7)

NPO:	129494859(TCF7)

AML:	100476528(TCF7)

UMR:	103663815(TCF7)

UAH:	113261735(TCF7)

UAR:	123790349(TCF7)

ELK:

111141244

LLV:

125099902

MPUF:

101678117(TCF7)

MNP:	132028516(TCF7)

MLK:	131832039(TCF7)

NVS:	122891699(TCF7)

MMAQ:

308342980(TCF7)

ORO:	101376237(TCF7)

EJU:	114209512(TCF7)

ZCA:	113928407(TCF7)

MLX:	118016638(TCF7)

MANO:

123856449(TCF7)

NSU:	110590995(TCF7)

LWW:	102733939(TCF7)

FCA:	101098768(TCF7)

PYU:	121010702(TCF7)

PCOO:

112861082(TCF7)

PBG:	122487396(TCF7)

PVIV:

125154231(TCF7)

LRUF:

124515627

LGF:	123603765(TCF7)

AJU:

106984911

PTG:	102957988(TCF7)

PPAD:

109250863(TCF7)

PUC:

125935489

PLEZ:

122217706(TCF7)

HHV:	120238500(TCF7)

CCRU:

144235191(TCF7)

BTA:	782690(TCF7)

BOM:	102266633(TCF7)

BIU:	109562015(TCF7)

BJV:	133251270(TCF7)

BBUB:

102408996(TCF7)

BKE:	129632259(TCF7)

BBIS:

104991933(TCF7)

CHX:	102173736(TCF7)

OAS:	101101980(TCF7)

OCAN:

138441292(TCF7)

BTAX:

128050871(TCF7)

CSUM:

138085852(TCF7)

ODA:	120863661(TCF7)

CCAD:

122439921(TCF7)

MREE:

136167824(TCF7)

OVR:	110146932(TCF7)

MBEZ:

129558296(TCF7)

SSC:	100512951(TCF7)

CFR:	102519063(TCF7)

CBAI:

105082121(TCF7)

CDK:	105090254(TCF7)

VPC:	102537589(TCF7)

BACU:

103018264(TCF7)

BMUS:

118892102(TCF7)

LVE:	103074150(TCF7)

OOR:	101289599(TCF7)

LALB:

132517062(TCF7)

GMF:	115860129(TCF7)

DDP:	132423285(TCF7)

SCOO:

307183721(TCF7)

PCRS:

137221670(TCF7)

DLE:	111182442(TCF7)

PCAD:

102992878(TCF7)

PSIU:

116752164(TCF7)

PPHC:

136119963(TCF7)

NASI:

112399678(TCF7)

HAMP:

307052435(TCF7)

ECB:	100072786(TCF7)

EPZ:	103543120(TCF7)

EAI:	106834657(TCF7)

MYB:	102250528(TCF7)

MYD:	102757003(TCF7)

MMYO:

118657631(TCF7)

MLF:	102433022(TCF7)

MDT:	132235660(TCF7)

MYUM:

139010487(TCF7)

PKL:	118711889(TCF7)

EFUS:

103286726(TCF7)

POTS:

308250352(TCF7)

MNA:	107525397(TCF7)

DRO:	112318180(TCF7)

SHON:

118990084(TCF7)

AJM:	119037608(TCF7)

PDIC:

114509934(TCF7)

PHAS:

123811661(TCF7)

MMF:	118643629(TCF7)

PPAM:

129066685(TCF7)

HAI:	109382635(TCF7)

RFQ:	117017071(TCF7)

RHII:

308491467(TCF7)

PALE:

102885788(TCF7)

PGIG:

120581289(TCF7)

PVP:	105293567(TCF7)

RAY:	107506797(TCF7)

MJV:	108406081(TCF7)

TOD:	119243471(TCF7)

SARA:

101540913(TCF7)

SFUM:

130032858(TCF7)

SETR:

126027752(TCF7)

LAV:	100663559(TCF7)

TMU:

101350837

ETF:	101657040(TCF7)

DNM:	101411457(TCF7)

MDO:	100017589(TCF7)

GAS:	123237636(TCF7)

SHR:	100930141(TCF7)

AFZ:

127549825

PCW:	110211723(TCF7)

TVP:	118841366(TCF7)

PBRV:

138164215(TCF7)

MLAO:

141506624(TCF7)

OAA:	100082332(TCF7)

TACU:

119950320(TCF7)

GGA:	395229(TCF7)

PCOC:

116232216(TCF7)

MGP:	100544924(TCF7)

CJO:	107320225(TCF7)

TPAI:

128083971(TCF7)

LMUT:

125700061(TCF7)

NMEL:

110405287(TCF7)

APLA:

101803610(TCF7)

AACU:

137864034(TCF7)

OJA:	118174009(TCF7)

BCLA:

308449165(TCF7)

ACYG:

106032766(TCF7)

ABRC:

308177760(TCF7)

CATA:

118254957(TCF7)

AFUL:

116495052(TCF7)

TGU:	100221008(TCF7)

LSR:	110481074(TCF7)

VMC:	128814774(TCF7)

VCHA:

128795584(TCF7)

AIB:	137483010(TCF7)

SCAN:

103817470(TCF7)

PMOA:

120498623(TCF7)

OTC:	121332492(TCF7)

PRUF:

121361301(TCF7)

ATRC:

139597662(TCF7)

MATE:

118692088(TCF7)

MAEN:

136563065(TCF7)

GFR:	102036749(TCF7)

FAB:	101820491(TCF7)

OMA:	130258940(TCF7)

PHI:	102110510(TCF7)

PMAJ:

107210639(TCF7)

CCAE:

111935599(TCF7)

CCW:	104683724(TCF7)

CBRC:

103614692(TCF7)

ACOE:

138118058(TCF7)

ETL:	114063910(TCF7)

ZAB:	102061135(TCF7)

ZLE:	135453706(TCF7)

ACHL:

103807821(TCF7)

SVG:	106862626(TCF7)

MMEA:

130576571(TCF7)

LCAI:

146431181(TCF7)

HRT:	120759054(TCF7)

SATI:

136367426(TCF7)

CFAI:

136297406(TCF7)

CCIC:

134049701(TCF7)

NNT:

104408659

SHAB:

115615905(TCF7)

POCC:

134173744(TCF7)

FPG:	101919678(TCF7)

FCH:	102058554(TCF7)

FRS:	119151989(TCF7)

ACUN:

113485114(TCF7)

ANOC:

141965028(TCF7)

SURA:

141949686(TCF7)

TALA:

104365223(TCF7)

ACHC:

115334089(TCF7)

HLE:	104839072(TCF7)

AGEN:

126051116

HHAR:

128155054(TCF7)

BBUT:

142044409(TCF7)

GCL:

127021964

CSTI:

104558021(TCF7)

LDI:

104346558

DPUB:

104310141(TCF7)

PPUS:

135185448(TCF7)

IIN:	128973197(TCF7)

AVIT:

104274978(TCF7)

BRHI:

104496022(TCF7)

EGZ:	104133478(TCF7)

NNI:	104012004(TCF7)

PLEC:

309596274(TCF7)

PCAO:

104051181(TCF7)

PARX:

142061606(TCF7)

PADL:

103915850(TCF7)

AFOR:

103904439(TCF7)

CBOR:

142088819(TCF7)

CBOY:

140656670(TCF7)

MAME:

142413440(TCF7)

CLV:	102094656(TCF7)

CNIC:

135993821(TCF7)

NMAY:

308045889(TCF7)

MUI:

104543267

PGUU:

104459059

EHS:	104509814(TCF7)

CUCA:

104060926(TCF7)

PCUR:

138727143(TCF7)

TEO:

104383729

GAME:

129212594(TCF7)

OHA:	104338062(TCF7)

ACAR:

104529243

CEUR:

306721457(TCF7)

CPEA:

104386840(TCF7)

HEK:	139803292(TCF7)

CVF:	104292051(TCF7)

RTD:	128915932(TCF7)

CRID:

134521745(TCF7)

LMIC:

141749677(TCF7)

NARQ:

141470569(TCF7)

AAM:	106487174(TCF7)

AROW:

112964702(TCF7)

NPD:	112952974(TCF7)

TGT:

104572832

DNE:	112994146(TCF7)

ASN:	102383175(TCF7)

AMJ:	102576120(TCF7)

CPOO:

109310088(TCF7)

GGN:	109289961(TCF7)

PSS:	102446665(TCF7)

CIZ:	142021376(TCF7)

CMY:	102943166(TCF7)

CCAY:

125641612(TCF7)

LKP:	140915619(TCF7)

NDS:	141991964(TCF7)

DCC:	119860601(TCF7)

CPIC:

101937399(TCF7)

TST:	117882270(TCF7)

EOB:	135883130(TCF7)

CABI:

116826639(TCF7)

MRV:	120370469(TCF7)

EMQ:	137165306(TCF7)

ACS:	100554608(tcf7)

ASAO:

132768881(TCF7)

PVT:	110079405(TCF7)

SUND:

121922739(TCF7)

PBI:	103067042(TCF7)

PMUR:

107294908(TCF7)

CTIG:

120305514(TCF7)

TSR:	106542632(TCF7)

PGUT:

117656083(TCF7)

PCAE:

139312478(TCF7)

PTEX:

113433747(TCF7)

NSS:	113425241(TCF7)

VKO:	123035726(TCF7)

PMUA:

114591268(TCF7)

PRAF:

128407866(TCF7)

ZVI:	118080356(TCF7)

HCG:	128344517(TCF7)

GJA:	107125983(TCF7)

STOW:

125429787(TCF7)

EMC:	129328416(TCF7)

XLA:	398658(tcf7.S)

XTR:	395061(tcf7)

NPR:	108792126(TCF7)

ACAT:

141132419

PADS:

140322410(TCF7)

BBUF:

121009361(TCF7)

BGAR:

122928266(TCF7)

DTC:	141087913(TCF7)

PCOB:

134933474

PWL:	138245534(TCF7)

MUO:	115475827(TCF7)

GSH:	117351675(TCF7)

DRE:	497649(tcf7)

DAES:

130215103(tcf7)

SRX:	107728269 107742437(tcf7)

SANH:

107661683(tcf7) 107692971

SGH:	107557295 107603263

CCAR:

109048020 109067898

CAUA:

113038246 113063835

CGIB:

127941480 127985702

PTET:

122326316(tcf7)

LROH:

127152460(tcf7)

OMC:	131528515(tcf7)

PPRM:

120473621(tcf7)

RKG:	130077508(tcf7)

SCEP:

307144620(tcf7)

PPHX:

306984048(tcf7)

MAMB:

125253085(tcf7)

CIDE:

127503210

CERY:

137012083(tcf7)

MASI:

127429142 127430673

TROS:

130570657(tcf7)

TDW:	130408426(tcf7)

MANU:

129423732(tcf7)

PDAB:

135776734(tcf7)

IPU:

108278866

IFU:	128621996(tcf7)

PHYP:

113535749

SMEO:

124397852(tcf7)

TFD:	113646522(tcf7)

TVC:	132860516(tcf7)

CGAR:

128507885(tcf7)

NGRA:

132895327(tcf7)

TRN:	134330139(tcf7)

AMEX:

103045826(tcf7)

CMAO:

118820197(tcf7)

EEE:	113578029(tcf7)

CHAR:

105893198(tcf7)

SPIL:

134079903(tcf7)

ASAD:

121708542(tcf7)

TRU:	101076516(tcf7)

TFS:	130537242(tcf7)

NCC:	104960861(tcf7)

TBEN:

117490735(tcf7)

CGOB:

115018803(tcf7)

PGEO:

117458286(tcf7)

GACU:

117540208(tcf7)

EMAC:

134871756(tcf7) 134876197

ELY:	117268549(tcf7)

EFO:	125898881(tcf7)

PLEP:

121952129(tcf7)

SLUC:

116055911(tcf7) 118493643

SVIT:

144528280(tcf7)

ECRA:

117955094(tcf7)

ESP:	116679407 116700180(tcf7)

PFLV:

114566424(tcf7)

PFLT:

120543862(tcf7)

GAT:	120821561(tcf7)

PPUG:

119215586(tcf7)

AFB:	129113131(tcf7)

CLUM:

117742499(tcf7)

PSWI:

130211081(tcf7)

CANA:

137802965(tcf7)

TBU:	306732865(tcf7)

CVE:	137887039 137888280(tcf7)

MSAM:

119895287(tcf7)

SCHU:

122888511(tcf7)

EARM:

139294957(tcf7)

CUD:	121518698(tcf7)

SPUL:

138596056(tcf7)

LMIX:

132958393 132988170(tcf7)

HTC:	141791511(tcf7)

ALAT:

119014087 119031550(tcf7)

ASTR:

137605908(tcf7)

PKLU:

139212925(tcf7)

LCO:

104924428

AMMM:

307260993(tcf7)

MZE:	101469770(tcf7)

ONL:	100710520(tcf7)

OAU:	116315805(tcf7)

OLA:	101162309(tcf7) 101162335 111947120

OML:	112137216 112142310(tcf7)

CSAI:

133460035(tcf7)

XMA:	102221228(tcf7) 111610761

XCO:	114152465(tcf7) 114157642

XHE:	116728111(tcf7) 116732626

PRET:

103460015(tcf7) 103480959

PFOR:

103155760(tcf7)

PLAI:

106935267(tcf7) 106958964

PMEI:

106910477 106916700(tcf7)

GAF:	122820847 122844686(tcf7)

PPRL:

129373420(tcf7)

CVG:	107085909(tcf7)

CTUL:

119797145 119797952(tcf7)

GMU:	124876424(tcf7) 124880979

NFU:	107378492 107386837(tcf7)

KMR:	108238102(tcf7)

ALIM:

106524564(tcf7) 106532889

NWH:	119420469(tcf7)

LTU:	140279969(tcf7)

TBT:	306761713(tcf7)

MCEP:

125020943(tcf7)

AOCE:

111566135(tcf7)

EJA:	138213651(tcf7)

BFRE:

138632072(tcf7)

LCF:

108893669

CSEM:

103394864(tcf7)

POV:	109635808(tcf7)

SSEN:

122776845 122779518(tcf7)

SSOE:

131458177(tcf7) 131468140

HHIP:

117751920 117771739 117772199 117774284(tcf7)

HSP:	118102942 118121778(tcf7)

PPLT:

128429971 128457663(tcf7)

SMAU:

118300136(tcf7)

SDU:	111234495(tcf7)

SLAL:

111659992(tcf7)

XGL:	120803038(tcf7)

HCQ:	109515640 109531063

SSCV:

125982336(tcf7)

SBIA:

133492132(tcf7)

PEE:	133415647(tcf7)

PTAO:

133467680(tcf7) 133471053 133471449 133489017

ENY:	140360708(tcf7)

MALB:

109966812(tcf7)

BSPL:

114869348(tcf7)

SJO:	128371950(tcf7)

SSCO:

133994542(tcf7)

TTY:	137195891(tcf7)

GMH:	115546617(tcf7)

ZFA:	307240381(tcf7)

SASA:

106567524 106603814

STRU:

115148559 115154022

OTW:	112228202 112258094

OMY:	101268913(tcf7) 110537729

OGO:	123999056 124013670

ONE:	115105282 115136184

OKI:	109873359 109892952

OKE:	118389828 118390897

OMM:	135548833(tcf7)

OCLA:

139418039 139420784

SALP:

111979956 112069673

SNH:	120044389(tcf7) 120056778

SFON:

129820815 129868188

CCLU:

121574004 121579234

ELS:

105026693

OEP:	134013922(tcf7)

SFM:	108929645 108934364

PKI:

111839551

AANG:

118236295(tcf7)

AROT:

135262665(tcf7)

CCOG:

133132643(tcf7)

LOC:	102694215(tcf7)

PSPA:

121297274 121324311

ARUT:

117413262 117431552

PSEX:

120542075(tcf7)

LCM:	102350321(TCF7)

CMK:	103183678(tcf7)

CPLA:

122556583(tcf7)

CPUN:

140492018

HOC:	132823436(tcf7)

SCAU:

119965316

LERI:

129701802(tcf7)

HAKA:

140739154(tcf7)

PMRN:

CLEP:

APLN:

VDE:

DFR:

GAE:

MYI:

ATEN:

MCAZ:

MFOO:

HSY:

RES:

CCLM:

Reference

PMID:1569101

Authors

van de Wetering M, Oosterwegel M, Holstege F, Dooyes D, Suijkerbuijk R, Geurts van Kessel A, Clevers H

Title

The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization.

Journal

J Biol Chem 267:8530-6 (1992)

Sequence

[hsa:6932]

Reference

PMID:17143293

Authors

Arce L, Yokoyama NN, Waterman ML

Title

Diversity of LEF/TCF action in development and disease.

Journal

Oncogene 25:7492-504 (2006)
DOI:10.1038/sj.onc.1210056

Reference

PMID:11477404

Authors

Ioannidis V, Beermann F, Clevers H, Held W

Title

The beta-catenin--TCF-1 pathway ensures CD4(+)CD8(+) thymocyte survival.

Journal

Nat Immunol 2:691-7 (2001)
DOI:10.1038/90623

Sequence

[mmu:21414]

All links

Gene (143)   
   MGENES (118)   
   RefGene (19)   
   OC (6)   
All databases (143)   

Download RDF

DBGET integrated database retrieval system