KEGG   ORTHOLOGY: K04363
Entry
K04363                      KO                                     
Symbol
PDGFRA, CD140A
Name
platelet-derived growth factor receptor alpha [EC:2.7.10.1]
Pathway
map01521  EGFR tyrosine kinase inhibitor resistance
map04010  MAPK signaling pathway
map04014  Ras signaling pathway
map04015  Rap1 signaling pathway
map04020  Calcium signaling pathway
map04072  Phospholipase D signaling pathway
map04144  Endocytosis
map04151  PI3K-Akt signaling pathway
map04510  Focal adhesion
map04540  Gap junction
map04630  JAK-STAT signaling pathway
map04810  Regulation of actin cytoskeleton
map05163  Human cytomegalovirus infection
map05200  Pathways in cancer
map05206  MicroRNAs in cancer
map05214  Glioma
map05215  Prostate cancer
map05218  Melanoma
map05230  Central carbon metabolism in cancer
map05231  Choline metabolism in cancer
Disease
H00042  Glioma
H01590  Chronic eosinophilic leukemia
H01591  Gastrotintestinal stromal tumor
H01599  Hypereosinophilic syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04014 Ras signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04015 Rap1 signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04630 JAK-STAT signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04020 Calcium signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04072 Phospholipase D signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04151 PI3K-Akt signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04540 Gap junction
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05206 MicroRNAs in cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05230 Central carbon metabolism in cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05231 Choline metabolism in cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  09162 Cancer: specific types
   05214 Glioma
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05218 Melanoma
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05215 Prostate cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  PDGFR family [OT]
   K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
CD molecules [BR:ko04090]
 Proteins
  K04363  CD140a, PDGFRA; platelet-derived growth factor receptor, alpha polypeptide
Other DBs
GO: 0005018
Genes
HSA: 5156(PDGFRA)
PTR: 461318(PDGFRA)
PPS: 100982337(PDGFRA)
GGO: 101124928(PDGFRA)
PON: 100431735(PDGFRA)
NLE: 100603207(PDGFRA)
MCC: 697002(PDGFRA)
MCF: 102138392(PDGFRA)
CSAB: 103235675(PDGFRA)
CATY: 105592013(PDGFRA)
PANU: 101022081(PDGFRA)
TGE: 112625154(PDGFRA)
RRO: 104658857(PDGFRA)
RBB: 108533750(PDGFRA)
TFN: 117085606(PDGFRA)
PTEH: 111520430(PDGFRA)
CJC: 100412331(PDGFRA)
SBQ: 101040156(PDGFRA)
CSYR: 103249185(PDGFRA)
MMUR: 105867837(PDGFRA)
OGA: 100961338(PDGFRA)
MMU: 18595(Pdgfra)
MCAL: 110295292(Pdgfra)
MPAH: 110331028(Pdgfra)
RNO: 25267(Pdgfra)
MCOC: 116071260(Pdgfra)
MUN: 110558105(Pdgfra)
CGE: 100760258(Pdgfra)
PLEU: 114683759(Pdgfra)
NGI: 103734393(Pdgfra)
HGL: 101697360(Pdgfra)
CPOC: 100726209(Pdgfra)
CCAN: 109685094(Pdgfra) 109702274
DORD: 105980318(Pdgfra)
DSP: 122106871(Pdgfra)
NCAR: 124995024
OCU: 100343006(PDGFRA)
OPI: 101516125(PDGFRA)
TUP: 102488187(PDGFRA)
CFA: 442860(PDGFRA)
VVP: 112933353(PDGFRA)
VLG: 121472891(PDGFRA)
AML: 100464991(PDGFRA)
UMR: 103672737(PDGFRA)
UAH: 113262493(PDGFRA)
UAR: 123804080(PDGFRA)
ELK: 111148924
LLV: 125093724
MPUF: 101684479(PDGFRA)
ORO: 101372359(PDGFRA)
EJU: 114206758(PDGFRA)
ZCA: 113925340(PDGFRA)
MLX: 118010522(PDGFRA)
FCA: 101090765(PDGFRA)
PYU: 121035565(PDGFRA)
PBG: 122478872(PDGFRA)
PTG: 102955481(PDGFRA)
PPAD: 109278988(PDGFRA)
AJU: 106983998(PDGFRA)
HHV: 120222584(PDGFRA)
BTA: 282301(PDGFRA)
BOM: 102282598(PDGFRA)
BIU: 109560475(PDGFRA)
BBUB: 102409620(PDGFRA)
CHX: 102174007(PDGFRA)
OAS: 101106012(PDGFRA)
ODA: 120862113(PDGFRA)
CCAD: 122427991(PDGFRA)
SSC: 100627123(PDGFRA)
CFR: 102512589(PDGFRA)
CBAI: 105077672(PDGFRA)
CDK: 105103397(PDGFRA)
VPC: 102528303(PDGFRA)
BACU: 102998016(PDGFRA)
LVE: 103071473(PDGFRA)
OOR: 101269459(PDGFRA)
DLE: 111169692(PDGFRA)
PCAD: 102994349(PDGFRA)
PSIU: 116754045(PDGFRA)
ECB: 100059815(PDGFRA)
EPZ: 103552305(PDGFRA)
EAI: 106839051(PDGFRA)
MYB: 102255326(PDGFRA)
MYD: 102761943(PDGFRA)
MMYO: 118668634(PDGFRA)
MLF: 102417415(PDGFRA)
MNA: 107532710(PDGFRA)
PKL: 118706667(PDGFRA)
HAI: 109381815(PDGFRA)
DRO: 112316918(PDGFRA)
SHON: 118978642(PDGFRA)
AJM: 119054288(PDGFRA)
PDIC: 114493180(PDGFRA)
PHAS: 123815579(PDGFRA)
MMF: 118624129(PDGFRA)
RFQ: 117022011(PDGFRA)
PALE: 102895362(PDGFRA)
PGIG: 120588066(PDGFRA)
PVP: 105293808(PDGFRA)
RAY: 107499793(PDGFRA)
MJV: 108385741(PDGFRA)
TOD: 119261223(PDGFRA)
SARA: 101539850(PDGFRA)
LAV: 100670735(PDGFRA)
TMU: 101348884
DNM: 101428297(PDGFRA)
MDO: 100013088(PDGFRA)
GAS: 123252399(PDGFRA)
SHR: 100925116(PDGFRA)
PCW: 110200158(PDGFRA)
OAA: 100084432(PDGFRA)
GGA: 395509(PDGFRA)
PCOC: 116225916(PDGFRA)
MGP: 100542010(PDGFRA)
CJO: 107313741(PDGFRA)
NMEL: 110397725(PDGFRA)
APLA: 101797285(PDGFRA)
ACYG: 106030788(PDGFRA)
AFUL: 116488453(PDGFRA)
TGU: 100218386(PDGFRA)
LSR: 110469831(PDGFRA)
SCAN: 103825217(PDGFRA)
PMOA: 120497403(PDGFRA)
OTC: 121334956(PDGFRA)
PRUF: 121349389(PDGFRA)
GFR: 102044274(PDGFRA)
FAB: 101820996(PDGFRA)
PHI: 102113476(PDGFRA)
PMAJ: 107203533(PDGFRA)
CCAE: 111928019(PDGFRA)
CCW: 104690630(PDGFRA)
ETL: 114058301(PDGFRA)
ZAB: 102070900 102075453(PDGFRA)
FPG: 101913531(PDGFRA)
FCH: 102054310(PDGFRA)
CLV: 102087625(PDGFRA)
EGZ: 104129386(PDGFRA)
NNI: 104020776(PDGFRA)
ACUN: 113479434(PDGFRA)
TALA: 104362833(PDGFRA)
PADL: 103926287(PDGFRA)
ACHC: 115341064(PDGFRA)
AAM: 106490172(PDGFRA)
AROW: 112974613(PDGFRA)
NPD: 112942568(PDGFRA)
DNE: 112979490(PDGFRA)
ASN: 102378120(PDGFRA)
AMJ: 102575338(PDGFRA)
CPOO: 109322084(PDGFRA)
GGN: 109303887(PDGFRA)
PSS: 102443708(PDGFRA)
CMY: 102935642(PDGFRA)
CPIC: 101935558(PDGFRA)
TST: 117878037(PDGFRA)
CABI: 116821225(PDGFRA)
MRV: 120407146(PDGFRA)
ACS: 100565834(pdgfra)
PVT: 110078407(PDGFRA)
SUND: 121930753(PDGFRA)
PBI: 103067713(PDGFRA)
PMUR: 107298631(PDGFRA)
PGUT: 117662144(PDGFRA)
VKO: 123016964(PDGFRA)
PMUA: 114604335(PDGFRA)
ZVI: 118083576(PDGFRA)
GJA: 107106036(PDGFRA)
STOW: 125440368(PDGFRA)
XLA: 108706592(pdgfra.S) 380245(pdgfra.L)
XTR: 100124862(pdgfra)
NPR: 108804111(PDGFRA)
RTEM: 120922903(PDGFRA)
BBUF: 120990209(PDGFRA)
BGAR: 122941740(PDGFRA)
DRE: 386856(pdgfra)
SRX: 107718396 107755213
SANH: 107665286 107683957
SGH: 107597438 107601905
CCAR: 109112741
CAUA: 113063319 113078680 113120986
PPRM: 120493762(pdgfra)
MAMB: 125277998(pdgfra)
IPU: 108258040(pdgfra)
PHYP: 113546841(pdgfra)
SMEO: 124377156(pdgfra)
TFD: 113642582(pdgfra)
AMEX: 103044267(pdgfra)
EEE: 113586382(pdgfra)
TRU: 101073543(pdgfra)
TNG: GSTEN00032764G001
LCO: 104919088(pdgfra)
NCC: 104947073(pdgfra)
CGOB: 115006742(pdgfra)
ELY: 117253552(pdgfra)
PLEP: 121940421(pdgfra)
SLUC: 116058814(pdgfra)
ECRA: 117950139(pdgfra)
PFLV: 114561192(pdgfra)
GAT: 120824143(pdgfra)
PPUG: 119216932(pdgfra)
MSAM: 119901064(pdgfra)
CUD: 121512171(pdgfra)
MZE: 101471693(pdgfra)
ONL: 100692594(pdgfra)
OAU: 116331096(pdgfra)
OLA: 100049280(pdgfra)
OML: 112137012(pdgfra)
XMA: 102219876(pdgfra)
XCO: 114151105(pdgfra)
XHE: 116726146(pdgfra)
PRET: 103463840(pdgfra)
PFOR: 103137117(pdgfra)
PLAI: 106963502(pdgfra)
PMEI: 106924185(pdgfra)
GAF: 122838005(pdgfra)
CVG: 107091563(pdgfra)
CTUL: 119780613(pdgfra)
GMU: 124873707(pdgfra)
NFU: 107393382(pdgfra)
KMR: 108243392(pdgfra)
ALIM: 106524096(pdgfra)
NWH: 119430861(pdgfra)
AOCE: 111569607(pdgfra)
CSEM: 103376707(pdgfra)
POV: 109625664(pdgfra)
SSEN: 122780311(pdgfra)
HHIP: 117760248(pdgfra)
LCF: 108879100(pdgfra)
SDU: 111226338(pdgfra)
SLAL: 111644345(pdgfra)
XGL: 120790742(pdgfra)
HCQ: 109532287(pdgfra)
BPEC: 110154688(pdgfra)
MALB: 109962087(pdgfra)
SASA: 106560269 106584117(pdgfra)
OTW: 112249110(pdgfra) 112251129
OMY: 110521671(pdgfra) 110523003
OGO: 123996500 124037857(pdgfra)
ONE: 115108534 115145127(pdgfra)
SALP: 111972315(pdgfra) 111976174
SNH: 120052582(pdgfra) 120054283
ELS: 105011836(pdgfra)
SFM: 108922803(pdgfra)
PKI: 111850064
AANG: 118225723(pdgfra)
LOC: 102682229(pdgfra)
PSPA: 121298148 121320036
ARUT: 117408343 117420605
LCM: 102353753(PDGFRA)
CMK: 103178167(pdgfra)
RTP: 109927411(pdgfra)
CGLO: 123271713
DMK: 116920053
PCHN: 125026672
PCLA: 123762807
DFR: 124497508
NVE: 5507990
EPA: 110240437 110244533
PDAM: 113683455
SPIS: 111322907 111327055 111344410
 » show all
Reference
PMID:2544881
  Authors
Claesson-Welsh L, Eriksson A, Westermark B, Heldin CH
  Title
cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor.
  Journal
Proc Natl Acad Sci U S A 86:4917-21 (1989)
DOI:10.1073/pnas.86.13.4917
  Sequence
[hsa:5156]
Reference
PMID:8188664
  Authors
Vassbotn FS, Havnen OK, Heldin CH, Holmsen H
  Title
Negative feedback regulation of human platelets via autocrine activation of the platelet-derived growth factor alpha-receptor.
  Journal
J Biol Chem 269:13874-9 (1994)
  Sequence
[hsa:5156]

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Ontology (5)   
   KEGG BRITE (4)   
   GO (1)   
Pathway (40)   
   KEGG PATHWAY (40)   
Disease (4)   
   KEGG DISEASE (4)   
Drug (25)   
   KEGG DRUG (25)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (900)   
   KEGG GENES (279)   
   KEGG MGENES (344)   
   RefGene (272)   
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Literature (2)   
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