ORTHOLOGY: K04363 Help
Entry
Symbol
PDGFRA, CD140A
Name
platelet-derived growth factor receptor alpha [EC:
2.7.10.1 ]
Pathway
map01521 EGFR tyrosine kinase inhibitor resistance
map04072 Phospholipase D signaling pathway
map04810 Regulation of actin cytoskeleton
map05163 Human cytomegalovirus infection
map05230 Central carbon metabolism in cancer
Disease
H01590 Chronic eosinophilic leukemia
H01591 Gastrotintestinal stromal tumor
H01599 Hypereosinophilic syndrome
Brite
KEGG Orthology (KO) [BR:ko00001 ]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
K04363 PDGFRA, CD140A; platelet-derived growth factor receptor alpha
04014 Ras signaling pathway
K04363 PDGFRA, CD140A; platelet-derived growth factor receptor alpha
04015 Rap1 signaling pathway
K04363 PDGFRA, CD140A; platelet-derived growth factor receptor alpha
04630 JAK-STAT signaling pathway
K04363 PDGFRA, CD140A; platelet-derived growth factor receptor alpha
04020 Calcium signaling pathway
K04363 PDGFRA, CD140A; platelet-derived growth factor receptor alpha
04072 Phospholipase D signaling pathway
K04363 PDGFRA, CD140A; platelet-derived growth factor receptor alpha
04151 PI3K-Akt signaling pathway
K04363 PDGFRA, CD140A; platelet-derived growth factor receptor alpha
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
K04363 PDGFRA, CD140A; platelet-derived growth factor receptor alpha
09144 Cellular community - eukaryotes
04510 Focal adhesion
K04363 PDGFRA, CD140A; platelet-derived growth factor receptor alpha
04540 Gap junction
K04363 PDGFRA, CD140A; platelet-derived growth factor receptor alpha
09142 Cell motility
04810 Regulation of actin cytoskeleton
K04363 PDGFRA, CD140A; platelet-derived growth factor receptor alpha
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
K04363 PDGFRA, CD140A; platelet-derived growth factor receptor alpha
05206 MicroRNAs in cancer
K04363 PDGFRA, CD140A; platelet-derived growth factor receptor alpha
05230 Central carbon metabolism in cancer
K04363 PDGFRA, CD140A; platelet-derived growth factor receptor alpha
05231 Choline metabolism in cancer
K04363 PDGFRA, CD140A; platelet-derived growth factor receptor alpha
09162 Cancer: specific types
05214 Glioma
K04363 PDGFRA, CD140A; platelet-derived growth factor receptor alpha
05218 Melanoma
K04363 PDGFRA, CD140A; platelet-derived growth factor receptor alpha
05215 Prostate cancer
K04363 PDGFRA, CD140A; platelet-derived growth factor receptor alpha
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
K04363 PDGFRA, CD140A; platelet-derived growth factor receptor alpha
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
K04363 PDGFRA, CD140A; platelet-derived growth factor receptor alpha
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases
K04363 PDGFRA, CD140A; platelet-derived growth factor receptor alpha
09183 Protein families: signaling and cellular processes
04090 CD molecules
K04363 PDGFRA, CD140A; platelet-derived growth factor receptor alpha
Enzymes [BR:ko01000 ]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.1 receptor protein-tyrosine kinase
K04363 PDGFRA, CD140A; platelet-derived growth factor receptor alpha
Protein kinases [BR:ko01001 ]
Receptor tyrosine kinases (RTK)
PDGFR family [OT]
K04363 PDGFRA, CD140A; platelet-derived growth factor receptor alpha
CD molecules [BR:ko04090 ]
Proteins
K04363 CD140a, PDGFRA; platelet-derived growth factor receptor, alpha polypeptide
BRITE hierarchy
Other DBs
Genes
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Taxonomy UniProt
Reference
Authors
Claesson-Welsh L, Eriksson A, Westermark B, Heldin CH
Title
cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor.
Journal
Sequence
Reference
Authors
Vassbotn FS, Havnen OK, Heldin CH, Holmsen H
Title
Negative feedback regulation of human platelets via autocrine activation of the platelet-derived growth factor alpha-receptor.
Journal
J Biol Chem 269:13874-9 (1994)
Sequence