KEGG   NETWORK: N00285
Entry
N00285                      Network                                
Name
AREG-overexpression to PI3K signaling pathway
Definition
AREG* -> EGFR -> PI3K -> PIP3 -> AKT -> S6K
  Expanded
374v1 -> 1956 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -> (6198,6199)
Class
nt06260 Colorectal cancer
nt06214 PI3K signaling (cancer)
Type
Variant
Pathway
hsa05210  Colorectal cancer
Disease
H00020  Colorectal cancer
Gene
374  AREG; amphiregulin
1956  EGFR; epidermal growth factor receptor
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
6198  RPS6KB1; ribosomal protein S6 kinase B1
6199  RPS6KB2; ribosomal protein S6 kinase B2
Variant
374v1 (AREG*)  AREG overexpression
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:20554751
  Authors
Dasari A, Messersmith WA
  Title
New strategies in colorectal cancer: biomarkers of response to epidermal growth factor receptor monoclonal antibodies and potential therapeutic targets in phosphoinositide 3-kinase and mitogen-activated protein kinase pathways.
  Journal
Clin Cancer Res 16:3811-8 (2010)
DOI:10.1158/1078-0432.CCR-09-2283
Reference
PMID:26149458
  Authors
Hutchinson RA, Adams RA, McArt DG, Salto-Tellez M, Jasani B, Hamilton PW
  Title
Epidermal growth factor receptor immunohistochemistry: new opportunities in metastatic colorectal cancer.
  Journal
J Transl Med 13:217 (2015)
DOI:10.1186/s12967-015-0531-z
Reference
PMID:21356164
  Authors
Yarom N, Jonker DJ
  Title
The role of the epidermal growth factor receptor in the mechanism and treatment of colorectal cancer.
  Journal
Discov Med 11:95-105 (2011)

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