| Entry |
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| Name |
NRG-ERBB2/ERBB3 pathway (RAS-ERK signaling)
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| Definition |
NRG -- ERBB3 -- ERBB2 -> (SHC+GRB2) -> SOS -> RAS -> RAF -> MEK -> ERK |
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| Expanded |
(3084,9542) -- 2065 -- 2064 -> (6464+2885) -> (6654,6655) -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595) |
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| Class |
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| Type |
Reference
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| Pathway |
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| Gene |
| 2065 | ERBB3; erb-b2 receptor tyrosine kinase 3 |
| 2064 | ERBB2; erb-b2 receptor tyrosine kinase 2 |
| 6464 | SHC1; SHC adaptor protein 1 |
| 2885 | GRB2; growth factor receptor bound protein 2 |
| 6654 | SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 |
| 6655 | SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 |
| 3265 | HRAS; HRas proto-oncogene, GTPase |
| 3845 | KRAS; KRAS proto-oncogene, GTPase |
| 4893 | NRAS; NRAS proto-oncogene, GTPase |
| 369 | ARAF; A-Raf proto-oncogene, serine/threonine kinase |
| 673 | BRAF; B-Raf proto-oncogene, serine/threonine kinase |
| 5894 | RAF1; Raf-1 proto-oncogene, serine/threonine kinase |
| 5604 | MAP2K1; mitogen-activated protein kinase kinase 1 |
| 5605 | MAP2K2; mitogen-activated protein kinase kinase 2 |
| 5594 | MAPK1; mitogen-activated protein kinase 1 |
| 5595 | MAPK3; mitogen-activated protein kinase 3 |
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| Reference |
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| Authors |
Black LE, Longo JF, Carroll SL |
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| Title |
Mechanisms of Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) Action in Human Neoplasia. |
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| Journal |
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| Reference |
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| Authors |
Zhang C, Mei W, Zeng C |
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| Title |
Oncogenic Neuregulin 1 gene (NRG1) fusions in cancer: A potential new therapeutic opportunities. |
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| Journal |
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| Reference |
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| Authors |
Kucharczyk T, Nicos M, Kucharczyk M, Kalinka E |
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| Title |
NRG1 Gene Fusions-What Promise Remains Behind These Rare Genetic Alterations? A Comprehensive Review of Biology, Diagnostic Approaches, and Clinical Implications. |
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| Journal |
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