KEGG   Canis lupus familiaris (dog): 403693
Entry
403693            CDS       T01007                                 
Symbol
MDM2
Name
(RefSeq) E3 ubiquitin-protein ligase Mdm2
  KO
K06643  E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27]
Organism
cfa  Canis lupus familiaris (dog)
Pathway
cfa01522  Endocrine resistance
cfa01524  Platinum drug resistance
cfa04068  FoxO signaling pathway
cfa04110  Cell cycle
cfa04115  p53 signaling pathway
cfa04120  Ubiquitin mediated proteolysis
cfa04144  Endocytosis
cfa04151  PI3K-Akt signaling pathway
cfa04218  Cellular senescence
cfa04625  C-type lectin receptor signaling pathway
cfa04919  Thyroid hormone signaling pathway
cfa05163  Human cytomegalovirus infection
cfa05165  Human papillomavirus infection
cfa05169  Epstein-Barr virus infection
cfa05200  Pathways in cancer
cfa05202  Transcriptional misregulation in cancer
cfa05203  Viral carcinogenesis
cfa05205  Proteoglycans in cancer
cfa05206  MicroRNAs in cancer
cfa05214  Glioma
cfa05215  Prostate cancer
cfa05218  Melanoma
cfa05219  Bladder cancer
cfa05220  Chronic myeloid leukemia
Brite
KEGG Orthology (KO) [BR:cfa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    403693 (MDM2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    403693 (MDM2)
   04151 PI3K-Akt signaling pathway
    403693 (MDM2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    403693 (MDM2)
  09143 Cell growth and death
   04110 Cell cycle
    403693 (MDM2)
   04115 p53 signaling pathway
    403693 (MDM2)
   04218 Cellular senescence
    403693 (MDM2)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    403693 (MDM2)
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    403693 (MDM2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    403693 (MDM2)
   05202 Transcriptional misregulation in cancer
    403693 (MDM2)
   05206 MicroRNAs in cancer
    403693 (MDM2)
   05205 Proteoglycans in cancer
    403693 (MDM2)
   05203 Viral carcinogenesis
    403693 (MDM2)
  09162 Cancer: specific types
   05214 Glioma
    403693 (MDM2)
   05220 Chronic myeloid leukemia
    403693 (MDM2)
   05218 Melanoma
    403693 (MDM2)
   05219 Bladder cancer
    403693 (MDM2)
   05215 Prostate cancer
    403693 (MDM2)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    403693 (MDM2)
   05169 Epstein-Barr virus infection
    403693 (MDM2)
   05165 Human papillomavirus infection
    403693 (MDM2)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    403693 (MDM2)
   01522 Endocrine resistance
    403693 (MDM2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:cfa04131]
    403693 (MDM2)
   04121 Ubiquitin system [BR:cfa04121]
    403693 (MDM2)
Enzymes [BR:cfa01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     403693 (MDM2)
Membrane trafficking [BR:cfa04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Ubiquitin E3 ligases
    403693 (MDM2)
Ubiquitin system [BR:cfa04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   MDM2/MDM4 proteins
    403693 (MDM2)
SSDB
Motif
Pfam: zf-C3HC4_3 Zn_ribbon_RanBP SWIB zf-RING_2 zf-FPG_IleRS SWIB_eIF2D
Other DBs
NCBI-GeneID: 403693
NCBI-ProteinID: NP_001003103
Ensembl: ENSCAFG00000000418
VGNC: 43106
UniProt: P56950
Position
10:10869091..10894634
AA seq 487 aa
MCNTNMSVSTDGAVSTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVIFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQHEPSDSGT
SVSENSCHREGGSDQKDPVQELQEEKPSSSDLISRPSTSSRRRTISETEEHADDLPGERQ
RKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDHHS
VSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYRVTVYQAGESDTDSFEEDPEISLA
DYWKCTSCNEMNPPLPPHCNRCWALRENWLPEDKGKIPEKATPENSTQVEEGFDVPDCKK
AAASDSRESCAEEIDDKITQASHSQESEDYSQPSTSNSIIYSSQEDVKEFEREETQDKEE
IVESSFPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQM
IVLTYFP
NT seq 1464 nt   +upstreamnt  +downstreamnt
atgtgcaataccaacatgtctgtgtctactgatggtgctgtaagcacctcacagattcca
gcttcggagcaggagaccctggttagaccaaagccattgcttttgaagttgttgaagtct
gtaggtgcacaaaaagacacttatactatgaaagaggtgatattttatcttggccagtat
attatgactaaacgattgtatgatgagaagcaacagcatattgtgtattgttccaatgat
cttctaggagatttgtttggagtgccaagcttctctgtgaaagagcacaggaaaatatat
acaatgatctacagaaacttggtagtagtcaatcagcatgaaccatcagattcaggcaca
tctgtgagtgaaaatagctgtcaccgtgaaggtgggagtgatcaaaaggaccctgtgcaa
gagttgcaggaagagaaaccttcatcttcagatttgatttctagaccatctacctcatct
agaaggagaacaattagtgagacagaagaacatgcagatgatttacctggtgaacggcag
agaaagcgccacaaatctgatagtatttccctttcctttgatgaaagccttgctctgtgt
gtaataagggagatatgttgtgaaagaagcagtagcagtgagtcaacagggacgccatca
aatccggatcttgatgctggtgtaagtgaacattcaggtgattggttggatcaccattca
gtttcagatcaattcagtgtagaatttgaagttgagtctcttgattcagaagattatagc
cttagtgaagaaggacaagaactctcagatgaagatgatgaggtgtatcgagtaactgtg
tatcaggcaggggagagtgatacagattcatttgaagaagatcctgaaatttccttagct
gactattggaagtgtacctcatgcaatgaaatgaatcctcctcttccacctcattgcaat
agatgttgggcccttcgtgagaattggcttcctgaagataaagggaaaatccctgagaaa
gccacaccagaaaactcaacacaagtagaagagggctttgatgtccctgattgtaaaaaa
gctgcagccagtgattccagagaatcatgtgctgaggaaattgatgataaaatcacacaa
gcctcccactcccaagaaagtgaggactattctcagccatcaacttctaacagcatcatt
tatagcagccaagaagatgtcaaagaatttgagagagaagaaacacaagacaaagaagaa
attgtggaatctagttttccccttaatgccattgaaccttgtgtgatttgccaaggtcga
cctaaaaacggttgcattgttcatggcaaaacaggacatcttatggcatgcttcacgtgt
gcaaagaagctaaagaaaaggaataagccctgtccagtatgtagacaaccaattcaaatg
attgtgctaacttatttcccctag

  All links  
Gene (16)   
   RefGene (11)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   VGNC (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (13)   
   RefSeq(nuc) (5)   
   GenBank (4)   
   EMBL (4)   
Protein domain (6)   
   Pfam (6)   
All databases (42)   

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