#=GF ID SWIB_eIF2D
#=GF AC PF26291.1
#=GF DE eIF2D, SWIB domain
#=GF AU Andreeva A;0000-0002-0450-0091
#=GF SE Andreeva A
#=GF GA 28.00 28.00;
#=GF TC 28.00 28.00;
#=GF NC 27.90 27.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 --cpu 8 -Z 90746521 HMM pfamseq
#=GF TP Domain
#=GF CL CL0906
#=GF RN [1]
#=GF RM 28732596
#=GF RT Structural and Functional Insights into Human Re-initiation
#=GF RT Complexes.
#=GF RA Weisser M, Schafer T, Leibundgut M, Bohringer D, Aylett CHS, Ban
#=GF RA N;
#=GF RL Mol Cell. 2017;67:447-456.
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This SWIB domain is found in the eukaryotic translation
#=GF CC reinitiation factor 2D (elF2D). This domain is unique to elF2D
#=GF CC and is not observed in other translation initiation factors.
#=GF CC This domain along with the PUA domain of elF2D stabilises the
#=GF CC initiator tRNA conformation. The SWIB domain laterally binds to
#=GF CC the acceptor stem via a patch of positively charged amino acids
#=GF CC [1].
#=GF SQ 2230
#=GS A0A453RJK8_AEGTS/334-417 AC A0A453RJK8.1
#=GS A0A2K6GY68_PROCO/386-468 AC A0A2K6GY68.1
#=GS A0A074W0F9_AURM1/441-528 AC A0A074W0F9.1
#=GS A0A7L1E8W0_OENON/379-461 AC A0A7L1E8W0.1
#=GS A0A4V3XIJ5_9APHY/345-426 AC A0A4V3XIJ5.1
#=GS A0A2I3GK44_NOMLE/261-343 AC A0A2I3GK44.1
#=GS A0AAD3CWD8_9STRA/452-530 AC A0AAD3CWD8.1
#=GS A0A9P0AJ30_BEMTA/370-452 AC A0A9P0AJ30.1
#=GS A0AAD9G651_9STRA/390-467 AC A0AAD9G651.1
#=GS A0A194Q7J5_PAPXU/398-471 AC A0A194Q7J5.1
#=GS A0A8I6AJ85_RAT/372-454 AC A0A8I6AJ85.1
#=GS A0A8C1RWD6_CYPCA/372-409 AC A0A8C1RWD6.1
#=GS A0A9Y3RJ92_9CICH/309-391 AC A0A9Y3RJ92.1
#=GS A0A8C0EW92_BUBBB/378-460 AC A0A8C0EW92.1
#=GS A0A151RMC0_CAJCA/406-490 AC A0A151RMC0.1
#=GS A7RTR9_NEMVE/421-501 AC A7RTR9.1
#=GS A0A8D0L6E1_SPHPU/396-478 AC A0A8D0L6E1.1
#=GS A0A6A6UIQ6_9PEZI/438-523 AC A0A6A6UIQ6.1
#=GS A0A8C1RWA2_CYPCA/393-431 AC A0A8C1RWA2.1
#=GS A0A9P4W7K1_CURKU/423-507 AC A0A9P4W7K1.1
#=GS A0A8C2X2F7_CYCLU/380-462 AC A0A8C2X2F7.1
#=GS A0A6P7G8M2_DIAVI/389-463 AC A0A6P7G8M2.1
#=GS A0A177WV27_BATDL/454-537 AC A0A177WV27.1
#=GS A0A8C2X1H6_CYCLU/363-442 AC A0A8C2X1H6.1
#=GS A0A6J5Y4P4_PRUAR/417-491 AC A0A6J5Y4P4.1
#=GS A0A815FGK3_9BILA/395-461 AC A0A815FGK3.1
#=GS A0A8C9CN48_PHOSS/261-343 AC A0A8C9CN48.1
#=GS A0A016VSY1_9BILA/286-361 AC A0A016VSY1.1
#=GS A0A6Q2ZG82_ESOLU/339-415 AC A0A6Q2ZG82.2
#=GS A0A1S3FAH5_DIPOR/386-468 AC A0A1S3FAH5.1
#=GS A0A7K6UR36_9PASS/382-464 AC A0A7K6UR36.1
#=GS A0A3Q0DYR7_CARSF/261-343 AC A0A3Q0DYR7.1
#=GS A0A9J6EPC5_RHIMP/377-452 AC A0A9J6EPC5.1
#=GS A0A9D4HRS1_DREPO/305-386 AC A0A9D4HRS1.1
#=GS A0A9P7W4M5_9AGAR/399-490 AC A0A9P7W4M5.1
#=GS A0A7K6Q4D6_9CORV/382-464 AC A0A7K6Q4D6.1
#=GS A0A7K8CWZ7_9CORV/400-482 AC A0A7K8CWZ7.1
#=GS A0AAE1H0P3_9NEOP/412-493 AC A0AAE1H0P3.1
#=GS A0A7K7R176_POEAT/382-464 AC A0A7K7R176.1
#=GS A0A1V8SKI6_9PEZI/775-857 AC A0A1V8SKI6.1
#=GS A0A409XU58_PSICY/404-498 AC A0A409XU58.1
#=GS A0A453RJH6_AEGTS/207-290 AC A0A453RJH6.1
#=GS G7JKR1_MEDTR/405-488 AC G7JKR1.1
#=GS A0AA36CW99_9BILA/347-423 AC A0AA36CW99.1
#=GS A0A2K5QQV7_CEBIM/385-467 AC A0A2K5QQV7.1
#=GS A0A316ZI98_9BASI/456-537 AC A0A316ZI98.1
#=GS A0A6A5UB26_9PLEO/441-526 AC A0A6A5UB26.1
#=GS A0A016VTQ0_9BILA/318-393 AC A0A016VTQ0.1
#=GS A0A8C8CLM0_ONCTS/328-410 AC A0A8C8CLM0.1
#=GS A0A1V8U656_9PEZI/775-857 AC A0A1V8U656.1
#=GS A0A4Z2B5X4_9TELE/380-462 AC A0A4Z2B5X4.1
#=GS A0AAJ0DQX6_9PEZI/446-530 AC A0AAJ0DQX6.1
#=GS A0A0D9RR06_CHLSB/385-467 AC A0A0D9RR06.1
#=GS A0A484M6S1_9ASTE/25-92 AC A0A484M6S1.1
#=GS A0A8C4F5B8_DICLA/354-436 AC A0A8C4F5B8.2
#=GS A0A8J6FD72_ELECQ/280-362 AC A0A8J6FD72.1
#=GS M5VKY6_PRUPE/417-491 AC M5VKY6.1
#=GS A0AA39V4T8_ACESA/417-486 AC A0AA39V4T8.1
#=GS A0AAD4IIA7_9PLEO/471-556 AC A0AAD4IIA7.1
#=GS A0A9P0BSK4_CHRIL/412-488 AC A0A9P0BSK4.1
#=GS A0AAE1ZII0_SCHME/372-444 AC A0AAE1ZII0.1
#=GS A0A8C3BX81_CAIMO/400-482 AC A0A8C3BX81.1
#=GS A0A8H4FM50_COLGL/427-510 AC A0A8H4FM50.1
#=GS A0A8C6CX46_MOSMO/381-463 AC A0A8C6CX46.1
#=GS A0A091RRA0_NESNO/381-463 AC A0A091RRA0.1
#=GS H0X226_OTOGA/386-468 AC H0X226.1
#=GS A0AA36HD82_CYLNA/371-446 AC A0AA36HD82.1
#=GS A0A3Q1HTV0_ANATE/395-477 AC A0A3Q1HTV0.2
#=GS A0A167W8P4_9AGAM/252-332 AC A0A167W8P4.1
#=GS A0A9D4AW13_9SAUR/400-482 AC A0A9D4AW13.1
#=GS A0A1A0H8I9_9ASCO/365-441 AC A0A1A0H8I9.1
#=GS A0A5B7DIB6_PORTR/344-391 AC A0A5B7DIB6.1
#=GS A0A7K9KCQ1_9PASE/377-459 AC A0A7K9KCQ1.1
#=GS A0A671XDP3_SPAAU/371-427 AC A0A671XDP3.1
#=GS A0A7K5GKE6_9AVES/382-464 AC A0A7K5GKE6.1
#=GS B9SBV7_RICCO/421-499 AC B9SBV7.1
#=GS A0A6P4ZEH5_BRABE/409-489 AC A0A6P4ZEH5.1
#=GS A0A8T1WRD7_9STRA/396-476 AC A0A8T1WRD7.1
#=GS A0A2P6PKJ4_ROSCH/188-256 AC A0A2P6PKJ4.1
#=GS A0A7K5YBR1_9AVES/382-464 AC A0A7K5YBR1.1
#=GS A0A8I6AFL6_RAT/333-404 AC A0A8I6AFL6.1
#=GS A0A4C1ZU97_EUMVA/440-509 AC A0A4C1ZU97.1
#=GS A0A2A2LY91_9BILA/413-489 AC A0A2A2LY91.1
#=GS A0A653BFR3_CALMS/381-457 AC A0A653BFR3.1
#=GS G3HAZ8_CRIGR/392-474 AC G3HAZ8.1
#=GS A0A9P4QJ06_9PLEO/438-523 AC A0A9P4QJ06.1
#=GS A0A7L1W5C9_9PASS/395-477 AC A0A7L1W5C9.1
#=GS A0AAI9SWP4_9ASCO/403-479 AC A0AAI9SWP4.1
#=GS A0A8H6TMP5_MYCCL/396-485 AC A0A8H6TMP5.1
#=GS A0A7K6YMK8_ALCTO/382-464 AC A0A7K6YMK8.1
#=GS A0A8T2UQ69_CERRI/305-381 AC A0A8T2UQ69.1
#=GS A0A0C2YLL9_HEBCY/408-500 AC A0A0C2YLL9.1
#=GS A0A167EC11_9ASCO/363-442 AC A0A167EC11.1
#=GS K5X0E5_AGABU/436-499 AC K5X0E5.1
#=GS A0A9E7F5Y6_9LILI/415-500 AC A0A9E7F5Y6.1
#=GS A0A8C9E6R1_PHOSS/385-467 AC A0A8C9E6R1.1
#=GS A0A9P3H3T9_9FUNG/427-507 AC A0A9P3H3T9.1
#=GS A0A482X9B7_LAOST/384-460 AC A0A482X9B7.1
#=GS A0A1Y2EPX0_9BASI/381-462 AC A0A1Y2EPX0.1
#=GS A0A1V2L468_CYBFA/356-433 AC A0A1V2L468.1
#=GS A0A3N4K2K8_9PEZI/442-516 AC A0A3N4K2K8.1
#=GS A0A9P7K4Z8_9AGAR/409-501 AC A0A9P7K4Z8.1
#=GS A0A8J9YZ23_BRALA/412-492 AC A0A8J9YZ23.1
#=GS A0A7K7C5Z0_APHCE/382-464 AC A0A7K7C5Z0.1
#=GS A0A9E7F4Z7_9LILI/476-561 AC A0A9E7F4Z7.1
#=GS A0A6A4VLM3_AMPAM/341-422 AC A0A6A4VLM3.1
#=GS A0A7K8FR68_9CORV/400-482 AC A0A7K8FR68.1
#=GS A0A2T7F7R7_9POAL/400-485 AC A0A2T7F7R7.1
#=GS A0A074RY23_9AGAM/391-470 AC A0A074RY23.1
#=GS A0A9X6NGQ7_HYPEX/404-490 AC A0A9X6NGQ7.1
#=GS J6ECH0_SACK1/361-444 AC J6ECH0.1
#=GS A0A7L3TJR0_RISTR/382-464 AC A0A7L3TJR0.1
#=GS A0A9Q5HTV4_SANBA/453-528 AC A0A9Q5HTV4.1
#=GS A0A9W8GRT0_9FUNG/45-128 AC A0A9W8GRT0.1
#=GS A0A669D4U9_ORENI/382-432 AC A0A669D4U9.1
#=GS A0A0D2R4T7_GOSRA/415-492 AC A0A0D2R4T7.1
#=GS A0AAD4PC88_PERFH/410-487 AC A0AAD4PC88.1
#=GS A0A6A5RGY4_9PLEO/430-515 AC A0A6A5RGY4.1
#=GS N1PV11_DOTSN/434-520 AC N1PV11.1
#=GS A0A9P6LG29_9PEZI/437-520 AC A0A9P6LG29.1
#=GS A0A6A6PFX6_9PEZI/440-523 AC A0A6A6PFX6.1
#=GS A0A4W2CJJ5_BOBOX/261-343 AC A0A4W2CJJ5.1
#=GS A0A852IP45_9PICI/376-458 AC A0A852IP45.1
#=GS A0A6I8NCR6_ORNAN/258-340 AC A0A6I8NCR6.1
#=GS A0A7K9PNE5_9CORV/382-464 AC A0A7K9PNE5.1
#=GS EIF2D_RAT/372-454 AC Q5PPG7.1
#=GS A0A1Y2D378_9FUNG/427-509 AC A0A1Y2D378.1
#=GS A0A7L3CGA6_PELUR/382-464 AC A0A7L3CGA6.1
#=GS A0A2U4CRI4_TURTR/273-355 AC A0A2U4CRI4.2
#=GS A0A7K9HZ23_9PICI/401-479 AC A0A7K9HZ23.1
#=GS A0A8J4KYG6_APTPA/382-464 AC A0A8J4KYG6.1
#=GS A0A7L2CUT9_CATFU/399-481 AC A0A7L2CUT9.1
#=GS A0A2K5QQX0_CEBIM/261-343 AC A0A2K5QQX0.1
#=GS A0A1S3B2E6_CUCME/350-420 AC A0A1S3B2E6.1
#=GS T0KVH1_COLGC/427-510 AC T0KVH1.1
#=GS A0A8T2WHV9_POPDE/65-134 AC A0A8T2WHV9.1
#=GS A0A139WNU2_TRICA/350-426 AC A0A139WNU2.1
#=GS A0A9W8F3Y0_9FUNG/421-504 AC A0A9W8F3Y0.1
#=GS A0A9C6TEN3_ARADU/419-488 AC A0A9C6TEN3.1
#=GS A0A6P3QYK4_PTEVA/255-337 AC A0A6P3QYK4.1
#=GS A0A8J5HPU5_ZINOF/514-596 AC A0A8J5HPU5.1
#=GS A0A9Q1HW13_CONCO/410-492 AC A0A9Q1HW13.1
#=GS A0A7L3RQ99_CEPGR/382-464 AC A0A7L3RQ99.1
#=GS A0A340YH33_LIPVE/261-343 AC A0A340YH33.1
#=GS A0A1D6HAM6_MAIZE/405-490 AC A0A1D6HAM6.1
#=GS H3AJI9_LATCH/397-479 AC H3AJI9.1
#=GS A0AAQ4QJ63_GASAC/392-474 AC A0AAQ4QJ63.1
#=GS A0A8X6U187_NEPPI/387-467 AC A0A8X6U187.1
#=GS A0A673A4T1_9TELE/387-469 AC A0A673A4T1.1
#=GS A0A8T0G1P2_ARGBR/353-433 AC A0A8T0G1P2.1
#=GS A0A2K5LGF7_CERAT/261-343 AC A0A2K5LGF7.1
#=GS A0A8C5AVH6_GADMO/395-477 AC A0A8C5AVH6.2
#=GS I2H9C3_HENB6/364-446 AC I2H9C3.1
#=GS Q7SXY6_DANRE/391-473 AC Q7SXY6.1
#=GS A0A2G2VMY7_CAPBA/415-499 AC A0A2G2VMY7.1
#=GS A0A2H3EMG9_ARMGA/397-486 AC A0A2H3EMG9.1
#=GS A0A4Y7IX61_PAPSO/417-501 AC A0A4Y7IX61.1
#=GS G5BP24_HETGA/377-459 AC G5BP24.1
#=GS A0A0E0NGE8_ORYRU/391-474 AC A0A0E0NGE8.1
#=GS A0A8B7UVE9_CASCN/343-414 AC A0A8B7UVE9.1
#=GS A0A0W0F324_MONRR/416-487 AC A0A0W0F324.1
#=GS A0A1X2HAK9_SYNRA/390-470 AC A0A1X2HAK9.1
#=GS A0A3Q3XFM1_MOLML/390-472 AC A0A3Q3XFM1.1
#=GS A0A850VX20_FREMA/382-464 AC A0A850VX20.1
#=GS A0A671XDN3_SPAAU/310-392 AC A0A671XDN3.1
#=GS A0A3P7J0D4_STRVU/118-157 AC A0A3P7J0D4.1
#=GS A0A7K6IX76_9CORV/391-473 AC A0A7K6IX76.1
#=GS A0AA88QQK9_9ASTE/547-615 AC A0AA88QQK9.1
#=GS A0A4Z2DRQ8_SCHJA/268-333 AC A0A4Z2DRQ8.1
#=GS A0A3Q3AZ33_KRYMA/397-479 AC A0A3Q3AZ33.1
#=GS A0A3B6TI72_WHEAT/401-484 AC A0A3B6TI72.1
#=GS A0A7K6LPQ3_9CORV/382-464 AC A0A7K6LPQ3.1
#=GS U4TZQ4_DENPD/367-444 AC U4TZQ4.1
#=GS A0A7L3I023_9PASS/379-461 AC A0A7L3I023.1
#=GS A0AAD7RCD3_9TELE/373-455 AC A0AAD7RCD3.1
#=GS A0A2G9H286_9LAMI/416-501 AC A0A2G9H286.1
#=GS A0A7K9VPW7_ANSSE/399-481 AC A0A7K9VPW7.1
#=GS A0A9W8EJ52_9FUNG/433-516 AC A0A9W8EJ52.1
#=GS A0A4E0RXG5_FASHE/405-465 AC A0A4E0RXG5.1
#=GS A0A9P5YZD9_9AGAR/400-469 AC A0A9P5YZD9.1
#=GS A0A091H7K5_BUCRH/373-455 AC A0A091H7K5.1
#=GS A0A8B7ATX6_ORYAF/386-468 AC A0A8B7ATX6.1
#=GS A0AAD5QXW2_PARTN/456-527 AC A0AAD5QXW2.1
#=GS A0A9W7TJI3_TRIRA/396-478 AC A0A9W7TJI3.1
#=GS A0A6A6GUC5_VIRVR/442-527 AC A0A6A6GUC5.1
#=GS A0AAD1U279_EUPCR/454-525 AC A0AAD1U279.1
#=GS A0A087SZI1_STEMI/402-481 AC A0A087SZI1.1
#=GS W2TKK8_NECAM/312-386 AC W2TKK8.1
#=GS A0A7J7SQ61_MYOMY/386-468 AC A0A7J7SQ61.1
#=GS A0A3B1J275_ASTMX/399-481 AC A0A3B1J275.1
#=GS A0A183DTW4_9BILA/139-212 AC A0A183DTW4.1
#=GS A0AAD6TU21_9AGAR/398-484 AC A0AAD6TU21.1
#=GS A0A9W4RJ13_9PEZI/427-510 AC A0A9W4RJ13.1
#=GS A0A9P4H124_9PLEO/443-526 AC A0A9P4H124.1
#=GS A0A8C5V6J7_MICMU/386-468 AC A0A8C5V6J7.1
#=GS A0A093PWN1_9PASS/386-468 AC A0A093PWN1.1
#=GS A0A8S1DBX5_9INSE/383-465 AC A0A8S1DBX5.1
#=GS A0A8D0GUD5_SPHPU/346-428 AC A0A8D0GUD5.1
#=GS A0AA38M2L1_9CUCU/375-451 AC A0AA38M2L1.1
#=GS A0A218XLG0_PUNGR/414-498 AC A0A218XLG0.1
#=GS A0A0K6G4B9_9AGAM/395-474 AC A0A0K6G4B9.1
#=GS A0A667Y3E2_9TELE/406-488 AC A0A667Y3E2.1
#=GS A0AAD6Q2H8_9ROSI/90-175 AC A0AAD6Q2H8.1
#=GS A0A8C3V9S0_CATUS/396-478 AC A0A8C3V9S0.1
#=GS A0A9P6M181_MORAP/432-512 AC A0A9P6M181.1
#=GS A0A4V1ADY4_9ASCO/369-445 AC A0A4V1ADY4.1
#=GS R7TKU9_CAPTE/365-445 AC R7TKU9.1
#=GS A0A8T1QYZ7_CARIL/417-494 AC A0A8T1QYZ7.1
#=GS A0A7K7GIN8_ERIRU/369-451 AC A0A7K7GIN8.1
#=GS A0A225VI79_9STRA/382-455 AC A0A225VI79.1
#=GS A0A5J5D9S7_9PERO/370-452 AC A0A5J5D9S7.1
#=GS A0AAD2E5N7_9LAMI/413-489 AC A0AAD2E5N7.1
#=GS A0A4T0WFT3_9PEZI/430-513 AC A0A4T0WFT3.1
#=GS A0A091W415_OPIHO/382-464 AC A0A091W415.1
#=GS A0A0L6WP66_9AGAR/364-455 AC A0A0L6WP66.1
#=GS A0A8C4QN06_EPTBU/417-499 AC A0A8C4QN06.1
#=GS A0A6J3ISH4_SAPAP/384-466 AC A0A6J3ISH4.1
#=GS A0A4U5M3T2_STECR/232-308 AC A0A4U5M3T2.1
#=GS A0A453RJK3_AEGTS/321-404 AC A0A453RJK3.1
#=GS G1MX71_MELGA/400-482 AC G1MX71.3
#=GS A0A9N9BVL4_9GLOM/410-492 AC A0A9N9BVL4.1
#=GS A0A8C6RFS9_NANGA/331-406 AC A0A8C6RFS9.1
#=GS A0A8C1M3Z6_CYPCA/283-326 AC A0A8C1M3Z6.1
#=GS A0A9N8PEJ2_9PEZI/441-528 AC A0A9N8PEJ2.1
#=GS C4XXQ8_CLAL4/371-448 AC C4XXQ8.1
#=GS A0A093CJZ7_9AVES/383-465 AC A0A093CJZ7.1
#=GS A0A662WRF8_NOTX5/423-499 AC A0A662WRF8.1
#=GS A0A7M7GZH9_APIME/427-502 AC A0A7M7GZH9.1
#=GS A0A397THK7_9GLOM/375-459 AC A0A397THK7.1
#=GS A0A8C5AE97_GADMO/279-354 AC A0A8C5AE97.1
#=GS A0A7K4YKB0_BUCAB/382-464 AC A0A7K4YKB0.1
#=GS A0A8B7ZAZ6_ACAPL/399-480 AC A0A8B7ZAZ6.1
#=GS A0A367K6M6_RHIAZ/358-441 AC A0A367K6M6.1
#=GS A0A9P0KEP3_ACAOB/382-458 AC A0A9P0KEP3.1
#=GS A0A6P9BG76_PANGU/402-484 AC A0A6P9BG76.1
#=GS A0A7J5ZG49_DISMA/336-378 AC A0A7J5ZG49.1
#=GS A0A7L3AG33_9AVES/369-451 AC A0A7L3AG33.1
#=GS A0A2G5B0X5_COERN/411-494 AC A0A2G5B0X5.1
#=GS A0A5D2U3G8_GOSMU/415-492 AC A0A5D2U3G8.1
#=GS T0QZF2_SAPDV/369-447 AC T0QZF2.1
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