KEGG   Capricornis sumatraensis (Sumatran serow): 138078664
Entry
138078664         CDS       T10522                                 
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
csum  Capricornis sumatraensis (Sumatran serow)
Pathway
csum00562  Inositol phosphate metabolism
csum01100  Metabolic pathways
csum01521  EGFR tyrosine kinase inhibitor resistance
csum01522  Endocrine resistance
csum01524  Platinum drug resistance
csum04012  ErbB signaling pathway
csum04014  Ras signaling pathway
csum04015  Rap1 signaling pathway
csum04024  cAMP signaling pathway
csum04062  Chemokine signaling pathway
csum04066  HIF-1 signaling pathway
csum04068  FoxO signaling pathway
csum04070  Phosphatidylinositol signaling system
csum04071  Sphingolipid signaling pathway
csum04072  Phospholipase D signaling pathway
csum04081  Hormone signaling
csum04140  Autophagy - animal
csum04145  Phagocytosis
csum04150  mTOR signaling pathway
csum04151  PI3K-Akt signaling pathway
csum04152  AMPK signaling pathway
csum04210  Apoptosis
csum04211  Longevity regulating pathway
csum04213  Longevity regulating pathway - multiple species
csum04218  Cellular senescence
csum04360  Axon guidance
csum04370  VEGF signaling pathway
csum04380  Osteoclast differentiation
csum04510  Focal adhesion
csum04517  IgSF CAM signaling
csum04518  Integrin signaling
csum04550  Signaling pathways regulating pluripotency of stem cells
csum04611  Platelet activation
csum04613  Neutrophil extracellular trap formation
csum04620  Toll-like receptor signaling pathway
csum04625  C-type lectin receptor signaling pathway
csum04630  JAK-STAT signaling pathway
csum04650  Natural killer cell mediated cytotoxicity
csum04660  T cell receptor signaling pathway
csum04662  B cell receptor signaling pathway
csum04664  Fc epsilon RI signaling pathway
csum04666  Fc gamma R-mediated phagosome formation
csum04668  TNF signaling pathway
csum04670  Leukocyte transendothelial migration
csum04722  Neurotrophin signaling pathway
csum04725  Cholinergic synapse
csum04750  Inflammatory mediator regulation of TRP channels
csum04810  Regulation of actin cytoskeleton
csum04910  Insulin signaling pathway
csum04914  Progesterone-mediated oocyte maturation
csum04915  Estrogen signaling pathway
csum04917  Prolactin signaling pathway
csum04919  Thyroid hormone signaling pathway
csum04923  Regulation of lipolysis in adipocytes
csum04926  Relaxin signaling pathway
csum04929  GnRH secretion
csum04930  Type II diabetes mellitus
csum04931  Insulin resistance
csum04932  Non-alcoholic fatty liver disease
csum04933  AGE-RAGE signaling pathway in diabetic complications
csum04935  Growth hormone synthesis, secretion and action
csum04960  Aldosterone-regulated sodium reabsorption
csum04973  Carbohydrate digestion and absorption
csum05010  Alzheimer disease
csum05017  Spinocerebellar ataxia
csum05020  Prion disease
csum05100  Bacterial invasion of epithelial cells
csum05132  Salmonella infection
csum05135  Yersinia infection
csum05142  Chagas disease
csum05146  Amoebiasis
csum05160  Hepatitis C
csum05161  Hepatitis B
csum05162  Measles
csum05163  Human cytomegalovirus infection
csum05164  Influenza A
csum05165  Human papillomavirus infection
csum05166  Human T-cell leukemia virus 1 infection
csum05167  Kaposi sarcoma-associated herpesvirus infection
csum05168  Herpes simplex virus 1 infection
csum05169  Epstein-Barr virus infection
csum05170  Human immunodeficiency virus 1 infection
csum05171  Coronavirus disease
csum05200  Pathways in cancer
csum05203  Viral carcinogenesis
csum05205  Proteoglycans in cancer
csum05206  MicroRNAs in cancer
csum05207  Chemical carcinogenesis - receptor activation
csum05208  Chemical carcinogenesis - reactive oxygen species
csum05210  Colorectal cancer
csum05211  Renal cell carcinoma
csum05212  Pancreatic cancer
csum05213  Endometrial cancer
csum05214  Glioma
csum05215  Prostate cancer
csum05218  Melanoma
csum05220  Chronic myeloid leukemia
csum05221  Acute myeloid leukemia
csum05222  Small cell lung cancer
csum05223  Non-small cell lung cancer
csum05224  Breast cancer
csum05225  Hepatocellular carcinoma
csum05226  Gastric cancer
csum05230  Central carbon metabolism in cancer
csum05231  Choline metabolism in cancer
csum05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
csum05415  Diabetic cardiomyopathy
csum05417  Lipid and atherosclerosis
csum05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:csum00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    138078664 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    138078664 (PIK3CA)
   04014 Ras signaling pathway
    138078664 (PIK3CA)
   04015 Rap1 signaling pathway
    138078664 (PIK3CA)
   04370 VEGF signaling pathway
    138078664 (PIK3CA)
   04630 JAK-STAT signaling pathway
    138078664 (PIK3CA)
   04668 TNF signaling pathway
    138078664 (PIK3CA)
   04066 HIF-1 signaling pathway
    138078664 (PIK3CA)
   04068 FoxO signaling pathway
    138078664 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    138078664 (PIK3CA)
   04072 Phospholipase D signaling pathway
    138078664 (PIK3CA)
   04071 Sphingolipid signaling pathway
    138078664 (PIK3CA)
   04024 cAMP signaling pathway
    138078664 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    138078664 (PIK3CA)
   04152 AMPK signaling pathway
    138078664 (PIK3CA)
   04150 mTOR signaling pathway
    138078664 (PIK3CA)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    138078664 (PIK3CA)
   04517 IgSF CAM signaling
    138078664 (PIK3CA)
   04518 Integrin signaling
    138078664 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    138078664 (PIK3CA)
   04140 Autophagy - animal
    138078664 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    138078664 (PIK3CA)
   04218 Cellular senescence
    138078664 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    138078664 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    138078664 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    138078664 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    138078664 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    138078664 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    138078664 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    138078664 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    138078664 (PIK3CA)
   04660 T cell receptor signaling pathway
    138078664 (PIK3CA)
   04662 B cell receptor signaling pathway
    138078664 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    138078664 (PIK3CA)
   04666 Fc gamma R-mediated phagosome formation
    138078664 (PIK3CA)
   04670 Leukocyte transendothelial migration
    138078664 (PIK3CA)
   04062 Chemokine signaling pathway
    138078664 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    138078664 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    138078664 (PIK3CA)
   04929 GnRH secretion
    138078664 (PIK3CA)
   04915 Estrogen signaling pathway
    138078664 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    138078664 (PIK3CA)
   04917 Prolactin signaling pathway
    138078664 (PIK3CA)
   04926 Relaxin signaling pathway
    138078664 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    138078664 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    138078664 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    138078664 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    138078664 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    138078664 (PIK3CA)
   04722 Neurotrophin signaling pathway
    138078664 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    138078664 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    138078664 (PIK3CA)
   04380 Osteoclast differentiation
    138078664 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    138078664 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    138078664 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    138078664 (PIK3CA)
   05206 MicroRNAs in cancer
    138078664 (PIK3CA)
   05205 Proteoglycans in cancer
    138078664 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    138078664 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    138078664 (PIK3CA)
   05203 Viral carcinogenesis
    138078664 (PIK3CA)
   05230 Central carbon metabolism in cancer
    138078664 (PIK3CA)
   05231 Choline metabolism in cancer
    138078664 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    138078664 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    138078664 (PIK3CA)
   05212 Pancreatic cancer
    138078664 (PIK3CA)
   05225 Hepatocellular carcinoma
    138078664 (PIK3CA)
   05226 Gastric cancer
    138078664 (PIK3CA)
   05214 Glioma
    138078664 (PIK3CA)
   05221 Acute myeloid leukemia
    138078664 (PIK3CA)
   05220 Chronic myeloid leukemia
    138078664 (PIK3CA)
   05218 Melanoma
    138078664 (PIK3CA)
   05211 Renal cell carcinoma
    138078664 (PIK3CA)
   05215 Prostate cancer
    138078664 (PIK3CA)
   05213 Endometrial cancer
    138078664 (PIK3CA)
   05224 Breast cancer
    138078664 (PIK3CA)
   05222 Small cell lung cancer
    138078664 (PIK3CA)
   05223 Non-small cell lung cancer
    138078664 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    138078664 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    138078664 (PIK3CA)
   05161 Hepatitis B
    138078664 (PIK3CA)
   05160 Hepatitis C
    138078664 (PIK3CA)
   05171 Coronavirus disease
    138078664 (PIK3CA)
   05164 Influenza A
    138078664 (PIK3CA)
   05162 Measles
    138078664 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    138078664 (PIK3CA)
   05163 Human cytomegalovirus infection
    138078664 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    138078664 (PIK3CA)
   05169 Epstein-Barr virus infection
    138078664 (PIK3CA)
   05165 Human papillomavirus infection
    138078664 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    138078664 (PIK3CA)
   05135 Yersinia infection
    138078664 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    138078664 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    138078664 (PIK3CA)
   05142 Chagas disease
    138078664 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    138078664 (PIK3CA)
   05017 Spinocerebellar ataxia
    138078664 (PIK3CA)
   05020 Prion disease
    138078664 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    138078664 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    138078664 (PIK3CA)
   05415 Diabetic cardiomyopathy
    138078664 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    138078664 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    138078664 (PIK3CA)
   04931 Insulin resistance
    138078664 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    138078664 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    138078664 (PIK3CA)
   01524 Platinum drug resistance
    138078664 (PIK3CA)
   01522 Endocrine resistance
    138078664 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:csum04131]
    138078664 (PIK3CA)
Enzymes [BR:csum01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     138078664 (PIK3CA)
Membrane trafficking [BR:csum04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    138078664 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 138078664
NCBI-ProteinID: XP_068827561
Position
1
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLVTIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatgggatgatagtgactttagaatgcctccgtgaggct
acgttagtaactataaagcatgagctatttaaagaagcaagaaaataccctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctttttcaaccctttttaaaa
gtaattgaaccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgct
atcggcatgccagtatgtgaattcgatatggttaaagatccagaagtacaggacttccga
agaaatattctcaatgtttgtaaagaagctgtggatcttagggatcttaattcacctcat
agtagagcaatgtatgtttatcctccaaatgtagaatcttcaccagaactgccaaagcac
atatataataaattggataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaaacagaagtatactctgaaaatcaaccatgactgtgtgccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgctatcgtctgaacaactaaaa
ctctgtgttttagaatatcagggcaagtatattttaaaagtgtgtggatgtgatgaatac
ttcctagaaaaatatcctctgagtcagtataagtatataagaagctgtataatgcttggg
aggatgcccaatttgatgctgatggctaaagaaagcctctactctcaactgccaatggac
tgttttacaatgccatcgtattccagacgcatctccacagctacgccatatatgaatgga
gaaacatctacaaaatccctttgggttataaatagtgcactcagaataaaaattctttgt
gcaacctatgtgaatgtaaatattcgagacattgacaagatttatgttcgaacaggtatc
taccatggaggagaacccttatgtgataatgtgaacactcaaagagtaccttgttccaat
cccaggtggaatgaatggctgaattacgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgttctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcctggggaaatataaacttgtttgattacacagatactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggactagaagatttgctgaaccctattggt
gttactggatcaaatccaaataaagaaactccatgtttagagttggagtttgactggttc
agcagtgtggtaaagtttccagatatgtcagtgattgaagagcatgccaactggtccgta
tcccgtgaagcaggatttagttattcccatgcaggactgagtaacagactagctagagac
aatgaattaagagaaaatgataaagaacagctccgagcaatttgtacacgagatcctcta
tctgaaatcactgagcaagagaaagattttctgtggagccacagacactattgtgtaact
atccccgaaattctacccaaattgcttctgtctgttaaatggaactctagagatgaagta
gctcagatgtactgcttggtaaaagattggcctccaatcaagcctgaacaggctatggag
cttctggactgcaattacccagatcctatggttcgaggttttgctgttcggtgcttagaa
aaatatttaacagatgacaaactttctcagtacctaattcagctagtacaggtactaaag
tatgaacagtatttggataacctgcttgtgagatttttactcaaaaaagcattaactaat
caaaggatcggtcactttttcttttggcatttaaaatctgagatgcacaataaaacagtt
agtcagaggtttggcctgcttttggagtcctattgccgtgcatgtgggatgtatctgaag
caccttaataggcaagttgaggctatggaaaagctcattaacttgactgacattctcaaa
caagagaagaaggatgaaacacaaaaggtacagatgaagtttttagttgagcaaatgcgg
cgaccagatttcatggatgctctccagggctttctgtctcctctaaaccctgctcatcag
ctgggaaatctcaggcttgaagagtgtcgaattatgtcttctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagaattactctttcagaacaatgagatcatc
tttaaaaatggggatgatttacggcaagatatgctaacccttcagattattcgcattatg
gaaaatatctggcaaaatcaaggtcttgatcttcgaatgttaccttatggatgtctgtca
attggtgattgtgtgggacttattgaggtggtgagaaattctcacactataatgcagatt
cagtgtaaaggaggcctgaaaggtgcactgcagttcaacagccacacactccatcagtgg
ctcaaagacaagaacaagggagaaatatatgatgcagccatcgatttgtttacacggtca
tgtgctggatactgtgttgcaaccttcatcttgggaattggagatcgtcacaatagtaat
atcatggttaaagatgatggacaactgtttcatatagattttggacactttttggatcac
aagaagaaaaaatttggttataaacgagagcgcgtgccgtttgttttgacacaagatttc
ttaatagtgattagtaaaggagcccaagaatgcacaaagacaagagaatttgagaggttt
caggagatgtgttacaaggcttatctagctattcggcagcatgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgatattgca
tacattcgaaagaccctagctttagataaaactgagcaagaggctttggaatatttcatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
acaattaagcagcatgctttgaactga

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (8)   
   Pfam (8)   
All databases (12)   

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