KEGG   Desmodus rotundus (common vampire bat): 112321016
Entry
112321016         CDS       T05907                                 
Symbol
PIK3R1
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
dro  Desmodus rotundus (common vampire bat)
Pathway
dro01521  EGFR tyrosine kinase inhibitor resistance
dro01522  Endocrine resistance
dro01524  Platinum drug resistance
dro04012  ErbB signaling pathway
dro04014  Ras signaling pathway
dro04015  Rap1 signaling pathway
dro04024  cAMP signaling pathway
dro04062  Chemokine signaling pathway
dro04066  HIF-1 signaling pathway
dro04068  FoxO signaling pathway
dro04070  Phosphatidylinositol signaling system
dro04071  Sphingolipid signaling pathway
dro04072  Phospholipase D signaling pathway
dro04081  Hormone signaling
dro04140  Autophagy - animal
dro04150  mTOR signaling pathway
dro04151  PI3K-Akt signaling pathway
dro04152  AMPK signaling pathway
dro04210  Apoptosis
dro04211  Longevity regulating pathway
dro04213  Longevity regulating pathway - multiple species
dro04218  Cellular senescence
dro04360  Axon guidance
dro04370  VEGF signaling pathway
dro04380  Osteoclast differentiation
dro04510  Focal adhesion
dro04550  Signaling pathways regulating pluripotency of stem cells
dro04611  Platelet activation
dro04613  Neutrophil extracellular trap formation
dro04620  Toll-like receptor signaling pathway
dro04625  C-type lectin receptor signaling pathway
dro04630  JAK-STAT signaling pathway
dro04650  Natural killer cell mediated cytotoxicity
dro04660  T cell receptor signaling pathway
dro04662  B cell receptor signaling pathway
dro04664  Fc epsilon RI signaling pathway
dro04666  Fc gamma R-mediated phagocytosis
dro04668  TNF signaling pathway
dro04670  Leukocyte transendothelial migration
dro04722  Neurotrophin signaling pathway
dro04725  Cholinergic synapse
dro04750  Inflammatory mediator regulation of TRP channels
dro04810  Regulation of actin cytoskeleton
dro04910  Insulin signaling pathway
dro04914  Progesterone-mediated oocyte maturation
dro04915  Estrogen signaling pathway
dro04917  Prolactin signaling pathway
dro04919  Thyroid hormone signaling pathway
dro04923  Regulation of lipolysis in adipocytes
dro04926  Relaxin signaling pathway
dro04929  GnRH secretion
dro04930  Type II diabetes mellitus
dro04931  Insulin resistance
dro04932  Non-alcoholic fatty liver disease
dro04933  AGE-RAGE signaling pathway in diabetic complications
dro04935  Growth hormone synthesis, secretion and action
dro04960  Aldosterone-regulated sodium reabsorption
dro04973  Carbohydrate digestion and absorption
dro05010  Alzheimer disease
dro05017  Spinocerebellar ataxia
dro05020  Prion disease
dro05100  Bacterial invasion of epithelial cells
dro05135  Yersinia infection
dro05142  Chagas disease
dro05146  Amoebiasis
dro05160  Hepatitis C
dro05161  Hepatitis B
dro05162  Measles
dro05163  Human cytomegalovirus infection
dro05164  Influenza A
dro05165  Human papillomavirus infection
dro05166  Human T-cell leukemia virus 1 infection
dro05167  Kaposi sarcoma-associated herpesvirus infection
dro05168  Herpes simplex virus 1 infection
dro05169  Epstein-Barr virus infection
dro05170  Human immunodeficiency virus 1 infection
dro05171  Coronavirus disease - COVID-19
dro05200  Pathways in cancer
dro05203  Viral carcinogenesis
dro05205  Proteoglycans in cancer
dro05206  MicroRNAs in cancer
dro05207  Chemical carcinogenesis - receptor activation
dro05208  Chemical carcinogenesis - reactive oxygen species
dro05210  Colorectal cancer
dro05211  Renal cell carcinoma
dro05212  Pancreatic cancer
dro05213  Endometrial cancer
dro05214  Glioma
dro05215  Prostate cancer
dro05218  Melanoma
dro05220  Chronic myeloid leukemia
dro05221  Acute myeloid leukemia
dro05222  Small cell lung cancer
dro05223  Non-small cell lung cancer
dro05224  Breast cancer
dro05225  Hepatocellular carcinoma
dro05226  Gastric cancer
dro05230  Central carbon metabolism in cancer
dro05231  Choline metabolism in cancer
dro05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
dro05415  Diabetic cardiomyopathy
dro05417  Lipid and atherosclerosis
dro05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:dro00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    112321016 (PIK3R1)
   04014 Ras signaling pathway
    112321016 (PIK3R1)
   04015 Rap1 signaling pathway
    112321016 (PIK3R1)
   04370 VEGF signaling pathway
    112321016 (PIK3R1)
   04630 JAK-STAT signaling pathway
    112321016 (PIK3R1)
   04668 TNF signaling pathway
    112321016 (PIK3R1)
   04066 HIF-1 signaling pathway
    112321016 (PIK3R1)
   04068 FoxO signaling pathway
    112321016 (PIK3R1)
   04070 Phosphatidylinositol signaling system
    112321016 (PIK3R1)
   04072 Phospholipase D signaling pathway
    112321016 (PIK3R1)
   04071 Sphingolipid signaling pathway
    112321016 (PIK3R1)
   04024 cAMP signaling pathway
    112321016 (PIK3R1)
   04151 PI3K-Akt signaling pathway
    112321016 (PIK3R1)
   04152 AMPK signaling pathway
    112321016 (PIK3R1)
   04150 mTOR signaling pathway
    112321016 (PIK3R1)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    112321016 (PIK3R1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    112321016 (PIK3R1)
  09143 Cell growth and death
   04210 Apoptosis
    112321016 (PIK3R1)
   04218 Cellular senescence
    112321016 (PIK3R1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    112321016 (PIK3R1)
   04550 Signaling pathways regulating pluripotency of stem cells
    112321016 (PIK3R1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    112321016 (PIK3R1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    112321016 (PIK3R1)
   04613 Neutrophil extracellular trap formation
    112321016 (PIK3R1)
   04620 Toll-like receptor signaling pathway
    112321016 (PIK3R1)
   04625 C-type lectin receptor signaling pathway
    112321016 (PIK3R1)
   04650 Natural killer cell mediated cytotoxicity
    112321016 (PIK3R1)
   04660 T cell receptor signaling pathway
    112321016 (PIK3R1)
   04662 B cell receptor signaling pathway
    112321016 (PIK3R1)
   04664 Fc epsilon RI signaling pathway
    112321016 (PIK3R1)
   04666 Fc gamma R-mediated phagocytosis
    112321016 (PIK3R1)
   04670 Leukocyte transendothelial migration
    112321016 (PIK3R1)
   04062 Chemokine signaling pathway
    112321016 (PIK3R1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    112321016 (PIK3R1)
   04923 Regulation of lipolysis in adipocytes
    112321016 (PIK3R1)
   04929 GnRH secretion
    112321016 (PIK3R1)
   04915 Estrogen signaling pathway
    112321016 (PIK3R1)
   04914 Progesterone-mediated oocyte maturation
    112321016 (PIK3R1)
   04917 Prolactin signaling pathway
    112321016 (PIK3R1)
   04926 Relaxin signaling pathway
    112321016 (PIK3R1)
   04935 Growth hormone synthesis, secretion and action
    112321016 (PIK3R1)
   04919 Thyroid hormone signaling pathway
    112321016 (PIK3R1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    112321016 (PIK3R1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    112321016 (PIK3R1)
  09156 Nervous system
   04725 Cholinergic synapse
    112321016 (PIK3R1)
   04722 Neurotrophin signaling pathway
    112321016 (PIK3R1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    112321016 (PIK3R1)
  09158 Development and regeneration
   04360 Axon guidance
    112321016 (PIK3R1)
   04380 Osteoclast differentiation
    112321016 (PIK3R1)
  09149 Aging
   04211 Longevity regulating pathway
    112321016 (PIK3R1)
   04213 Longevity regulating pathway - multiple species
    112321016 (PIK3R1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    112321016 (PIK3R1)
   05206 MicroRNAs in cancer
    112321016 (PIK3R1)
   05205 Proteoglycans in cancer
    112321016 (PIK3R1)
   05207 Chemical carcinogenesis - receptor activation
    112321016 (PIK3R1)
   05208 Chemical carcinogenesis - reactive oxygen species
    112321016 (PIK3R1)
   05203 Viral carcinogenesis
    112321016 (PIK3R1)
   05230 Central carbon metabolism in cancer
    112321016 (PIK3R1)
   05231 Choline metabolism in cancer
    112321016 (PIK3R1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    112321016 (PIK3R1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    112321016 (PIK3R1)
   05212 Pancreatic cancer
    112321016 (PIK3R1)
   05225 Hepatocellular carcinoma
    112321016 (PIK3R1)
   05226 Gastric cancer
    112321016 (PIK3R1)
   05214 Glioma
    112321016 (PIK3R1)
   05221 Acute myeloid leukemia
    112321016 (PIK3R1)
   05220 Chronic myeloid leukemia
    112321016 (PIK3R1)
   05218 Melanoma
    112321016 (PIK3R1)
   05211 Renal cell carcinoma
    112321016 (PIK3R1)
   05215 Prostate cancer
    112321016 (PIK3R1)
   05213 Endometrial cancer
    112321016 (PIK3R1)
   05224 Breast cancer
    112321016 (PIK3R1)
   05222 Small cell lung cancer
    112321016 (PIK3R1)
   05223 Non-small cell lung cancer
    112321016 (PIK3R1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    112321016 (PIK3R1)
   05170 Human immunodeficiency virus 1 infection
    112321016 (PIK3R1)
   05161 Hepatitis B
    112321016 (PIK3R1)
   05160 Hepatitis C
    112321016 (PIK3R1)
   05171 Coronavirus disease - COVID-19
    112321016 (PIK3R1)
   05164 Influenza A
    112321016 (PIK3R1)
   05162 Measles
    112321016 (PIK3R1)
   05168 Herpes simplex virus 1 infection
    112321016 (PIK3R1)
   05163 Human cytomegalovirus infection
    112321016 (PIK3R1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    112321016 (PIK3R1)
   05169 Epstein-Barr virus infection
    112321016 (PIK3R1)
   05165 Human papillomavirus infection
    112321016 (PIK3R1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    112321016 (PIK3R1)
   05100 Bacterial invasion of epithelial cells
    112321016 (PIK3R1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    112321016 (PIK3R1)
   05142 Chagas disease
    112321016 (PIK3R1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    112321016 (PIK3R1)
   05017 Spinocerebellar ataxia
    112321016 (PIK3R1)
   05020 Prion disease
    112321016 (PIK3R1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    112321016 (PIK3R1)
   05418 Fluid shear stress and atherosclerosis
    112321016 (PIK3R1)
   05415 Diabetic cardiomyopathy
    112321016 (PIK3R1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    112321016 (PIK3R1)
   04932 Non-alcoholic fatty liver disease
    112321016 (PIK3R1)
   04931 Insulin resistance
    112321016 (PIK3R1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    112321016 (PIK3R1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    112321016 (PIK3R1)
   01524 Platinum drug resistance
    112321016 (PIK3R1)
   01522 Endocrine resistance
    112321016 (PIK3R1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:dro04131]
    112321016 (PIK3R1)
Membrane trafficking [BR:dro04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    112321016 (PIK3R1)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH2_1 SH3_1 AAA_13 SH3_2 Laminin_I SH3_9 CCDC113_CCDC96_CC ACDC FANCI_S2
Other DBs
NCBI-GeneID: 112321016
NCBI-ProteinID: XP_024434215
Position
Unknown
AA seq 724 aa
MSAEAYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEEIGWLNGYN
ETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKTEAESEQQALVLPDLAE
QFAPPDIAPPLLIKLVEAIEKKGLECSTLYRTQSSSNPAELRQLLDCDAASMDVETVDVQ
VLADAFKRYLLDLPNPVIPVAVYNEMISLAQEVQSSEEYIQLLKKLIRSPNIPHQYWLTL
QYLLKHFFKLSQSSSKNLLTARVLSELFSPLLFRFPAASSENTEHLIKVVEILISTEWNE
RQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDA
STKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKL
DVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEDYTRTSQEIQMK
RTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYEKLKSRISEIVD
SRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN
ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACS
VVVDGEVKHCVINKTATGYGFAEPYNLYGSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA
QQRR
NT seq 2175 nt   +upstreamnt  +downstreamnt
atgagtgccgaggcgtatcagtacagagcactgtacgactataaaaaggaacgagaagaa
gacattgacttacacttgggtgatatcttgacggtgaataaggggtctttagtagctctc
ggattcagtgatggacaggaagccaggccagaagaaattggctggttaaatggctacaat
gaaaccacaggggagagaggagactttccaggaacttacgtcgaatacattggaaggaaa
aaaatctcaccgcccaccccaaagccccggccacctcgaccccttcctgttgcaccaggt
tcttcaaaaactgaagcagaaagtgagcagcaagctttggtccttccggatcttgcagaa
cagtttgcccctcctgacattgctccacctcttcttatcaaactagtagaagccattgaa
aagaaaggtctggaatgttcaactctatacagaacacagagctccagcaacccagcagaa
ttacgacagcttcttgattgtgatgctgcctccatggacgtggaaacagttgatgttcaa
gttttagcagacgccttcaaacgctatctcttggacctgccgaatcctgtcattccagta
gcggtttacaatgagatgatttctttagcccaagaagttcaaagctctgaagaatatatc
cagctgttgaagaagctcattaggtcacctaacatacctcatcagtattggcttacgctt
cagtatttgctaaaacatttcttcaagctctcccaaagctccagcaaaaaccttctgact
gcaagagtgctctctgaacttttcagccctctgcttttcagattcccagcagccagctct
gagaatactgaacacctcataaaagttgtagaaatcttaatctcaacggaatggaacgag
cgacagcctgcaccagcactgcctcctaaaccaccaaaacccactactgtggccaacaac
ggtatgaataacaatatgtccttacaagatgccgagtggtactggggagatatctctagg
gaagaagtgaatgagaaacttcgagacacagctgacgggacctttctggtacgagacgcg
tccactaaaatgcatggtgattatactcttacactaaggaaaggaggaaataacaaatta
atcaaaatatttcaccgagatgggaaatatggcttctctgacccattaaccttcaactct
gtggttgaattaataaaccactaccggaatgaatctctagctcagtacaatcccaagctg
gatgtgaaattactttatccagtatccaaataccaacaggatcaagttgtcaaagaagat
aatatcgaagctgtagggaaaaaattacatgaatataacactcaatttcaagaaaaaagt
cgggaatatgatagattatatgaggattatacccgtacttcccaggaaatccaaatgaaa
agaacagctattgaagcatttaatgaaaccataaaaatatttgaagaacaatgccagacc
caggagcgctacagcaaagagtacatagaaaagtttaaacgtgaaggcaatgagaaagaa
atacaaaggattatgcataattatgaaaagttaaagtctcgaatcagtgaaattgtggac
agcagaagacgactggaggaagacttgaagaagcaggcagctgagtatcgggagattgac
aaacgcatgaacagcattaaacccgacctcatccaactgagaaagacgagagaccaatac
ttgatgtggttgactcagaaaggtgttcggcagaagaagctgaacgagtggttgggcaat
gaaaacactgaagaccaatattcgctggtggaagatgatgaggatttgccccaccacgac
gagaagacatggaatgtcgggagcagcaaccgaaacaaagctgagaacctgctgcgaggg
aagcgagacggcacttttcttgtccgggaaagcagtaaacagggctgctacgcctgctct
gtggtggtggacggtgaggtgaagcactgcgtcatcaacaaaacggcgaccggctatggc
tttgccgagccctacaacctgtacggctccctgaaagaactggtgctccattaccaacac
acctccctggtgcagcacaacgactccctcaacgtcacactagcctaccccgtgtatgcg
cagcagaggcgatga

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (4)   
   RefSeq(pep) (4)   
DNA sequence (6)   
   RefSeq(nuc) (4)   
   GenBank (1)   
   EMBL (1)   
Protein domain (12)   
   Pfam (12)   
All databases (24)   

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