KEGG   Eumetopias jubatus (Steller sea lion): 114221305
Entry
114221305         CDS       T07240                                 
Symbol
PLCB2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
eju  Eumetopias jubatus (Steller sea lion)
Pathway
eju00562  Inositol phosphate metabolism
eju01100  Metabolic pathways
eju04015  Rap1 signaling pathway
eju04020  Calcium signaling pathway
eju04022  cGMP-PKG signaling pathway
eju04062  Chemokine signaling pathway
eju04070  Phosphatidylinositol signaling system
eju04071  Sphingolipid signaling pathway
eju04072  Phospholipase D signaling pathway
eju04081  Hormone signaling
eju04082  Neuroactive ligand signaling
eju04261  Adrenergic signaling in cardiomyocytes
eju04270  Vascular smooth muscle contraction
eju04310  Wnt signaling pathway
eju04371  Apelin signaling pathway
eju04540  Gap junction
eju04611  Platelet activation
eju04613  Neutrophil extracellular trap formation
eju04621  NOD-like receptor signaling pathway
eju04713  Circadian entrainment
eju04720  Long-term potentiation
eju04723  Retrograde endocannabinoid signaling
eju04724  Glutamatergic synapse
eju04725  Cholinergic synapse
eju04726  Serotonergic synapse
eju04728  Dopaminergic synapse
eju04730  Long-term depression
eju04742  Taste transduction
eju04750  Inflammatory mediator regulation of TRP channels
eju04911  Insulin secretion
eju04912  GnRH signaling pathway
eju04915  Estrogen signaling pathway
eju04916  Melanogenesis
eju04918  Thyroid hormone synthesis
eju04919  Thyroid hormone signaling pathway
eju04921  Oxytocin signaling pathway
eju04922  Glucagon signaling pathway
eju04924  Renin secretion
eju04925  Aldosterone synthesis and secretion
eju04926  Relaxin signaling pathway
eju04927  Cortisol synthesis and secretion
eju04928  Parathyroid hormone synthesis, secretion and action
eju04929  GnRH secretion
eju04933  AGE-RAGE signaling pathway in diabetic complications
eju04934  Cushing syndrome
eju04935  Growth hormone synthesis, secretion and action
eju04961  Endocrine and other factor-regulated calcium reabsorption
eju04970  Salivary secretion
eju04971  Gastric acid secretion
eju04972  Pancreatic secretion
eju04973  Carbohydrate digestion and absorption
eju05010  Alzheimer disease
eju05016  Huntington disease
eju05017  Spinocerebellar ataxia
eju05022  Pathways of neurodegeneration - multiple diseases
eju05142  Chagas disease
eju05143  African trypanosomiasis
eju05146  Amoebiasis
eju05163  Human cytomegalovirus infection
eju05200  Pathways in cancer
eju05415  Diabetic cardiomyopathy
eju05417  Lipid and atherosclerosis
Module
eju_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:eju00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    114221305 (PLCB2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    114221305 (PLCB2)
   04310 Wnt signaling pathway
    114221305 (PLCB2)
   04371 Apelin signaling pathway
    114221305 (PLCB2)
   04020 Calcium signaling pathway
    114221305 (PLCB2)
   04070 Phosphatidylinositol signaling system
    114221305 (PLCB2)
   04072 Phospholipase D signaling pathway
    114221305 (PLCB2)
   04071 Sphingolipid signaling pathway
    114221305 (PLCB2)
   04022 cGMP-PKG signaling pathway
    114221305 (PLCB2)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    114221305 (PLCB2)
   04081 Hormone signaling
    114221305 (PLCB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    114221305 (PLCB2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    114221305 (PLCB2)
   04613 Neutrophil extracellular trap formation
    114221305 (PLCB2)
   04621 NOD-like receptor signaling pathway
    114221305 (PLCB2)
   04062 Chemokine signaling pathway
    114221305 (PLCB2)
  09152 Endocrine system
   04911 Insulin secretion
    114221305 (PLCB2)
   04922 Glucagon signaling pathway
    114221305 (PLCB2)
   04929 GnRH secretion
    114221305 (PLCB2)
   04912 GnRH signaling pathway
    114221305 (PLCB2)
   04915 Estrogen signaling pathway
    114221305 (PLCB2)
   04921 Oxytocin signaling pathway
    114221305 (PLCB2)
   04926 Relaxin signaling pathway
    114221305 (PLCB2)
   04935 Growth hormone synthesis, secretion and action
    114221305 (PLCB2)
   04918 Thyroid hormone synthesis
    114221305 (PLCB2)
   04919 Thyroid hormone signaling pathway
    114221305 (PLCB2)
   04928 Parathyroid hormone synthesis, secretion and action
    114221305 (PLCB2)
   04916 Melanogenesis
    114221305 (PLCB2)
   04924 Renin secretion
    114221305 (PLCB2)
   04925 Aldosterone synthesis and secretion
    114221305 (PLCB2)
   04927 Cortisol synthesis and secretion
    114221305 (PLCB2)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    114221305 (PLCB2)
   04270 Vascular smooth muscle contraction
    114221305 (PLCB2)
  09154 Digestive system
   04970 Salivary secretion
    114221305 (PLCB2)
   04971 Gastric acid secretion
    114221305 (PLCB2)
   04972 Pancreatic secretion
    114221305 (PLCB2)
   04973 Carbohydrate digestion and absorption
    114221305 (PLCB2)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    114221305 (PLCB2)
  09156 Nervous system
   04724 Glutamatergic synapse
    114221305 (PLCB2)
   04725 Cholinergic synapse
    114221305 (PLCB2)
   04728 Dopaminergic synapse
    114221305 (PLCB2)
   04726 Serotonergic synapse
    114221305 (PLCB2)
   04720 Long-term potentiation
    114221305 (PLCB2)
   04730 Long-term depression
    114221305 (PLCB2)
   04723 Retrograde endocannabinoid signaling
    114221305 (PLCB2)
  09157 Sensory system
   04742 Taste transduction
    114221305 (PLCB2)
   04750 Inflammatory mediator regulation of TRP channels
    114221305 (PLCB2)
  09159 Environmental adaptation
   04713 Circadian entrainment
    114221305 (PLCB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    114221305 (PLCB2)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    114221305 (PLCB2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    114221305 (PLCB2)
   05142 Chagas disease
    114221305 (PLCB2)
   05143 African trypanosomiasis
    114221305 (PLCB2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    114221305 (PLCB2)
   05016 Huntington disease
    114221305 (PLCB2)
   05017 Spinocerebellar ataxia
    114221305 (PLCB2)
   05022 Pathways of neurodegeneration - multiple diseases
    114221305 (PLCB2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    114221305 (PLCB2)
   05415 Diabetic cardiomyopathy
    114221305 (PLCB2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    114221305 (PLCB2)
   04934 Cushing syndrome
    114221305 (PLCB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:eju04131]
    114221305 (PLCB2)
Enzymes [BR:eju01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     114221305 (PLCB2)
Membrane trafficking [BR:eju04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    114221305 (PLCB2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    114221305 (PLCB2)
SSDB
Motif
Pfam: PLC-beta_C PH_14 PI-PLC-X PI-PLC-Y PLCB1-4-like_EFh C2 Collagen Gp58
Other DBs
NCBI-GeneID: 114221305
NCBI-ProteinID: XP_027975226
Position
Unknown
AA seq 1115 aa
MSLLNSVLLPPKVKAYLSQGERFIKWDDETTIASPVILRVDPKGYYLYWTYQSKEMEFLD
ITSIRDTRFGKFAKIPKSQKLRDVFNMDFPDNNFLLKTLTVVSGPDMVDLTFHNFVSYKE
NVGKNWAEDVLALVKHPLTANASRSTFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKR
VEAALSACHLPKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYPRLPPPPSGSAG
QFSGLSSAEMYRQVLLAGCRCVELDCWKGKPPDEEPIITHGFTMTTDIYFKEAIEAIAES
AFKTSPYPVILSFENHVDSPRQQAKMAEYCRMMFGDMLLTEPLEKFPLKPGIPLPSPEDL
RGKILIKNKKNQFSGPAAPSTEGSCSPTASVGEDTVWAGEQGAEPEEEEAEEAEEEEEEE
EEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFISFEFSAQKNRSY
VISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQMVALN
FQTMDLPMQQNMALFEFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSITVISG
QFLSDRSVRTYVEVELFGLPGDPKRRYRTKLSPSANSINPVWKEEPFVFEKILMPELASL
RVAVMEEGNKFLGHRIIPINALNSGYHHLCLHSESNMPLTMPALFVFLEMKDYVPDTWAD
LTVALANPIKFFSAHDKKSLKLKEAMGGLPEKPFPLGSPVVGRVNGALAPTSNGSAAAGY
RAKEETTKKAAEPQTASPEELRELKGVVKLQRRHEKELRDLERRGARRWEELLQRGAAQL
AELGPPGAGGCGGRRLGPGKGSRKKRTLLSEQAAGAAPSEGREGREGREGREGREGPEGR
EGPEGADARARELKDRLELELLQQGEEQYECILKRKEQHVAEQIAKMMELAREKQAAELK
TLKETLETDTKEMKKKLEAKRLERIQAMVKVTSDKMAQERLKREINNSHIQEVVQVIKQM
TENLEKHQEKLEEKQAACLEQIREMEKQLQQDALAEYAARMKGLEAEVKESVKACLRDCL
PSEAKDKPERPCEAFRELCEQDPLTAKAGAQESCL
NT seq 3348 nt   +upstreamnt  +downstreamnt
atgtctctgctcaactctgtcctgctgccccccaaggtgaaggcttatctgagccaaggg
gagcgcttcatcaaatgggacgatgaaactacaatagcctccccggttatcctccgtgtg
gatcccaaggggtactacttatattggacatatcagagtaaggagatggagtttctggat
atcaccagcatcagggatacccgctttgggaagtttgccaagatacccaagagccagaag
ctccgggatgtcttcaacatggacttccccgacaacaacttcctgctcaagacgctcact
gtggtgtctggccctgacatggtggacctcaccttccacaacttcgtctcctacaaggag
aatgtgggcaagaactgggccgaagatgtgctggccctggttaagcaccccctgacggcc
aatgcctcccgcagcaccttcttggacaaaatcctggtaaaactcaagatgcagctcaac
cctgaaggaaagattcctgtgaaaaattttttccagatgtttcctgctgaccgcaagcgg
gtggaagctgccctcagtgcctgtcacctcccaaaaggcaagaacgatgccatcaatcct
gaggacttcccagaatccgtctacaagagtttcctcatgagcctctgtcctcggccagaa
atagacgagatcttcacttcctacccccgcctccccccacccccctctggctcagccggc
cagttctctggcctttcgtcggccgagatgtaccgccaggtgctgctggctggctgccgc
tgcgtggagctggactgctggaagggcaagccccctgacgaggagcccattatcacccac
ggcttcaccatgaccacagacatctacttcaaggaagcaattgaagccattgcagaaagt
gcctttaagacctccccctatcctgtcatcctgtcatttgaaaaccacgtggactcaccc
cgccaacaagccaagatggccgagtactgccggatgatgtttggggatatgctgctcaca
gagcccctggaaaagttcccgttgaaaccaggcatccccctgcccagccctgaggatctc
cgaggcaagatcctcatcaagaacaaaaagaaccagttttctggcccagcagcccccagc
actgagggcagctgctcccccaccgcctctgtgggtgaggacaccgtgtgggctggtgag
caaggggccgagccggaggaggaggaggcggaagaggcggaggaggaggaggaggaggag
gaggaggaggaggaggagtcggggaacctggatgaggaggagatcaagaagatgcagtcg
gatgagggcacagcgggcctggaggtgacagcttatgaggagatgtccagcctagtgaac
tacatccagcccaccaagttcatatcctttgagttctctgcccagaagaaccgaagttac
gtcatctcgtccttcacagagctcaaggcctatgacctgctttccaaggcctcagtgcag
tttgtggactacaacaagcgccagatgagccgcatttaccctaagggcacccgcatggac
tcctccaactacatgccccagatgttctggaatgccggttgccagatggttgccctcaac
ttccagacgatggacctgcccatgcagcagaacatggcgctgtttgagttcaatgggcag
agtggctacctcctcaagcatgagttcatgcggcggcccgacaagcagttcaaccccttc
tcggtggaccgcatcgatgtggttgtagccaccaccctttctattacggtgatttctggg
cagttcctgtcggatcgcagtgtgcgcacctatgtggaagtggagctgtttggccttcct
ggggaccccaagaggcgctatcgcaccaagctctcacccagcgccaactccatcaatcct
gtctggaaggaggagccttttgtctttgagaagatcttgatgcctgagctggcctccctc
agggtggctgtaatggaggaaggcaacaaatttcttggacaccgcatcatccccattaat
gccctgaattctggctaccaccatctgtgcctacacagcgagagcaacatgccccttacc
atgcctgcactttttgtcttcctggagatgaaggactatgtacctgacacctgggcagat
ctcaccgtggctcttgccaatcccatcaagttcttcagtgcccatgacaagaagtctttg
aagctgaaggaagccatgggaggtctgcctgagaaacccttcccgcttgggagtccagtt
gtcggccgggtcaatggggcgttggccccaacgagcaacggctctgcagctgccgggtac
agggccaaggaggagaccacgaaaaaagctgcggagccgcagaccgccagcccggaggag
ctgcgggagctaaagggcgtcgtgaagctgcagcggcggcacgagaaggagctgcgggac
ctggagcggcggggcgcgcggcgctgggaggagctgctgcagaggggcgcggcgcagctg
gccgagctggggccgccgggcgcggggggctgcgggggtcgcaggctcggcccggggaaa
ggctctcgcaagaagaggaccctgctcagcgagcaggccgccggggccgcgcccagcgag
ggccgcgagggccgcgagggccgcgagggccgcgagggccgcgagggccccgagggccgc
gagggccccgagggcgcggacgcgcgtgcgcgcgagctgaaggaccggctggagctggag
ctgctgcagcagggtgaggagcagtacgagtgcatcctgaagcgcaaggagcagcacgtg
gctgagcaaatcgccaagatgatggagctggccagagagaagcaggctgcggagctgaag
accctcaaggagaccttggagactgacaccaaagagatgaagaagaagctggaggccaag
aggctggagcggattcaggccatggtcaaagtcacctcagacaagatggctcaggaaagg
ctgaagagagagattaacaactctcacatccaggaggtggtgcaggtcattaagcagatg
acagagaacctggagaagcaccaggagaagctggaggagaagcaggcggcctgcctcgaa
cagatccgggagatggaaaagcagctccagcaggatgcgctggccgagtacgcagccagg
atgaagggcctggaggctgaggtgaaggagtcagtgaaggcctgcctcagggactgctta
ccctctgaggccaaggacaagcctgagaggccctgtgaggccttcagggagctgtgtgag
caggacccgctcacggccaaggcgggggcccaggagagctgcctctga

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (8)   
   Pfam (8)   
All databases (12)   

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