KEGG   Echinops telfairi (small Madagascar hedgehog): 101644253
Entry
101644253         CDS       T08707                                 
Symbol
PLCG2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
  KO
K05859  phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Organism
etf  Echinops telfairi (small Madagascar hedgehog)
Pathway
etf00562  Inositol phosphate metabolism
etf01100  Metabolic pathways
etf01521  EGFR tyrosine kinase inhibitor resistance
etf04012  ErbB signaling pathway
etf04014  Ras signaling pathway
etf04020  Calcium signaling pathway
etf04062  Chemokine signaling pathway
etf04064  NF-kappa B signaling pathway
etf04066  HIF-1 signaling pathway
etf04070  Phosphatidylinositol signaling system
etf04072  Phospholipase D signaling pathway
etf04360  Axon guidance
etf04370  VEGF signaling pathway
etf04380  Osteoclast differentiation
etf04611  Platelet activation
etf04613  Neutrophil extracellular trap formation
etf04625  C-type lectin receptor signaling pathway
etf04650  Natural killer cell mediated cytotoxicity
etf04662  B cell receptor signaling pathway
etf04664  Fc epsilon RI signaling pathway
etf04666  Fc gamma R-mediated phagocytosis
etf04670  Leukocyte transendothelial migration
etf04722  Neurotrophin signaling pathway
etf04750  Inflammatory mediator regulation of TRP channels
etf04919  Thyroid hormone signaling pathway
etf04933  AGE-RAGE signaling pathway in diabetic complications
etf04935  Growth hormone synthesis, secretion and action
etf05167  Kaposi sarcoma-associated herpesvirus infection
etf05169  Epstein-Barr virus infection
etf05170  Human immunodeficiency virus 1 infection
etf05171  Coronavirus disease - COVID-19
etf05200  Pathways in cancer
etf05205  Proteoglycans in cancer
etf05206  MicroRNAs in cancer
etf05214  Glioma
etf05223  Non-small cell lung cancer
etf05225  Hepatocellular carcinoma
Module
etf_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:etf00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    101644253 (PLCG2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    101644253 (PLCG2)
   04014 Ras signaling pathway
    101644253 (PLCG2)
   04370 VEGF signaling pathway
    101644253 (PLCG2)
   04064 NF-kappa B signaling pathway
    101644253 (PLCG2)
   04066 HIF-1 signaling pathway
    101644253 (PLCG2)
   04020 Calcium signaling pathway
    101644253 (PLCG2)
   04070 Phosphatidylinositol signaling system
    101644253 (PLCG2)
   04072 Phospholipase D signaling pathway
    101644253 (PLCG2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    101644253 (PLCG2)
   04613 Neutrophil extracellular trap formation
    101644253 (PLCG2)
   04625 C-type lectin receptor signaling pathway
    101644253 (PLCG2)
   04650 Natural killer cell mediated cytotoxicity
    101644253 (PLCG2)
   04662 B cell receptor signaling pathway
    101644253 (PLCG2)
   04664 Fc epsilon RI signaling pathway
    101644253 (PLCG2)
   04666 Fc gamma R-mediated phagocytosis
    101644253 (PLCG2)
   04670 Leukocyte transendothelial migration
    101644253 (PLCG2)
   04062 Chemokine signaling pathway
    101644253 (PLCG2)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    101644253 (PLCG2)
   04919 Thyroid hormone signaling pathway
    101644253 (PLCG2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    101644253 (PLCG2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101644253 (PLCG2)
  09158 Development and regeneration
   04360 Axon guidance
    101644253 (PLCG2)
   04380 Osteoclast differentiation
    101644253 (PLCG2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101644253 (PLCG2)
   05206 MicroRNAs in cancer
    101644253 (PLCG2)
   05205 Proteoglycans in cancer
    101644253 (PLCG2)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    101644253 (PLCG2)
   05214 Glioma
    101644253 (PLCG2)
   05223 Non-small cell lung cancer
    101644253 (PLCG2)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    101644253 (PLCG2)
   05171 Coronavirus disease - COVID-19
    101644253 (PLCG2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101644253 (PLCG2)
   05169 Epstein-Barr virus infection
    101644253 (PLCG2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    101644253 (PLCG2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101644253 (PLCG2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:etf04131]
    101644253 (PLCG2)
Enzymes [BR:etf01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     101644253 (PLCG2)
Membrane trafficking [BR:etf04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    101644253 (PLCG2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    101644253 (PLCG2)
SSDB
Motif
Pfam: PI-PLC-X SH2 EF-hand_PLCG2 PI-PLC-Y SH3_1 C2 SH3_9 PH PH_12 SH3_2 EF-hand_like GDPD
Other DBs
NCBI-GeneID: 101644253
NCBI-ProteinID: XP_004704831
Position
Unknown
AA seq 1217 aa
MMTLANVDALPEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK
IEGFVDIMEIKEIRPGRSSKDFERAKAVRQREDCCFTIFYGSQFVLSTLSLAADSKEDAA
KWLSGLRILHREVLNASTPTIIESWLRKQIYSVDQTRRNRAVPTPLLRRHRDELLRGAPE
IGAHRDELSFEQFHLFYKKLMFEQQKTILDEFKKDSFAFVLGNTDRPDASAVHLHDFQRF
LLHEQQESWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENSIWDEKYDVV
NMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDCWDGPDGKPV
IYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEQHCGVEQQRYMAKVFTEVLDGLL
LVKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDINMEDKKDEHKQQGELSMWDSIDQ
KWTRHYCAIADAKLSFSDDIEQVVEEELPQDTPPTELHFGEKWFHKKVEKRTSAEKLLQE
YCAESGAKDGTFLVRESETYPNDYTLSFWRSGRVQHCRIRSTMEGGTMKYYLTDNLMFTS
IYALVQHYRESHLRCAEFELRLTDPVPNPNPHESKPWYYDGLSRGEAEDMLMRVPRDGAF
LVRKREGADSYAITFRARGKVKHCRVTRDGRHFVLGTSAYFESLVELVSYYEKHALYRKM
RLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSTPQRTVKALYDYRAKRSDELS
FCRGALIHNVSKEPGGWWKGDYGARIQQYFPSNYVEDISTVDVEELEKQIIEDNPLGSLC
RGILDLNTYNVVKAPQGKNQKSFVFILEPKKQGDPPVEFATDRVEELFEWFQSIREITWK
MDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVETKADSIVRQ
KPMELLKYNQKGLTRIYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALVL
GARHLPKLGRSIACPFVEVEICGAEYDNNKFKTTVVNDNGLNPVWAPTQEKVTFEIYDPN
LAFLRFVVYEEDMFSDPNFLAHATYPIKGIRSGFRSVPLKNGHSEDVELASLLVCCEMRP
VLESEEELYSSCRQLRRRQEELNNQLFLYDTQQNLRNAPRDALVKEFNTNENQLQLYQET
CNRRLREKRVSNSKFYS
NT seq 3654 nt   +upstreamnt  +downstreamnt
atgatgaccctggccaacgtggacgccctcccggagtatgagaagagtcagatcaagaga
gcgctggagctgggcacggtgatgaccgtcttcagcttccgcaagtccacgcctgagcgc
aggaccgtccaggtgatcatggagacgcggcaggtggcctggagcaagacagccgacaag
atcgagggctttgtggacatcatggagatcaaggagatccggcccgggaggagctccaag
gacttcgagcgagccaaggctgtgcggcagagggaggactgctgcttcaccatcttctac
ggctcccagttcgtgctcagcaccctgagcctggcagcggattccaaggaggatgctgcc
aagtggctctctggcttgaggatcctgcaccgagaggtcctgaatgcctccacgcccaca
attatcgagagttggctgaggaagcagatttattccgtggaccaaaccagaaggaacagg
gctgtgcccacgcccctcctgcgtcgtcatcgggacgagctgctgcgaggagcacccgaa
ataggcgcgcacagagacgaactcagcttcgaacagttccacctcttctataaaaaactc
atgtttgagcagcagaaaacgattctcgacgagttcaagaaagactccttcgcctttgtc
ctggggaacactgaccggccagatgcctcggccgtccacctgcacgacttccagaggttt
ctcttacacgagcagcaggagtcgtgggcacaggatctcaacaaagtccgcgagcggatg
acgaagttcattgacgacaccatgcgggagacggccgagcccttcctgtttgtcgacgag
ttcctcacgtacctgttctcgcgagaaaacagcatctgggacgagaagtatgatgtggtc
aacatgcaggacatgaacaaccccttgtctcactactggatctcctcgtcacataacacg
tacctcacaggtgaccagctgcgcagtgagtcgtccccagaggcatacatccggtgcttg
cgcatgggctgccgctgcatcgagttggactgctgggacgggccagacgggaagcccgtc
atttaccacggctggacgcggaccaccaagatcaagtttgacgacgtggtgcaggccatc
aaagaccacgcctttgtcacctcaagcttccctgtgatcctgtccatcgagcagcactgt
ggggtggagcagcagcgctacatggccaaggtcttcacggaggtgctggacggcctgctg
cttgtgaagcccacggaggccagcgctgaccagctgccttcccccagccagctgcgcgag
aagatcatcatcaagcataagaagctgggcccccgcggggacgtggacatcaacatggag
gacaagaaggacgagcacaagcagcagggcgagctgtccatgtgggactccattgaccag
aagtggacccggcactactgtgccattgccgacgccaagctgtccttcagtgacgacatt
gaacaggtggtggaagaggagctgccccaggacacgccccccacggagctgcacttcggg
gagaagtggttccacaagaaggtggagaagcgcaccagcgccgagaagctgctgcaggag
tactgtgccgagtccggggccaaggatgggaccttcttggtgcgcgagagcgagacctac
cccaacgactacaccctctccttctggcggtcaggccgggtccagcactgccgcatccgc
tccaccatggagggcgggaccatgaagtactacctgacggacaacctcatgttcaccagc
atctacgccctggtgcagcactaccgcgagagccacctgcgctgcgcggagttcgagctg
cggctcacagacccagtgcccaaccccaacccgcatgaatcaaaaccgtggtactacgat
gggttgagccgtggggaagcagaggacatgctgatgagggtcccccgggacggggccttc
ctcgtccggaagcgagaaggggccgactcctatgccatcaccttcagggcccgggggaag
gtgaagcactgccgggtcacgcgggacggccggcactttgtgctggggacctcggcctac
ttcgagagcctggtggagctggtcagctactacgagaagcacgcgctgtaccgaaagatg
aggctgcgctaccccgtgacacccgagctgctggagcgatacaacatggaaagagatata
aactccctctatgacgtcagcaggatgtacgtggatcccagcgagattaacccttccacg
cctcagcgaactgtgaaagccctgtatgactacagagccaagcgcagcgatgagctgagc
ttctgccgcggagccctcatccacaacgtctccaaggagccaggcggctggtggaaaggc
gactacggggcccggatccagcagtacttcccatccaactacgttgaggacatctctacg
gttgacgttgaggagctagaaaagcagatcattgaagacaaccccttaggctctctctgc
agagggatcctggacctcaatacctacaacgtcgtgaaggccccccaggggaagaaccag
aagtcctttgtcttcatcctggagcccaagaagcagggcgaccctccggtggagtttgcc
acggaccgggtggaggagctcttcgagtggttccagagcatccgggagatcacctggaag
atggacaccaaggagaacaacatgaagtactgggagaagaaccagtccatcgccatcgag
ctgtccgaccttgtcgtctactgcaaacccaccagtaaaactaaggacaatttagagaac
cctgacttcagagaaatccgctccttcgtggagaccaaggcggacagcatcgtccggcag
aagcccatggagctcctcaagtacaaccagaaggggctgacccgcatctaccccaagggc
cagagggtggactcctccaactacgaccccttccgcctctggctgtgtggctctcagatg
gtggcgctcaacttccagacggcagacaagtacatgcagatgaaccacgccctcgtcctg
ggtgcccggcacctccccaagctcggccggagcatcgcctgccccttcgtggaggtagag
atctgcggagcggagtacgacaacaacaagttcaagacgaccgttgtgaatgacaacggc
ttaaatcccgtgtgggccccgacccaggagaaggtaaccttcgagatctatgaccccaac
ctcgccttcctgcgctttgtggtgtacgaggaagacatgttcagcgaccccaacttcctg
gctcacgcaacgtaccccattaaaggcatccggtcaggcttcaggtcggttcctctcaag
aatgggcacagcgaagatgtggagctggcgtccctgctggtgtgctgtgagatgcggccg
gtcctggagagcgaggaggagctgtactcctcctgccggcagctgcggaggcggcaagag
gagctcaacaaccagctcttcctgtacgacacccagcagaacctgcggaacgcgccccgg
gatgcgctggtgaaggaattcaacaccaacgagaaccagctgcagctgtaccaggagacg
tgcaaccggaggcttcgtgagaagagggtcagcaacagcaagttctactcctag

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (12)   
   Pfam (12)   
All databases (16)   

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