KEGG   Echinops telfairi (small Madagascar hedgehog): 101657011
Entry
101657011         CDS       T08707                                 
Symbol
IKBKB
Name
(RefSeq) inhibitor of nuclear factor kappa-B kinase subunit beta
  KO
K07209  inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
Organism
etf  Echinops telfairi (small Madagascar hedgehog)
Pathway
etf01523  Antifolate resistance
etf04010  MAPK signaling pathway
etf04014  Ras signaling pathway
etf04062  Chemokine signaling pathway
etf04064  NF-kappa B signaling pathway
etf04068  FoxO signaling pathway
etf04150  mTOR signaling pathway
etf04151  PI3K-Akt signaling pathway
etf04210  Apoptosis
etf04380  Osteoclast differentiation
etf04620  Toll-like receptor signaling pathway
etf04621  NOD-like receptor signaling pathway
etf04622  RIG-I-like receptor signaling pathway
etf04623  Cytosolic DNA-sensing pathway
etf04625  C-type lectin receptor signaling pathway
etf04657  IL-17 signaling pathway
etf04658  Th1 and Th2 cell differentiation
etf04659  Th17 cell differentiation
etf04660  T cell receptor signaling pathway
etf04662  B cell receptor signaling pathway
etf04668  TNF signaling pathway
etf04722  Neurotrophin signaling pathway
etf04910  Insulin signaling pathway
etf04920  Adipocytokine signaling pathway
etf04930  Type II diabetes mellitus
etf04931  Insulin resistance
etf04932  Non-alcoholic fatty liver disease
etf04936  Alcoholic liver disease
etf05010  Alzheimer disease
etf05132  Salmonella infection
etf05135  Yersinia infection
etf05142  Chagas disease
etf05145  Toxoplasmosis
etf05160  Hepatitis C
etf05161  Hepatitis B
etf05162  Measles
etf05163  Human cytomegalovirus infection
etf05164  Influenza A
etf05165  Human papillomavirus infection
etf05166  Human T-cell leukemia virus 1 infection
etf05167  Kaposi sarcoma-associated herpesvirus infection
etf05168  Herpes simplex virus 1 infection
etf05169  Epstein-Barr virus infection
etf05170  Human immunodeficiency virus 1 infection
etf05171  Coronavirus disease - COVID-19
etf05200  Pathways in cancer
etf05206  MicroRNAs in cancer
etf05208  Chemical carcinogenesis - reactive oxygen species
etf05212  Pancreatic cancer
etf05215  Prostate cancer
etf05220  Chronic myeloid leukemia
etf05221  Acute myeloid leukemia
etf05222  Small cell lung cancer
etf05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
etf05417  Lipid and atherosclerosis
etf05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:etf00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101657011 (IKBKB)
   04014 Ras signaling pathway
    101657011 (IKBKB)
   04064 NF-kappa B signaling pathway
    101657011 (IKBKB)
   04668 TNF signaling pathway
    101657011 (IKBKB)
   04068 FoxO signaling pathway
    101657011 (IKBKB)
   04151 PI3K-Akt signaling pathway
    101657011 (IKBKB)
   04150 mTOR signaling pathway
    101657011 (IKBKB)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    101657011 (IKBKB)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    101657011 (IKBKB)
   04621 NOD-like receptor signaling pathway
    101657011 (IKBKB)
   04622 RIG-I-like receptor signaling pathway
    101657011 (IKBKB)
   04623 Cytosolic DNA-sensing pathway
    101657011 (IKBKB)
   04625 C-type lectin receptor signaling pathway
    101657011 (IKBKB)
   04660 T cell receptor signaling pathway
    101657011 (IKBKB)
   04658 Th1 and Th2 cell differentiation
    101657011 (IKBKB)
   04659 Th17 cell differentiation
    101657011 (IKBKB)
   04657 IL-17 signaling pathway
    101657011 (IKBKB)
   04662 B cell receptor signaling pathway
    101657011 (IKBKB)
   04062 Chemokine signaling pathway
    101657011 (IKBKB)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101657011 (IKBKB)
   04920 Adipocytokine signaling pathway
    101657011 (IKBKB)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    101657011 (IKBKB)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    101657011 (IKBKB)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101657011 (IKBKB)
   05206 MicroRNAs in cancer
    101657011 (IKBKB)
   05208 Chemical carcinogenesis - reactive oxygen species
    101657011 (IKBKB)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101657011 (IKBKB)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    101657011 (IKBKB)
   05221 Acute myeloid leukemia
    101657011 (IKBKB)
   05220 Chronic myeloid leukemia
    101657011 (IKBKB)
   05215 Prostate cancer
    101657011 (IKBKB)
   05222 Small cell lung cancer
    101657011 (IKBKB)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101657011 (IKBKB)
   05170 Human immunodeficiency virus 1 infection
    101657011 (IKBKB)
   05161 Hepatitis B
    101657011 (IKBKB)
   05160 Hepatitis C
    101657011 (IKBKB)
   05171 Coronavirus disease - COVID-19
    101657011 (IKBKB)
   05164 Influenza A
    101657011 (IKBKB)
   05162 Measles
    101657011 (IKBKB)
   05168 Herpes simplex virus 1 infection
    101657011 (IKBKB)
   05163 Human cytomegalovirus infection
    101657011 (IKBKB)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101657011 (IKBKB)
   05169 Epstein-Barr virus infection
    101657011 (IKBKB)
   05165 Human papillomavirus infection
    101657011 (IKBKB)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    101657011 (IKBKB)
   05135 Yersinia infection
    101657011 (IKBKB)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    101657011 (IKBKB)
   05142 Chagas disease
    101657011 (IKBKB)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101657011 (IKBKB)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101657011 (IKBKB)
   05418 Fluid shear stress and atherosclerosis
    101657011 (IKBKB)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    101657011 (IKBKB)
   04936 Alcoholic liver disease
    101657011 (IKBKB)
   04932 Non-alcoholic fatty liver disease
    101657011 (IKBKB)
   04931 Insulin resistance
    101657011 (IKBKB)
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    101657011 (IKBKB)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:etf01001]
    101657011 (IKBKB)
Enzymes [BR:etf01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     101657011 (IKBKB)
Protein kinases [BR:etf01001]
 Serine/threonine kinases: Other
  IKK family [OT]
   101657011 (IKBKB)
SSDB
Motif
Pfam: IKBKB_SDD Pkinase PK_Tyr_Ser-Thr IKKbetaNEMObind Pkinase_fungal ubiquitin Kdo APH YrbL-PhoP_reg EspB_PE
Other DBs
NCBI-GeneID: 101657011
NCBI-ProteinID: XP_045142789
Position
Unknown
AA seq 886 aa
MSWSPSLQTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL
EIQIMRRLNHPNVVAKAASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKE
LDQSSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWH
SKVRQKSEMDIVVSEDLSGTVKFSSSLPYPNNLNRVLAQRLEKWLQLMLMWHPRQRGTDP
MYGPNGCFKALDDILNLELVHILNMVTGTIHTYPVTADESLQSLKARIQQDTGIPEADQE
LLQEAGLALIPDKPATQCISDGKPNEGRTLDMDLVFLFDNSKITYETQISPRPQPESVSC
ILQEPKRNLTFFHLRKVWGQVWHSIQALKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSM
ASMSQQLKAKLDFFKTSVQIDLEKYSEQTEFGITSDKLLLAWREMEQSVERYGRENEVKH
LVERMMALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTDGDSQEMVR
LLLQAIQGFEKKVRVIYTQLRYNAPSLLSGGLWRSHKAVCGPTSLPLLGCAQLPEEAYSF
NLLVSGIPSQKRTPVDSETLCKLACKVSAAVCFPLKLRFHTYIIPSFNHVKSNCTIATKI
HFQTFFFCMVSLTSAPFYPTTTTVPPPHPEPLLLLSAVVLVHDVDRSFLEEPLVPYSQMT
AQKTLRHEARLGSSQTFSQCSVKRCQQRRYCGAQLCPAPVGLPSAGANSQRDSLEPPFFH
RGGDSLSGFVLQSKVRGPVSGSPDSMNASRLSHPGQLMSQPAPAPDSLAQSVKKSEELVA
EAHTLCTQLETAMQDTLKDQDQSFMTLDWSWLQTEEEEQNRLEQAS
NT seq 2661 nt   +upstreamnt  +downstreamnt
atgagctggtcaccttccctgcaaactcagacatgtggggcctgggaaatgaaggaacga
cttgggacagggggatttggaaacgtcatccgatggcacaaccaggaaacaggtgagcag
attgctatcaagcagtgccgacaggagctcagcccccggaaccgggagcggtggtgcctg
gaaatccagatcatgcgaaggctgaaccaccccaacgtggtggctaaggcagcctcggcg
cttcgataccttcacgagaacaggatcatccaccgagatctgaagccggagaacatcgtc
ctgcagcagggggagcagaggttaatacacaagattattgacctcggatatgccaaggag
ctggaccagagcagtctttgcacgtcctttgtagggaccctgcagtacctggccccggag
ctgctggagcagcagaagtacacggtgacagtggactactggagcttcggcaccctggct
tttgagtgcatcacgggcttccggcctttcctccccaactggcagcctgtgcagtggcac
tcgaaggtccggcagaagagcgagatggacattgtcgtcagtgaggacttgagcggaacg
gtgaagttttccagctccttgccctaccccaataatctcaacagagtcctggcacagcga
ctggagaagtggctgcagctgatgttgatgtggcacccccggcagaggggcacagacccc
atgtacgggcccaacggctgcttcaaggccctggatgacatcttgaacttggagctggtt
cacatcttgaacatggtaacgggcaccatccacacttacccagtgacggcagatgagagt
ctgcagagtttgaaggcccggatccagcaagacacaggaattccagaggcagaccaggaa
ctgctgcaagaggcagggctggcattgatccccgacaagcctgccacccagtgtatttcc
gacggcaagccaaatgagggccgcaccttggacatggatcttgtgttcctctttgacaac
agcaaaatcacctatgagacacagatctctcctcggcctcaaccggaaagtgtcagctgt
atccttcaggagcccaagaggaatctcaccttcttccacctgaggaaggtgtggggccag
gtctggcacagcatccaagccctgaaggaggattgtaaccggttgcagcagggacagcga
gcggccatgatgaacctcctccggaacaacagctgcctctccaagatgaagaactccatg
gcctccatgtcccagcagctcaaggccaagctggacttctttaagaccagcgtccagatt
gacctggagaagtacagcgagcagaccgagtttgggatcacatcagataaattgctgctg
gcctggagggaaatggagcagtcggtggagcgctacgggcgggagaatgaagtgaagcat
ctggtggagcgaatgatggcgctgcagacagacatcgtggacttacagaggagcccgatg
ggtcggaagcagggtgggacgctggatgacctagaggagcaggcaagggagctctacagg
agactgagggaaaaaccaagagaccagcggactgatggggacagtcaggaaatggtgcgg
ctgctgcttcaggcaatccagggcttcgagaagaaagtgcgagtgatttacacgcagctc
aggtacaacgccccttccctgctctctggtgggctgtggagaagccacaaggctgtgtgt
gggcccacttccctccctctactcggctgtgcccagctgcctgaagaagcttactcattc
aatctccttgtttctggaatcccttctcaaaaaaggacacctgtagattcagaaacactt
tgtaagctggcatgcaaagtatcagcagctgtctgttttcccttaaaattgcgatttcat
acatacatcattccatcatttaatcacgtcaagtcgaattgtacaattgctaccaaaatc
catttccaaacattctttttctgcatggtctccttgacatcggctcccttttaccccacc
accaccactgtaccccctccccaccccgaaccccttcttctactttcagcagttgtctta
gttcatgatgttgaccgatcttttttggaagaaccgctagtgccctacagccaaatgact
gcacagaaaacactccggcatgaagcgaggctgggatcgtctcaaaccttctcccagtgc
tccgtgaaacgttgccaacaacgaagatactgcggagcgcagctctgcccggcacctgtg
ggcctgccatcagctggagccaactcccagagagactctctggaaccccctttcttccac
cgtggtggcgactctctttctggttttgtccttcagagcaaggtccgcggtcctgtcagt
ggaagcccagatagcatgaacgcgtcgcgcctcagtcaccctggccagctgatgtcacag
cctgcccctgcccccgacagcttagctcagtccgtcaagaagagtgaagaactggtggcc
gaagcacatactctctgtacccagctggaaacggccatgcaagacaccctgaaagaccag
gaccagagtttcatgactctcgactggagctggttacaaacagaggaagaggagcagaat
cgcctggagcaggcctcgtga

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (10)   
   Pfam (10)   
All databases (14)   

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