KEGG   PATHWAY: hsa00760
Entry
hsa00760                    Pathway                                
Name
Nicotinate and nicotinamide metabolism - Homo sapiens (human)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
hsa00760  Nicotinate and nicotinamide metabolism
hsa00760

Module
hsa_M00912  NAD biosynthesis, tryptophan => quinolinate => NAD [PATH:hsa00760]
Network
nt06036  Lysine degradation
  Element
N01723  NAD biosynthesis
N01724  NAD+ phosphorylation
Drug
D04245  Forodesine hydrochloride (JAN/USAN)
D05396  Peldesine (USAN)
D06596  Forodesine (USAN/INN)
D09678  Teglarinad chloride (USAN/INN)
D10431  Ulodesine (USAN/INN)
D10432  Ulodesine succinate (USAN)
D12373  Quemliclustat (USAN/INN)
D12401  Uliledlimab (USAN/INN)
D13109  Forvisirvat (USAN)
D13146  Mavrostobart (USAN/INN)
Other DBs
UMBBD: nic
GO: 0046497 0006769
Organism
Homo sapiens (human) [GN:hsa]
Gene
100526794  NT5C1B-RDH14; NT5C1B-RDH14 protein isoform 1 [KO:K01081] [EC:3.1.3.5]
10135  NAMPT; nicotinamide phosphoribosyltransferase precursor [KO:K03462] [EC:2.4.2.12]
133686  NADK2; NAD kinase 2, mitochondrial isoform 1 [KO:K00858] [EC:2.7.1.23]
22933  SIRT2; NAD-dependent protein deacetylase sirtuin-2 isoform 1 [KO:K11412] [EC:2.3.1.286]
22978  NT5C2; cytosolic purine 5'-nucleotidase isoform 1 [KO:K01081] [EC:3.1.3.5]
23057  NMNAT2; nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 isoform 1 [KO:K06210] [EC:2.7.7.1 2.7.7.18]
23098  SARM1; NAD(+) hydrolase SARM1 precursor [KO:K27536]
23408  SIRT5; NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1 [KO:K11415] [EC:2.3.1.286]
23409  SIRT4; NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform 1 [KO:K11414] [EC:2.3.1.286 2.3.1.313]
23410  SIRT3; NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform a [KO:K11413] [EC:2.3.1.286]
23411  SIRT1; NAD-dependent protein deacetylase sirtuin-1 isoform a [KO:K11411] [EC:2.3.1.286]
23475  QPRT; nicotinate-nucleotide pyrophosphorylase [carboxylating] isoform 1 [KO:K00767] [EC:2.4.2.19]
23530  NNT; NAD(P) transhydrogenase, mitochondrial isoform 1 [KO:K00323] [EC:7.1.1.1]
25961  NUDT13; NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform a [KO:K03426] [EC:3.6.1.22]
27231  NMRK2; nicotinamide riboside kinase 2 isoform 2 [KO:K10524] [EC:2.7.1.22 2.7.1.173]
284958  NT5DC4; 5'-nucleotidase domain-containing protein 4 isoform 2 [KO:K01081] [EC:3.1.3.5]
30833  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type isoform 1 [KO:K01081] [EC:3.1.3.5]
316  AOX1; aldehyde oxidase [KO:K00157] [EC:1.2.3.1]
349565  NMNAT3; nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform 4 [KO:K06210] [EC:2.7.7.1 2.7.7.18]
4837  NNMT; nicotinamide N-methyltransferase [KO:K00541] [EC:2.1.1.1]
4860  PNP; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
4907  NT5E; 5'-nucleotidase isoform 1 preproprotein [KO:K19970] [EC:3.1.3.5]
51547  SIRT7; NAD-dependent protein deacetylase sirtuin-7 [KO:K11417] [EC:2.3.1.286]
51548  SIRT6; NAD-dependent protein deacylase sirtuin-6 isoform 1 [KO:K11416] [EC:2.3.1.286]
5167  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
5169  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
54981  NMRK1; nicotinamide riboside kinase 1 isoform 1 [KO:K10524] [EC:2.7.1.22 2.7.1.173]
55191  NADSYN1; glutamine-dependent NAD(+) synthetase [KO:K01950] [EC:6.3.5.1]
554235  ASPDH; aspartate dehydrogenase domain-containing protein isoform 1 [KO:K06989] [EC:1.4.1.21]
56953  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial isoform 4 precursor [KO:K01081] [EC:3.1.3.5]
64802  NMNAT1; nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 isoform 1 [KO:K06210] [EC:2.7.7.1 2.7.7.18]
65220  NADK; NAD kinase isoform 1 [KO:K00858] [EC:2.7.1.23]
683  BST1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 precursor [KO:K18152] [EC:3.2.2.6 2.4.99.20]
83594  NUDT12; NAD-capped RNA hydrolase NUDT12 isoform 1 [KO:K03426] [EC:3.6.1.22]
84618  NT5C1A; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
93034  NT5C1B; cytosolic 5'-nucleotidase 1B isoform 1 [KO:K01081] [EC:3.1.3.5]
93100  NAPRT; nicotinate phosphoribosyltransferase isoform 1 [KO:K00763] [EC:6.3.4.21]
952  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
Compound
C00003  NAD+
C00006  NADP+
C00022  Pyruvate
C00042  Succinate
C00049  L-Aspartate
C00111  Glycerone phosphate
C00122  Fumarate
C00153  Nicotinamide
C00163  Propanoate
C00232  Succinate semialdehyde
C00253  Nicotinate
C00334  4-Aminobutanoate
C00455  Nicotinamide D-ribonucleotide
C00745  Nicotine
C00857  Deamino-NAD+
C00922  2,3-Dimethylmaleate
C01020  6-Hydroxynicotinate
C01056  (S)-6-Hydroxynicotine
C01059  2,5-Dihydroxypyridine
C01185  Nicotinate D-ribonucleotide
C01297  6-Hydroxypseudooxynicotine
C01384  Maleic acid
C01596  Maleamate
C02295  Methylitaconate
C02918  1-Methylnicotinamide
C02930  2-Methyleneglutarate
C03043  (R)-6-Hydroxynicotine
C03056  2,6-Dihydroxypyridine
C03150  Nicotinamide-beta-riboside
C03458  2,3,6-Trihydroxypyridine
C03652  (2R,3S)-2,3-Dimethylmalate
C03722  Quinolinate
C04226  6-Oxo-1,4,5,6-tetrahydronicotinate
C05380  Nicotinurate
C05840  Iminoaspartate
C05841  Nicotinate D-ribonucleoside
C05842  N1-Methyl-2-pyridone-5-carboxamide
C05843  N1-Methyl-4-pyridone-5-carboxamide
C06178  1-Methylpyrrolinium
C15523  2,6-Dihydroxynicotinate
C15986  2,6-Dihydroxypseudooxynicotine
C15987  4-Methylaminobutyrate
C16151  2,6-Dihydroxy-N-methylmyosmine
C16152  Blue pigment
C16159  2-Formylglutarate
C16386  (R)-Nicotine
C16390  (S)-2-(Hydroxymethyl)glutarate
C18232  N-Formylmaleamic acid
C19567  4-Oxo-1-(3-pyridyl)-1-butanone
C19569  3-Succinoylpyridine
C19631  6-Hydroxy-3-succinoylpyridine
C20361  Pseudooxynicotine
C20381  3,3'-Bipyridine-2,2',5,5',6,6'-hexol
C21154  N-Methylmyosmine
C23137  5-(6-Hydroxypyridin-3-yl)-1-methyl-3,4-dihydro-2H-pyrrol-1-ium
Reference
PMID:13475371
  Authors
BEHRMAN EJ, STANIER RY.
  Title
The bacterial oxidation of nicotinic acid.
  Journal
J Biol Chem 228:923-45 (1957)
Reference
PMID:16894175
  Authors
Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ.
  Title
Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri.
  Journal
Proc Natl Acad Sci U S A 103:12341-6 (2006)
DOI:10.1073/pnas.0601635103
Reference
PMID:11514508
  Authors
Baitsch D, Sandu C, Brandsch R, Igloi GL.
  Title
Gene cluster on pAO1 of Arthrobacter nicotinovorans involved in degradation of the plant alkaloid nicotine: cloning, purification, and characterization of 2,6-dihydroxypyridine 3-hydroxylase.
  Journal
J Bacteriol 183:5262-7 (2001)
DOI:10.1128/JB.183.18.5262-5267.2001
Reference
PMID:16321959
  Authors
Sachelaru P, Schiltz E, Igloi GL, Brandsch R.
  Title
An alpha/beta-fold C--C bond hydrolase is involved in a central step of nicotine catabolism by Arthrobacter nicotinovorans.
  Journal
J Bacteriol 187:8516-9 (2005)
DOI:10.1128/JB.187.24.8516-8519.2005
Reference
PMID:5835946
  Authors
Gherna RL, Richardson SH, Rittenberg SC
  Title
The bacterial oxidation of nicotine. VI. The metabolism of 2,6-dihydroxypseudooxynicotine.
  Journal
J Biol Chem 240:3669-74 (1965)
Reference
PMID:21953451
  Authors
Galeazzi L, Bocci P, Amici A, Brunetti L, Ruggieri S, Romine M, Reed S, Osterman AL, Rodionov DA, Sorci L, Raffaelli N
  Title
Identification of nicotinamide mononucleotide deamidase of the bacterial pyridine nucleotide cycle reveals a novel broadly conserved amidohydrolase family.
  Journal
J Biol Chem 286:40365-75 (2011)
DOI:10.1074/jbc.M111.275818
Related
pathway
hsa00020  Citrate cycle (TCA cycle)
hsa00250  Alanine, aspartate and glutamate metabolism
hsa00380  Tryptophan metabolism
hsa00620  Pyruvate metabolism
hsa00660  C5-Branched dibasic acid metabolism
KO pathway
ko00760   

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