KEGG   Homo sapiens (human): 2237
Entry
2237              CDS       T01001                                 
Symbol
FEN1, FEN-1, MF1, RAD2
Name
(RefSeq) flap endonuclease 1
  KO
K04799  flap endonuclease-1 [EC:3.1.-.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03030  DNA replication
hsa03410  Base excision repair
hsa03450  Non-homologous end-joining
Network
nt06504  Base excision repair
nt06509  DNA replication
  Element
N01436  Long patch BER
N01472  Okazaki fragment maturation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03030 DNA replication
    2237 (FEN1)
   03410 Base excision repair
    2237 (FEN1)
   03450 Non-homologous end-joining
    2237 (FEN1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    2237 (FEN1)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    2237 (FEN1)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    2237 (FEN1)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Elongation Factors
   Other elongation factors
    2237 (FEN1)
 Prokaryotic type
   Elongation factors (archaeal)
    Other elongation factors
     2237 (FEN1)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   BER (base exicision repair)
    Long Patch-BER factors
     2237 (FEN1)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   2237 (FEN1)
SSDB
Motif
Pfam: XPG_N XPG_I 5_3_exonuc XPG_I_2 5_3_exonuc_N HHH_5 Maelstrom
Other DBs
NCBI-GeneID: 2237
NCBI-ProteinID: NP_004102
OMIM: 600393
HGNC: 3650
Ensembl: ENSP00000305480.2
UniProt: P39748 Q6FHX6
Structure
Position
11:61792911..61797238
AA seq 380 aa
MGIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGET
TSHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQAAGAE
QEVEKFTKRLVKVTKQHNDECKHLLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDM
DCLTFGSPVLMRHLTASEAKKLPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRG
IGPKRAVDLIQKHKSIEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPESVELKWSE
PNEEELIKFMCGEKQFSEERIRSGVKRLSKSRQGSTQGRLDDFFKVTGSLSSAKRKEPEP
KGSTKKKAKTGAAGKFKRGK
NT seq 1143 nt   +upstreamnt  +downstreamnt
atgggaattcaaggcctggccaaactaattgctgatgtggcccccagtgccatccgggag
aatgacatcaagagctactttggccgtaaggtggccattgatgcctctatgagcatttat
cagttcctgattgctgttcgccagggtggggatgtgctgcagaatgaggagggtgagacc
accagccacctgatgggcatgttctaccgcaccattcgcatgatggagaacggcatcaag
cccgtgtatgtctttgatggcaagccgccacagctcaagtcaggcgagctggccaaacgc
agtgagcggcgggctgaggcagagaagcagctgcagcaggctcaggctgctggggccgag
caggaggtggaaaaattcactaagcggctggtgaaggtcactaagcagcacaatgatgag
tgcaaacatctgctgagcctcatgggcatcccttatcttgatgcacccagtgaggcagag
gccagctgtgctgccctggtgaaggctggcaaagtctatgctgcggctaccgaggacatg
gactgcctcaccttcggcagccctgtgctaatgcgacacctgactgccagtgaagccaaa
aagctgccaatccaggaattccacctgagccggattctgcaggagctgggcctgaaccag
gaacagtttgtggatctgtgcatcctgctaggcagtgactactgtgagagtatccggggt
attgggcccaagcgggctgtggacctcatccagaagcacaagagcatcgaggagatcgtg
cggcgacttgaccccaacaagtaccctgtgccagaaaattggctccacaaggaggctcac
cagctcttcttggaacctgaggtgctggacccagagtctgtggagctgaagtggagcgag
ccaaatgaagaagagctgatcaagttcatgtgtggtgaaaagcagttctctgaggagcga
atccgcagtggggtcaagaggctgagtaagagccgccaaggcagcacccagggccgcctg
gatgatttcttcaaggtgaccggctcactctcttcagctaagcgcaaggagccagaaccc
aagggatccactaagaagaaggcaaagactggggcagcagggaagtttaaaaggggaaaa
taa

  All links  
Disease (1)   
   OMIM (1)   
Gene (17)   
   RefGene (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (11)   
   OC (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (21)   
   RefSeq(nuc) (1)   
   GenBank (10)   
   EMBL (10)   
3D Structure (28)   
   PDB (28)   
Protein domain (7)   
   Pfam (7)   
All databases (78)   

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