KEGG   NETWORK: N01436
Entry
N01436                      Network                                
Name
Long patch BER
Definition
POLB == (POLD,POLE) == PCNA == RFC -> PCNA+FEN1 -> PCNA+LIG1
  Expanded
5423 == (5424+5425+10714+57804),(5426+5427+54107+56655) == 5111 == (5981+5982+5983+5984+5985) -> 5111+2237 -> 5111+3978
Class
nt06504 Base excision repair
Type
Reference
Pathway
hsa03410  Base excision repair
Gene
5423  POLB; DNA polymerase beta
5424  POLD1; DNA polymerase delta 1, catalytic subunit
5425  POLD2; DNA polymerase delta 2, accessory subunit
10714  POLD3; DNA polymerase delta 3, accessory subunit
57804  POLD4; DNA polymerase delta 4, accessory subunit
5426  POLE; DNA polymerase epsilon, catalytic subunit
5427  POLE2; DNA polymerase epsilon 2, accessory subunit
54107  POLE3; DNA polymerase epsilon 3, accessory subunit
56655  POLE4; DNA polymerase epsilon 4, accessory subunit
5111  PCNA; proliferating cell nuclear antigen
5981  RFC1; replication factor C subunit 1
5982  RFC2; replication factor C subunit 2
5983  RFC3; replication factor C subunit 3
5984  RFC4; replication factor C subunit 4
5985  RFC5; replication factor C subunit 5
2237  FEN1; flap structure-specific endonuclease 1
3978  LIG1; DNA ligase 1
Reference
  Authors
Grundy GJ, Parsons JL
  Title
Base excision repair and its implications to cancer therapy.
  Journal
Essays Biochem 64:831-843 (2020)
DOI:10.1042/EBC20200013
Reference
  Authors
Hegde ML, Hazra TK, Mitra S
  Title
Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells.
  Journal
Cell Res 18:27-47 (2008)
DOI:10.1038/cr.2008.8

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