KEGG   Homo sapiens (human): 3615
Entry
3615              CDS       T01001                                 
Symbol
IMPDH2, IMPD2, IMPDH-II
Name
(RefSeq) inosine-5'-monophosphate dehydrogenase 2 isoform 2
  KO
K00088  IMP dehydrogenase [EC:1.1.1.205]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00230  Purine metabolism
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
hsa01232  Nucleotide metabolism
Module
hsa_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP
Drug target
Merimepodib: D04936
Mizoribine: D01392<JP>
Mycophenolic acid (DG00739): D00752<JP/US> D05094<US> D05095<US> D05096
Tiazofurine: D06130
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    3615 (IMPDH2)
  09111 Xenobiotics biodegradation and metabolism
   00983 Drug metabolism - other enzymes
    3615 (IMPDH2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    3615 (IMPDH2)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.205  IMP dehydrogenase
     3615 (IMPDH2)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   3615 (IMPDH2)
  Exosomal proteins of breast cancer cells
   3615 (IMPDH2)
SSDB
Motif
Pfam: IMPDH CBS NMO FMN_dh His_biosynth NanE ThiG Dus Glu_synthase B12-binding YceG_bac DUF561 DHO_dh
Other DBs
NCBI-GeneID: 3615
NCBI-ProteinID: NP_000875
OMIM: 146691
HGNC: 6053
Ensembl: ENSP00000321584.4
UniProt: P12268 A0A384N6C2
Structure
Position
3:complement(49024325..49029398)
AA seq 514 aa
MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKIT
LKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVV
LSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMT
KREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDA
KKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVI
GGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVP
VIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAM
DKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVR
AMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF
NT seq 1545 nt   +upstreamnt  +downstreamnt
atggccgactacctgattagtgggggcacgtcctacgtgccagacgacggactcacagca
cagcagctcttcaactgcggagacggcctcacctacaatgactttctcattctccctggg
tacatcgacttcactgcagaccaggtggacctgacttctgctctgaccaagaaaatcact
cttaagaccccactggtttcctctcccatggacacagtcacagaggctgggatggccata
gcaatggcgcttacaggcggtattggcttcatccaccacaactgtacacctgaattccag
gccaatgaagttcggaaagtgaagaaatatgaacagggattcatcacagaccctgtggtc
ctcagccccaaggatcgcgtgcgggatgtttttgaggccaaggcccggcatggtttctgc
ggtatcccaatcacagacacaggccggatggggagccgcttggtgggcatcatctcctcc
agggacattgattttctcaaagaggaggaacatgactgtttcttggaagagataatgaca
aagagggaagacttggtggtagcccctgcaggcatcacactgaaggaggcaaatgaaatt
ctgcagcgcagcaagaagggaaagttgcccattgtaaatgaagatgatgagcttgtggcc
atcattgcccggacagacctgaagaagaatcgggactacccactagcctccaaagatgcc
aagaaacagctgctgtgtggggcagccattggcactcatgaggatgacaagtataggctg
gacttgctcgcccaggctggtgtggatgtagtggttttggactcttcccagggaaattcc
atcttccagatcaatatgatcaagtacatcaaagacaaataccctaatctccaagtcatt
ggaggcaatgtggtcactgctgcccaggccaagaacctcattgatgcaggtgtggatgcc
ctgcgggtgggcatgggaagtggctccatctgcattacgcaggaagtgctggcctgtggg
cggccccaagcaacagcagtgtacaaggtgtcagagtatgcacggcgctttggtgttccg
gtcattgctgatggaggaatccaaaatgtgggtcatattgcgaaagccttggcccttggg
gcctccacagtcatgatgggctctctcctggctgccaccactgaggcccctggtgaatac
ttcttttccgatgggatccggctaaagaaatatcgcggtatgggttctctcgatgccatg
gacaagcacctcagcagccagaacagatatttcagtgaagctgacaaaatcaaagtggcc
cagggagtgtctggtgctgtgcaggacaaagggtcaatccacaaatttgtcccttacctg
attgctggcatccaacactcatgccaggacattggtgccaagagcttgacccaagtccga
gccatgatgtactctggggagcttaagtttgagaagagaacgtcctcagcccaggtggaa
ggtggcgtccatagcctccattcgtatgagaagcggcttttctga

  All links  
Disease (2)   
   OMIM (2)   
Gene (25)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (12)   
   OC (1)   
Protein sequence (7)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (20)   
   RefSeq(nuc) (4)   
   GenBank (8)   
   EMBL (8)   
3D Structure (25)   
   PDB (25)   
Protein domain (13)   
   Pfam (13)   
All databases (92)   

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