KEGG   Homo sapiens (human): 6710
Entry
6710              CDS       T01001                                 
Symbol
SPTB, EL3, HS2, HSPTB1, SPH2
Name
(RefSeq) spectrin beta chain, erythrocytic isoform b
  KO
K27409  spectrin beta, erythrocytic
Organism
hsa  Homo sapiens (human)
Disease
H00230  Hereditary spherocytosis
H00231  Hereditary elliptocytosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    6710 (SPTB)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    Cross-linking proteins
     6710 (SPTB)
  Intermediate filaments
   Intermediate filament-binding proteins
    6710 (SPTB)
SSDB
Motif
Pfam: Spectrin CH CAMSAP_CH CREPT Tnp_22_trimer
Other DBs
NCBI-GeneID: 6710
NCBI-ProteinID: NP_001342366
OMIM: 182870
HGNC: 11274
UniProt: P11277
Structure
Position
14:complement(64746283..64879907)
AA seq 2137 aa
MTSATEFENVGNQPPYSRINARWDAPDDELDNDNSSARLFERSRIKALADEREVVQKKTF
TKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHCLENVDKAL
QFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRETRSAKDALL
LWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARHNLEHAFNV
AERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVGKVIDHAIET
EKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKG
NLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKL
EQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRA
LEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHS
IDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGY
QPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIY
SSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKE
VSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRA
LGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLR
QQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTL
MTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYC
VDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQ
LMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSIT
QKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLG
QRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSL
EAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNN
EKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVA
ELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS
SDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFA
QVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPL
AQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLG
HLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAI
VMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAE
ERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETG
AIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLH
RYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVAT
RLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWME
SIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEI
REKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHT
VDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERPAEETGPQEEEGETAG
EAPVSHHAATERTSPVSLWSRLSSSWESLQPEPSHPY
NT seq 6414 nt   +upstreamnt  +downstreamnt
atgacatcggccacagagtttgaaaatgtgggcaaccagccaccttacagcaggatcaat
gcccgctgggacgccccagacgacgagctggataatgacaacagctcagccaggctcttt
gagaggtcccggataaaggccttggcagatgagcgggaagttgttcagaaaaagaccttc
acgaaatgggtgaactcgcacctggctcgagtgtcctgccgcatcaccgatctctacaag
gacctgcgggatgggcgcatgctcatcaagctgctggaggtgctctctggagagatgctg
ccaaagcccaccaaggggaagatgcgcatccactgcctggagaatgtggacaaggctctc
cagttcctcaaggagcagcgtgtacacctggagaacatgggctcccacgacattgtagat
ggcaaccaccgcctggtcctgggcctcatctggaccatcatcctccgcttccagattcag
gacattgtggtccaaactcaggaaggtcgtgaaacacgctcagccaaggatgcgttgctg
ttgtggtgtcagatgaagacggcaggctaccctcatgttaatgtcaccaactttacctcc
agctggaaggatggcttggcctttaatgccctgatacacaagcaccggcccgacctgatc
gactttgataagctgaaggactccaatgcccggcacaacctggagcacgcattcaatgtg
gctgagcgccagctgggcatcatcccgctcctcgaccccgaagatgtctttacggaaaac
cctgatgagaaatccatcatcacctatgtggtggccttttaccactacttctccaagatg
aaggtgctggcagtggagggcaagcgtgtcggcaaggttattgaccatgccattgagact
gagaagatgattgaaaagtacagcgggctagcctcggacctgctcacctggatcgagcag
accatcactgtcctgaacagccgcaagtttgccaactcgctgacgggcgtccagcagcag
ctgcaggccttcagcacctaccgcaccgtggagaagccgcccaagtttcaagagaagggg
aatctggaagttctactttttaccatccagtcccggatgagagccaacaatcagaaagtg
tacacaccccacgatgggaaactagtgtctgacatcaacagggcctgggaaagcctggag
gaagctgagtatcggcgggagctggccctgagaaatgagctcattcggcaggagaagcta
gagcaactggcccggcgctttgaccggaaggccgcaatgagagagacctggctcagtgaa
aaccagcgcctcgtggcccaggataactttgggtatgacctggcagctgtggaggccgcc
aagaagaagcatgaggccatcgagaccgacacggctgcctacgaggagcgggtgagagcc
ctggaggacctggctcaggagctggagaaagagaactaccatgaccagaagcgcatcacg
gcccgcaaggacaatatactgcgcctatggagctacctgcaggagctgctgcagtcccgg
cgccagaggctcgagaccaccctggcactgcagaagctcttccaggacatgctgcacagc
atcgactggatggatgagatcaaggctcacctcttgtctgccgagtttgggaagcacttg
ttggaggttgaagacctgctacagaagcacaagttgatggaagctgacatcgccatccaa
ggggacaaagtgaaggccatcaccgcagccaccctgaagttcaccgaggggaaagggtac
cagccttgtgacccccaggtcatccaggaccgcatcagccacttggagcagtgctttgag
gagctgagcaacatggcagctgggcggaaggcccaactggagcagtccaaacgactctgg
aagttcttctgggagatggatgaggctgagagctggatcaaggagaaggagcagatctat
tcttccctggactatggcaaagacctgaccagtgtgctcatcttacagcgcaagcacaag
gcctttgaggatgagctccgtgggctggatgctcacctggagcagatcttccaggaggct
catggcatggttgcgcgcaagcagtttgggcacccgcagatcgaggcccgcataaaggag
gtgtcggcacagtgggaccagctgaaggacctggctgccttctgcaagaagaacctccag
gatgctgagaactttttccagttccagggcgatgcggatgacctgaaggcttggctgcaa
gacgcccaccggctgctctctggtgaagatgtggggcaggacgaaggggccacgcgggcc
ctggggaaaaagcacaaggacttcctggaggagctggaggagagccgtggggtgatggag
cacctggagcagcaggcccagggattccccgaagagtttcgggattccccagatgtgacc
catcggctgcaggccctgcgggagctctaccaacaggtggtggcccaggcggacctgcgt
cagcagaggctgcaggaagccctggacctgtacacggtgttcggggagacagacgcctgt
gagctgtggatgggagagaaggagaagtggctggccgagatggaaatgccagacaccctg
gaggacctggaggtcgtgcagcacaggttcgacatcctggaccaggagatgaagaccttg
atgactcagattgatggtgtgaacctcgctgccaacagcttggtagagagtggccaccca
cgcagcagggaggtgaagcagtaccaggaccatctgaacaccaggtggcaggcatttcag
accctggtgtcggagcggcgggaggctgtggactcagccctccgagtgcacaactactgc
gtagattgcgaggagaccagcaagtggatcacggacaagacaaaggtagtggagtccaca
aaagacctggggcgggacctggcaggtatcatcgccatccagaggaagttgtcagggctg
gagcgtgacgtggccgccatccaggcccgtgtggatgccctggagcgtgagtcccagcag
ctgatggactcgcaccctgagcagaaggaggatattggtcagcggcaaaaacacttggag
gagctgtggcagggcctgcagcaatccctgcagggccaggaggacttgctgggggaagtc
agccagctgcaggccttcctgcaggatctggatgacttccaggcctggctctccatcacc
cagaaggctgtggcctctgaggacatgcccgaatccctcccagaggctgagcagctcctg
cagcagcatgcaggtatcaaggatgagattgacgggcaccaagacagctaccagcgtgtt
aaggagtctggggagaaagtgatccaaggccagacggacccagagtatctgcttctgggc
cagcggctggagggcctggatactggctggaatgccctgggcaggatgtgggagagccgc
agccacaccctcgctcagtgccttggcttccaggagttccagaaagatgccaagcaggct
gaagccatcctcagcaaccaggaatacactctggctcacttggagcccccagactccctg
gaagctgcagaggctgggatccggaagtttgaggatttcttggggtctatggagaacaac
cgggataaggtcttgagtcctgtggactctggaaacaagctggtagctgagggaaaccta
tactcagacaagatcaaggagaaggtgcagctgattgaggacaggcacaggaagaacaac
gagaaggcccaggaggcctctgtcctactgagagacaacctggagctacagaacttcctc
cagaactgccaggagctcactctctggatcaacgacaagctgctgacatctcaggatgtc
tcctatgatgaagcacgaaaccttcacaataaatggctaaagcaccaggcgtttgtggca
gagctggcttcccatgaagggtggctagagaacatcgatgcggaaggaaagcagctgatg
gatgagaagccccagtttacagccctggtgtcccaaaagctggaagccctgcaccggctc
tgggacgagctgcaggccaccacaaaggagaagacccagcacctctcggctgccaggagc
tccgacctgcgcttgcagacccatgctgacctcaacaagtggatcagcgccatggaggac
cagctgcggtcagacgacccgggcaaggacctgaccagtgtcaatcggatgttggctaag
ctgaagcgagtggaggaccaagtgaatgtgcgaaaagaggagctgggggagctgtttgcc
caggtgccttcaatgggagaggagggaggagatgcagacttgagcatcgagaagcggttc
ctggacctcctggaacccctaggaaggaggaagaagcagctggaatcatccagagccaag
ctgcagatcagccgggacttagaggatgagacgctttgggtggaggagaggctgcctctg
gcccagtcagccgactatggcactaatctgcaaactgtgcaactgttcatgaagaagaac
cagacactgcagaatgagattctgggccatacgccgcgggttgaggatgtgctgcagaga
gggcagcagctggtggaggcggcggagatcgactgccaggaccttgaggagcgcctgggg
cacctgcagagctcctgggacaggctgcgggaggcagcggccgggaggctgcagcgactg
agggacgccaacgaggcacagcagtactacctggatgcagacgaggctgaggcctggatt
ggcgagcaggagctctacgtcatctccgatgagatccccaaggatgaagagggcgccatt
gtgatgctgaagcgacatttgcggcagcagcgtgcggtggaggactacggccggaacatc
aagcagctggccagccgggcccagggcctgctgtctgcaggccaccctgagggggaacag
atcatcagacttcaggggcaagtggacaagcactacgcagggctgaaggacgtggcggaa
gagcgcaagcgcaagctggagaacatgtaccacctgttccagctcaagcgggagaccgac
gacctggagcagtggatttcagaaaaggagctagtggcctcttccccggaaatggggcaa
gactttgaccacgtgactcttctgcgggacaagttccgggactttgcccgggagaccggg
gcgattgggcaggagcgggtggacaatgtgaatgccttcatcgagcgactcatcgacgcg
ggccacagcgaggcggccaccatcgccgagtggaaggacgggctgaacgagatgtgggca
gacctcctggagctcattgacacgcgcatgcagctgctggccgcctcctatgacctgcac
cgctacttctacacgggtgccgagatcctgggcctcatcgacgagaagcaccgcgagctg
cccgaggacgtggggctggacgccagcacggccgagtccttccaccgggtgcacacagcc
ttcgagcgggagctccacctgctgggtgtccaggtgcagcagttccaggacgtggccacc
cgtctgcagacagcatatgctggggagaaggcagaggccatccagaacaaggagcaggag
gtgtctgccgcgtggcaggcgctgctcgatgcctgtgccgggcgccggacccagctagtg
gacacggcggataaattccgcttcttcagcatggcccgtgacctcctctcctggatggag
agcatcatccggcagatcgagacccaggagaggcccagggatgtctcctctgtggaactg
ctcatgaagtatcaccagggcatcaatgcagagattgaaacccggagcaagaacttcagt
gcctgcctggagcttggcgagtccctgctgcagcggcagcaccaggcctcagaggagatc
cgcgagaaactgcagcaggtgatgtccaggaggaaagagatgaatgagaagtgggaagcc
cgctgggagcggctccgcatgttgctggaggtgtgccagttctcgagggatgcctctgtg
gctgaggcgtggctgattgcccaggagccctacctggccagcggggactttggacacaca
gtggacagtgtggagaagctcatcaagaggcatgaggcttttgagaagtccacggccagc
tgggcagagcgctttgctgccctggagaagcccaccacgcttgagctgaaagaacgccag
attgcagagagacccgcagaggagactgggcctcaagaggaggaaggcgagacagcaggg
gaggctccagtttcccaccatgcggccaccgagagaacgtccccggtcagtctctggtct
cgtttgtctagttcctgggagtcactgcagccagagccctctcacccctactag

  All links  
Disease (3)   
   OMIM (3)   
Gene (26)   
   RefGene (13)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   RIKEN BRC-DNA (9)   
   OC (1)   
Protein sequence (15)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (13)   
DNA sequence (68)   
   RefSeq(nuc) (14)   
   GenBank (27)   
   EMBL (27)   
3D Structure (6)   
   PDB (6)   
Protein domain (5)   
   Pfam (5)   
All databases (123)   

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