KEGG   Homo sapiens (human): 8573
Entry
8573              CDS       T01001                                 
Symbol
CASK, CAGH39, CAMGUK, CMG, FGS4, LIN2, MICPCH, MRXSNA, TNRC8, hCASK
Name
(RefSeq) peripheral plasma membrane protein CASK isoform 4
  KO
K06103  calcium/calmodulin-dependent serine protein kinase [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04517  IgSF CAM signaling
Network
nt06546  IgSF CAM signaling
  Element
N01946  PTPRF interactions
N01947  PTPRS interactions
N01948  PTPRD interactions
Disease
H00894  FG syndrome
H01921  MICPCH syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    8573 (CASK)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    8573 (CASK)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    8573 (CASK)
  09183 Protein families: signaling and cellular processes
   03037 Cilium and associated proteins [BR:hsa03037]
    8573 (CASK)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     8573 (CASK)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CAMK group
  CASK family
   8573 (CASK)
Membrane trafficking [BR:hsa04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Kinases and associated proteins
    8573 (CASK)
Cilium and associated proteins [BR:hsa03037]
 Primary cilia and associated proteins
  USH complex and associated proteins
   8573 (CASK)
SSDB
Motif
Pfam: Pkinase Guanylate_kin PK_Tyr_Ser-Thr L27 PDZ SH3_2 SH3_1 PDZ_6 Pkinase_fungal SH3_9 PDZ_2
Other DBs
NCBI-GeneID: 8573
NCBI-ProteinID: NP_001354650
OMIM: 300172
HGNC: 1497
Ensembl: ENSP00000367405.1
UniProt: O14936
Structure
Position
X:complement(41514934..41923554)
AA seq 926 aa
MADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLK
REASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASH
YMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRV
GTPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPR
QWSHISESAKDLVRRMLMLDPAERITVYEALNHPWLKERDRYAYKIHLPETVEQLRKFNA
RRKLKGAVLAAVSSHKFNSFYGDPPEELPDFSEDPTSSGLLAAERAVSQVLDSLEEIHAL
TDCSEKDLDFLHSVFQDQHLHTLLDLYDKINTKSSPQIRNPPSDAVQRAKEVLEEISCYP
ENNDAKELKRILTQPHFMALLQTHDVVAHEVYSDEALRVTPPPTSPYLNGDSPESANGDM
DMENVTRVRLVQFQKNTDEPMGITLKMNELNHCIVARIMHGGMIHRQGTLHVGDEIREIN
GISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCERDSPSTSRQSPANGHSSTNNS
VSDLPSTTQPKGRQIYVRAQFEYDPAKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGK
LENSKNGTAGLIPSPELQEWRVACIAMEKTKQEQQASCTWFGKKKKQYKDKYLAKHNAVF
DQLDLVTYEEVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKK
DEENGKNYYFVSHDQMMQDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQ
ALKVLRTAEFAPFVVFIAAPTITPGLNEDESLQRLQKESDILQRTYAHYFDLTIINNEID
ETIRHLEEAVELVCTAPQWVPVSWVY
NT seq 2781 nt   +upstreamnt  +downstreamnt
atggccgacgacgacgtgctgttcgaggatgtgtacgagctgtgcgaggtgatcggaaag
ggtcccttcagtgttgtacgacgatgtatcaacagagaaactgggcaacaatttgctgta
aaaattgttgatgtagccaagttcacatcaagtccagggttaagtacagaagatctaaag
cgggaagccagtatctgtcatatgctgaaacatccacacattgtagagttattggagaca
tatagctcagatggaatgctttacatggttttcgaatttatggatggagcagatctgtgt
tttgaaatcgtaaagcgagctgacgctggttttgtgtacagtgaagctgtagccagccat
tatatgagacagatactggaagctctacgctactgccatgataataacataattcacagg
gatgtgaagccccactgtgttctccttgcctcaaaagaaaactcggcacctgttaaactt
ggaggctttggggtagctattcaattaggggagtctggacttgtagctggaggacgtgtt
ggaacacctcattttatggcaccagaagtggtcaaaagagagccttacggaaagcctgta
gacgtctgggggtgcggtgtgatcctttttatcctgctcagtggttgtttgcctttttac
ggaaccaaggaaagattgtttgaaggcattattaaaggaaaatataagatgaatccaagg
cagtggagccatatctctgaaagtgccaaagacctagtacgtcgcatgctgatgctggat
ccagctgaaaggatcactgtttatgaagcactgaatcacccatggcttaaggagcgggat
cgttacgcctacaagattcatcttccagaaacagtagagcagctgaggaaattcaatgca
aggaggaaactaaagggtgcagtactagccgctgtgtcaagtcacaaattcaactcattc
tatggggatccccctgaagagttaccagatttctccgaagaccctacctcctcaggactt
ctagcagcagaaagagcagtctcacaggtgctggacagcctggaagagattcatgcgctt
acagactgcagtgaaaaggacctagattttctacacagtgttttccaggatcagcatctt
cacacactactagatctgtatgacaaaattaacacaaagtcttcaccacaaatcaggaat
cctccaagcgatgcagtacagagagccaaagaggtattggaagaaatttcatgttaccct
gagaataacgacgcaaaggaactaaagcgtattttaacacaacctcatttcatggcctta
cttcagactcacgacgtagtggcacatgaagtttacagtgatgaagcattgagggtcaca
cctcctcccacctctccctatttaaacggcgattctccagaaagtgctaacggagacatg
gatatggagaatgtgaccagagttcggctggtacagtttcaaaagaacacagatgaacca
atgggaatcactttaaaaatgaatgaactaaatcattgtattgttgcaagaattatgcat
gggggcatgattcacaggcaaggtacacttcatgttggtgatgaaattcgagaaatcaat
ggcatcagtgtggctaaccaaacagtggaacaactgcaaaaaatgcttagggaaatgcgg
gggagtattaccttcaagattgtgccaagttaccgcactcagtcttcgtcctgtgagaga
gattccccttccacttccagacagtccccagctaatggtcatagcagcactaacaattct
gtttcggacttgccatcaactacccaaccaaaaggacgacagatctatgtaagagcacaa
tttgaatatgatccagccaaggatgacctcatcccctgtaaagaagctggcattcgattc
agagttggtgacatcatccagattattagtaaggatgatcataattggtggcagggtaaa
ctggaaaactccaaaaatggaactgcaggtctcattccttctcctgaacttcaggaatgg
cgagtagcttgcattgccatggagaagaccaaacaggagcagcaggccagctgtacttgg
tttggcaagaaaaagaagcagtacaaagataaatatttggcaaagcacaatgcagtgttt
gatcaattagatcttgtcacatatgaagaagtagtaaaactgccagcattcaagaggaaa
acactagtcttattaggcgcacatggtgttgggagaagacacataaaaaacactctcatc
acaaagcacccagaccggtttgcgtaccctattccacatacaaccagacctccaaagaaa
gacgaagaaaatggaaagaattattactttgtatctcatgaccaaatgatgcaagacatc
tctaataacgagtacttggagtacggcagccacgaggatgcgatgtatgggacaaaactg
gagaccatccggaagatccacgagcaggggctgattgcaatactggacgtggagcctcag
gcactgaaggtcctgagaactgcagagtttgctccttttgttgttttcattgctgcacca
actattactccaggtttaaatgaggatgaatctcttcagcgtctgcagaaggagtctgac
atcttacagagaacatatgcacactacttcgatctcacaattatcaacaatgaaattgat
gagacaatcagacatctggaggaagctgttgagctcgtgtgcacagccccacagtgggtc
cctgtctcctgggtctattag

  All links  
Disease (4)   
   OMIM (4)   
Gene (24)   
   RefGene (18)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (21)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (19)   
DNA sequence (53)   
   RefSeq(nuc) (19)   
   GenBank (17)   
   EMBL (17)   
3D Structure (19)   
   PDB (19)   
Protein domain (11)   
   Pfam (11)   
All databases (132)   

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