KEGG   Ictidomys tridecemlineatus (thirteen-lined ground squirrel): 101976353
Entry
101976353         CDS       T10664                                 
Symbol
Pik3ca
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
iti  Ictidomys tridecemlineatus (thirteen-lined ground squirrel)
Pathway
iti00562  Inositol phosphate metabolism
iti01100  Metabolic pathways
iti01521  EGFR tyrosine kinase inhibitor resistance
iti01522  Endocrine resistance
iti01524  Platinum drug resistance
iti04012  ErbB signaling pathway
iti04014  Ras signaling pathway
iti04015  Rap1 signaling pathway
iti04024  cAMP signaling pathway
iti04062  Chemokine signaling pathway
iti04066  HIF-1 signaling pathway
iti04068  FoxO signaling pathway
iti04070  Phosphatidylinositol signaling system
iti04071  Sphingolipid signaling pathway
iti04072  Phospholipase D signaling pathway
iti04081  Hormone signaling
iti04140  Autophagy - animal
iti04145  Phagocytosis
iti04150  mTOR signaling pathway
iti04151  PI3K-Akt signaling pathway
iti04152  AMPK signaling pathway
iti04210  Apoptosis
iti04211  Longevity regulating pathway
iti04213  Longevity regulating pathway - multiple species
iti04218  Cellular senescence
iti04360  Axon guidance
iti04370  VEGF signaling pathway
iti04380  Osteoclast differentiation
iti04510  Focal adhesion
iti04517  IgSF CAM signaling
iti04518  Integrin signaling
iti04550  Signaling pathways regulating pluripotency of stem cells
iti04611  Platelet activation
iti04613  Neutrophil extracellular trap formation
iti04620  Toll-like receptor signaling pathway
iti04625  C-type lectin receptor signaling pathway
iti04630  JAK-STAT signaling pathway
iti04650  Natural killer cell mediated cytotoxicity
iti04660  T cell receptor signaling pathway
iti04662  B cell receptor signaling pathway
iti04664  Fc epsilon RI signaling pathway
iti04666  Fc gamma R-mediated phagosome formation
iti04668  TNF signaling pathway
iti04670  Leukocyte transendothelial migration
iti04722  Neurotrophin signaling pathway
iti04725  Cholinergic synapse
iti04750  Inflammatory mediator regulation of TRP channels
iti04810  Regulation of actin cytoskeleton
iti04910  Insulin signaling pathway
iti04914  Progesterone-mediated oocyte maturation
iti04915  Estrogen signaling pathway
iti04917  Prolactin signaling pathway
iti04919  Thyroid hormone signaling pathway
iti04923  Regulation of lipolysis in adipocytes
iti04926  Relaxin signaling pathway
iti04929  GnRH secretion
iti04930  Type II diabetes mellitus
iti04931  Insulin resistance
iti04932  Non-alcoholic fatty liver disease
iti04933  AGE-RAGE signaling pathway in diabetic complications
iti04935  Growth hormone synthesis, secretion and action
iti04960  Aldosterone-regulated sodium reabsorption
iti04973  Carbohydrate digestion and absorption
iti05010  Alzheimer disease
iti05017  Spinocerebellar ataxia
iti05020  Prion disease
iti05100  Bacterial invasion of epithelial cells
iti05132  Salmonella infection
iti05135  Yersinia infection
iti05142  Chagas disease
iti05146  Amoebiasis
iti05160  Hepatitis C
iti05161  Hepatitis B
iti05162  Measles
iti05163  Human cytomegalovirus infection
iti05164  Influenza A
iti05165  Human papillomavirus infection
iti05166  Human T-cell leukemia virus 1 infection
iti05167  Kaposi sarcoma-associated herpesvirus infection
iti05168  Herpes simplex virus 1 infection
iti05169  Epstein-Barr virus infection
iti05170  Human immunodeficiency virus 1 infection
iti05171  Coronavirus disease
iti05200  Pathways in cancer
iti05203  Viral carcinogenesis
iti05205  Proteoglycans in cancer
iti05206  MicroRNAs in cancer
iti05207  Chemical carcinogenesis - receptor activation
iti05208  Chemical carcinogenesis - reactive oxygen species
iti05210  Colorectal cancer
iti05211  Renal cell carcinoma
iti05212  Pancreatic cancer
iti05213  Endometrial cancer
iti05214  Glioma
iti05215  Prostate cancer
iti05218  Melanoma
iti05220  Chronic myeloid leukemia
iti05221  Acute myeloid leukemia
iti05222  Small cell lung cancer
iti05223  Non-small cell lung cancer
iti05224  Breast cancer
iti05225  Hepatocellular carcinoma
iti05226  Gastric cancer
iti05230  Central carbon metabolism in cancer
iti05231  Choline metabolism in cancer
iti05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
iti05415  Diabetic cardiomyopathy
iti05417  Lipid and atherosclerosis
iti05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:iti00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    101976353 (Pik3ca)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    101976353 (Pik3ca)
   04014 Ras signaling pathway
    101976353 (Pik3ca)
   04015 Rap1 signaling pathway
    101976353 (Pik3ca)
   04370 VEGF signaling pathway
    101976353 (Pik3ca)
   04630 JAK-STAT signaling pathway
    101976353 (Pik3ca)
   04668 TNF signaling pathway
    101976353 (Pik3ca)
   04066 HIF-1 signaling pathway
    101976353 (Pik3ca)
   04068 FoxO signaling pathway
    101976353 (Pik3ca)
   04070 Phosphatidylinositol signaling system
    101976353 (Pik3ca)
   04072 Phospholipase D signaling pathway
    101976353 (Pik3ca)
   04071 Sphingolipid signaling pathway
    101976353 (Pik3ca)
   04024 cAMP signaling pathway
    101976353 (Pik3ca)
   04151 PI3K-Akt signaling pathway
    101976353 (Pik3ca)
   04152 AMPK signaling pathway
    101976353 (Pik3ca)
   04150 mTOR signaling pathway
    101976353 (Pik3ca)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    101976353 (Pik3ca)
   04517 IgSF CAM signaling
    101976353 (Pik3ca)
   04518 Integrin signaling
    101976353 (Pik3ca)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    101976353 (Pik3ca)
   04140 Autophagy - animal
    101976353 (Pik3ca)
  09143 Cell growth and death
   04210 Apoptosis
    101976353 (Pik3ca)
   04218 Cellular senescence
    101976353 (Pik3ca)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101976353 (Pik3ca)
   04550 Signaling pathways regulating pluripotency of stem cells
    101976353 (Pik3ca)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    101976353 (Pik3ca)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    101976353 (Pik3ca)
   04613 Neutrophil extracellular trap formation
    101976353 (Pik3ca)
   04620 Toll-like receptor signaling pathway
    101976353 (Pik3ca)
   04625 C-type lectin receptor signaling pathway
    101976353 (Pik3ca)
   04650 Natural killer cell mediated cytotoxicity
    101976353 (Pik3ca)
   04660 T cell receptor signaling pathway
    101976353 (Pik3ca)
   04662 B cell receptor signaling pathway
    101976353 (Pik3ca)
   04664 Fc epsilon RI signaling pathway
    101976353 (Pik3ca)
   04666 Fc gamma R-mediated phagosome formation
    101976353 (Pik3ca)
   04670 Leukocyte transendothelial migration
    101976353 (Pik3ca)
   04062 Chemokine signaling pathway
    101976353 (Pik3ca)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101976353 (Pik3ca)
   04923 Regulation of lipolysis in adipocytes
    101976353 (Pik3ca)
   04929 GnRH secretion
    101976353 (Pik3ca)
   04915 Estrogen signaling pathway
    101976353 (Pik3ca)
   04914 Progesterone-mediated oocyte maturation
    101976353 (Pik3ca)
   04917 Prolactin signaling pathway
    101976353 (Pik3ca)
   04926 Relaxin signaling pathway
    101976353 (Pik3ca)
   04935 Growth hormone synthesis, secretion and action
    101976353 (Pik3ca)
   04919 Thyroid hormone signaling pathway
    101976353 (Pik3ca)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    101976353 (Pik3ca)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    101976353 (Pik3ca)
  09156 Nervous system
   04725 Cholinergic synapse
    101976353 (Pik3ca)
   04722 Neurotrophin signaling pathway
    101976353 (Pik3ca)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101976353 (Pik3ca)
  09158 Development and regeneration
   04360 Axon guidance
    101976353 (Pik3ca)
   04380 Osteoclast differentiation
    101976353 (Pik3ca)
  09149 Aging
   04211 Longevity regulating pathway
    101976353 (Pik3ca)
   04213 Longevity regulating pathway - multiple species
    101976353 (Pik3ca)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101976353 (Pik3ca)
   05206 MicroRNAs in cancer
    101976353 (Pik3ca)
   05205 Proteoglycans in cancer
    101976353 (Pik3ca)
   05207 Chemical carcinogenesis - receptor activation
    101976353 (Pik3ca)
   05208 Chemical carcinogenesis - reactive oxygen species
    101976353 (Pik3ca)
   05203 Viral carcinogenesis
    101976353 (Pik3ca)
   05230 Central carbon metabolism in cancer
    101976353 (Pik3ca)
   05231 Choline metabolism in cancer
    101976353 (Pik3ca)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101976353 (Pik3ca)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101976353 (Pik3ca)
   05212 Pancreatic cancer
    101976353 (Pik3ca)
   05225 Hepatocellular carcinoma
    101976353 (Pik3ca)
   05226 Gastric cancer
    101976353 (Pik3ca)
   05214 Glioma
    101976353 (Pik3ca)
   05221 Acute myeloid leukemia
    101976353 (Pik3ca)
   05220 Chronic myeloid leukemia
    101976353 (Pik3ca)
   05218 Melanoma
    101976353 (Pik3ca)
   05211 Renal cell carcinoma
    101976353 (Pik3ca)
   05215 Prostate cancer
    101976353 (Pik3ca)
   05213 Endometrial cancer
    101976353 (Pik3ca)
   05224 Breast cancer
    101976353 (Pik3ca)
   05222 Small cell lung cancer
    101976353 (Pik3ca)
   05223 Non-small cell lung cancer
    101976353 (Pik3ca)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101976353 (Pik3ca)
   05170 Human immunodeficiency virus 1 infection
    101976353 (Pik3ca)
   05161 Hepatitis B
    101976353 (Pik3ca)
   05160 Hepatitis C
    101976353 (Pik3ca)
   05171 Coronavirus disease
    101976353 (Pik3ca)
   05164 Influenza A
    101976353 (Pik3ca)
   05162 Measles
    101976353 (Pik3ca)
   05168 Herpes simplex virus 1 infection
    101976353 (Pik3ca)
   05163 Human cytomegalovirus infection
    101976353 (Pik3ca)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101976353 (Pik3ca)
   05169 Epstein-Barr virus infection
    101976353 (Pik3ca)
   05165 Human papillomavirus infection
    101976353 (Pik3ca)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    101976353 (Pik3ca)
   05135 Yersinia infection
    101976353 (Pik3ca)
   05100 Bacterial invasion of epithelial cells
    101976353 (Pik3ca)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    101976353 (Pik3ca)
   05142 Chagas disease
    101976353 (Pik3ca)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101976353 (Pik3ca)
   05017 Spinocerebellar ataxia
    101976353 (Pik3ca)
   05020 Prion disease
    101976353 (Pik3ca)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101976353 (Pik3ca)
   05418 Fluid shear stress and atherosclerosis
    101976353 (Pik3ca)
   05415 Diabetic cardiomyopathy
    101976353 (Pik3ca)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    101976353 (Pik3ca)
   04932 Non-alcoholic fatty liver disease
    101976353 (Pik3ca)
   04931 Insulin resistance
    101976353 (Pik3ca)
   04933 AGE-RAGE signaling pathway in diabetic complications
    101976353 (Pik3ca)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101976353 (Pik3ca)
   01524 Platinum drug resistance
    101976353 (Pik3ca)
   01522 Endocrine resistance
    101976353 (Pik3ca)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:iti04131]
    101976353 (Pik3ca)
Enzymes [BR:iti01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     101976353 (Pik3ca)
Membrane trafficking [BR:iti04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    101976353 (Pik3ca)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Sll1247_N
Other DBs
NCBI-GeneID: 101976353
NCBI-ProteinID: XP_005330340
UniProt: I3MK14
Position
Unknown
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLYQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFV
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRQPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccacgaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgactttagaatgcctccgtgaggct
acattaataactataaagcatgaactatttaaagaagcaagaaaataccctctctatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctttttcaaccctttttaaaa
gttattgaaccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgtt
atcggtatgccagtgtgtgaatttgatatggttaaagatccagaagtacaggacttccga
agaaatattctgaatgtttgtaaagaagctgtagatcttagggatctcaattcacctcat
agtagagcaatgtatgtgtatcctccaaatgtggaatcttcaccagaactgccaaagcac
atatataataaattagataaaggacaaataatagtggtgatttgggtaatagtttcgcca
aataatgacaagcagaagtatactctaaaaatcaaccatgactgtgtgccagaacaagta
attgctgaggcaatcaggaaaaaaactcgaagtatgttgctatcctctgaacaactaaaa
ctctgtgttttagaatatcagggcaaatatattttaaaagtgtgtggatgtgatgaatac
tttctagaaaaatatcctctgagtcagtataagtacataagaagctgtataatgcttggg
aggatgcccaatttgatgctgatggctaaagaaagcctgtactctcaactgccaatggac
tgttttacaatgccatcttattctagacgcatctccacagctacaccatatatgaatgga
gaaacatctaccaaatccctttgggttataaatagcgcactcagaataaaaattctttgt
gcaacctatgtaaatgtaaatattcgagacattgataagatttatgttagaacaggtatc
taccatggaggagaacccttatgtgacaatgtgaacactcagagagttccttgttccaat
cccaggtggaatgaatggctgaattatgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgctctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcctggggaaatataaacttgtttgattatactgacaccctagtatcaggaaaa
atggctttgaatctttggccagtacctcatggattagaggatctgctaaaccctattggt
gttactgggtcaaatccaaataaagaaactccatgcttagagttggagtttgattggttc
agcagtgtggtaaagtttccagatatgtcagtgattgaagaacatgccaattggtctgta
tcccgagaagcaggatttagttattcccatgcaggactgagtaacagactagctagagac
aatgaattaagagaaaatgacaaagaacaactccgagcaatttgtacacgagatcctcta
tctgaaatcactgaacaagagaaagattttctatggagccacagacactattgcgtaact
atacctgaaattctacccaaattgcttctgtctgttaaatggaattccagagatgaagta
gcccagatgtactgcttagtaaaagattggcctccaatcaagcctgaacaggcaatggag
cttctggattgtaattacccagatcctatggttcgaggttttgctgttcgatgcttagaa
aaatatttaacagacgacaaactttctcagtacctgattcagctagtacaggtcctgaaa
tatgagcaatatttggataacctgcttgtgagatttttactcaagaaagcattgacaaat
caaaggattgggcactttttcttttggcacttaaaatctgagatgcacaataaaacagtt
agtcagaggtttggcctgcttttagagtcctactgtcgtgcctgtgggatgtatttgaag
cacctgaataggcaagttgaggctatggaaaagctcattaacttaactgacattctcaaa
caagaaaaaaaggatgaaacacaaaaggtacagatgaagtttttagttgagcaaatgagg
caaccagatttcatggatgctctacaaggctttctgtctcctttaaaccctgctcatcaa
ctaggaaatctccggcttgaggagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcggagttactgtttcagaacaatgagatcatc
tttaaaaatggagatgatttacggcaagatatgctaacacttcaaattattcgcattatg
gaaaacatctggcaaaatcaaggtcttgatcttcgaatgttaccttatggttgtctgtca
attggtgactgtgtaggacttattgaggtggtaagaaattctcacactatcatgcaaatt
caatgcaaaggtggcctgaaaggcgcactgcagttcaacagccacacactacatcagtgg
ctcaaagataagaacaaaggagaaatatatgatgcagccatagacctgtttacacgttca
tgtgctggatattgtgtggctaccttcattttgggaattggagatcggcacaatagtaac
atcatggtgaaagatgatggacaactgtttcatatagattttggacactttttggatcac
aagaagaaaaaatttggttataaacgagaacgtgtacccttcgttttgacacaagatttc
ttaattgtgattagtaaaggagctcaagaatgtacaaagaccagagaatttgagaggttt
caggagatgtgttacaaggcttatctagctattcgacagcatgccaatctcttcattaat
cttttctcaatgatgcttggctctggaatgccagaactacagtcttttgatgacattgca
tatattcgaaagaccctagccttagataaaactgagcaagaggctttggaatatttcatg
aaacaaatgaatgatgcacaccatggtggctggacaacaaaaatggattggatcttccac
acaattaagcagcatgcattgaactga

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (8)   
   Pfam (8)   
All databases (13)   

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