KEGG   Lemur catta (Ring-tailed lemur): 123630278
Entry
123630278         CDS       T08326                                 
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
lcat  Lemur catta (Ring-tailed lemur)
Pathway
lcat00562  Inositol phosphate metabolism
lcat01100  Metabolic pathways
lcat01521  EGFR tyrosine kinase inhibitor resistance
lcat01522  Endocrine resistance
lcat01524  Platinum drug resistance
lcat04012  ErbB signaling pathway
lcat04014  Ras signaling pathway
lcat04015  Rap1 signaling pathway
lcat04024  cAMP signaling pathway
lcat04062  Chemokine signaling pathway
lcat04066  HIF-1 signaling pathway
lcat04068  FoxO signaling pathway
lcat04070  Phosphatidylinositol signaling system
lcat04071  Sphingolipid signaling pathway
lcat04072  Phospholipase D signaling pathway
lcat04081  Hormone signaling
lcat04140  Autophagy - animal
lcat04145  Phagocytosis
lcat04150  mTOR signaling pathway
lcat04151  PI3K-Akt signaling pathway
lcat04152  AMPK signaling pathway
lcat04210  Apoptosis
lcat04211  Longevity regulating pathway
lcat04213  Longevity regulating pathway - multiple species
lcat04218  Cellular senescence
lcat04360  Axon guidance
lcat04370  VEGF signaling pathway
lcat04380  Osteoclast differentiation
lcat04510  Focal adhesion
lcat04517  IgSF CAM signaling
lcat04518  Integrin signaling
lcat04550  Signaling pathways regulating pluripotency of stem cells
lcat04611  Platelet activation
lcat04613  Neutrophil extracellular trap formation
lcat04620  Toll-like receptor signaling pathway
lcat04625  C-type lectin receptor signaling pathway
lcat04630  JAK-STAT signaling pathway
lcat04650  Natural killer cell mediated cytotoxicity
lcat04660  T cell receptor signaling pathway
lcat04662  B cell receptor signaling pathway
lcat04664  Fc epsilon RI signaling pathway
lcat04666  Fc gamma R-mediated phagosome formation
lcat04668  TNF signaling pathway
lcat04670  Leukocyte transendothelial migration
lcat04722  Neurotrophin signaling pathway
lcat04725  Cholinergic synapse
lcat04750  Inflammatory mediator regulation of TRP channels
lcat04810  Regulation of actin cytoskeleton
lcat04910  Insulin signaling pathway
lcat04914  Progesterone-mediated oocyte maturation
lcat04915  Estrogen signaling pathway
lcat04917  Prolactin signaling pathway
lcat04919  Thyroid hormone signaling pathway
lcat04923  Regulation of lipolysis in adipocytes
lcat04926  Relaxin signaling pathway
lcat04929  GnRH secretion
lcat04930  Type II diabetes mellitus
lcat04931  Insulin resistance
lcat04932  Non-alcoholic fatty liver disease
lcat04933  AGE-RAGE signaling pathway in diabetic complications
lcat04935  Growth hormone synthesis, secretion and action
lcat04960  Aldosterone-regulated sodium reabsorption
lcat04973  Carbohydrate digestion and absorption
lcat05010  Alzheimer disease
lcat05017  Spinocerebellar ataxia
lcat05020  Prion disease
lcat05100  Bacterial invasion of epithelial cells
lcat05132  Salmonella infection
lcat05135  Yersinia infection
lcat05142  Chagas disease
lcat05146  Amoebiasis
lcat05160  Hepatitis C
lcat05161  Hepatitis B
lcat05162  Measles
lcat05163  Human cytomegalovirus infection
lcat05164  Influenza A
lcat05165  Human papillomavirus infection
lcat05166  Human T-cell leukemia virus 1 infection
lcat05167  Kaposi sarcoma-associated herpesvirus infection
lcat05168  Herpes simplex virus 1 infection
lcat05169  Epstein-Barr virus infection
lcat05170  Human immunodeficiency virus 1 infection
lcat05171  Coronavirus disease
lcat05200  Pathways in cancer
lcat05203  Viral carcinogenesis
lcat05205  Proteoglycans in cancer
lcat05206  MicroRNAs in cancer
lcat05207  Chemical carcinogenesis - receptor activation
lcat05208  Chemical carcinogenesis - reactive oxygen species
lcat05210  Colorectal cancer
lcat05211  Renal cell carcinoma
lcat05212  Pancreatic cancer
lcat05213  Endometrial cancer
lcat05214  Glioma
lcat05215  Prostate cancer
lcat05218  Melanoma
lcat05220  Chronic myeloid leukemia
lcat05221  Acute myeloid leukemia
lcat05222  Small cell lung cancer
lcat05223  Non-small cell lung cancer
lcat05224  Breast cancer
lcat05225  Hepatocellular carcinoma
lcat05226  Gastric cancer
lcat05230  Central carbon metabolism in cancer
lcat05231  Choline metabolism in cancer
lcat05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
lcat05415  Diabetic cardiomyopathy
lcat05417  Lipid and atherosclerosis
lcat05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:lcat00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    123630278 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    123630278 (PIK3CA)
   04014 Ras signaling pathway
    123630278 (PIK3CA)
   04015 Rap1 signaling pathway
    123630278 (PIK3CA)
   04370 VEGF signaling pathway
    123630278 (PIK3CA)
   04630 JAK-STAT signaling pathway
    123630278 (PIK3CA)
   04668 TNF signaling pathway
    123630278 (PIK3CA)
   04066 HIF-1 signaling pathway
    123630278 (PIK3CA)
   04068 FoxO signaling pathway
    123630278 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    123630278 (PIK3CA)
   04072 Phospholipase D signaling pathway
    123630278 (PIK3CA)
   04071 Sphingolipid signaling pathway
    123630278 (PIK3CA)
   04024 cAMP signaling pathway
    123630278 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    123630278 (PIK3CA)
   04152 AMPK signaling pathway
    123630278 (PIK3CA)
   04150 mTOR signaling pathway
    123630278 (PIK3CA)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    123630278 (PIK3CA)
   04517 IgSF CAM signaling
    123630278 (PIK3CA)
   04518 Integrin signaling
    123630278 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    123630278 (PIK3CA)
   04140 Autophagy - animal
    123630278 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    123630278 (PIK3CA)
   04218 Cellular senescence
    123630278 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    123630278 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    123630278 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    123630278 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    123630278 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    123630278 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    123630278 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    123630278 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    123630278 (PIK3CA)
   04660 T cell receptor signaling pathway
    123630278 (PIK3CA)
   04662 B cell receptor signaling pathway
    123630278 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    123630278 (PIK3CA)
   04666 Fc gamma R-mediated phagosome formation
    123630278 (PIK3CA)
   04670 Leukocyte transendothelial migration
    123630278 (PIK3CA)
   04062 Chemokine signaling pathway
    123630278 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    123630278 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    123630278 (PIK3CA)
   04929 GnRH secretion
    123630278 (PIK3CA)
   04915 Estrogen signaling pathway
    123630278 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    123630278 (PIK3CA)
   04917 Prolactin signaling pathway
    123630278 (PIK3CA)
   04926 Relaxin signaling pathway
    123630278 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    123630278 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    123630278 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    123630278 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    123630278 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    123630278 (PIK3CA)
   04722 Neurotrophin signaling pathway
    123630278 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    123630278 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    123630278 (PIK3CA)
   04380 Osteoclast differentiation
    123630278 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    123630278 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    123630278 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    123630278 (PIK3CA)
   05206 MicroRNAs in cancer
    123630278 (PIK3CA)
   05205 Proteoglycans in cancer
    123630278 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    123630278 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    123630278 (PIK3CA)
   05203 Viral carcinogenesis
    123630278 (PIK3CA)
   05230 Central carbon metabolism in cancer
    123630278 (PIK3CA)
   05231 Choline metabolism in cancer
    123630278 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    123630278 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    123630278 (PIK3CA)
   05212 Pancreatic cancer
    123630278 (PIK3CA)
   05225 Hepatocellular carcinoma
    123630278 (PIK3CA)
   05226 Gastric cancer
    123630278 (PIK3CA)
   05214 Glioma
    123630278 (PIK3CA)
   05221 Acute myeloid leukemia
    123630278 (PIK3CA)
   05220 Chronic myeloid leukemia
    123630278 (PIK3CA)
   05218 Melanoma
    123630278 (PIK3CA)
   05211 Renal cell carcinoma
    123630278 (PIK3CA)
   05215 Prostate cancer
    123630278 (PIK3CA)
   05213 Endometrial cancer
    123630278 (PIK3CA)
   05224 Breast cancer
    123630278 (PIK3CA)
   05222 Small cell lung cancer
    123630278 (PIK3CA)
   05223 Non-small cell lung cancer
    123630278 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    123630278 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    123630278 (PIK3CA)
   05161 Hepatitis B
    123630278 (PIK3CA)
   05160 Hepatitis C
    123630278 (PIK3CA)
   05171 Coronavirus disease
    123630278 (PIK3CA)
   05164 Influenza A
    123630278 (PIK3CA)
   05162 Measles
    123630278 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    123630278 (PIK3CA)
   05163 Human cytomegalovirus infection
    123630278 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    123630278 (PIK3CA)
   05169 Epstein-Barr virus infection
    123630278 (PIK3CA)
   05165 Human papillomavirus infection
    123630278 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    123630278 (PIK3CA)
   05135 Yersinia infection
    123630278 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    123630278 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    123630278 (PIK3CA)
   05142 Chagas disease
    123630278 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    123630278 (PIK3CA)
   05017 Spinocerebellar ataxia
    123630278 (PIK3CA)
   05020 Prion disease
    123630278 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    123630278 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    123630278 (PIK3CA)
   05415 Diabetic cardiomyopathy
    123630278 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    123630278 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    123630278 (PIK3CA)
   04931 Insulin resistance
    123630278 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    123630278 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    123630278 (PIK3CA)
   01524 Platinum drug resistance
    123630278 (PIK3CA)
   01522 Endocrine resistance
    123630278 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:lcat04131]
    123630278 (PIK3CA)
Enzymes [BR:lcat01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     123630278 (PIK3CA)
Membrane trafficking [BR:lcat04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    123630278 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 123630278
NCBI-ProteinID: XP_045395667
Position
1:204967869..205026295
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccacgaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgactttagaatgcctccgtgaggct
acattaataactataaagcatgaactatttaaagaagcaagaaaataccctctacatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctttttcaaccctttttgaaa
gtaattgaaccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgct
attggcatgccagtgtgtgaatttgatatggttaaagatccagaagtacaagacttccga
agaaatattctgaatgtttgtaaagaagctgtggatcttagggatctcaattcacctcat
agtagagcaatgtatgtctatcccccaaatgtagaatcttcaccagaactgccaaagcac
atatataataaattagataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaaccatgactgtgtgccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgctatcctctgaacaactaaaa
ctctgtgttttagaatatcagggcaaatatattttaaaagtctgtggatgtgatgaatac
ttcctagaaaaatatcctctgagtcagtacaagtatataagaagctgtataatgcttggg
aggatgcccaatttgatgctgatggctaaagaaagcctttactctcaactgccaatggac
tgttttacaatgccatcttattccagacgtatttccacagctacaccatatatgaatgga
gaaacatctacaaaatctctttgggttataaatagtgcactcagaataaaaattctttgt
gcaacctatgtgaatgtaaatattcgagacattgataagatctatgttcgaacaggtatc
taccatggaggagaacccttatgtgacaatgtaaacactcagagagtgccttgttccaat
cccagatggaatgaatggctgaattatgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgctctgttaaaggccgcaagggtgctaaagaggaacattgt
ccattggcctggggaaatataaacttatttgattacacagacactctagtatctggaaaa
atggctttgaatctttggccggtacctcatggattagaagatttactgaaccctattggt
gttactggatcaaatccaaataaggaaactccatgcttagagttggagtttgactggttc
agcagtgtggtaaagtttccagatatgtcagtgattgaagagcatgccaattggtctgtg
tcccgagaagcaggattcagttattcccatgcaggactgagtaacagactagctagagac
aatgaattaagagaaaatgacaaagaacagctccgagcaatttgtacacgagatcctcta
tctgaaattactgagcaagagaaagattttctgtggagccacagacactattgtgtaact
atccctgaaattctacctaaactgcttctgtctgttaaatggaattctagagatgaagta
gcccagatgtactgcttggtgaaagattggcctccaatcaaacctgaacaggctatggag
cttctggactgtaattatccagatcctatggttcgaggttttgctgttcgatgcttggaa
aagtatttaacagatgacaaactttctcagtacttaattcagctagtacaggtcctaaaa
tatgaacaatatttggataacctgcttgtgagatttttactcaagaaagcattgactaat
caaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaacagtg
agtcagaggtttggtctgctcttggagtcctattgtcgtgcatgtgggatgtatttgaag
cacctgaataggcaagttgaggcaatggaaaagctcattaacttaactgacattctcaaa
caggagaagaaggatgaaacacaaaaggtacagatgaagtttttagttgagcaaatgagg
cgaccagatttcatggatgctctacagggctttctatctcctctaaaccctgctcatcaa
ctaggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactgtttcagaacaatgagatcatc
tttaaaaatggggatgatttacggcaagatatgctaacacttcaaattattcgcattatg
gaaaatatctggcaaaatcaaggtcttgatcttcgaatgttaccttatggttgcctgtca
attggtgactgtgtgggacttattgaggtggtgagaaattctcacactattatgcaaatt
cagtgcaaaggcggcctgaaaggcgcattgcagttcaacagccacacactacatcagtgg
ctaaaagacaagaataaaggagaaatatatgatgcagccattgacctgtttacacgttca
tgtgctggatattgtgtagctaccttcattttggggattggagatcgtcacaatagtaac
atcatggtgaaagatgatggacaactgtttcatatagattttggacactttttggatcac
aagaagaaaaaatttggttataaacgagaacgtgtgccctttgttttgacacaagatttc
ttaatagtgattagtaaaggagcccaagaatgcacaaagacaagagaatttgagaggttt
caggagatgtgttacaaggcttacctagctattcggcagcatgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgacattgca
tacattcgaaagactctagccttagataaaactgagcaagaggctttggaatattttatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
acaattaagcagcatgcattgaactga

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (8)   
   Pfam (8)   
All databases (12)   

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