KEGG   Mesocricetus auratus (golden hamster): 101835039
Entry
101835039         CDS       T08306                                 
Symbol
Pik3r1
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
maua  Mesocricetus auratus (golden hamster)
Pathway
maua01521  EGFR tyrosine kinase inhibitor resistance
maua01522  Endocrine resistance
maua01524  Platinum drug resistance
maua04012  ErbB signaling pathway
maua04014  Ras signaling pathway
maua04015  Rap1 signaling pathway
maua04024  cAMP signaling pathway
maua04062  Chemokine signaling pathway
maua04066  HIF-1 signaling pathway
maua04068  FoxO signaling pathway
maua04070  Phosphatidylinositol signaling system
maua04071  Sphingolipid signaling pathway
maua04072  Phospholipase D signaling pathway
maua04081  Hormone signaling
maua04140  Autophagy - animal
maua04145  Phagocytosis
maua04150  mTOR signaling pathway
maua04151  PI3K-Akt signaling pathway
maua04152  AMPK signaling pathway
maua04210  Apoptosis
maua04211  Longevity regulating pathway
maua04213  Longevity regulating pathway - multiple species
maua04218  Cellular senescence
maua04360  Axon guidance
maua04370  VEGF signaling pathway
maua04380  Osteoclast differentiation
maua04510  Focal adhesion
maua04517  IgSF CAM signaling
maua04518  Integrin signaling
maua04550  Signaling pathways regulating pluripotency of stem cells
maua04611  Platelet activation
maua04613  Neutrophil extracellular trap formation
maua04620  Toll-like receptor signaling pathway
maua04625  C-type lectin receptor signaling pathway
maua04630  JAK-STAT signaling pathway
maua04650  Natural killer cell mediated cytotoxicity
maua04660  T cell receptor signaling pathway
maua04662  B cell receptor signaling pathway
maua04664  Fc epsilon RI signaling pathway
maua04666  Fc gamma R-mediated phagosome formation
maua04668  TNF signaling pathway
maua04670  Leukocyte transendothelial migration
maua04722  Neurotrophin signaling pathway
maua04725  Cholinergic synapse
maua04750  Inflammatory mediator regulation of TRP channels
maua04810  Regulation of actin cytoskeleton
maua04910  Insulin signaling pathway
maua04914  Progesterone-mediated oocyte maturation
maua04915  Estrogen signaling pathway
maua04917  Prolactin signaling pathway
maua04919  Thyroid hormone signaling pathway
maua04923  Regulation of lipolysis in adipocytes
maua04926  Relaxin signaling pathway
maua04929  GnRH secretion
maua04930  Type II diabetes mellitus
maua04931  Insulin resistance
maua04932  Non-alcoholic fatty liver disease
maua04933  AGE-RAGE signaling pathway in diabetic complications
maua04935  Growth hormone synthesis, secretion and action
maua04960  Aldosterone-regulated sodium reabsorption
maua04973  Carbohydrate digestion and absorption
maua05010  Alzheimer disease
maua05017  Spinocerebellar ataxia
maua05020  Prion disease
maua05100  Bacterial invasion of epithelial cells
maua05135  Yersinia infection
maua05142  Chagas disease
maua05146  Amoebiasis
maua05160  Hepatitis C
maua05161  Hepatitis B
maua05162  Measles
maua05163  Human cytomegalovirus infection
maua05164  Influenza A
maua05165  Human papillomavirus infection
maua05166  Human T-cell leukemia virus 1 infection
maua05167  Kaposi sarcoma-associated herpesvirus infection
maua05168  Herpes simplex virus 1 infection
maua05169  Epstein-Barr virus infection
maua05170  Human immunodeficiency virus 1 infection
maua05171  Coronavirus disease
maua05200  Pathways in cancer
maua05203  Viral carcinogenesis
maua05205  Proteoglycans in cancer
maua05206  MicroRNAs in cancer
maua05207  Chemical carcinogenesis - receptor activation
maua05208  Chemical carcinogenesis - reactive oxygen species
maua05210  Colorectal cancer
maua05211  Renal cell carcinoma
maua05212  Pancreatic cancer
maua05213  Endometrial cancer
maua05214  Glioma
maua05215  Prostate cancer
maua05218  Melanoma
maua05220  Chronic myeloid leukemia
maua05221  Acute myeloid leukemia
maua05222  Small cell lung cancer
maua05223  Non-small cell lung cancer
maua05224  Breast cancer
maua05225  Hepatocellular carcinoma
maua05226  Gastric cancer
maua05230  Central carbon metabolism in cancer
maua05231  Choline metabolism in cancer
maua05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
maua05415  Diabetic cardiomyopathy
maua05417  Lipid and atherosclerosis
maua05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:maua00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    101835039 (Pik3r1)
   04014 Ras signaling pathway
    101835039 (Pik3r1)
   04015 Rap1 signaling pathway
    101835039 (Pik3r1)
   04370 VEGF signaling pathway
    101835039 (Pik3r1)
   04630 JAK-STAT signaling pathway
    101835039 (Pik3r1)
   04668 TNF signaling pathway
    101835039 (Pik3r1)
   04066 HIF-1 signaling pathway
    101835039 (Pik3r1)
   04068 FoxO signaling pathway
    101835039 (Pik3r1)
   04070 Phosphatidylinositol signaling system
    101835039 (Pik3r1)
   04072 Phospholipase D signaling pathway
    101835039 (Pik3r1)
   04071 Sphingolipid signaling pathway
    101835039 (Pik3r1)
   04024 cAMP signaling pathway
    101835039 (Pik3r1)
   04151 PI3K-Akt signaling pathway
    101835039 (Pik3r1)
   04152 AMPK signaling pathway
    101835039 (Pik3r1)
   04150 mTOR signaling pathway
    101835039 (Pik3r1)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    101835039 (Pik3r1)
   04517 IgSF CAM signaling
    101835039 (Pik3r1)
   04518 Integrin signaling
    101835039 (Pik3r1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    101835039 (Pik3r1)
   04140 Autophagy - animal
    101835039 (Pik3r1)
  09143 Cell growth and death
   04210 Apoptosis
    101835039 (Pik3r1)
   04218 Cellular senescence
    101835039 (Pik3r1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101835039 (Pik3r1)
   04550 Signaling pathways regulating pluripotency of stem cells
    101835039 (Pik3r1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    101835039 (Pik3r1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    101835039 (Pik3r1)
   04613 Neutrophil extracellular trap formation
    101835039 (Pik3r1)
   04620 Toll-like receptor signaling pathway
    101835039 (Pik3r1)
   04625 C-type lectin receptor signaling pathway
    101835039 (Pik3r1)
   04650 Natural killer cell mediated cytotoxicity
    101835039 (Pik3r1)
   04660 T cell receptor signaling pathway
    101835039 (Pik3r1)
   04662 B cell receptor signaling pathway
    101835039 (Pik3r1)
   04664 Fc epsilon RI signaling pathway
    101835039 (Pik3r1)
   04666 Fc gamma R-mediated phagosome formation
    101835039 (Pik3r1)
   04670 Leukocyte transendothelial migration
    101835039 (Pik3r1)
   04062 Chemokine signaling pathway
    101835039 (Pik3r1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101835039 (Pik3r1)
   04923 Regulation of lipolysis in adipocytes
    101835039 (Pik3r1)
   04929 GnRH secretion
    101835039 (Pik3r1)
   04915 Estrogen signaling pathway
    101835039 (Pik3r1)
   04914 Progesterone-mediated oocyte maturation
    101835039 (Pik3r1)
   04917 Prolactin signaling pathway
    101835039 (Pik3r1)
   04926 Relaxin signaling pathway
    101835039 (Pik3r1)
   04935 Growth hormone synthesis, secretion and action
    101835039 (Pik3r1)
   04919 Thyroid hormone signaling pathway
    101835039 (Pik3r1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    101835039 (Pik3r1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    101835039 (Pik3r1)
  09156 Nervous system
   04725 Cholinergic synapse
    101835039 (Pik3r1)
   04722 Neurotrophin signaling pathway
    101835039 (Pik3r1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101835039 (Pik3r1)
  09158 Development and regeneration
   04360 Axon guidance
    101835039 (Pik3r1)
   04380 Osteoclast differentiation
    101835039 (Pik3r1)
  09149 Aging
   04211 Longevity regulating pathway
    101835039 (Pik3r1)
   04213 Longevity regulating pathway - multiple species
    101835039 (Pik3r1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101835039 (Pik3r1)
   05206 MicroRNAs in cancer
    101835039 (Pik3r1)
   05205 Proteoglycans in cancer
    101835039 (Pik3r1)
   05207 Chemical carcinogenesis - receptor activation
    101835039 (Pik3r1)
   05208 Chemical carcinogenesis - reactive oxygen species
    101835039 (Pik3r1)
   05203 Viral carcinogenesis
    101835039 (Pik3r1)
   05230 Central carbon metabolism in cancer
    101835039 (Pik3r1)
   05231 Choline metabolism in cancer
    101835039 (Pik3r1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101835039 (Pik3r1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101835039 (Pik3r1)
   05212 Pancreatic cancer
    101835039 (Pik3r1)
   05225 Hepatocellular carcinoma
    101835039 (Pik3r1)
   05226 Gastric cancer
    101835039 (Pik3r1)
   05214 Glioma
    101835039 (Pik3r1)
   05221 Acute myeloid leukemia
    101835039 (Pik3r1)
   05220 Chronic myeloid leukemia
    101835039 (Pik3r1)
   05218 Melanoma
    101835039 (Pik3r1)
   05211 Renal cell carcinoma
    101835039 (Pik3r1)
   05215 Prostate cancer
    101835039 (Pik3r1)
   05213 Endometrial cancer
    101835039 (Pik3r1)
   05224 Breast cancer
    101835039 (Pik3r1)
   05222 Small cell lung cancer
    101835039 (Pik3r1)
   05223 Non-small cell lung cancer
    101835039 (Pik3r1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101835039 (Pik3r1)
   05170 Human immunodeficiency virus 1 infection
    101835039 (Pik3r1)
   05161 Hepatitis B
    101835039 (Pik3r1)
   05160 Hepatitis C
    101835039 (Pik3r1)
   05171 Coronavirus disease
    101835039 (Pik3r1)
   05164 Influenza A
    101835039 (Pik3r1)
   05162 Measles
    101835039 (Pik3r1)
   05168 Herpes simplex virus 1 infection
    101835039 (Pik3r1)
   05163 Human cytomegalovirus infection
    101835039 (Pik3r1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101835039 (Pik3r1)
   05169 Epstein-Barr virus infection
    101835039 (Pik3r1)
   05165 Human papillomavirus infection
    101835039 (Pik3r1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    101835039 (Pik3r1)
   05100 Bacterial invasion of epithelial cells
    101835039 (Pik3r1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    101835039 (Pik3r1)
   05142 Chagas disease
    101835039 (Pik3r1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101835039 (Pik3r1)
   05017 Spinocerebellar ataxia
    101835039 (Pik3r1)
   05020 Prion disease
    101835039 (Pik3r1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101835039 (Pik3r1)
   05418 Fluid shear stress and atherosclerosis
    101835039 (Pik3r1)
   05415 Diabetic cardiomyopathy
    101835039 (Pik3r1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    101835039 (Pik3r1)
   04932 Non-alcoholic fatty liver disease
    101835039 (Pik3r1)
   04931 Insulin resistance
    101835039 (Pik3r1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    101835039 (Pik3r1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101835039 (Pik3r1)
   01524 Platinum drug resistance
    101835039 (Pik3r1)
   01522 Endocrine resistance
    101835039 (Pik3r1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:maua04131]
    101835039 (Pik3r1)
Membrane trafficking [BR:maua04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    101835039 (Pik3r1)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH2_1 SH3_1 SH3_2 CEP135_TSGA10_CC Laminin_I SH3_9 ODF2_C Imm6 DicA_C Exonuc_VII_L
Other DBs
NCBI-GeneID: 101835039
NCBI-ProteinID: XP_005065653
UniProt: A0A1U7Q814
Position
Unknown
AA seq 724 aa
MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEDIGWLNGYN
ETTGERGDFPGTYVEYIGRKRISPPTPKPRPPRPLPVAPGSSKTEADTEQPALTLPDLAE
QFAPPDVAPPLLIKLVEAIEKKGLECSTLYRTHCSSNPAELRQLLDCDAASVDLEMIDVQ
VLADAFKRYLLDLPNPVIPVAVYNEMMSLAQEVQSSEDYIQLLKKLIRSPNIPHQYWLTL
QYLLKHFFKLSQASSKNLLNSRVLSEIFSPVLFRFPAASSDNTEHLIKVIEILISTEWNE
RQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDA
STKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKL
DVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMK
RTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIID
SRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN
ENTEDQYSLVEDEEDLPHHDEKTWNVGSSNRNKAESLLRGKRDGTFLVRESSKQGCYACS
VVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA
QQRR
NT seq 2175 nt   +upstreamnt  +downstreamnt
atgagtgccgagggataccagtacagagcgctgtatgactacaagaaggagagagaggag
gacatcgacctgcacttgggtgacatactaactgtgaataaagggtccttagtggcactc
ggattcagtgatggacaggaagcccggcctgaagatattggctggttaaacggctacaat
gaaaccaccggggagaggggagactttccaggaacatatgttgaatatattggaaggaaa
agaatttcacctcccactcccaagccccggccccctcgacctcttcctgttgcaccaggt
tcttcaaaaactgaagcagacactgagcaaccagctttgacccttcccgatctggctgag
cagtttgcccctcctgatgttgccccacctctccttatcaagcttgtggaagccatcgag
aagaaaggactggaatgttcgactctatacagaacacattgctccagcaaccctgcagaa
ttacgacagcttcttgattgtgatgccgcctcagtggacttggaaatgattgatgtacaa
gttttagcagatgctttcaaacgctatctcttggacttaccaaatcccgtcattccagta
gctgtttacaatgaaatgatgtctttagcccaagaagtacaaagctctgaagactacatc
caactattgaagaagctcattaggtcgcctaatatacctcatcagtattggcttacgctt
cagtatttgcttaaacatttcttcaagctctctcaagcctccagcaaaaatcttttgaat
tcaagagtactctctgagattttcagccctgtgctttttagattcccagcagccagctct
gataatactgaacacctcataaaagtgatagagattttaatctcaactgaatggaatgaa
cgacagccagcaccagcactgccccctaagccacccaagcccactactgtagccaacaac
ggcatgaacaacaatatgtccttacaggatgctgaatggtactggggagacatctcaagg
gaagaagtgaatgaaaaactccgagatacagctgacggcacctttttggtacgagatgcg
tctactaaaatgcacggcgattatactcttacactaaggaaaggaggaaataacaaatta
atcaaaatatttcaccgagatggaaaatatggcttctctgatccattaaccttcaactct
gtggttgaactaataaaccactaccggaatgagtctctagctcagtacaaccccaagcta
gatgtgaagctactctacccagtgtccaagtaccagcaggatcaagttgtcaaagaagat
aatattgaagctgtagggaaaaagttacatgaatataatactcaatttcaagaaaaaagt
cgggaatacgatagattatatgaagaatacacccgtacttcccaggaaattcaaatgaaa
agaacagctattgaagcattcaatgaaaccataaaaatatttgaagaacaatgccagacc
caggagcggtacagcaaggaatacatagaaaagtttaagcgtgaaggcaacgagaaagaa
attcaaaggatcatgcataactatgataagctaaagtctcgcatcagtgagatcattgac
agcaggaggagattagaggaagacttgaagaagcaggcagccgaataccgcgagattgac
aagcgcatgaacagcattaagccagacctcattcagctgagaaagacaagagaccaatac
ttgatgtggctgacgcagaaaggggttcggcagaagaagttgaacgagtggctgggaaat
gaaaacaccgaagaccaatactccctggtggaagacgaggaggacttgccccaccacgat
gaaaagacatggaatgttggcagcagcaatcgaaacaaagccgagagtctattacgaggg
aagcgagatggcacttttcttgtccgggagagcagcaagcagggctgctacgcctgctct
gtagtggtagatggcgaagtcaagcattgtgtcatcaacaagactgccaccggctatggc
tttgccgagccctacaacctgtacagctccctgaaggagctggtgctacattaccaacac
acgtccctcgtgcagcacaatgactccctcaatgtcacactagcatacccggtatatgca
caacagaggcgatga

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (4)   
   UniProt (1)   
   RefSeq(pep) (3)   
DNA sequence (3)   
   RefSeq(nuc) (3)   
Protein domain (13)   
   Pfam (13)   
All databases (22)   

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