KEGG   Mus caroli (Ryukyu mouse): 110290798
Entry
110290798         CDS       T05910                                 
Symbol
Pik3ca
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
mcal  Mus caroli (Ryukyu mouse)
Pathway
mcal00562  Inositol phosphate metabolism
mcal01100  Metabolic pathways
mcal01521  EGFR tyrosine kinase inhibitor resistance
mcal01522  Endocrine resistance
mcal01524  Platinum drug resistance
mcal04012  ErbB signaling pathway
mcal04014  Ras signaling pathway
mcal04015  Rap1 signaling pathway
mcal04024  cAMP signaling pathway
mcal04062  Chemokine signaling pathway
mcal04066  HIF-1 signaling pathway
mcal04068  FoxO signaling pathway
mcal04070  Phosphatidylinositol signaling system
mcal04071  Sphingolipid signaling pathway
mcal04072  Phospholipase D signaling pathway
mcal04081  Hormone signaling
mcal04140  Autophagy - animal
mcal04145  Phagocytosis
mcal04150  mTOR signaling pathway
mcal04151  PI3K-Akt signaling pathway
mcal04152  AMPK signaling pathway
mcal04210  Apoptosis
mcal04211  Longevity regulating pathway
mcal04213  Longevity regulating pathway - multiple species
mcal04218  Cellular senescence
mcal04360  Axon guidance
mcal04370  VEGF signaling pathway
mcal04380  Osteoclast differentiation
mcal04510  Focal adhesion
mcal04517  IgSF CAM signaling
mcal04518  Integrin signaling
mcal04550  Signaling pathways regulating pluripotency of stem cells
mcal04611  Platelet activation
mcal04613  Neutrophil extracellular trap formation
mcal04620  Toll-like receptor signaling pathway
mcal04625  C-type lectin receptor signaling pathway
mcal04630  JAK-STAT signaling pathway
mcal04650  Natural killer cell mediated cytotoxicity
mcal04660  T cell receptor signaling pathway
mcal04662  B cell receptor signaling pathway
mcal04664  Fc epsilon RI signaling pathway
mcal04666  Fc gamma R-mediated phagosome formation
mcal04668  TNF signaling pathway
mcal04670  Leukocyte transendothelial migration
mcal04722  Neurotrophin signaling pathway
mcal04725  Cholinergic synapse
mcal04750  Inflammatory mediator regulation of TRP channels
mcal04810  Regulation of actin cytoskeleton
mcal04910  Insulin signaling pathway
mcal04914  Progesterone-mediated oocyte maturation
mcal04915  Estrogen signaling pathway
mcal04917  Prolactin signaling pathway
mcal04919  Thyroid hormone signaling pathway
mcal04923  Regulation of lipolysis in adipocytes
mcal04926  Relaxin signaling pathway
mcal04929  GnRH secretion
mcal04930  Type II diabetes mellitus
mcal04931  Insulin resistance
mcal04932  Non-alcoholic fatty liver disease
mcal04933  AGE-RAGE signaling pathway in diabetic complications
mcal04935  Growth hormone synthesis, secretion and action
mcal04960  Aldosterone-regulated sodium reabsorption
mcal04973  Carbohydrate digestion and absorption
mcal05010  Alzheimer disease
mcal05017  Spinocerebellar ataxia
mcal05020  Prion disease
mcal05100  Bacterial invasion of epithelial cells
mcal05132  Salmonella infection
mcal05135  Yersinia infection
mcal05142  Chagas disease
mcal05146  Amoebiasis
mcal05160  Hepatitis C
mcal05161  Hepatitis B
mcal05162  Measles
mcal05163  Human cytomegalovirus infection
mcal05164  Influenza A
mcal05165  Human papillomavirus infection
mcal05166  Human T-cell leukemia virus 1 infection
mcal05167  Kaposi sarcoma-associated herpesvirus infection
mcal05168  Herpes simplex virus 1 infection
mcal05169  Epstein-Barr virus infection
mcal05170  Human immunodeficiency virus 1 infection
mcal05171  Coronavirus disease
mcal05200  Pathways in cancer
mcal05203  Viral carcinogenesis
mcal05205  Proteoglycans in cancer
mcal05206  MicroRNAs in cancer
mcal05207  Chemical carcinogenesis - receptor activation
mcal05208  Chemical carcinogenesis - reactive oxygen species
mcal05210  Colorectal cancer
mcal05211  Renal cell carcinoma
mcal05212  Pancreatic cancer
mcal05213  Endometrial cancer
mcal05214  Glioma
mcal05215  Prostate cancer
mcal05218  Melanoma
mcal05220  Chronic myeloid leukemia
mcal05221  Acute myeloid leukemia
mcal05222  Small cell lung cancer
mcal05223  Non-small cell lung cancer
mcal05224  Breast cancer
mcal05225  Hepatocellular carcinoma
mcal05226  Gastric cancer
mcal05230  Central carbon metabolism in cancer
mcal05231  Choline metabolism in cancer
mcal05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mcal05415  Diabetic cardiomyopathy
mcal05417  Lipid and atherosclerosis
mcal05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mcal00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    110290798 (Pik3ca)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    110290798 (Pik3ca)
   04014 Ras signaling pathway
    110290798 (Pik3ca)
   04015 Rap1 signaling pathway
    110290798 (Pik3ca)
   04370 VEGF signaling pathway
    110290798 (Pik3ca)
   04630 JAK-STAT signaling pathway
    110290798 (Pik3ca)
   04668 TNF signaling pathway
    110290798 (Pik3ca)
   04066 HIF-1 signaling pathway
    110290798 (Pik3ca)
   04068 FoxO signaling pathway
    110290798 (Pik3ca)
   04070 Phosphatidylinositol signaling system
    110290798 (Pik3ca)
   04072 Phospholipase D signaling pathway
    110290798 (Pik3ca)
   04071 Sphingolipid signaling pathway
    110290798 (Pik3ca)
   04024 cAMP signaling pathway
    110290798 (Pik3ca)
   04151 PI3K-Akt signaling pathway
    110290798 (Pik3ca)
   04152 AMPK signaling pathway
    110290798 (Pik3ca)
   04150 mTOR signaling pathway
    110290798 (Pik3ca)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    110290798 (Pik3ca)
   04517 IgSF CAM signaling
    110290798 (Pik3ca)
   04518 Integrin signaling
    110290798 (Pik3ca)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    110290798 (Pik3ca)
   04140 Autophagy - animal
    110290798 (Pik3ca)
  09143 Cell growth and death
   04210 Apoptosis
    110290798 (Pik3ca)
   04218 Cellular senescence
    110290798 (Pik3ca)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    110290798 (Pik3ca)
   04550 Signaling pathways regulating pluripotency of stem cells
    110290798 (Pik3ca)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    110290798 (Pik3ca)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    110290798 (Pik3ca)
   04613 Neutrophil extracellular trap formation
    110290798 (Pik3ca)
   04620 Toll-like receptor signaling pathway
    110290798 (Pik3ca)
   04625 C-type lectin receptor signaling pathway
    110290798 (Pik3ca)
   04650 Natural killer cell mediated cytotoxicity
    110290798 (Pik3ca)
   04660 T cell receptor signaling pathway
    110290798 (Pik3ca)
   04662 B cell receptor signaling pathway
    110290798 (Pik3ca)
   04664 Fc epsilon RI signaling pathway
    110290798 (Pik3ca)
   04666 Fc gamma R-mediated phagosome formation
    110290798 (Pik3ca)
   04670 Leukocyte transendothelial migration
    110290798 (Pik3ca)
   04062 Chemokine signaling pathway
    110290798 (Pik3ca)
  09152 Endocrine system
   04910 Insulin signaling pathway
    110290798 (Pik3ca)
   04923 Regulation of lipolysis in adipocytes
    110290798 (Pik3ca)
   04929 GnRH secretion
    110290798 (Pik3ca)
   04915 Estrogen signaling pathway
    110290798 (Pik3ca)
   04914 Progesterone-mediated oocyte maturation
    110290798 (Pik3ca)
   04917 Prolactin signaling pathway
    110290798 (Pik3ca)
   04926 Relaxin signaling pathway
    110290798 (Pik3ca)
   04935 Growth hormone synthesis, secretion and action
    110290798 (Pik3ca)
   04919 Thyroid hormone signaling pathway
    110290798 (Pik3ca)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    110290798 (Pik3ca)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    110290798 (Pik3ca)
  09156 Nervous system
   04725 Cholinergic synapse
    110290798 (Pik3ca)
   04722 Neurotrophin signaling pathway
    110290798 (Pik3ca)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    110290798 (Pik3ca)
  09158 Development and regeneration
   04360 Axon guidance
    110290798 (Pik3ca)
   04380 Osteoclast differentiation
    110290798 (Pik3ca)
  09149 Aging
   04211 Longevity regulating pathway
    110290798 (Pik3ca)
   04213 Longevity regulating pathway - multiple species
    110290798 (Pik3ca)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    110290798 (Pik3ca)
   05206 MicroRNAs in cancer
    110290798 (Pik3ca)
   05205 Proteoglycans in cancer
    110290798 (Pik3ca)
   05207 Chemical carcinogenesis - receptor activation
    110290798 (Pik3ca)
   05208 Chemical carcinogenesis - reactive oxygen species
    110290798 (Pik3ca)
   05203 Viral carcinogenesis
    110290798 (Pik3ca)
   05230 Central carbon metabolism in cancer
    110290798 (Pik3ca)
   05231 Choline metabolism in cancer
    110290798 (Pik3ca)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    110290798 (Pik3ca)
  09162 Cancer: specific types
   05210 Colorectal cancer
    110290798 (Pik3ca)
   05212 Pancreatic cancer
    110290798 (Pik3ca)
   05225 Hepatocellular carcinoma
    110290798 (Pik3ca)
   05226 Gastric cancer
    110290798 (Pik3ca)
   05214 Glioma
    110290798 (Pik3ca)
   05221 Acute myeloid leukemia
    110290798 (Pik3ca)
   05220 Chronic myeloid leukemia
    110290798 (Pik3ca)
   05218 Melanoma
    110290798 (Pik3ca)
   05211 Renal cell carcinoma
    110290798 (Pik3ca)
   05215 Prostate cancer
    110290798 (Pik3ca)
   05213 Endometrial cancer
    110290798 (Pik3ca)
   05224 Breast cancer
    110290798 (Pik3ca)
   05222 Small cell lung cancer
    110290798 (Pik3ca)
   05223 Non-small cell lung cancer
    110290798 (Pik3ca)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    110290798 (Pik3ca)
   05170 Human immunodeficiency virus 1 infection
    110290798 (Pik3ca)
   05161 Hepatitis B
    110290798 (Pik3ca)
   05160 Hepatitis C
    110290798 (Pik3ca)
   05171 Coronavirus disease
    110290798 (Pik3ca)
   05164 Influenza A
    110290798 (Pik3ca)
   05162 Measles
    110290798 (Pik3ca)
   05168 Herpes simplex virus 1 infection
    110290798 (Pik3ca)
   05163 Human cytomegalovirus infection
    110290798 (Pik3ca)
   05167 Kaposi sarcoma-associated herpesvirus infection
    110290798 (Pik3ca)
   05169 Epstein-Barr virus infection
    110290798 (Pik3ca)
   05165 Human papillomavirus infection
    110290798 (Pik3ca)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    110290798 (Pik3ca)
   05135 Yersinia infection
    110290798 (Pik3ca)
   05100 Bacterial invasion of epithelial cells
    110290798 (Pik3ca)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    110290798 (Pik3ca)
   05142 Chagas disease
    110290798 (Pik3ca)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    110290798 (Pik3ca)
   05017 Spinocerebellar ataxia
    110290798 (Pik3ca)
   05020 Prion disease
    110290798 (Pik3ca)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    110290798 (Pik3ca)
   05418 Fluid shear stress and atherosclerosis
    110290798 (Pik3ca)
   05415 Diabetic cardiomyopathy
    110290798 (Pik3ca)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    110290798 (Pik3ca)
   04932 Non-alcoholic fatty liver disease
    110290798 (Pik3ca)
   04931 Insulin resistance
    110290798 (Pik3ca)
   04933 AGE-RAGE signaling pathway in diabetic complications
    110290798 (Pik3ca)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    110290798 (Pik3ca)
   01524 Platinum drug resistance
    110290798 (Pik3ca)
   01522 Endocrine resistance
    110290798 (Pik3ca)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mcal04131]
    110290798 (Pik3ca)
Enzymes [BR:mcal01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     110290798 (Pik3ca)
Membrane trafficking [BR:mcal04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    110290798 (Pik3ca)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Sll1247_N
Other DBs
NCBI-GeneID: 110290798
NCBI-ProteinID: XP_021013222
Ensembl: MGP_CAROLIEiJ_G0024915
UniProt: A0A6P5PIV6
Position
3:27411470..27480514
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLVTIKHELFKEARKYPLHQ
LLQDETSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFV
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPID
SFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHTGLSNRLARDNELRENDKEQLRALCTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRSFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRQPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQEYTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFTKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccacgaccatcttcgggtgaactgtggggcatccacttgatgcccccacgaatc
ctagtggaatgtttactccccaatggaatgatagtgactttagaatgcctccgtgaggcc
acactagtcaccatcaaacatgaactgttcaaagaggccaggaaataccctctccatcag
cttctgcaagatgaaacttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacggctttgtgaccttcggctttttcaaccctttttaaaa
gttattgaaccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgtt
attggcatgccagtgtgtgaatttgatatggttaaagatccagaagtccaagactttcga
aggaacattctgaatgtttgcaaagaagctgtggacctgcgggatctcaactcgcctcat
agcagagcaatgtatgtctaccctccaaatgtcgagtcttccccagaactgccaaagcac
atctacaacaagttagataaaggacaaatcatagtggtgatttgggtaatagtctctcca
aacaacgacaagcagaagtacactctgaagatcaaccatgactgtgtgccagagcaagtc
attgctgaagccatcaggaaaaagactcggagcatgttgttgtcctctgagcagctgaaa
ctctgtgtcttagaatatcagggcaagtatattctgaaagtgtgtggctgtgacgagtac
ttcctagaaaagtaccctctgagtcagtacaagtacataagaagctgtataatgctgggg
aggatgcccaacttgatgctgatggccaaagaaagcctatactctcagctgccaattgat
agcttcaccatgccttcatactccaggcgcatctccacagccacaccctacatgaatgga
gagacatctacgaaatccctctgggtcataaatagtgcgctcagaataaaaattctttgt
gcaacctatgtaaatgtaaatattcgagacattgataagatctatgttcgaacaggtatc
taccatggaggagaacccttatgtgacaatgtgaacactcaaagagtaccttgttccaat
cctaggtggaatgaatggctgaattatgacatatacattcctgatcttcctcgtgctgcg
cgcctttgcctttcaatctgctctgttaaaggccgaaagggtgctaaggaggagcactgt
ccgttggcctggggaaacataaacttgtttgattatacagacaccctagtgtccgggaaa
atggctttgaatctctggcctgtaccacatgggttagaagatctgctgaaccctattggt
gttactgggtcaaatccaaataaagaaactccatgcttagagttggagtttgattggttc
agcagtgtggtgaagtttccagacatgtctgtgatcgaagaacatgccaattggtccgtg
tcccgagaagctggattcagttactctcatacaggactgagtaacagactagccagagac
aatgagttaagagaaaatgacaaggaacagctccgagcactttgcacccgggacccactg
tctgaaatcactgaacaagagaaagacttcctatggagccacagacactactgcgtaact
attcctgaaatcctacccaaattgcttctgtctgtcaagtggaattccagagacgaagtg
gcccagatgtactgcttagtaaaagattggcctccaatcaaaccagagcaagccatggaa
ctcctggactgtaactatccagatcctatggttcggagttttgctgttcggtgcttggaa
aaatatttaacagatgacaaactttctcagtacctcattcagcttgtacaggtcttaaaa
tatgaacaatatttggataacctgcttgtgagatttttactcaagaaagcattgacaaat
caaaggattggccattttttcttttggcatttaaaatctgagatgcacaataagactgtc
agtcagaggtttggcctgctattggagtcctactgccgtgcctgtgggatgtatctgaag
cacctgaacagacaagtagaggccatggagaagctcatcaacctaacggatatcctcaag
caggagaagaaggatgagacacaaaaggtacagatgaagtttttggttgaacagatgaga
cagccagacttcatggatgctttgcagggttttctgtcccctctgaatcctgctcaccaa
ctaggaaacctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagctactgtttcagaacaatgagatcatc
tttaaaaatggcgacgacttacggcaagatatgttaacccttcagatcatccgaatcatg
gagaacatctggcaaaaccaaggccttgaccttcgcatgctaccttatggctgtctatcc
attggggactgtgtgggtctcatcgaggtagtgagaaactctcacaccatcatgcaaatc
cagtgcaaaggaggcctgaagggggcgctgcagttcaacagccacacactgcatcagtgg
ctcaaggacaagaacaagggcgagatatatgatgcagccattgacctgttcactcggtcc
tgcgcggggtactgcgtggcaacctttatcttgggaattggagaccggcacaacagcaac
atcatggtgaaagatgacggacagctgtttcatatagattttgggcactttttggatcac
aagaagaaaaaatttggttataagcgggaacgtgtgccgtttgtgttgacgcaggatttc
ttgattgtgattagtaaaggagcacaagagtacaccaagaccagagagtttgagaggttt
caggagatgtgttacaaggcttacctagcgattcggcagcatgccaatctcttcatcaac
cttttttcaatgatgcttggctctggaatgccagaactgcaatcttttgatgacattgca
tatatccgaaagactctagccttggacaaaactgagcaagaagctttggaatatttcaca
aagcaaatgaatgatgcacatcatggtggatggacgacaaaaatggattggatcttccac
accatcaagcagcatgcattgaactga

  All links  
Gene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (8)   
   Pfam (8)   
All databases (14)   

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