KEGG   Macrotis lagotis (bilby): 141501125
Entry
141501125         CDS       T11097                                 
Symbol
PIK3R2
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit beta
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
mlao  Macrotis lagotis (bilby)
Pathway
mlao01521  EGFR tyrosine kinase inhibitor resistance
mlao01522  Endocrine resistance
mlao01524  Platinum drug resistance
mlao04012  ErbB signaling pathway
mlao04014  Ras signaling pathway
mlao04015  Rap1 signaling pathway
mlao04024  cAMP signaling pathway
mlao04062  Chemokine signaling pathway
mlao04066  HIF-1 signaling pathway
mlao04068  FoxO signaling pathway
mlao04070  Phosphatidylinositol signaling system
mlao04071  Sphingolipid signaling pathway
mlao04072  Phospholipase D signaling pathway
mlao04081  Hormone signaling
mlao04140  Autophagy - animal
mlao04145  Phagocytosis
mlao04150  mTOR signaling pathway
mlao04151  PI3K-Akt signaling pathway
mlao04152  AMPK signaling pathway
mlao04210  Apoptosis
mlao04211  Longevity regulating pathway
mlao04213  Longevity regulating pathway - multiple species
mlao04218  Cellular senescence
mlao04360  Axon guidance
mlao04370  VEGF signaling pathway
mlao04380  Osteoclast differentiation
mlao04510  Focal adhesion
mlao04517  IgSF CAM signaling
mlao04518  Integrin signaling
mlao04550  Signaling pathways regulating pluripotency of stem cells
mlao04611  Platelet activation
mlao04613  Neutrophil extracellular trap formation
mlao04620  Toll-like receptor signaling pathway
mlao04625  C-type lectin receptor signaling pathway
mlao04630  JAK-STAT signaling pathway
mlao04650  Natural killer cell mediated cytotoxicity
mlao04660  T cell receptor signaling pathway
mlao04662  B cell receptor signaling pathway
mlao04664  Fc epsilon RI signaling pathway
mlao04666  Fc gamma R-mediated phagosome formation
mlao04668  TNF signaling pathway
mlao04670  Leukocyte transendothelial migration
mlao04722  Neurotrophin signaling pathway
mlao04725  Cholinergic synapse
mlao04750  Inflammatory mediator regulation of TRP channels
mlao04810  Regulation of actin cytoskeleton
mlao04910  Insulin signaling pathway
mlao04914  Progesterone-mediated oocyte maturation
mlao04915  Estrogen signaling pathway
mlao04917  Prolactin signaling pathway
mlao04919  Thyroid hormone signaling pathway
mlao04923  Regulation of lipolysis in adipocytes
mlao04926  Relaxin signaling pathway
mlao04929  GnRH secretion
mlao04930  Type II diabetes mellitus
mlao04931  Insulin resistance
mlao04932  Non-alcoholic fatty liver disease
mlao04933  AGE-RAGE signaling pathway in diabetic complications
mlao04935  Growth hormone synthesis, secretion and action
mlao04960  Aldosterone-regulated sodium reabsorption
mlao04973  Carbohydrate digestion and absorption
mlao05010  Alzheimer disease
mlao05017  Spinocerebellar ataxia
mlao05020  Prion disease
mlao05100  Bacterial invasion of epithelial cells
mlao05135  Yersinia infection
mlao05142  Chagas disease
mlao05146  Amoebiasis
mlao05160  Hepatitis C
mlao05161  Hepatitis B
mlao05162  Measles
mlao05163  Human cytomegalovirus infection
mlao05164  Influenza A
mlao05165  Human papillomavirus infection
mlao05166  Human T-cell leukemia virus 1 infection
mlao05167  Kaposi sarcoma-associated herpesvirus infection
mlao05168  Herpes simplex virus 1 infection
mlao05169  Epstein-Barr virus infection
mlao05170  Human immunodeficiency virus 1 infection
mlao05171  Coronavirus disease
mlao05200  Pathways in cancer
mlao05203  Viral carcinogenesis
mlao05205  Proteoglycans in cancer
mlao05206  MicroRNAs in cancer
mlao05207  Chemical carcinogenesis - receptor activation
mlao05208  Chemical carcinogenesis - reactive oxygen species
mlao05210  Colorectal cancer
mlao05211  Renal cell carcinoma
mlao05212  Pancreatic cancer
mlao05213  Endometrial cancer
mlao05214  Glioma
mlao05215  Prostate cancer
mlao05218  Melanoma
mlao05220  Chronic myeloid leukemia
mlao05221  Acute myeloid leukemia
mlao05222  Small cell lung cancer
mlao05223  Non-small cell lung cancer
mlao05224  Breast cancer
mlao05225  Hepatocellular carcinoma
mlao05226  Gastric cancer
mlao05230  Central carbon metabolism in cancer
mlao05231  Choline metabolism in cancer
mlao05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mlao05415  Diabetic cardiomyopathy
mlao05417  Lipid and atherosclerosis
mlao05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mlao00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    141501125 (PIK3R2)
   04014 Ras signaling pathway
    141501125 (PIK3R2)
   04015 Rap1 signaling pathway
    141501125 (PIK3R2)
   04370 VEGF signaling pathway
    141501125 (PIK3R2)
   04630 JAK-STAT signaling pathway
    141501125 (PIK3R2)
   04668 TNF signaling pathway
    141501125 (PIK3R2)
   04066 HIF-1 signaling pathway
    141501125 (PIK3R2)
   04068 FoxO signaling pathway
    141501125 (PIK3R2)
   04070 Phosphatidylinositol signaling system
    141501125 (PIK3R2)
   04072 Phospholipase D signaling pathway
    141501125 (PIK3R2)
   04071 Sphingolipid signaling pathway
    141501125 (PIK3R2)
   04024 cAMP signaling pathway
    141501125 (PIK3R2)
   04151 PI3K-Akt signaling pathway
    141501125 (PIK3R2)
   04152 AMPK signaling pathway
    141501125 (PIK3R2)
   04150 mTOR signaling pathway
    141501125 (PIK3R2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    141501125 (PIK3R2)
   04517 IgSF CAM signaling
    141501125 (PIK3R2)
   04518 Integrin signaling
    141501125 (PIK3R2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    141501125 (PIK3R2)
   04140 Autophagy - animal
    141501125 (PIK3R2)
  09143 Cell growth and death
   04210 Apoptosis
    141501125 (PIK3R2)
   04218 Cellular senescence
    141501125 (PIK3R2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    141501125 (PIK3R2)
   04550 Signaling pathways regulating pluripotency of stem cells
    141501125 (PIK3R2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    141501125 (PIK3R2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    141501125 (PIK3R2)
   04613 Neutrophil extracellular trap formation
    141501125 (PIK3R2)
   04620 Toll-like receptor signaling pathway
    141501125 (PIK3R2)
   04625 C-type lectin receptor signaling pathway
    141501125 (PIK3R2)
   04650 Natural killer cell mediated cytotoxicity
    141501125 (PIK3R2)
   04660 T cell receptor signaling pathway
    141501125 (PIK3R2)
   04662 B cell receptor signaling pathway
    141501125 (PIK3R2)
   04664 Fc epsilon RI signaling pathway
    141501125 (PIK3R2)
   04666 Fc gamma R-mediated phagosome formation
    141501125 (PIK3R2)
   04670 Leukocyte transendothelial migration
    141501125 (PIK3R2)
   04062 Chemokine signaling pathway
    141501125 (PIK3R2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    141501125 (PIK3R2)
   04923 Regulation of lipolysis in adipocytes
    141501125 (PIK3R2)
   04929 GnRH secretion
    141501125 (PIK3R2)
   04915 Estrogen signaling pathway
    141501125 (PIK3R2)
   04914 Progesterone-mediated oocyte maturation
    141501125 (PIK3R2)
   04917 Prolactin signaling pathway
    141501125 (PIK3R2)
   04926 Relaxin signaling pathway
    141501125 (PIK3R2)
   04935 Growth hormone synthesis, secretion and action
    141501125 (PIK3R2)
   04919 Thyroid hormone signaling pathway
    141501125 (PIK3R2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    141501125 (PIK3R2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    141501125 (PIK3R2)
  09156 Nervous system
   04725 Cholinergic synapse
    141501125 (PIK3R2)
   04722 Neurotrophin signaling pathway
    141501125 (PIK3R2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    141501125 (PIK3R2)
  09158 Development and regeneration
   04360 Axon guidance
    141501125 (PIK3R2)
   04380 Osteoclast differentiation
    141501125 (PIK3R2)
  09149 Aging
   04211 Longevity regulating pathway
    141501125 (PIK3R2)
   04213 Longevity regulating pathway - multiple species
    141501125 (PIK3R2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    141501125 (PIK3R2)
   05206 MicroRNAs in cancer
    141501125 (PIK3R2)
   05205 Proteoglycans in cancer
    141501125 (PIK3R2)
   05207 Chemical carcinogenesis - receptor activation
    141501125 (PIK3R2)
   05208 Chemical carcinogenesis - reactive oxygen species
    141501125 (PIK3R2)
   05203 Viral carcinogenesis
    141501125 (PIK3R2)
   05230 Central carbon metabolism in cancer
    141501125 (PIK3R2)
   05231 Choline metabolism in cancer
    141501125 (PIK3R2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    141501125 (PIK3R2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    141501125 (PIK3R2)
   05212 Pancreatic cancer
    141501125 (PIK3R2)
   05225 Hepatocellular carcinoma
    141501125 (PIK3R2)
   05226 Gastric cancer
    141501125 (PIK3R2)
   05214 Glioma
    141501125 (PIK3R2)
   05221 Acute myeloid leukemia
    141501125 (PIK3R2)
   05220 Chronic myeloid leukemia
    141501125 (PIK3R2)
   05218 Melanoma
    141501125 (PIK3R2)
   05211 Renal cell carcinoma
    141501125 (PIK3R2)
   05215 Prostate cancer
    141501125 (PIK3R2)
   05213 Endometrial cancer
    141501125 (PIK3R2)
   05224 Breast cancer
    141501125 (PIK3R2)
   05222 Small cell lung cancer
    141501125 (PIK3R2)
   05223 Non-small cell lung cancer
    141501125 (PIK3R2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    141501125 (PIK3R2)
   05170 Human immunodeficiency virus 1 infection
    141501125 (PIK3R2)
   05161 Hepatitis B
    141501125 (PIK3R2)
   05160 Hepatitis C
    141501125 (PIK3R2)
   05171 Coronavirus disease
    141501125 (PIK3R2)
   05164 Influenza A
    141501125 (PIK3R2)
   05162 Measles
    141501125 (PIK3R2)
   05168 Herpes simplex virus 1 infection
    141501125 (PIK3R2)
   05163 Human cytomegalovirus infection
    141501125 (PIK3R2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    141501125 (PIK3R2)
   05169 Epstein-Barr virus infection
    141501125 (PIK3R2)
   05165 Human papillomavirus infection
    141501125 (PIK3R2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    141501125 (PIK3R2)
   05100 Bacterial invasion of epithelial cells
    141501125 (PIK3R2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    141501125 (PIK3R2)
   05142 Chagas disease
    141501125 (PIK3R2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    141501125 (PIK3R2)
   05017 Spinocerebellar ataxia
    141501125 (PIK3R2)
   05020 Prion disease
    141501125 (PIK3R2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    141501125 (PIK3R2)
   05418 Fluid shear stress and atherosclerosis
    141501125 (PIK3R2)
   05415 Diabetic cardiomyopathy
    141501125 (PIK3R2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    141501125 (PIK3R2)
   04932 Non-alcoholic fatty liver disease
    141501125 (PIK3R2)
   04931 Insulin resistance
    141501125 (PIK3R2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    141501125 (PIK3R2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    141501125 (PIK3R2)
   01524 Platinum drug resistance
    141501125 (PIK3R2)
   01522 Endocrine resistance
    141501125 (PIK3R2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mlao04131]
    141501125 (PIK3R2)
Membrane trafficking [BR:mlao04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    141501125 (PIK3R2)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH3_1 SH2_1 SH3_9 SH3_2 Ribosomal_L22e Tyr_recomb_halo_M Mod_r
Other DBs
NCBI-GeneID: 141501125
NCBI-ProteinID: XP_074060911
Position
X:complement(650561452..650588900)
AA seq 739 aa
MGSAEGFQYRALYQYHKEREEDLDLLPGDILVVSKGTLEALGFHDGDEQSPHQIGWILGV
NERTKQKGDFPGTYVEYLGPVKIALPSHRPRGHRPLPATPGAGPVRARDSPEPAGTLLPD
LPEQFMPPEVAPPILQKLVEAIEQKGLDSEMLYRPSGSELRPLRIDWTLSDVDQWDVATL
SEALKGYLQALPRPLVPPGSHGDILHALQEVTSPAAAAASAGWRRQQLQAVLEPPLVPLH
NALTLRFLLQHLGRVAQQAQTQAQGSSLSPQALGEIFGPLLLRLSATGSEQTPDFSALFL
EMLLQDQEEEQEPPPPALPPKPPKPKVQPGNLSNGSNAPLQEAEWYWGDISREEVNEKLR
DTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGQYGFSEPLTFGSVVELITHY
RHESLAQYNAKLDTRLLYPVSKHQQDQVVKEDSVEAVGEQLKVYHQQYQDKSREYDLLYE
EYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQEKCSKDYLERFRREGNEKEIQRILMNS
EKLKSRIAEIHDSKMKLEQDLRAQAADNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKG
ARQKKINEWLGIKNETEDQYSMVDEEEDLPHHEERTWYVGKINRGRAEEMLSGKRDGTFL
IRESSQRGCYACSVVVDGDTKHCVIYKTVTGYGFAEPYNLYASLKDLVLHYKHTSLVQHN
DSLNVTLAHPVLSPPPPAR
NT seq 2220 nt   +upstreamnt  +downstreamnt
atgggcagcgctgagggcttccagtaccgggccctttaccagtatcacaaggaacgtgag
gaggaccttgacctgctacctggcgacatcctagtggtgagcaagggcacgttggaggct
ctcggctttcatgatggggacgaacagagccctcaccaaattggctggatcctgggcgtc
aacgagcggaccaaacagaagggagatttcccaggcacctacgtggagtatctggggcct
gtgaagattgccctgccctcccaccgtccccgaggccacaggccattgcctgccacacca
ggggcagggcctgtccgtgcccgggactccccagagccagctggtaccctgcttcctgac
ctgccggagcagtttatgccccctgaggtggcaccacccatccttcagaagttggtggaa
gccattgaacaaaaagggctggacagtgagatgctctacagaccatctggttctgagcta
cgaccactgagaattgactggactctgagtgatgtggatcagtgggatgtggccaccctt
tctgaggccctgaagggttacttacaagctttgcccaggccccttgtgccgcctggatcc
cacggggatattcttcatgccttgcaggaggtaaccagcccagctgcagcagcggcatca
gcagggtggaggaggcagcagctgcaggcagtgctggagccccccctggtccctctgcac
aatgccctgactctgcgcttcctgctccagcatctggggcgggtggcccagcaggcccag
acccaagcccagggcagcagcctgagcccccaggccctgggggagatctttggacctctc
ctacttaggctgtcggccactgggtctgaacagacccctgacttctcagctctgttcctg
gaaatgctgctacaggaccaggaggaggaacaggaaccaccgcccccagccctaccccca
aagcctcctaagcccaaggtccagcctggcaacctgtctaatgggagcaatgccccactc
caggaagctgagtggtattggggtgacatttccagggaagaggtgaatgagaaacttcgt
gacactccagatggtaccttcctagtccgggatgcttctagcaagatccagggcgaatac
acgttgaccctcaggaagggtggcaacaacaaactgatcaaagtcttccaccgagatgga
cagtatggcttctccgagcccctgacctttggttccgtagtggagctcatcacccactac
agacatgagtctctggcccagtacaacgccaagttggacactcgactgctctatcccgta
tccaagcatcagcaggaccaggtggtgaaggaggacagcgttgaggcagttggagaacag
ctgaaggtttatcatcagcagtatcaggacaagagtcgagaatacgatcttctctatgag
gagtacacccggacttcgcaggagctgcagatgaagcggactgccatcgaggccttcaac
gagaccatcaaaatctttgaggaacagggtcagactcaggagaagtgcagcaaggattat
ctagaacgcttccggagagagggcaatgagaaggagattcagcggatcctgatgaactca
gagaagctcaagtcccgaatagcggagattcacgacagcaagatgaagttggagcaggac
ctgcgggcccaggctgctgacaaccgagagatcgacaagcgcatgaacagcctcaagccc
gacctcatgcagctgcggaagatccgggaccagtacctcgtgtggttgacccaaaaggga
gcccggcagaagaagattaatgagtggctgggaatcaagaatgagactgaagaccagtat
tccatggtggatgaggaagaggacctgcctcatcacgaggaacggacttggtatgttggg
aagatcaaccgcgggcgagcagaggagatgctgagcggcaaacgggatggcaccttcctc
atccgggaaagcagccagaggggatgttatgcctgctctgtggtggtggatggagatacc
aaacactgcgtcatctacaagacggtgactggctatggcttcgcggagccctacaacctg
tacgcctccctcaaagacttggtgctacactataagcatacatcgcttgttcagcataat
gactccctcaatgtgacgctggcccatcccgtgctgtcgccgccgccaccggcgcgctga

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (2)   
   RefSeq(pep) (2)   
DNA sequence (2)   
   RefSeq(nuc) (2)   
Protein domain (10)   
   Pfam (10)   
All databases (16)   

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