KEGG   Mirounga leonina (Southern elephant seal): 118016863
Entry
118016863         CDS       T07472                                 
Symbol
PIK3R1
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
mlx  Mirounga leonina (Southern elephant seal)
Pathway
mlx01521  EGFR tyrosine kinase inhibitor resistance
mlx01522  Endocrine resistance
mlx01524  Platinum drug resistance
mlx04012  ErbB signaling pathway
mlx04014  Ras signaling pathway
mlx04015  Rap1 signaling pathway
mlx04024  cAMP signaling pathway
mlx04062  Chemokine signaling pathway
mlx04066  HIF-1 signaling pathway
mlx04068  FoxO signaling pathway
mlx04070  Phosphatidylinositol signaling system
mlx04071  Sphingolipid signaling pathway
mlx04072  Phospholipase D signaling pathway
mlx04081  Hormone signaling
mlx04140  Autophagy - animal
mlx04145  Phagocytosis
mlx04150  mTOR signaling pathway
mlx04151  PI3K-Akt signaling pathway
mlx04152  AMPK signaling pathway
mlx04210  Apoptosis
mlx04211  Longevity regulating pathway
mlx04213  Longevity regulating pathway - multiple species
mlx04218  Cellular senescence
mlx04360  Axon guidance
mlx04370  VEGF signaling pathway
mlx04380  Osteoclast differentiation
mlx04510  Focal adhesion
mlx04517  IgSF CAM signaling
mlx04518  Integrin signaling
mlx04550  Signaling pathways regulating pluripotency of stem cells
mlx04611  Platelet activation
mlx04613  Neutrophil extracellular trap formation
mlx04620  Toll-like receptor signaling pathway
mlx04625  C-type lectin receptor signaling pathway
mlx04630  JAK-STAT signaling pathway
mlx04650  Natural killer cell mediated cytotoxicity
mlx04660  T cell receptor signaling pathway
mlx04662  B cell receptor signaling pathway
mlx04664  Fc epsilon RI signaling pathway
mlx04666  Fc gamma R-mediated phagosome formation
mlx04668  TNF signaling pathway
mlx04670  Leukocyte transendothelial migration
mlx04722  Neurotrophin signaling pathway
mlx04725  Cholinergic synapse
mlx04750  Inflammatory mediator regulation of TRP channels
mlx04810  Regulation of actin cytoskeleton
mlx04910  Insulin signaling pathway
mlx04914  Progesterone-mediated oocyte maturation
mlx04915  Estrogen signaling pathway
mlx04917  Prolactin signaling pathway
mlx04919  Thyroid hormone signaling pathway
mlx04923  Regulation of lipolysis in adipocytes
mlx04926  Relaxin signaling pathway
mlx04929  GnRH secretion
mlx04930  Type II diabetes mellitus
mlx04931  Insulin resistance
mlx04932  Non-alcoholic fatty liver disease
mlx04933  AGE-RAGE signaling pathway in diabetic complications
mlx04935  Growth hormone synthesis, secretion and action
mlx04960  Aldosterone-regulated sodium reabsorption
mlx04973  Carbohydrate digestion and absorption
mlx05010  Alzheimer disease
mlx05017  Spinocerebellar ataxia
mlx05020  Prion disease
mlx05100  Bacterial invasion of epithelial cells
mlx05135  Yersinia infection
mlx05142  Chagas disease
mlx05146  Amoebiasis
mlx05160  Hepatitis C
mlx05161  Hepatitis B
mlx05162  Measles
mlx05163  Human cytomegalovirus infection
mlx05164  Influenza A
mlx05165  Human papillomavirus infection
mlx05166  Human T-cell leukemia virus 1 infection
mlx05167  Kaposi sarcoma-associated herpesvirus infection
mlx05168  Herpes simplex virus 1 infection
mlx05169  Epstein-Barr virus infection
mlx05170  Human immunodeficiency virus 1 infection
mlx05171  Coronavirus disease
mlx05200  Pathways in cancer
mlx05203  Viral carcinogenesis
mlx05205  Proteoglycans in cancer
mlx05206  MicroRNAs in cancer
mlx05207  Chemical carcinogenesis - receptor activation
mlx05208  Chemical carcinogenesis - reactive oxygen species
mlx05210  Colorectal cancer
mlx05211  Renal cell carcinoma
mlx05212  Pancreatic cancer
mlx05213  Endometrial cancer
mlx05214  Glioma
mlx05215  Prostate cancer
mlx05218  Melanoma
mlx05220  Chronic myeloid leukemia
mlx05221  Acute myeloid leukemia
mlx05222  Small cell lung cancer
mlx05223  Non-small cell lung cancer
mlx05224  Breast cancer
mlx05225  Hepatocellular carcinoma
mlx05226  Gastric cancer
mlx05230  Central carbon metabolism in cancer
mlx05231  Choline metabolism in cancer
mlx05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mlx05415  Diabetic cardiomyopathy
mlx05417  Lipid and atherosclerosis
mlx05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mlx00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    118016863 (PIK3R1)
   04014 Ras signaling pathway
    118016863 (PIK3R1)
   04015 Rap1 signaling pathway
    118016863 (PIK3R1)
   04370 VEGF signaling pathway
    118016863 (PIK3R1)
   04630 JAK-STAT signaling pathway
    118016863 (PIK3R1)
   04668 TNF signaling pathway
    118016863 (PIK3R1)
   04066 HIF-1 signaling pathway
    118016863 (PIK3R1)
   04068 FoxO signaling pathway
    118016863 (PIK3R1)
   04070 Phosphatidylinositol signaling system
    118016863 (PIK3R1)
   04072 Phospholipase D signaling pathway
    118016863 (PIK3R1)
   04071 Sphingolipid signaling pathway
    118016863 (PIK3R1)
   04024 cAMP signaling pathway
    118016863 (PIK3R1)
   04151 PI3K-Akt signaling pathway
    118016863 (PIK3R1)
   04152 AMPK signaling pathway
    118016863 (PIK3R1)
   04150 mTOR signaling pathway
    118016863 (PIK3R1)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    118016863 (PIK3R1)
   04517 IgSF CAM signaling
    118016863 (PIK3R1)
   04518 Integrin signaling
    118016863 (PIK3R1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    118016863 (PIK3R1)
   04140 Autophagy - animal
    118016863 (PIK3R1)
  09143 Cell growth and death
   04210 Apoptosis
    118016863 (PIK3R1)
   04218 Cellular senescence
    118016863 (PIK3R1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    118016863 (PIK3R1)
   04550 Signaling pathways regulating pluripotency of stem cells
    118016863 (PIK3R1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    118016863 (PIK3R1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    118016863 (PIK3R1)
   04613 Neutrophil extracellular trap formation
    118016863 (PIK3R1)
   04620 Toll-like receptor signaling pathway
    118016863 (PIK3R1)
   04625 C-type lectin receptor signaling pathway
    118016863 (PIK3R1)
   04650 Natural killer cell mediated cytotoxicity
    118016863 (PIK3R1)
   04660 T cell receptor signaling pathway
    118016863 (PIK3R1)
   04662 B cell receptor signaling pathway
    118016863 (PIK3R1)
   04664 Fc epsilon RI signaling pathway
    118016863 (PIK3R1)
   04666 Fc gamma R-mediated phagosome formation
    118016863 (PIK3R1)
   04670 Leukocyte transendothelial migration
    118016863 (PIK3R1)
   04062 Chemokine signaling pathway
    118016863 (PIK3R1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    118016863 (PIK3R1)
   04923 Regulation of lipolysis in adipocytes
    118016863 (PIK3R1)
   04929 GnRH secretion
    118016863 (PIK3R1)
   04915 Estrogen signaling pathway
    118016863 (PIK3R1)
   04914 Progesterone-mediated oocyte maturation
    118016863 (PIK3R1)
   04917 Prolactin signaling pathway
    118016863 (PIK3R1)
   04926 Relaxin signaling pathway
    118016863 (PIK3R1)
   04935 Growth hormone synthesis, secretion and action
    118016863 (PIK3R1)
   04919 Thyroid hormone signaling pathway
    118016863 (PIK3R1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    118016863 (PIK3R1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    118016863 (PIK3R1)
  09156 Nervous system
   04725 Cholinergic synapse
    118016863 (PIK3R1)
   04722 Neurotrophin signaling pathway
    118016863 (PIK3R1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    118016863 (PIK3R1)
  09158 Development and regeneration
   04360 Axon guidance
    118016863 (PIK3R1)
   04380 Osteoclast differentiation
    118016863 (PIK3R1)
  09149 Aging
   04211 Longevity regulating pathway
    118016863 (PIK3R1)
   04213 Longevity regulating pathway - multiple species
    118016863 (PIK3R1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    118016863 (PIK3R1)
   05206 MicroRNAs in cancer
    118016863 (PIK3R1)
   05205 Proteoglycans in cancer
    118016863 (PIK3R1)
   05207 Chemical carcinogenesis - receptor activation
    118016863 (PIK3R1)
   05208 Chemical carcinogenesis - reactive oxygen species
    118016863 (PIK3R1)
   05203 Viral carcinogenesis
    118016863 (PIK3R1)
   05230 Central carbon metabolism in cancer
    118016863 (PIK3R1)
   05231 Choline metabolism in cancer
    118016863 (PIK3R1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    118016863 (PIK3R1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    118016863 (PIK3R1)
   05212 Pancreatic cancer
    118016863 (PIK3R1)
   05225 Hepatocellular carcinoma
    118016863 (PIK3R1)
   05226 Gastric cancer
    118016863 (PIK3R1)
   05214 Glioma
    118016863 (PIK3R1)
   05221 Acute myeloid leukemia
    118016863 (PIK3R1)
   05220 Chronic myeloid leukemia
    118016863 (PIK3R1)
   05218 Melanoma
    118016863 (PIK3R1)
   05211 Renal cell carcinoma
    118016863 (PIK3R1)
   05215 Prostate cancer
    118016863 (PIK3R1)
   05213 Endometrial cancer
    118016863 (PIK3R1)
   05224 Breast cancer
    118016863 (PIK3R1)
   05222 Small cell lung cancer
    118016863 (PIK3R1)
   05223 Non-small cell lung cancer
    118016863 (PIK3R1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    118016863 (PIK3R1)
   05170 Human immunodeficiency virus 1 infection
    118016863 (PIK3R1)
   05161 Hepatitis B
    118016863 (PIK3R1)
   05160 Hepatitis C
    118016863 (PIK3R1)
   05171 Coronavirus disease
    118016863 (PIK3R1)
   05164 Influenza A
    118016863 (PIK3R1)
   05162 Measles
    118016863 (PIK3R1)
   05168 Herpes simplex virus 1 infection
    118016863 (PIK3R1)
   05163 Human cytomegalovirus infection
    118016863 (PIK3R1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    118016863 (PIK3R1)
   05169 Epstein-Barr virus infection
    118016863 (PIK3R1)
   05165 Human papillomavirus infection
    118016863 (PIK3R1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    118016863 (PIK3R1)
   05100 Bacterial invasion of epithelial cells
    118016863 (PIK3R1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    118016863 (PIK3R1)
   05142 Chagas disease
    118016863 (PIK3R1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    118016863 (PIK3R1)
   05017 Spinocerebellar ataxia
    118016863 (PIK3R1)
   05020 Prion disease
    118016863 (PIK3R1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    118016863 (PIK3R1)
   05418 Fluid shear stress and atherosclerosis
    118016863 (PIK3R1)
   05415 Diabetic cardiomyopathy
    118016863 (PIK3R1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    118016863 (PIK3R1)
   04932 Non-alcoholic fatty liver disease
    118016863 (PIK3R1)
   04931 Insulin resistance
    118016863 (PIK3R1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    118016863 (PIK3R1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    118016863 (PIK3R1)
   01524 Platinum drug resistance
    118016863 (PIK3R1)
   01522 Endocrine resistance
    118016863 (PIK3R1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mlx04131]
    118016863 (PIK3R1)
Membrane trafficking [BR:mlx04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    118016863 (PIK3R1)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH2_1 SH3_1 AAA_13 CEP135_TSGA10_CC SH3_9 SH3_2 CCDC113_CCDC96_CC ODF2_C Laminin_I ACDC Exonuc_VII_L
Other DBs
NCBI-GeneID: 118016863
NCBI-ProteinID: XP_034870456
Position
Unknown
AA seq 725 aa
MSAEGYQYRALYDYKKERDEDIDLHLGDVLTVNKGSLVALGFSDGQEARPEEIGWLNGYN
ETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKAEADSEQQQALALPDLA
EQFAPPDIAPPLLVKLVEAIEKKGLECSTLYRTQSSSNPAELRQLLDCDAASMDLEMIDV
QVLGDAFKRYLVDLPNPVIPVAVYNEMIYLAQEVQSPEEYIQLLKKLIRAPNIPHQYWLT
LQYLLKHFFKLSQTSSKNLLSARVLSELFSPLLFRFPAASSENTEHLIKVIEILISTEWN
ERQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRD
ASTKMHGDYTLTLRKGGNNKLIKIFHQDGKYGFSDPLTFNSVVELINHYRNESLAQYNPK
LDVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEDYTRTSQEIQM
KRTAIEAFNETIKIFEEQCQSQERYSKEYIEKFKREGNEKEIQRIMHNYEKLKSRISEIV
DSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLG
NENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYAC
SVVVDGEVKHCVINKTATGYGFAEPYNLYGSLKELVLHYQHTSLVQHNDSLNVTLAYPVY
AQQRR
NT seq 2178 nt   +upstreamnt  +downstreamnt
atgagtgccgagggctatcagtaccgagcgctgtatgattacaagaaggaacgagacgaa
gatattgacttgcacttgggtgatgttttgactgtgaataaagggtccttagtagctctt
ggattcagtgacggacaggaagccaggcctgaagaaatcggctggttaaatggttataat
gaaaccacaggggaaagaggggactttccaggaacttatgttgaatatattggaaggaaa
aaaatctcgcctcccacaccaaagccccgaccacctcgaccccttcctgttgcaccaggt
tcttcgaaagctgaagcagacagtgagcaacagcaagctttggcccttccagatctcgcc
gagcagtttgcccctcctgacattgccccgcctcttctcgtgaagctagtggaagccatt
gaaaagaaaggtctggaatgttcaactctatacagaacacagagctccagcaacccagca
gaattacgacagcttcttgattgtgatgccgcctccatggacttggaaatgatcgatgtg
caagttttaggagacgcttttaaacgctatcttgtggacttaccgaatcctgtcattcca
gtagccgtttacaatgaaatgatttatttagcccaagaagtacagagccctgaagaatat
atccagctgttgaagaagctcattagggcacctaacatacctcatcagtattggcttacg
cttcagtatttgctaaaacatttcttcaagctctctcaaacctccagcaagaatcttctg
agtgcaagagtactctctgaacttttcagccctctgcttttcagattcccggcagccagc
tctgagaatactgaacacctcataaaagttatagaaattttaatctcaactgagtggaat
gaacgacagcctgcaccagcattgcctcctaaaccaccaaaacccactactgtagccaac
aacggtatgaataacaatatgtccttacaagatgctgaatggtactggggagatatctca
agggaagaagtgaatgaaaaacttcgagatacagctgacgggacctttttggtacgagac
gcatctactaaaatgcatggtgattatactcttacactaaggaaaggaggaaataacaaa
ttaatcaaaatatttcaccaagatgggaaatacggcttctctgacccactgaccttcaac
tctgtggttgaactaataaaccactaccggaatgagtctctagctcagtataatcccaaa
ctggatgtaaagttactttatccagtatccaaataccaacaggatcaagttgtcaaagaa
gataatattgaagctgtaggaaaaaagttacatgaatataacactcaatttcaagaaaaa
agtcgggaatatgatagattatatgaagattatacccgtacttcccaggaaatccaaatg
aaaagaacagctattgaagcctttaatgaaaccataaaaatatttgaagaacagtgccaa
agtcaggaacggtacagcaaagaatacatagaaaaatttaaacgtgaaggcaatgagaaa
gaaatacaaaggattatgcataattatgagaagttaaagtcccgaatcagtgaaattgtg
gacagtcgaagaagactggaggaagacttgaagaagcaggcagctgagtaccgggagatt
gacaaacgcatgaacagcattaaaccagacctcattcagctgagaaagacaagagaccaa
tacttgatgtggttgactcagaaaggtgttcggcagaagaagctgaatgagtggttgggc
aatgaaaatacggaagaccaatattcgctggtggaagatgatgaggatttgccgcaccac
gacgagaagacctggaatgtgggcagcagcaacagaaacaaagctgagaacctcctccga
gggaaacgagacggcaccttcctggtccgggagagcagcaaacagggctgctacgcctgc
tccgtagtggtggacggcgaagtcaagcactgtgtcatcaacaaaacggccaccggctac
ggcttcgccgagccctataacctgtacggctctctgaaagaactggtgcttcattaccag
cacacgtccctcgtgcagcacaatgactcgctcaacgtcacactggcctacccagtatac
gcacagcagagacgatga

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (4)   
   RefSeq(pep) (4)   
DNA sequence (4)   
   RefSeq(nuc) (4)   
Protein domain (14)   
   Pfam (14)   
All databases (24)   

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