KEGG   Martes martes (European pine marten): 308343853
Entry
308343853         CDS       T12008                                 
Symbol
PIK3R1
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
mmaq  Martes martes (European pine marten)
Pathway
mmaq01521  EGFR tyrosine kinase inhibitor resistance
mmaq01522  Endocrine resistance
mmaq01524  Platinum drug resistance
mmaq04012  ErbB signaling pathway
mmaq04014  Ras signaling pathway
mmaq04015  Rap1 signaling pathway
mmaq04024  cAMP signaling pathway
mmaq04062  Chemokine signaling pathway
mmaq04066  HIF-1 signaling pathway
mmaq04068  FoxO signaling pathway
mmaq04070  Phosphatidylinositol signaling system
mmaq04071  Sphingolipid signaling pathway
mmaq04072  Phospholipase D signaling pathway
mmaq04081  Hormone signaling
mmaq04140  Autophagy - animal
mmaq04145  Phagocytosis
mmaq04150  mTOR signaling pathway
mmaq04151  PI3K-Akt signaling pathway
mmaq04152  AMPK signaling pathway
mmaq04210  Apoptosis
mmaq04211  Longevity regulating pathway
mmaq04213  Longevity regulating pathway - multiple species
mmaq04218  Cellular senescence
mmaq04360  Axon guidance
mmaq04370  VEGF signaling pathway
mmaq04380  Osteoclast differentiation
mmaq04510  Focal adhesion
mmaq04517  IgSF CAM signaling
mmaq04518  Integrin signaling
mmaq04550  Signaling pathways regulating pluripotency of stem cells
mmaq04611  Platelet activation
mmaq04613  Neutrophil extracellular trap formation
mmaq04620  Toll-like receptor signaling pathway
mmaq04625  C-type lectin receptor signaling pathway
mmaq04630  JAK-STAT signaling pathway
mmaq04650  Natural killer cell mediated cytotoxicity
mmaq04660  T cell receptor signaling pathway
mmaq04662  B cell receptor signaling pathway
mmaq04664  Fc epsilon RI signaling pathway
mmaq04666  Fc gamma R-mediated phagosome formation
mmaq04668  TNF signaling pathway
mmaq04670  Leukocyte transendothelial migration
mmaq04722  Neurotrophin signaling pathway
mmaq04725  Cholinergic synapse
mmaq04750  Inflammatory mediator regulation of TRP channels
mmaq04810  Regulation of actin cytoskeleton
mmaq04910  Insulin signaling pathway
mmaq04914  Progesterone-mediated oocyte maturation
mmaq04915  Estrogen signaling pathway
mmaq04917  Prolactin signaling pathway
mmaq04919  Thyroid hormone signaling pathway
mmaq04923  Regulation of lipolysis in adipocytes
mmaq04926  Relaxin signaling pathway
mmaq04929  GnRH secretion
mmaq04930  Type II diabetes mellitus
mmaq04931  Insulin resistance
mmaq04932  Non-alcoholic fatty liver disease
mmaq04933  AGE-RAGE signaling pathway in diabetic complications
mmaq04935  Growth hormone synthesis, secretion and action
mmaq04960  Aldosterone-regulated sodium reabsorption
mmaq04973  Carbohydrate digestion and absorption
mmaq05010  Alzheimer disease
mmaq05017  Spinocerebellar ataxia
mmaq05020  Prion disease
mmaq05100  Bacterial invasion of epithelial cells
mmaq05135  Yersinia infection
mmaq05142  Chagas disease
mmaq05146  Amoebiasis
mmaq05160  Hepatitis C
mmaq05161  Hepatitis B
mmaq05162  Measles
mmaq05163  Human cytomegalovirus infection
mmaq05164  Influenza A
mmaq05165  Human papillomavirus infection
mmaq05166  Human T-cell leukemia virus 1 infection
mmaq05167  Kaposi sarcoma-associated herpesvirus infection
mmaq05168  Herpes simplex virus 1 infection
mmaq05169  Epstein-Barr virus infection
mmaq05170  Human immunodeficiency virus 1 infection
mmaq05171  Coronavirus disease
mmaq05200  Pathways in cancer
mmaq05203  Viral carcinogenesis
mmaq05205  Proteoglycans in cancer
mmaq05206  MicroRNAs in cancer
mmaq05207  Chemical carcinogenesis - receptor activation
mmaq05208  Chemical carcinogenesis - reactive oxygen species
mmaq05210  Colorectal cancer
mmaq05211  Renal cell carcinoma
mmaq05212  Pancreatic cancer
mmaq05213  Endometrial cancer
mmaq05214  Glioma
mmaq05215  Prostate cancer
mmaq05218  Melanoma
mmaq05220  Chronic myeloid leukemia
mmaq05221  Acute myeloid leukemia
mmaq05222  Small cell lung cancer
mmaq05223  Non-small cell lung cancer
mmaq05224  Breast cancer
mmaq05225  Hepatocellular carcinoma
mmaq05226  Gastric cancer
mmaq05230  Central carbon metabolism in cancer
mmaq05231  Choline metabolism in cancer
mmaq05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mmaq05415  Diabetic cardiomyopathy
mmaq05417  Lipid and atherosclerosis
mmaq05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mmaq00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    308343853 (PIK3R1)
   04014 Ras signaling pathway
    308343853 (PIK3R1)
   04015 Rap1 signaling pathway
    308343853 (PIK3R1)
   04370 VEGF signaling pathway
    308343853 (PIK3R1)
   04630 JAK-STAT signaling pathway
    308343853 (PIK3R1)
   04668 TNF signaling pathway
    308343853 (PIK3R1)
   04066 HIF-1 signaling pathway
    308343853 (PIK3R1)
   04068 FoxO signaling pathway
    308343853 (PIK3R1)
   04070 Phosphatidylinositol signaling system
    308343853 (PIK3R1)
   04072 Phospholipase D signaling pathway
    308343853 (PIK3R1)
   04071 Sphingolipid signaling pathway
    308343853 (PIK3R1)
   04024 cAMP signaling pathway
    308343853 (PIK3R1)
   04151 PI3K-Akt signaling pathway
    308343853 (PIK3R1)
   04152 AMPK signaling pathway
    308343853 (PIK3R1)
   04150 mTOR signaling pathway
    308343853 (PIK3R1)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    308343853 (PIK3R1)
   04517 IgSF CAM signaling
    308343853 (PIK3R1)
   04518 Integrin signaling
    308343853 (PIK3R1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    308343853 (PIK3R1)
   04140 Autophagy - animal
    308343853 (PIK3R1)
  09143 Cell growth and death
   04210 Apoptosis
    308343853 (PIK3R1)
   04218 Cellular senescence
    308343853 (PIK3R1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    308343853 (PIK3R1)
   04550 Signaling pathways regulating pluripotency of stem cells
    308343853 (PIK3R1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    308343853 (PIK3R1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    308343853 (PIK3R1)
   04613 Neutrophil extracellular trap formation
    308343853 (PIK3R1)
   04620 Toll-like receptor signaling pathway
    308343853 (PIK3R1)
   04625 C-type lectin receptor signaling pathway
    308343853 (PIK3R1)
   04650 Natural killer cell mediated cytotoxicity
    308343853 (PIK3R1)
   04660 T cell receptor signaling pathway
    308343853 (PIK3R1)
   04662 B cell receptor signaling pathway
    308343853 (PIK3R1)
   04664 Fc epsilon RI signaling pathway
    308343853 (PIK3R1)
   04666 Fc gamma R-mediated phagosome formation
    308343853 (PIK3R1)
   04670 Leukocyte transendothelial migration
    308343853 (PIK3R1)
   04062 Chemokine signaling pathway
    308343853 (PIK3R1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    308343853 (PIK3R1)
   04923 Regulation of lipolysis in adipocytes
    308343853 (PIK3R1)
   04929 GnRH secretion
    308343853 (PIK3R1)
   04915 Estrogen signaling pathway
    308343853 (PIK3R1)
   04914 Progesterone-mediated oocyte maturation
    308343853 (PIK3R1)
   04917 Prolactin signaling pathway
    308343853 (PIK3R1)
   04926 Relaxin signaling pathway
    308343853 (PIK3R1)
   04935 Growth hormone synthesis, secretion and action
    308343853 (PIK3R1)
   04919 Thyroid hormone signaling pathway
    308343853 (PIK3R1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    308343853 (PIK3R1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    308343853 (PIK3R1)
  09156 Nervous system
   04725 Cholinergic synapse
    308343853 (PIK3R1)
   04722 Neurotrophin signaling pathway
    308343853 (PIK3R1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    308343853 (PIK3R1)
  09158 Development and regeneration
   04360 Axon guidance
    308343853 (PIK3R1)
   04380 Osteoclast differentiation
    308343853 (PIK3R1)
  09149 Aging
   04211 Longevity regulating pathway
    308343853 (PIK3R1)
   04213 Longevity regulating pathway - multiple species
    308343853 (PIK3R1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    308343853 (PIK3R1)
   05206 MicroRNAs in cancer
    308343853 (PIK3R1)
   05205 Proteoglycans in cancer
    308343853 (PIK3R1)
   05207 Chemical carcinogenesis - receptor activation
    308343853 (PIK3R1)
   05208 Chemical carcinogenesis - reactive oxygen species
    308343853 (PIK3R1)
   05203 Viral carcinogenesis
    308343853 (PIK3R1)
   05230 Central carbon metabolism in cancer
    308343853 (PIK3R1)
   05231 Choline metabolism in cancer
    308343853 (PIK3R1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    308343853 (PIK3R1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    308343853 (PIK3R1)
   05212 Pancreatic cancer
    308343853 (PIK3R1)
   05225 Hepatocellular carcinoma
    308343853 (PIK3R1)
   05226 Gastric cancer
    308343853 (PIK3R1)
   05214 Glioma
    308343853 (PIK3R1)
   05221 Acute myeloid leukemia
    308343853 (PIK3R1)
   05220 Chronic myeloid leukemia
    308343853 (PIK3R1)
   05218 Melanoma
    308343853 (PIK3R1)
   05211 Renal cell carcinoma
    308343853 (PIK3R1)
   05215 Prostate cancer
    308343853 (PIK3R1)
   05213 Endometrial cancer
    308343853 (PIK3R1)
   05224 Breast cancer
    308343853 (PIK3R1)
   05222 Small cell lung cancer
    308343853 (PIK3R1)
   05223 Non-small cell lung cancer
    308343853 (PIK3R1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    308343853 (PIK3R1)
   05170 Human immunodeficiency virus 1 infection
    308343853 (PIK3R1)
   05161 Hepatitis B
    308343853 (PIK3R1)
   05160 Hepatitis C
    308343853 (PIK3R1)
   05171 Coronavirus disease
    308343853 (PIK3R1)
   05164 Influenza A
    308343853 (PIK3R1)
   05162 Measles
    308343853 (PIK3R1)
   05168 Herpes simplex virus 1 infection
    308343853 (PIK3R1)
   05163 Human cytomegalovirus infection
    308343853 (PIK3R1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    308343853 (PIK3R1)
   05169 Epstein-Barr virus infection
    308343853 (PIK3R1)
   05165 Human papillomavirus infection
    308343853 (PIK3R1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    308343853 (PIK3R1)
   05100 Bacterial invasion of epithelial cells
    308343853 (PIK3R1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    308343853 (PIK3R1)
   05142 Chagas disease
    308343853 (PIK3R1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    308343853 (PIK3R1)
   05017 Spinocerebellar ataxia
    308343853 (PIK3R1)
   05020 Prion disease
    308343853 (PIK3R1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    308343853 (PIK3R1)
   05418 Fluid shear stress and atherosclerosis
    308343853 (PIK3R1)
   05415 Diabetic cardiomyopathy
    308343853 (PIK3R1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    308343853 (PIK3R1)
   04932 Non-alcoholic fatty liver disease
    308343853 (PIK3R1)
   04931 Insulin resistance
    308343853 (PIK3R1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    308343853 (PIK3R1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    308343853 (PIK3R1)
   01524 Platinum drug resistance
    308343853 (PIK3R1)
   01522 Endocrine resistance
    308343853 (PIK3R1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mmaq04131]
    308343853 (PIK3R1)
Membrane trafficking [BR:mmaq04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    308343853 (PIK3R1)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH2_1 SH3_1 AAA_13 CEP135_TSGA10_CC SH3_9 SH3_2 CCDC113_CCDC96_CC ODF2_C Laminin_I Exonuc_VII_L
Other DBs
NCBI-GeneID: 308343853
NCBI-ProteinID: XP_080661174
Position
5:complement(70167398..>70251637)
AA seq 725 aa
MSAEGYQYRALYDYKKERDEDIDLHLGDVLTVNKGSLVALGFSDGQEARPEEIGWLNGYN
ETTGERGDFPGTYVEYIGRKRISPPTPKPRPPRPLPVAPGSSKAEADSEQQQALALPDLA
EQFAPPDIAPPLLVKLLEAIEKKGLECSTLYRTQSSSNPAELRQLLDCDAASMDLEMIDV
QVLGDAFKRYLLDLPNPVIPVAVYNEMIYLAQEVQSSEDYIQLLKKLIRAPNIPHQYWLT
LQYLLKHFFKLCQTSSKNLLSARVLSELFSPLLFRFPAASSENTEHLIKVIEILISTEWN
ERQPAPALPPKPPKPTSVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRD
ASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPK
LDVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEDYTRTSQEIQM
KRTAIEAFNETIKIFEEQCQSQERYSKEYIEKFKREGNEKEIQRIMHNYEKLKSRISEIV
DSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLG
NENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYAC
SVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVY
AQQRR
NT seq 2178 nt   +upstreamnt  +downstreamnt
atgagtgccgagggctaccagtaccgagcactgtatgattacaaaaaggaacgagacgaa
gatattgacttgcacttgggtgatgtcttgactgtgaataaagggtccttagtagctctt
ggattcagtgacggacaggaagccaggcctgaagaaatcggctggttaaatggttataat
gaaaccacaggggaaagaggagactttccgggaacttatgttgaatatattggaaggaaa
agaatctcacctcccacaccaaagccccgaccacctcgaccccttcctgttgcaccaggt
tcttcgaaagctgaagcagatagtgaacaacagcaagctttggctcttccagatctcgct
gagcagtttgcccctcccgacattgctccgcctcttctcgtgaagctcctggaagccatt
gaaaagaaaggtctggaatgttcaactctatacagaacacagagctccagcaacccggcc
gaattgcgacagcttcttgattgtgatgccgcctccatggacttggaaatgattgatgtg
caagttttgggagacgctttcaaacgctatcttttggacttaccgaatcctgtcattcca
gtagccgtttacaatgaaatgatttatttagcccaagaagtacaaagctctgaggactac
atccagctgttgaagaagctcattagggcacctaacatacctcatcagtattggctgacg
cttcagtatttgctaaaacatttcttcaagctctgtcagacctccagcaagaatctcctg
agtgcgagagtactctctgaacttttcagccctctgcttttcagattcccagcagccagc
tctgagaatactgaacacctcattaaagttatagaaattttaatctcaactgagtggaat
gaacgacagcctgcaccagcattgcctcctaaaccaccaaaacccactagtgtagccaac
aacggtatgaataacaatatgtccttacaagatgctgagtggtactggggagatatctca
agggaagaagtgaatgaaaaacttcgagatacagctgatgggacctttttggtacgagac
gcatctactaaaatgcatggggattatactcttacactaaggaaaggaggaaataacaaa
ttaatcaaaatatttcaccgagatgggaaatatggcttctctgacccactgaccttcaac
tccgtggttgaactaataaaccactaccggaatgagtctctagctcagtataatcccaaa
ctggacgtgaaattactttatccagtgtccaaataccaacaggatcaagttgtcaaagaa
gataatattgaagctgtagggaaaaaattacatgaatataacactcaatttcaagaaaaa
agccgggaatatgatagattatatgaagattatacccgtacttcccaggaaatccaaatg
aaaagaacagccattgaagcatttaatgaaaccataaaaatatttgaagaacagtgccaa
agccaggaacggtacagcaaagaatacatagaaaaatttaaacgtgaaggcaatgagaaa
gaaatacaaaggattatgcataattatgagaagttaaagtcccgaatcagtgaaattgtg
gacagtagaaggagactggaggaagacctgaagaagcaggcagctgagtaccgggagatt
gacaaacgcatgaacagcattaaaccagacctcattcagctgagaaagacaagagaccaa
tacttgatgtggttgactcagaaaggtgttcggcagaagaagctgaatgagtggctgggc
aatgaaaatacggaagaccaatattcgctggtggaagatgatgaggatttgccgcaccat
gacgagaagacctggaatgtgggcagcagcaacaggaacaaagctgagaacctactccga
gggaaacgagacggcaccttcctggtccgggagagcagcaaacagggctgctatgcctgc
tctgtcgtggtggacggcgaggtcaagcattgtgtcatcaacaaaacggccaccggctat
ggcttcgccgaaccctataacttgtacagctccctgaaagaactggtgctacattaccaa
cacacatccctcgtgcagcacaatgactcgctcaacgtcacactagcctacccggtatat
gcacagcagaggcgatga

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (3)   
   RefSeq(pep) (3)   
DNA sequence (3)   
   RefSeq(nuc) (3)   
Protein domain (13)   
   Pfam (13)   
All databases (21)   

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