KEGG   Myotis myotis (greater mouse-eared bat): 118662889
Entry
118662889         CDS       T07220                                 
Symbol
PLCG1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1
  KO
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
mmyo  Myotis myotis (greater mouse-eared bat)
Pathway
mmyo00562  Inositol phosphate metabolism
mmyo01100  Metabolic pathways
mmyo01521  EGFR tyrosine kinase inhibitor resistance
mmyo04012  ErbB signaling pathway
mmyo04014  Ras signaling pathway
mmyo04015  Rap1 signaling pathway
mmyo04020  Calcium signaling pathway
mmyo04062  Chemokine signaling pathway
mmyo04064  NF-kappa B signaling pathway
mmyo04066  HIF-1 signaling pathway
mmyo04070  Phosphatidylinositol signaling system
mmyo04072  Phospholipase D signaling pathway
mmyo04360  Axon guidance
mmyo04370  VEGF signaling pathway
mmyo04613  Neutrophil extracellular trap formation
mmyo04650  Natural killer cell mediated cytotoxicity
mmyo04658  Th1 and Th2 cell differentiation
mmyo04659  Th17 cell differentiation
mmyo04660  T cell receptor signaling pathway
mmyo04664  Fc epsilon RI signaling pathway
mmyo04666  Fc gamma R-mediated phagocytosis
mmyo04670  Leukocyte transendothelial migration
mmyo04722  Neurotrophin signaling pathway
mmyo04750  Inflammatory mediator regulation of TRP channels
mmyo04919  Thyroid hormone signaling pathway
mmyo04933  AGE-RAGE signaling pathway in diabetic complications
mmyo04935  Growth hormone synthesis, secretion and action
mmyo05012  Parkinson disease
mmyo05022  Pathways of neurodegeneration - multiple diseases
mmyo05135  Yersinia infection
mmyo05167  Kaposi sarcoma-associated herpesvirus infection
mmyo05170  Human immunodeficiency virus 1 infection
mmyo05171  Coronavirus disease - COVID-19
mmyo05200  Pathways in cancer
mmyo05205  Proteoglycans in cancer
mmyo05206  MicroRNAs in cancer
mmyo05214  Glioma
mmyo05223  Non-small cell lung cancer
mmyo05225  Hepatocellular carcinoma
mmyo05231  Choline metabolism in cancer
mmyo05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mmyo05417  Lipid and atherosclerosis
Module
mmyo_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mmyo00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    118662889 (PLCG1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    118662889 (PLCG1)
   04014 Ras signaling pathway
    118662889 (PLCG1)
   04015 Rap1 signaling pathway
    118662889 (PLCG1)
   04370 VEGF signaling pathway
    118662889 (PLCG1)
   04064 NF-kappa B signaling pathway
    118662889 (PLCG1)
   04066 HIF-1 signaling pathway
    118662889 (PLCG1)
   04020 Calcium signaling pathway
    118662889 (PLCG1)
   04070 Phosphatidylinositol signaling system
    118662889 (PLCG1)
   04072 Phospholipase D signaling pathway
    118662889 (PLCG1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    118662889 (PLCG1)
   04650 Natural killer cell mediated cytotoxicity
    118662889 (PLCG1)
   04660 T cell receptor signaling pathway
    118662889 (PLCG1)
   04658 Th1 and Th2 cell differentiation
    118662889 (PLCG1)
   04659 Th17 cell differentiation
    118662889 (PLCG1)
   04664 Fc epsilon RI signaling pathway
    118662889 (PLCG1)
   04666 Fc gamma R-mediated phagocytosis
    118662889 (PLCG1)
   04670 Leukocyte transendothelial migration
    118662889 (PLCG1)
   04062 Chemokine signaling pathway
    118662889 (PLCG1)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    118662889 (PLCG1)
   04919 Thyroid hormone signaling pathway
    118662889 (PLCG1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    118662889 (PLCG1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    118662889 (PLCG1)
  09158 Development and regeneration
   04360 Axon guidance
    118662889 (PLCG1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    118662889 (PLCG1)
   05206 MicroRNAs in cancer
    118662889 (PLCG1)
   05205 Proteoglycans in cancer
    118662889 (PLCG1)
   05231 Choline metabolism in cancer
    118662889 (PLCG1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    118662889 (PLCG1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    118662889 (PLCG1)
   05214 Glioma
    118662889 (PLCG1)
   05223 Non-small cell lung cancer
    118662889 (PLCG1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    118662889 (PLCG1)
   05171 Coronavirus disease - COVID-19
    118662889 (PLCG1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    118662889 (PLCG1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    118662889 (PLCG1)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    118662889 (PLCG1)
   05022 Pathways of neurodegeneration - multiple diseases
    118662889 (PLCG1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    118662889 (PLCG1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    118662889 (PLCG1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    118662889 (PLCG1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mmyo04131]
    118662889 (PLCG1)
Enzymes [BR:mmyo01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     118662889 (PLCG1)
Membrane trafficking [BR:mmyo04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    118662889 (PLCG1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    118662889 (PLCG1)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 PH C2 SH3_1 EF-hand_PLCG1 SH3_9 SH3_2 PH_12 GDPD PH_9 EF-hand_6 EF-hand_7
Other DBs
NCBI-GeneID: 118662889
NCBI-ProteinID: XP_036177775
Position
Unknown
AA seq 1282 aa
MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRSLRERLTDLELRSSDITYGQFAQVYRSLMYSDQKTMDLPFLEACAPRA
GERPELCRMSLPEFQQFLLEYQAELWAVDRLQVQEFMLDFLRDPLREIEEPYFSLDEFVT
FLFSKENSVWNSQLDVVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQHFKKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPSSVM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASG
STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQRDDELTFTKSAIIQNVEKQDGGWWRGDYGGKKQLW
FPSNYVEEMVSPAVLEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRPFVFSIS
MASVAQWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGGHCGYVLQPSTMRDEAFDPFDKS
SLRGLEPRAICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDNNKQKTEFVVDNGLNPVW
PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDL
ELASLLVKVDIFPAKQENGDLSPFSGMSLRERGSDASGQLFHGRAREGSFEARYQQPFED
FRISQEHLPDNFDSRERRPYCQ
NT seq 3849 nt   +upstreamnt  +downstreamnt
atggcgggcgccgcgtccccctgcgccaacggctgcgggcccggcgcgccctccgacgcc
gaggtgctgcacctctgccgcagcctcgaggtgggcaccgtcatgactttgttctactcc
aagaagtcgcagcggcccgagcggaagaccttccaggtcaagctggagactcggcagatc
acgtggagccgcggcgccgacaagatcgagggggccattgacattcgagaaatcaaggag
atccgcccagggaagacttcacgggactttgatcgctatcaagaggaccctgctttccga
ccagaccagtcacattgctttgtcatcctgtatgggatggaattccgcctgaagaccctg
agtctgcaagctacatctgaggatgaagtgaacatgtggatcaagggcttgacttggctg
atggaggacacattgcaggcagccacacccctgcagattgagaggtggctgcggaagcag
ttctactcggtggatcggaatcgtgaggatcgtatatcagccaaggacctgaagaatatg
ctgtcccaggtcaactaccgggtccccaacatgcgctccctccgagagcgtctgacggac
ctggagctgcgcagcagcgatatcacctatgggcagtttgctcaggtgtaccgcagcctc
atgtacagcgaccagaagacgatggacctccccttcttggaagcctgcgccccaagggca
ggggagcggccagagctctgccgaatgtcccttccggagttccagcaattcctcctcgag
taccaggcggagctgtgggctgtcgaccgactccaggtgcaggagttcatgctcgacttc
ctccgagaccccttgagagagattgaggagccatacttctccctggatgagtttgtcacc
ttcctgttctctaaggagaacagtgtgtggaactcgcagctggatgtggtgtgcccggac
accatgaacaaccctctctcccactactggatctcctcctcgcacaacacgtacctgacc
ggggaccagttctccagcgagtcctccctggaagcctatgctcgctgcctgcgcatgggc
tgccgctgtattgagttggactgctgggacggcccagacgggatgccagtcatttaccat
ggacacacccttacgaccaagatcaagttctcagacgtcctgcacaccatcaaggagcat
gccttcgtggcctcagagtacccggtcatcctgtccatcgaggaccactgcagcattgct
cagcagaggaacatggcccagcacttcaagaaggtgctcggggacacactcctcaccaag
cccgtggacattgctgccgacgggctcccttcccccaaccagctcaagaggaagatcctt
atcaagcacaagaagctggctgagggcagtgcctatgaggaggtgccttcgtctgtgatg
tactctgagaacgacatcagcaactccatcaagaatggcatcctctacctggaagaccct
gtgaaccatgagtggtatccccactactttgttctgaccagcagcaagatctactactct
gaggagaccagcagtgaccagggcaatgaggatgaggaagagcccaaggaggccagtggc
agcaccgagctgcactccaatgagaagtggttccatgggaagcttggggcaggacgggac
gggaggcacattgccgagcgcctgctgactgagtactgcattgagaccggggcccctgat
ggctccttcctagtgcgcgagagcgagaccttcgttggcgactacaccctctctttctgg
cggaacgggaaggtccaacactgccggatccactcccggcaggatgctgggacccccaag
ttcttcttgacagacaaccttgtatttgactcactctatgacctcatcacgcactaccag
caggtgcccctgcgctgcaatgaatttgagatgcgcctctcggagcctgtcccccagacc
aatgcccacgaaagcaaagaatggtaccacgcgagcctgaccagagcgcaggctgagcac
atgctgatgcgcgtcccccgtgacggggccttcctggtgcggaaacggaatgagcccaac
tcctacgccatctccttccgggctgaaggcaagatcaagcattgccgtgtccagcaggag
ggccagacagtgatgctgggcaactcggagtttgacagccttgtcgacctcatcagttac
tacgagaagcatccactgtatcgaaagatgaagctgcgctatcccatcaatgaggaggca
ctggagaagataggcacagctgagcctgactatggggccttgtatgagggacgcaaccct
ggcttttatgtggaggcaaaccctatgccgacttttaagtgtgcagtcaaagccctcttt
gactacaaggcccagagagacgacgagctgactttcaccaagagcgccatcatccagaat
gtggagaagcaggacggaggctggtggcggggagactatggtgggaagaagcaactctgg
ttcccgtcaaactacgtggaggagatggtcagcccagcagtcctggagcctgagagggag
cacttggacgagaacagccccctgggggacttgctgcggggagtcttggatgttccagct
tgtcagattgccatccgtcctgagggcaagaacaatcggccattcgtcttctccatcagt
atggcatcggtggcgcagtggtccctggatgttgctgccgactcacaggaggagctgcag
gactgggtgaaaaagatccgtgaagtggcccagaccgcagatgccaggctcactgagggg
aagatgatggagcggaggaagaagatcgcccttgaactgtccgagcttgtcgtctactgc
cgacctgttcccttcgatgaagagaagattggcacagaacgtgcctgctaccgggacatg
tcgtccttcccggaaaccaaggcggagaagtatgtgaacaaggccaaaggcaagaagttc
ctgcagtacaaccggctgcagctctcccgcatctaccccaaaggccagcggctagactcc
tccaattatgaccccttgcccatgtggatctgtggcagtcagctggtggccctcaacttc
cagaccccagacaagcccatgcagatgaaccaggccctcttcatgaccggcgggcactgc
ggctacgtgctgcagcccagcaccatgcgggacgaggccttcgacccctttgacaagagc
agcctccgagggctggagccacgcgccatctgcatcgaggtgctgggcgcccggcatcta
ccaaagaatggccgaggcattgtgtgtccctttgtggagattgaggttgctggagctgag
tatgacaacaacaagcagaagacagagtttgtggtggacaatggcctcaaccccgtgtgg
ccggccaagcccttccacttccaaatcagtaaccctgaattcgctttcctgcgctttgtg
gtgtatgaggaagacatgtttagtgaccagaacttcctggctcaggctactttcccggtg
aaaggcctgaagacaggatacagagcagtgcctttgaagaacaactacagtgaggacctg
gagttggcttccctgctggtcaaggtcgacattttccctgccaagcaggagaacggtgac
ctcagtcccttcagtggcatgtccctgcgggagcggggctctgatgcctcgggccagctg
ttccatggccgggcccgcgaaggctcctttgaagcgcgctaccagcagccatttgaagac
tttcgcatctcccaggagcatctcccagacaattttgacagccgggagagaaggccctac
tgccagtaa

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (5)   
   RefSeq(pep) (5)   
DNA sequence (5)   
   RefSeq(nuc) (5)   
Protein domain (15)   
   Pfam (15)   
All databases (27)   

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