KEGG   Macaca nemestrina (pig-tailed macaque): 105475205
Entry
105475205         CDS       T08765                                 
Symbol
PIK3R1
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
mni  Macaca nemestrina (pig-tailed macaque)
Pathway
mni01521  EGFR tyrosine kinase inhibitor resistance
mni01522  Endocrine resistance
mni01524  Platinum drug resistance
mni04012  ErbB signaling pathway
mni04014  Ras signaling pathway
mni04015  Rap1 signaling pathway
mni04024  cAMP signaling pathway
mni04062  Chemokine signaling pathway
mni04066  HIF-1 signaling pathway
mni04068  FoxO signaling pathway
mni04070  Phosphatidylinositol signaling system
mni04071  Sphingolipid signaling pathway
mni04072  Phospholipase D signaling pathway
mni04081  Hormone signaling
mni04140  Autophagy - animal
mni04145  Phagocytosis
mni04150  mTOR signaling pathway
mni04151  PI3K-Akt signaling pathway
mni04152  AMPK signaling pathway
mni04210  Apoptosis
mni04211  Longevity regulating pathway
mni04213  Longevity regulating pathway - multiple species
mni04218  Cellular senescence
mni04360  Axon guidance
mni04370  VEGF signaling pathway
mni04380  Osteoclast differentiation
mni04510  Focal adhesion
mni04517  IgSF CAM signaling
mni04518  Integrin signaling
mni04550  Signaling pathways regulating pluripotency of stem cells
mni04611  Platelet activation
mni04613  Neutrophil extracellular trap formation
mni04620  Toll-like receptor signaling pathway
mni04625  C-type lectin receptor signaling pathway
mni04630  JAK-STAT signaling pathway
mni04650  Natural killer cell mediated cytotoxicity
mni04660  T cell receptor signaling pathway
mni04662  B cell receptor signaling pathway
mni04664  Fc epsilon RI signaling pathway
mni04666  Fc gamma R-mediated phagosome formation
mni04668  TNF signaling pathway
mni04670  Leukocyte transendothelial migration
mni04722  Neurotrophin signaling pathway
mni04725  Cholinergic synapse
mni04750  Inflammatory mediator regulation of TRP channels
mni04810  Regulation of actin cytoskeleton
mni04910  Insulin signaling pathway
mni04914  Progesterone-mediated oocyte maturation
mni04915  Estrogen signaling pathway
mni04917  Prolactin signaling pathway
mni04919  Thyroid hormone signaling pathway
mni04923  Regulation of lipolysis in adipocytes
mni04926  Relaxin signaling pathway
mni04929  GnRH secretion
mni04930  Type II diabetes mellitus
mni04931  Insulin resistance
mni04932  Non-alcoholic fatty liver disease
mni04933  AGE-RAGE signaling pathway in diabetic complications
mni04935  Growth hormone synthesis, secretion and action
mni04960  Aldosterone-regulated sodium reabsorption
mni04973  Carbohydrate digestion and absorption
mni05010  Alzheimer disease
mni05017  Spinocerebellar ataxia
mni05020  Prion disease
mni05100  Bacterial invasion of epithelial cells
mni05135  Yersinia infection
mni05142  Chagas disease
mni05146  Amoebiasis
mni05160  Hepatitis C
mni05161  Hepatitis B
mni05162  Measles
mni05163  Human cytomegalovirus infection
mni05164  Influenza A
mni05165  Human papillomavirus infection
mni05166  Human T-cell leukemia virus 1 infection
mni05167  Kaposi sarcoma-associated herpesvirus infection
mni05168  Herpes simplex virus 1 infection
mni05169  Epstein-Barr virus infection
mni05170  Human immunodeficiency virus 1 infection
mni05171  Coronavirus disease
mni05200  Pathways in cancer
mni05203  Viral carcinogenesis
mni05205  Proteoglycans in cancer
mni05206  MicroRNAs in cancer
mni05207  Chemical carcinogenesis - receptor activation
mni05208  Chemical carcinogenesis - reactive oxygen species
mni05210  Colorectal cancer
mni05211  Renal cell carcinoma
mni05212  Pancreatic cancer
mni05213  Endometrial cancer
mni05214  Glioma
mni05215  Prostate cancer
mni05218  Melanoma
mni05220  Chronic myeloid leukemia
mni05221  Acute myeloid leukemia
mni05222  Small cell lung cancer
mni05223  Non-small cell lung cancer
mni05224  Breast cancer
mni05225  Hepatocellular carcinoma
mni05226  Gastric cancer
mni05230  Central carbon metabolism in cancer
mni05231  Choline metabolism in cancer
mni05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mni05415  Diabetic cardiomyopathy
mni05417  Lipid and atherosclerosis
mni05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mni00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    105475205 (PIK3R1)
   04014 Ras signaling pathway
    105475205 (PIK3R1)
   04015 Rap1 signaling pathway
    105475205 (PIK3R1)
   04370 VEGF signaling pathway
    105475205 (PIK3R1)
   04630 JAK-STAT signaling pathway
    105475205 (PIK3R1)
   04668 TNF signaling pathway
    105475205 (PIK3R1)
   04066 HIF-1 signaling pathway
    105475205 (PIK3R1)
   04068 FoxO signaling pathway
    105475205 (PIK3R1)
   04070 Phosphatidylinositol signaling system
    105475205 (PIK3R1)
   04072 Phospholipase D signaling pathway
    105475205 (PIK3R1)
   04071 Sphingolipid signaling pathway
    105475205 (PIK3R1)
   04024 cAMP signaling pathway
    105475205 (PIK3R1)
   04151 PI3K-Akt signaling pathway
    105475205 (PIK3R1)
   04152 AMPK signaling pathway
    105475205 (PIK3R1)
   04150 mTOR signaling pathway
    105475205 (PIK3R1)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    105475205 (PIK3R1)
   04517 IgSF CAM signaling
    105475205 (PIK3R1)
   04518 Integrin signaling
    105475205 (PIK3R1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    105475205 (PIK3R1)
   04140 Autophagy - animal
    105475205 (PIK3R1)
  09143 Cell growth and death
   04210 Apoptosis
    105475205 (PIK3R1)
   04218 Cellular senescence
    105475205 (PIK3R1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    105475205 (PIK3R1)
   04550 Signaling pathways regulating pluripotency of stem cells
    105475205 (PIK3R1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    105475205 (PIK3R1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    105475205 (PIK3R1)
   04613 Neutrophil extracellular trap formation
    105475205 (PIK3R1)
   04620 Toll-like receptor signaling pathway
    105475205 (PIK3R1)
   04625 C-type lectin receptor signaling pathway
    105475205 (PIK3R1)
   04650 Natural killer cell mediated cytotoxicity
    105475205 (PIK3R1)
   04660 T cell receptor signaling pathway
    105475205 (PIK3R1)
   04662 B cell receptor signaling pathway
    105475205 (PIK3R1)
   04664 Fc epsilon RI signaling pathway
    105475205 (PIK3R1)
   04666 Fc gamma R-mediated phagosome formation
    105475205 (PIK3R1)
   04670 Leukocyte transendothelial migration
    105475205 (PIK3R1)
   04062 Chemokine signaling pathway
    105475205 (PIK3R1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    105475205 (PIK3R1)
   04923 Regulation of lipolysis in adipocytes
    105475205 (PIK3R1)
   04929 GnRH secretion
    105475205 (PIK3R1)
   04915 Estrogen signaling pathway
    105475205 (PIK3R1)
   04914 Progesterone-mediated oocyte maturation
    105475205 (PIK3R1)
   04917 Prolactin signaling pathway
    105475205 (PIK3R1)
   04926 Relaxin signaling pathway
    105475205 (PIK3R1)
   04935 Growth hormone synthesis, secretion and action
    105475205 (PIK3R1)
   04919 Thyroid hormone signaling pathway
    105475205 (PIK3R1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    105475205 (PIK3R1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    105475205 (PIK3R1)
  09156 Nervous system
   04725 Cholinergic synapse
    105475205 (PIK3R1)
   04722 Neurotrophin signaling pathway
    105475205 (PIK3R1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    105475205 (PIK3R1)
  09158 Development and regeneration
   04360 Axon guidance
    105475205 (PIK3R1)
   04380 Osteoclast differentiation
    105475205 (PIK3R1)
  09149 Aging
   04211 Longevity regulating pathway
    105475205 (PIK3R1)
   04213 Longevity regulating pathway - multiple species
    105475205 (PIK3R1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    105475205 (PIK3R1)
   05206 MicroRNAs in cancer
    105475205 (PIK3R1)
   05205 Proteoglycans in cancer
    105475205 (PIK3R1)
   05207 Chemical carcinogenesis - receptor activation
    105475205 (PIK3R1)
   05208 Chemical carcinogenesis - reactive oxygen species
    105475205 (PIK3R1)
   05203 Viral carcinogenesis
    105475205 (PIK3R1)
   05230 Central carbon metabolism in cancer
    105475205 (PIK3R1)
   05231 Choline metabolism in cancer
    105475205 (PIK3R1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    105475205 (PIK3R1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    105475205 (PIK3R1)
   05212 Pancreatic cancer
    105475205 (PIK3R1)
   05225 Hepatocellular carcinoma
    105475205 (PIK3R1)
   05226 Gastric cancer
    105475205 (PIK3R1)
   05214 Glioma
    105475205 (PIK3R1)
   05221 Acute myeloid leukemia
    105475205 (PIK3R1)
   05220 Chronic myeloid leukemia
    105475205 (PIK3R1)
   05218 Melanoma
    105475205 (PIK3R1)
   05211 Renal cell carcinoma
    105475205 (PIK3R1)
   05215 Prostate cancer
    105475205 (PIK3R1)
   05213 Endometrial cancer
    105475205 (PIK3R1)
   05224 Breast cancer
    105475205 (PIK3R1)
   05222 Small cell lung cancer
    105475205 (PIK3R1)
   05223 Non-small cell lung cancer
    105475205 (PIK3R1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    105475205 (PIK3R1)
   05170 Human immunodeficiency virus 1 infection
    105475205 (PIK3R1)
   05161 Hepatitis B
    105475205 (PIK3R1)
   05160 Hepatitis C
    105475205 (PIK3R1)
   05171 Coronavirus disease
    105475205 (PIK3R1)
   05164 Influenza A
    105475205 (PIK3R1)
   05162 Measles
    105475205 (PIK3R1)
   05168 Herpes simplex virus 1 infection
    105475205 (PIK3R1)
   05163 Human cytomegalovirus infection
    105475205 (PIK3R1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    105475205 (PIK3R1)
   05169 Epstein-Barr virus infection
    105475205 (PIK3R1)
   05165 Human papillomavirus infection
    105475205 (PIK3R1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    105475205 (PIK3R1)
   05100 Bacterial invasion of epithelial cells
    105475205 (PIK3R1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    105475205 (PIK3R1)
   05142 Chagas disease
    105475205 (PIK3R1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    105475205 (PIK3R1)
   05017 Spinocerebellar ataxia
    105475205 (PIK3R1)
   05020 Prion disease
    105475205 (PIK3R1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    105475205 (PIK3R1)
   05418 Fluid shear stress and atherosclerosis
    105475205 (PIK3R1)
   05415 Diabetic cardiomyopathy
    105475205 (PIK3R1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    105475205 (PIK3R1)
   04932 Non-alcoholic fatty liver disease
    105475205 (PIK3R1)
   04931 Insulin resistance
    105475205 (PIK3R1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    105475205 (PIK3R1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    105475205 (PIK3R1)
   01524 Platinum drug resistance
    105475205 (PIK3R1)
   01522 Endocrine resistance
    105475205 (PIK3R1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mni04131]
    105475205 (PIK3R1)
Membrane trafficking [BR:mni04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    105475205 (PIK3R1)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH2_1 SH3_1 SH3_2 CEP135_TSGA10_CC Laminin_I SH3_9 ODF2_C DicA_C FANCI_S2 Exonuc_VII_L
Other DBs
NCBI-GeneID: 105475205
NCBI-ProteinID: XP_011728589
Ensembl: ENSMNEG00000038802
UniProt: A0A2K6D4C7
Position
Unknown
AA seq 724 aa
MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEEIGWLNGYN
ETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKTEADVEQQGLTLPDLAE
QFAPPDVAPPLLIKLVEAIEKKGLECSTLYRTQSSGNLAELRQLLDCDTASVDLEMIDVH
ILADAFKRYLLDLPNPVIPAAVYSEMISLAQEVQSSEEYIQLLKKLIRSPSIPHQYWLTL
QYLLKHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLIKVIEILISTEWNE
RQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDA
STKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKL
DVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMK
RTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIID
SRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN
ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACS
VVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA
QQRR
NT seq 2175 nt   +upstreamnt  +downstreamnt
atgagtgctgaggggtaccagtacagagcgctgtatgattataaaaaagaaagagaagaa
gatattgacttgcacttgggtgacatattgactgtgaataaagggtccttagtagctctt
ggattcagtgatggacaggaagccaggcctgaagaaattggctggttaaatggctataat
gaaaccacaggggaaaggggggactttccgggaacttatgtagaatatattggaaggaaa
aaaatctcgcctcccacgccaaagccccggccgcctcggcctcttcctgttgcaccaggt
tcttcgaaaactgaagcagatgttgaacaacaaggtttgactctcccggatcttgcagag
cagtttgcccctcctgacgttgccccacctcttcttatcaagctcgtggaagccattgaa
aagaaaggtctggaatgttcaactctatacagaacacagagctccggcaacctggcggaa
ttacgacagcttcttgattgtgatacagcctctgtggacttggaaatgatcgatgtgcac
attttggccgatgctttcaaacgctatctcctggacttaccaaatcctgtcattccagca
gccgtttacagtgaaatgatttctttagctcaagaagtacaaagctccgaagaatatatt
cagctactgaagaagcttattaggtcgcctagcatacctcatcagtattggcttacgctt
cagtatttgttaaaacatttcttcaagctctctcaaacgtccagcaaaaatctgttgaat
gcaagagtactctctgaaattttcagccctatgcttttcagattctcagcagccagctct
gataatactgaaaacctcataaaagttatagaaattttaatctcaactgaatggaatgaa
cgacagcctgcaccagcactgcctcctaaaccaccaaaacccactactgtagccaacaac
ggtatgaataacaatatgtccttacaagatgctgaatggtactggggagatatctcgagg
gaagaagtgaatgaaaaacttcgagatacagcagatgggacctttttggtacgagatgcg
tctactaaaatgcatggtgattatactcttacactaaggaaagggggaaataacaaatta
atcaaaatatttcatcgagatgggaaatatggcttctctgacccattaaccttcaattct
gtggttgaattaataaaccactaccggaatgaatctctagctcagtataatcccaagctg
gacgtgaaattactttatccagtatccaaataccaacaggatcaagttgtcaaagaagat
aatattgaagctgtagggaaaaaattacatgaatataacactcagtttcaagaaaaaagt
agagaatatgatagattatatgaagaatatacccgtacatcccaggaaatccaaatgaaa
aggacagctattgaagcatttaatgaaaccataaaaatatttgaagaacagtgccagacc
caggagcgctacagcaaagaatacatagaaaagtttaaacgtgagggcaatgagaaagaa
atacaaaggattatgcataattatgataagttgaagtctcgaatcagtgaaattattgac
agtagaagaagattggaagaagacttgaagaagcaggcagctgagtatcgagaaattgac
aaacgtatgaacagcattaaaccagaccttatccagctgagaaagacgagagaccaatac
ttgatgtggttgactcaaaaaggtgttcggcaaaagaagttgaacgagtggttgggcaat
gaaaacactgaagaccaatattcgctggtggaagatgatgaagatttaccccatcatgat
gagaagacttggaatgttggaagcagcaaccgaaacaaagctgaaaacctgttgcgaggg
aagcgagatggcacttttcttgtccgggagagcagtaaacagggctgctacgcctgctct
gtagtggtggacggcgaagtaaagcattgtgtcataaacaaaacagcgactggctatggc
tttgccgagccctataacttgtacagctctctgaaagaactggtgctacattaccaacac
acctccctcgtgcagcacaacgactccctcaatgtcacactagcctacccagtatatgca
cagcagaggcgatga

  All links  
Gene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
Protein sequence (5)   
   UniProt (1)   
   RefSeq(pep) (4)   
DNA sequence (4)   
   RefSeq(nuc) (4)   
Protein domain (13)   
   Pfam (13)   
All databases (25)   

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