KEGG   Prionailurus bengalensis (leopard cat): 122491710
Entry
122491710         CDS       T07574                                 
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
pbg  Prionailurus bengalensis (leopard cat)
Pathway
pbg00562  Inositol phosphate metabolism
pbg01100  Metabolic pathways
pbg01521  EGFR tyrosine kinase inhibitor resistance
pbg01522  Endocrine resistance
pbg01524  Platinum drug resistance
pbg04012  ErbB signaling pathway
pbg04014  Ras signaling pathway
pbg04015  Rap1 signaling pathway
pbg04024  cAMP signaling pathway
pbg04062  Chemokine signaling pathway
pbg04066  HIF-1 signaling pathway
pbg04068  FoxO signaling pathway
pbg04070  Phosphatidylinositol signaling system
pbg04071  Sphingolipid signaling pathway
pbg04072  Phospholipase D signaling pathway
pbg04081  Hormone signaling
pbg04140  Autophagy - animal
pbg04145  Phagocytosis
pbg04150  mTOR signaling pathway
pbg04151  PI3K-Akt signaling pathway
pbg04152  AMPK signaling pathway
pbg04210  Apoptosis
pbg04211  Longevity regulating pathway
pbg04213  Longevity regulating pathway - multiple species
pbg04218  Cellular senescence
pbg04360  Axon guidance
pbg04370  VEGF signaling pathway
pbg04380  Osteoclast differentiation
pbg04510  Focal adhesion
pbg04517  IgSF CAM signaling
pbg04518  Integrin signaling
pbg04550  Signaling pathways regulating pluripotency of stem cells
pbg04611  Platelet activation
pbg04613  Neutrophil extracellular trap formation
pbg04620  Toll-like receptor signaling pathway
pbg04625  C-type lectin receptor signaling pathway
pbg04630  JAK-STAT signaling pathway
pbg04650  Natural killer cell mediated cytotoxicity
pbg04660  T cell receptor signaling pathway
pbg04662  B cell receptor signaling pathway
pbg04664  Fc epsilon RI signaling pathway
pbg04666  Fc gamma R-mediated phagosome formation
pbg04668  TNF signaling pathway
pbg04670  Leukocyte transendothelial migration
pbg04722  Neurotrophin signaling pathway
pbg04725  Cholinergic synapse
pbg04750  Inflammatory mediator regulation of TRP channels
pbg04810  Regulation of actin cytoskeleton
pbg04910  Insulin signaling pathway
pbg04914  Progesterone-mediated oocyte maturation
pbg04915  Estrogen signaling pathway
pbg04917  Prolactin signaling pathway
pbg04919  Thyroid hormone signaling pathway
pbg04923  Regulation of lipolysis in adipocytes
pbg04926  Relaxin signaling pathway
pbg04929  GnRH secretion
pbg04930  Type II diabetes mellitus
pbg04931  Insulin resistance
pbg04932  Non-alcoholic fatty liver disease
pbg04933  AGE-RAGE signaling pathway in diabetic complications
pbg04935  Growth hormone synthesis, secretion and action
pbg04960  Aldosterone-regulated sodium reabsorption
pbg04973  Carbohydrate digestion and absorption
pbg05010  Alzheimer disease
pbg05017  Spinocerebellar ataxia
pbg05020  Prion disease
pbg05100  Bacterial invasion of epithelial cells
pbg05132  Salmonella infection
pbg05135  Yersinia infection
pbg05142  Chagas disease
pbg05146  Amoebiasis
pbg05160  Hepatitis C
pbg05161  Hepatitis B
pbg05162  Measles
pbg05163  Human cytomegalovirus infection
pbg05164  Influenza A
pbg05165  Human papillomavirus infection
pbg05166  Human T-cell leukemia virus 1 infection
pbg05167  Kaposi sarcoma-associated herpesvirus infection
pbg05168  Herpes simplex virus 1 infection
pbg05169  Epstein-Barr virus infection
pbg05170  Human immunodeficiency virus 1 infection
pbg05171  Coronavirus disease
pbg05200  Pathways in cancer
pbg05203  Viral carcinogenesis
pbg05205  Proteoglycans in cancer
pbg05206  MicroRNAs in cancer
pbg05207  Chemical carcinogenesis - receptor activation
pbg05208  Chemical carcinogenesis - reactive oxygen species
pbg05210  Colorectal cancer
pbg05211  Renal cell carcinoma
pbg05212  Pancreatic cancer
pbg05213  Endometrial cancer
pbg05214  Glioma
pbg05215  Prostate cancer
pbg05218  Melanoma
pbg05220  Chronic myeloid leukemia
pbg05221  Acute myeloid leukemia
pbg05222  Small cell lung cancer
pbg05223  Non-small cell lung cancer
pbg05224  Breast cancer
pbg05225  Hepatocellular carcinoma
pbg05226  Gastric cancer
pbg05230  Central carbon metabolism in cancer
pbg05231  Choline metabolism in cancer
pbg05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pbg05415  Diabetic cardiomyopathy
pbg05417  Lipid and atherosclerosis
pbg05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pbg00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    122491710 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    122491710 (PIK3CA)
   04014 Ras signaling pathway
    122491710 (PIK3CA)
   04015 Rap1 signaling pathway
    122491710 (PIK3CA)
   04370 VEGF signaling pathway
    122491710 (PIK3CA)
   04630 JAK-STAT signaling pathway
    122491710 (PIK3CA)
   04668 TNF signaling pathway
    122491710 (PIK3CA)
   04066 HIF-1 signaling pathway
    122491710 (PIK3CA)
   04068 FoxO signaling pathway
    122491710 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    122491710 (PIK3CA)
   04072 Phospholipase D signaling pathway
    122491710 (PIK3CA)
   04071 Sphingolipid signaling pathway
    122491710 (PIK3CA)
   04024 cAMP signaling pathway
    122491710 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    122491710 (PIK3CA)
   04152 AMPK signaling pathway
    122491710 (PIK3CA)
   04150 mTOR signaling pathway
    122491710 (PIK3CA)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    122491710 (PIK3CA)
   04517 IgSF CAM signaling
    122491710 (PIK3CA)
   04518 Integrin signaling
    122491710 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    122491710 (PIK3CA)
   04140 Autophagy - animal
    122491710 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    122491710 (PIK3CA)
   04218 Cellular senescence
    122491710 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    122491710 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    122491710 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    122491710 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    122491710 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    122491710 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    122491710 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    122491710 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    122491710 (PIK3CA)
   04660 T cell receptor signaling pathway
    122491710 (PIK3CA)
   04662 B cell receptor signaling pathway
    122491710 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    122491710 (PIK3CA)
   04666 Fc gamma R-mediated phagosome formation
    122491710 (PIK3CA)
   04670 Leukocyte transendothelial migration
    122491710 (PIK3CA)
   04062 Chemokine signaling pathway
    122491710 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    122491710 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    122491710 (PIK3CA)
   04929 GnRH secretion
    122491710 (PIK3CA)
   04915 Estrogen signaling pathway
    122491710 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    122491710 (PIK3CA)
   04917 Prolactin signaling pathway
    122491710 (PIK3CA)
   04926 Relaxin signaling pathway
    122491710 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    122491710 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    122491710 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    122491710 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    122491710 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    122491710 (PIK3CA)
   04722 Neurotrophin signaling pathway
    122491710 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    122491710 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    122491710 (PIK3CA)
   04380 Osteoclast differentiation
    122491710 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    122491710 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    122491710 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    122491710 (PIK3CA)
   05206 MicroRNAs in cancer
    122491710 (PIK3CA)
   05205 Proteoglycans in cancer
    122491710 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    122491710 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    122491710 (PIK3CA)
   05203 Viral carcinogenesis
    122491710 (PIK3CA)
   05230 Central carbon metabolism in cancer
    122491710 (PIK3CA)
   05231 Choline metabolism in cancer
    122491710 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    122491710 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    122491710 (PIK3CA)
   05212 Pancreatic cancer
    122491710 (PIK3CA)
   05225 Hepatocellular carcinoma
    122491710 (PIK3CA)
   05226 Gastric cancer
    122491710 (PIK3CA)
   05214 Glioma
    122491710 (PIK3CA)
   05221 Acute myeloid leukemia
    122491710 (PIK3CA)
   05220 Chronic myeloid leukemia
    122491710 (PIK3CA)
   05218 Melanoma
    122491710 (PIK3CA)
   05211 Renal cell carcinoma
    122491710 (PIK3CA)
   05215 Prostate cancer
    122491710 (PIK3CA)
   05213 Endometrial cancer
    122491710 (PIK3CA)
   05224 Breast cancer
    122491710 (PIK3CA)
   05222 Small cell lung cancer
    122491710 (PIK3CA)
   05223 Non-small cell lung cancer
    122491710 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    122491710 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    122491710 (PIK3CA)
   05161 Hepatitis B
    122491710 (PIK3CA)
   05160 Hepatitis C
    122491710 (PIK3CA)
   05171 Coronavirus disease
    122491710 (PIK3CA)
   05164 Influenza A
    122491710 (PIK3CA)
   05162 Measles
    122491710 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    122491710 (PIK3CA)
   05163 Human cytomegalovirus infection
    122491710 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    122491710 (PIK3CA)
   05169 Epstein-Barr virus infection
    122491710 (PIK3CA)
   05165 Human papillomavirus infection
    122491710 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    122491710 (PIK3CA)
   05135 Yersinia infection
    122491710 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    122491710 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    122491710 (PIK3CA)
   05142 Chagas disease
    122491710 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    122491710 (PIK3CA)
   05017 Spinocerebellar ataxia
    122491710 (PIK3CA)
   05020 Prion disease
    122491710 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    122491710 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    122491710 (PIK3CA)
   05415 Diabetic cardiomyopathy
    122491710 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    122491710 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    122491710 (PIK3CA)
   04931 Insulin resistance
    122491710 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    122491710 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    122491710 (PIK3CA)
   01524 Platinum drug resistance
    122491710 (PIK3CA)
   01522 Endocrine resistance
    122491710 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pbg04131]
    122491710 (PIK3CA)
Enzymes [BR:pbg01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     122491710 (PIK3CA)
Membrane trafficking [BR:pbg04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    122491710 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 122491710
NCBI-ProteinID: XP_043450800
Position
C2:complement(88284851..88366501)
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgacgttagaatgcctccgtgaggct
acattaataactataaagcatgaattatttaaagaagcaagaaaatatcctcttcatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctttttcaaccctttttaaaa
gtaattgagccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgct
attggcatgccagtgtgtgaatttgatatggttaaagatccagaagtacaggacttccga
agaaatattctgaatgtttgtaaagaagctgtggatcttcgggatcttaattcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcaccagaactgccaaagcac
atatataataaactagataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaaccatgactgtgtgccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgctatcatctgaacaactaaaa
ctctgtgttttagaataccagggcaagtatattttaaaagtgtgtggatgtgatgaatac
ttccttgaaaaatatcctctaagtcagtataagtacataagaagctgtataatgcttggg
aggatgcccaatttgatgctgatggctaaagaaagcctttactcccaactgccaatggac
tgtttcacaatgccatcttattccagacgcatctccacagctacaccatatatgaatgga
gaaacatctacaaagtccctttgggttataaatagtgcactcagaataaaaatcctttgt
gcaacctatgtgaatgtaaatattcgagacatcgacaagatctatgttcgaacaggtatc
tatcatggaggagaacccttatgtgataatgtgaacactcaaagagtaccttgttctaat
cccaggtggaatgaatggctaaattacgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgttctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcctggggaaatataaacttgtttgattacacagatactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggattagaagatttgctgaaccctattggt
gttactgggtcaaatccaaataaagaaaccccatgcttagagttggagtttgactggttc
agcagtgtggtaaagttcccagatatgtcagtgattgaagagcatgccaactggtctgtg
tctcgagaagcaggatttagttattcccatgcaggactgagtaacagactagctagagac
aacgaattaagagaaaatgataaagaacagctccgagcaatttgtacccgagatcctcta
tctgaaatcactgagcaagagaaagattttctgtggagccacagacactattgtgtaact
atccctgaaattctacccaaactgcttctgtctgttaaatggaattctagagatgaagta
gctcagatgtactgcttagtaaaagattggcctccaatcaaacctgaacaggcaatggag
cttctggattgtaattacccagatcctatggttcgaggttttgctgttcgatgcttggaa
aaatacttaacagatgacaagctttctcagtacttaattcagctagtacaggtcctaaaa
tatgaacagtatttggataacctgcttgtgagatttttactcaagaaagcattgactaat
caaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaacagtt
agtcagaggtttggcctgcttttggagtcgtattgtcgtgcatgtgggatgtatttgaag
cacctaaataggcaagttgaagctatggaaaagctcattaacttaactgacattctcaaa
caagaaaagaaggatgaaacacaaaaggtacagatgaagtttttagttgagcaaatgcgg
agaccagatttcatggatgctctacagggttttctgtctcctctaaatcctgctcatcaa
ctaggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactctttcagaacaatgagatcatc
tttaaaaatggggatgatttacggcaagatatgttaacactgcagatcattcgcattatg
gaaaatatctggcaaaatcaaggccttgatcttcgaatgttaccttatggttgtctgtca
atcggtgactgtgtgggacttattgaggtggtgagaaattctcatactattatgcagatt
caatgcaaaggtggcctgaaaggcgcactgcagttcaacagccacactctacaccagtgg
ctcaaagacaagaacaaaggcgaaatatacgatgcagccattgacctgttcacacgttca
tgtgctggatattgtgttgctacctttatactgggaatcggagatcgtcacaatagtaac
atcatggttaaagatgatggacaactatttcatatagattttggacactttttggatcat
aagaagaaaaaatttggttataaacgggaacgtgtgccgtttgttttgacacaagatttc
ttaatagtgattagtaaaggagcccaagaatgcacaaagacaagagaattcgaaaggttt
caggagatgtgttacaaggcttatctagctattcggcagcatgccaatctcttcataaat
ctcttctcaatgatgcttggctctggaatgccagaactgcaatcttttgatgatattgca
tacattcgaaagaccctagctttagataaaactgaacaagaggctttggaatatttcatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
acaattaagcagcatgctttgaactga

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (8)   
   Pfam (8)   
All databases (12)   

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