KEGG   Puma concolor (puma): 112855387
Entry
112855387         CDS       T08890                                 
Symbol
HIF1A
Name
(RefSeq) hypoxia-inducible factor 1-alpha
  KO
K08268  hypoxia-inducible factor 1 alpha
Organism
pcoo  Puma concolor (puma)
Pathway
pcoo04066  HIF-1 signaling pathway
pcoo04137  Mitophagy - animal
pcoo04140  Autophagy - animal
pcoo04148  Efferocytosis
pcoo04659  Th17 cell differentiation
pcoo04919  Thyroid hormone signaling pathway
pcoo05167  Kaposi sarcoma-associated herpesvirus infection
pcoo05200  Pathways in cancer
pcoo05205  Proteoglycans in cancer
pcoo05208  Chemical carcinogenesis - reactive oxygen species
pcoo05211  Renal cell carcinoma
pcoo05230  Central carbon metabolism in cancer
pcoo05231  Choline metabolism in cancer
pcoo05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:pcoo00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    112855387 (HIF1A)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    112855387 (HIF1A)
   04137 Mitophagy - animal
    112855387 (HIF1A)
   04148 Efferocytosis
    112855387 (HIF1A)
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    112855387 (HIF1A)
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    112855387 (HIF1A)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    112855387 (HIF1A)
   05205 Proteoglycans in cancer
    112855387 (HIF1A)
   05208 Chemical carcinogenesis - reactive oxygen species
    112855387 (HIF1A)
   05230 Central carbon metabolism in cancer
    112855387 (HIF1A)
   05231 Choline metabolism in cancer
    112855387 (HIF1A)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    112855387 (HIF1A)
  09162 Cancer: specific types
   05211 Renal cell carcinoma
    112855387 (HIF1A)
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    112855387 (HIF1A)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:pcoo03000]
    112855387 (HIF1A)
Transcription factors [BR:pcoo03000]
 Eukaryotic type
  Basic helix-loop-helix (bHLH)
   Factors with PAS domain
    112855387 (HIF1A)
SSDB
Motif
Pfam: bHLH_HIF1A PAS_3 PAS_11 HIF-1a_CTAD PAS HIF-1 PAS_9 PAS_4 HLH DDRGK
Other DBs
NCBI-GeneID: 112855387
NCBI-ProteinID: XP_025774817
UniProt: A0A6P6HGF3
Position
Unknown
AA seq 824 aa
MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVM
RLTISYLRVRKLLDAGDLDIEDEMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYM
GLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR
TMNIKSATWKVLHCTGHIHVYDTNSNQSQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSK
TFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV
TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV
LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTET
DDQQLEEVPLYNDVMLPSSNEKLQNINLAMSPLPASETPKPLRSSADPALNQEVVLKLEP
NPESLELSFTMPQIQDQPASPSDGSTRQSSPEPTSPSEYCFDVDSDMVNEFKLELVEKLF
AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSTSPQSVGTITVFQ
PAQMQEEPPVTTTSTTATTDELKTVTKDGIEDIKILIASPSPTHVPKVTTGATTSLYGDT
GSRTASPNRAGKGVIEQTEKSHPRSPNVLSVTLSQRTTIPEEELNPKILALQNAQRKRKI
EHDGSLFQAVGIGTLLQQPDDRATTTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLACRL
LGQSMDESGLPQLTSYDCEVNAPVQGSRNLLQGEELLRALDQVN
NT seq 2475 nt   +upstreamnt  +downstreamnt
atggagggcgccggcggcgcgaacgacaagaaaaagataagttctgaacgtcgaaaagaa
aagtctagagatgcagcgagatctcggcgaagtaaagaatctgaagttttctatgaactt
gctcatcagttgccacttccccataatgtgagctcgcatctcgataaggcttctgttatg
aggctcaccatcagctatttgcgtgtgaggaaacttctggatgctggtgatttagatatt
gaagatgaaatgaaggcacagatgaattgcttttatttgaaagccttggatggttttgtt
atggttctcacagatgatggtgacatgatctacatttctgataatgtgaacaagtacatg
ggattaactcagtttgaactaactggacacagtgtgtttgattttactcatccatgtgac
catgaagaaatgagagagatgcttacacatagaaatggccttgtgaagaagggtaaagag
cagaatacacagcgaagcttttttctcagaatgaagtgtaccctaactagccgagggaga
accatgaacataaagtcagcaacgtggaaagtacttcactgcacaggccatattcatgtc
tacgataccaatagtaaccaatctcagtgtgggtataagaaaccacccatgacgtgcttg
gtgctgatttgtgaacccattcctcatccatcaaatattgaaattcctttagatagcaag
acttttctgagtcgtcatagtctggatatgaaattttcttattgtgatgaaagaattact
gaattgatgggatacgagccagaggaacttttgggccgctcgatatatgaatattaccac
gctttggactctgaccatctgaccaaaactcatcatgacatgtttactaaaggtcaagtc
accacaggacagtacaggatgcttgccaaaagaggtggatatgtctgggttgaaactcaa
gcgaccgtcatatataacactaagaactctcaaccacagtgcattgtatgtgtaaattac
gttgtgagtggtattattcagcacgacttgattttctcccttcaacaaacagaatgtgtc
ctcaaaccagttgaatcttcagatatgaaaatgactcagctgttcaccaaagttgaatca
gaagacacaagtagtctgtttgataaacttaagaaggaacctgatgctttaactttgctg
gcaccagctgctggagacacaatcatatctttagatttcggcagcaatgacacagaaact
gatgaccagcaacttgaggaagttccattgtataatgatgtaatgcttccctcatccaat
gaaaaattacagaacataaatttggcaatgtctccattacctgcttctgaaactccaaag
ccacttcgaagtagtgctgaccctgcactcaatcaagaagttgtactaaaattagagcca
aatccagaatcactggaactttcttttactatgccccagattcaagatcagccagctagt
ccttctgatggaagcactagacagagttcacctgagcctaccagtcccagtgaatattgt
tttgatgtggatagtgatatggtcaatgaatttaagctggaattggtagagaaacttttt
gctgaagacacagaagccaagaatccattttccacccaggacactgatttagacttggag
atgttagctccttacatcccaatggatgatgacttccagttacggtcctttgatcagttg
tcgccactggaaagcagttctacaagccctcaaagcgtgggcacaattacagtattccag
ccggctcaaatgcaggaggaacctcctgttaccactaccagtaccactgccaccactgat
gaattaaaaacagtgacaaaagatggtatagaagacattaaaatactgattgcatctcca
tctcctacccatgtacccaaagtaactactggtgccacaacatcactgtatggtgatact
ggaagtcggacagcctcaccaaacagagcaggaaaaggagtcatagaacagacagaaaaa
tctcatccaagaagccctaatgtgttgtctgtcactttgagtcaaagaactaccattcct
gaagaagaactaaatccaaagatactagctttgcagaatgctcagagaaagcgaaaaata
gaacatgacggttcactttttcaagcagtaggaattggaacattattacagcagccagat
gatcgtgcaactactacatcactttcttggaaacgcgtaaaaggatgcaaatctagtgag
cagaatggaatggagcaaaagacaattattttaataccctctgatttagcgtgtagactg
ctggggcaatcaatggatgagagtggattaccacaactgaccagttatgattgtgaagtt
aatgctcctgtacaaggcagcagaaacctactgcagggtgaagaattactcagagctttg
gatcaagttaactga

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (10)   
   Pfam (10)   
All databases (15)   

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