#=GF ID HMUDK_hel
#=GF AC PF18723.7
#=GF DE 5-hmdU DNA kinase, helical domain
#=GF PI aGPT-Pplase1;
#=GF AU Iyer LM;0000-0002-4844-2022
#=GF AU Aravind L;0000-0003-0771-253X
#=GF AU Burroughs AM;0000-0002-2229-8771
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF SE Iyer LM
#=GF GA 25.00 25.00;
#=GF TC 25.10 25.00;
#=GF NC 24.20 24.20;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 --cpu 8 -Z 90746521 HMM pfamseq
#=GF TP Domain
#=GF CL CL0686
#=GF RN [1]
#=GF RM 23814188
#=GF RT Computational identification of novel biochemical systems
#=GF RT involved in oxidation, glycosylation and other complex
#=GF RT modifications of bases in DNA.
#=GF RA Iyer LM, Zhang D, Burroughs AM, Aravind L;
#=GF RL Nucleic Acids Res. 2013;41:7635-7655.
#=GF RN [2]
#=GF RM 34522950
#=GF RT Pathways of thymidine hypermodification.
#=GF RA Lee YJ, Dai N, Muller SI, Guan C, Parker MJ, Fraser ME, Walsh
#=GF RA SE, Sridar J, Mulholland A, Nayak K, Sun Z, Lin YC, Comb DG,
#=GF RA Marks K, Gonzalez R, Dowling DP, Bandarian V, Saleh L, Correa
#=GF RA IR, Weigele PR;
#=GF RL Nucleic Acids Res. 2022;50:3001-3017.
#=GF RN [3]
#=GF RM 29555775
#=GF RT Identification and biosynthesis of thymidine hypermodifications
#=GF RT in the genomic DNA of widespread bacterial viruses.
#=GF RA Lee YJ, Dai N, Walsh SE, Muller S, Fraser ME, Kauffman KM, Guan
#=GF RA C, Correa IR Jr, Weigele PR;
#=GF RL Proc Natl Acad Sci U S A. 2018;115:E3116.
#=GF DR INTERPRO; IPR040684;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This entry represents an alpha-helical domain found in 5-hmdU
#=GF CC DNA kinase (HMUDK), a P-loop nucleotide kinase that
#=GF CC phosphorylates 5-hydroxymethyluracil (5hmdU) into
#=GF CC 5-phosphomethyl-2'-deoxyuridine (5-PmdU) on DNA as a step in the
#=GF CC pathway leading to thymidine hypermodifications in the viral
#=GF CC genome [2]. HMUDK also transfers glutamate to
#=GF CC 5-pyrophosphoryloxymethyldeoxyuridine (5-PPmdU) to produce
#=GF CC 5-Nalpha-glyutamylthymidine (Nalpha-GluT) [2,3]. These
#=GF CC modifications probably prevent degradation of viral genome by
#=GF CC the host restriction-modification antiviral defense system
#=GF CC [1,2]. Members of this entry (formerly known as aGPT-Pplase1)
#=GF CC are found in phages with hypermodified bases and eukaryotes such
#=GF CC as fungi and stramenopiles [1,2].
#=GF SQ 505
#=GS A0A5B8UKT9_9BACT/14-292 AC A0A5B8UKT9.1
#=GS A0A0V7ZZF8_9CYAN/48-329 AC A0A0V7ZZF8.1
#=GS A0AAE0BS79_9CHLO/136-470 AC A0AAE0BS79.1
#=GS A0A0C3CNE2_PILCF/54-337 AC A0A0C3CNE2.1
#=GS A0A369LN44_9ACTN/7-288 AC A0A369LN44.1
#=GS A0A165HW32_EXIGL/79-361 AC A0A165HW32.1
#=GS A0A1L2BX66_9CAUD/4-282 AC A0A1L2BX66.1
#=GS A0A9P8ZQ29_9AGAM/37-308 AC A0A9P8ZQ29.1
#=GS HMUDK_BPS10/311-604 AC F8WQ30.1
#=GS K1W9H2_TRIAC/240-540 AC K1W9H2.1
#=GS A0A923MDY7_9BURK/9-277 AC A0A923MDY7.1
#=GS A0A4U0S6V0_9ACTN/9-286 AC A0A4U0S6V0.1
#=GS K3WK74_GLOUD/219-491 AC K3WK74.1
#=GS A0A1A7QFH4_9SPHN/4-284 AC A0A1A7QFH4.1
#=GS A0A7G1KTH6_9NOCA/9-290 AC A0A7G1KTH6.1
#=GS A0A938WVD5_9BACT/11-291 AC A0A938WVD5.1
#=GS A0A1H4A6J9_9EURY/17-305 AC A0A1H4A6J9.1
#=GS T0AMA9_9RHOO/35-316 AC T0AMA9.1
#=GS A0A4Q9Q1B5_9APHY/54-338 AC A0A4Q9Q1B5.1
#=GS A0AAE7Y122_9CAUD/28-366 AC A0AAE7Y122.1
#=GS A0A1B9IKH1_9TREE/280-579 AC A0A1B9IKH1.1
#=GS A0A813B7Y0_9DINO/165-416 AC A0A813B7Y0.1
#=GS A0A165MIV9_9APHY/98-235 AC A0A165MIV9.1
#=GS A0A9N7Q9D1_9BACT/22-303 AC A0A9N7Q9D1.1
#=GS A0A1R4HZZ1_9MICO/1-221 AC A0A1R4HZZ1.1
#=GS A0A075E0Y9_9CAUD/27-367 AC A0A075E0Y9.1
#=GS A0A1Y1UFY5_9TREE/73-358 AC A0A1Y1UFY5.1
#=GS A0A0G4EY44_VITBC/34-344 AC A0A0G4EY44.1
#=GS A0A0D3JWC8_EMIH1/525-617 AC A0A0D3JWC8.1
#=GS S8EY74_FOMSC/26-308 AC S8EY74.1
#=GS A0A0X3W8S2_9ACTN/9-286 AC A0A0X3W8S2.1
#=GS A0AAD7D6Y3_MYCRO/74-362 AC A0AAD7D6Y3.1
#=GS A0AAD2HB01_9AGAR/54-133 AC A0AAD2HB01.1
#=GS A0A369JLL1_HYPMA/107-395 AC A0A369JLL1.1
#=GS A0A5C3EHP7_9BASI/86-369 AC A0A5C3EHP7.1
#=GS A0A0W7X8L7_9ACTN/9-286 AC A0A0W7X8L7.1
#=GS A0A559QPG2_9ALTE/17-298 AC A0A559QPG2.1
#=GS A0A387BDT0_9MICO/14-290 AC A0A387BDT0.1
#=GS A0A1Z5JFH2_FISSO/138-428 AC A0A1Z5JFH2.1
#=GS A0A5M3MT80_CONPW/13-290 AC A0A5M3MT80.1
#=GS F0YFZ2_AURAN/177-460 AC F0YFZ2.1
#=GS A0A8J2X752_9STRA/294-473 AC A0A8J2X752.1
#=GS A0A0P0C5I5_9BACT/14-292 AC A0A0P0C5I5.1
#=GS A0A4S4LAN5_9AGAM/41-321 AC A0A4S4LAN5.1
#=GS A0A7W5ASJ4_9ACTN/44-321 AC A0A7W5ASJ4.1
#=GS A0A9N9CBC9_9GLOM/204-407 AC A0A9N9CBC9.1
#=GS A0A5R9QDH5_9GAMM/24-305 AC A0A5R9QDH5.1
#=GS A0A2P0AY71_9SPHN/9-291 AC A0A2P0AY71.1
#=GS A0A385D3H3_9CAUD/4-268 AC A0A385D3H3.1
#=GS A0A9E9P463_9CAUD/16-307 AC A0A9E9P463.1
#=GS A0A4S4MDQ6_9AGAM/22-304 AC A0A4S4MDQ6.1
#=GS A0AA48I1Y8_9TREE/230-529 AC A0AA48I1Y8.1
#=GS A0A427Y5E4_9TREE/45-321 AC A0A427Y5E4.1
#=GS A0A3D9F9I8_9SPHN/37-319 AC A0A3D9F9I8.1
#=GS D0N3B1_PHYIT/194-469 AC D0N3B1.1
#=GS A0A4R0RKC1_9APHY/45-330 AC A0A4R0RKC1.1
#=GS A0A8K2A8Y6_9CYAN/27-100 AC A0A8K2A8Y6.1
#=GS A0A8H7U5N1_9APHY/525-636 AC A0A8H7U5N1.1
#=GS A0A4Q2DG84_9AGAR/1-113 AC A0A4Q2DG84.1
#=GS A0A7Z1AEB1_9GAMM/17-298 AC A0A7Z1AEB1.1
#=GS A0A8H6WWP3_9AGAR/68-362 AC A0A8H6WWP3.1
#=GS A0A501XPL6_9SPHN/52-333 AC A0A501XPL6.1
#=GS A0A225WU55_9STRA/279-447 AC A0A225WU55.1
#=GS A0A1Q9D278_SYMMI/599-895 AC A0A1Q9D278.1
#=GS A0A1Y2C3P8_9FUNG/74-373 AC A0A1Y2C3P8.1
#=GS A0A7L5DRR3_9BACT/14-291 AC A0A7L5DRR3.1
#=GS A0AAD4EJI7_9AGAM/45-321 AC A0AAD4EJI7.1
#=GS A0A9Q5HRT6_SANBA/121-406 AC A0A9Q5HRT6.1
#=GS A0A1X6N6L2_9APHY/525-636 AC A0A1X6N6L2.1
#=GS A0AA36J387_9DINO/28-362 AC A0AA36J387.1
#=GS A0A4R5DAN1_9ACTN/11-289 AC A0A4R5DAN1.1
#=GS A0A0L0HNA6_SPIPD/14-289 AC A0A0L0HNA6.1
#=GS A0A1Q5AZ98_9ACTN/11-288 AC A0A1Q5AZ98.1
#=GS A0A1H8SMC8_9BACI/230-510 AC A0A1H8SMC8.1
#=GS A0AA39MJC9_9AGAR/101-388 AC A0AA39MJC9.1
#=GS A0A285JAX4_9ACTN/44-321 AC A0A285JAX4.1
#=GS A0A2R5FH40_NOSCO/5-287 AC A0A2R5FH40.1
#=GS A0AAD9GJ79_9STRA/202-469 AC A0AAD9GJ79.1
#=GS A0A9W8K815_9AGAR/210-387 AC A0A9W8K815.1
#=GS A0A8T1X014_9STRA/191-466 AC A0A8T1X014.1
#=GS A0A5C3NBM2_9AGAM/29-308 AC A0A5C3NBM2.1
#=GS A0A1H7TP17_STIAU/39-316 AC A0A1H7TP17.1
#=GS A0A812VPS5_9DINO/700-764 AC A0A812VPS5.1
#=GS A0A9P5JVV9_9AGAM/42-330 AC A0A9P5JVV9.1
#=GS A0A7D3QK86_9CAUD/30-333 AC A0A7D3QK86.1
#=GS A0A409V9N2_9AGAR/98-385 AC A0A409V9N2.1
#=GS A0A060SM14_PYCCI/127-408 AC A0A060SM14.1
#=GS A0A8H4VVN8_9AGAR/83-369 AC A0A8H4VVN8.1
#=GS A0AAD7URV0_9STRA/302-593 AC A0AAD7URV0.1
#=GS A0A0B7FT16_THACB/190-477 AC A0A0B7FT16.1
#=GS A0A6A4I6C6_9AGAR/8-226 AC A0A6A4I6C6.1
#=GS A0A9N8W3Q7_9GLOM/127-384 AC A0A9N8W3Q7.1
#=GS A0A0D3KD61_EMIH1/25-98 AC A0A0D3KD61.1
#=GS A0A4Y9FMF8_9MICO/1-147 AC A0A4Y9FMF8.1
#=GS A0A401GVV8_9APHY/48-328 AC A0A401GVV8.1
#=GS A0A9P7RQ28_9AGAR/23-326 AC A0A9P7RQ28.1
#=GS A0A2H3BLF3_9AGAR/101-388 AC A0A2H3BLF3.1
#=GS A0A1I0J9P8_9BACT/44-325 AC A0A1I0J9P8.1
#=GS A0A4S4MWG3_9APHY/45-352 AC A0A4S4MWG3.1
#=GS A0A813FHD7_POLGL/53-121 AC A0A813FHD7.1
#=GS V9FD58_PHYNI/194-469 AC V9FD58.1
#=GS A0A200H2U3_9ACTN/14-290 AC A0A200H2U3.1
#=GS A0A1V1UV14_9CAUL/4-283 AC A0A1V1UV14.1
#=GS A0A4Y7QG94_9AGAM/33-314 AC A0A4Y7QG94.1
#=GS A0A8T1WAN3_9STRA/193-468 AC A0A8T1WAN3.1
#=GS A0A9W8JGV7_9AGAR/1-113 AC A0A9W8JGV7.1
#=GS A0A1Z5K9C5_FISSO/220-432 AC A0A1Z5K9C5.1
#=GS A0AAD5TKR2_9FUNG/40-315 AC A0AAD5TKR2.1
#=GS A0A9N9F410_9GLOM/47-304 AC A0A9N9F410.1
#=GS A0A067Q8V2_9AGAM/64-344 AC A0A067Q8V2.1
#=GS A0AA36NHR8_9DINO/212-326 AC A0AA36NHR8.1
#=GS A0A2P6NWZ1_9EUKA/14-316 AC A0A2P6NWZ1.1
#=GS A0A6J4EHX3_9CAUD/11-316 AC A0A6J4EHX3.1
#=GS A0A934MLY2_9HYPH/12-293 AC A0A934MLY2.1
#=GS A0A8H6HN95_9AGAR/1-268 AC A0A8H6HN95.1
#=GS A0A9P3GBX8_9APHY/46-328 AC A0A9P3GBX8.1
#=GS G4YU69_PHYSP/267-439 AC G4YU69.1
#=GS A0A1Q3E376_LENED/110-395 AC A0A1Q3E376.1
#=GS A0AAD7ABR9_9AGAR/72-363 AC A0AAD7ABR9.1
#=GS A0AAD7CAL0_9AGAR/59-348 AC A0AAD7CAL0.1
#=GS D3SXC8_NATMM/17-305 AC D3SXC8.1
#=GS S7RW32_GLOTA/26-285 AC S7RW32.1
#=GS A0A4S4LTD9_9AGAM/1-49 AC A0A4S4LTD9.1
#=GS A0A1Z5K9C5_FISSO/141-212 AC A0A1Z5K9C5.1
#=GS A0A2D0W946_9CAUD/2-328 AC A0A2D0W946.1
#=GS A0A166L2J5_9AGAM/54-339 AC A0A166L2J5.1
#=GS A0AAD5X4E6_9FUNG/54-123 AC A0AAD5X4E6.1
#=GS H3GCD3_PHYRM/189-464 AC H3GCD3.1
#=GS A0A550C5S8_9AGAR/69-355 AC A0A550C5S8.1
#=GS A0A061H389_9BASI/82-366 AC A0A061H389.1
#=GS A0A4Y9YW51_9AGAM/40-232 AC A0A4Y9YW51.1
#=GS A0A8H6WQJ7_MYCCL/69-382 AC A0A8H6WQJ7.1
#=GS A0A164R9D2_9AGAM/50-338 AC A0A164R9D2.1
#=GS A0A137QZR2_9AGAR/83-370 AC A0A137QZR2.1
#=GS A0A9Y1ALT5_9CAUD/28-368 AC A0A9Y1ALT5.1
#=GS A0A108T246_BACSE/6-289 AC A0A108T246.1
#=GS A0A1B6ZC16_9SPHN/21-302 AC A0A1B6ZC16.1
#=GS A0A0C3PUG2_PISTI/1-143 AC A0A0C3PUG2.1
#=GS A0A9P1D6G9_9DINO/300-626 AC A0A9P1D6G9.1
#=GS A0AAD3DDU1_9STRA/225-510 AC A0AAD3DDU1.1
#=GS A0A8J2SNN7_9STRA/248-438 AC A0A8J2SNN7.1
#=GS A0A1M2VPU2_TRAPU/12-116 AC A0A1M2VPU2.1
#=GS A0A9P7KJR1_9AGAR/96-383 AC A0A9P7KJR1.1
#=GS A0A519WK23_9SPHI/23-104 AC A0A519WK23.1
#=GS A0A0S0N2G3_BPPAM/2-283 AC A0A0S0N2G3.1
#=GS A0AAE8C7G6_9CAUD/28-366 AC A0AAE8C7G6.1
#=GS A0A4S8LW06_DENBC/102-388 AC A0A4S8LW06.1
#=GS A0A482MI17_9CAUD/4-282 AC A0A482MI17.1
#=GS A0A316FZ82_9GAMM/18-298 AC A0A316FZ82.1
#=GS A0A9E8MBP1_9CAUD/56-359 AC A0A9E8MBP1.1
#=GS A0AB74VLH6_CLOBE/9-289 AC A0AB74VLH6.1
#=GS A0A7W9XJU8_9SPHI/29-310 AC A0A7W9XJU8.1
#=GS A0A9E7MDL3_9CAUD/4-269 AC A0A9E7MDL3.1
#=GS A0A0C2YLJ1_HEBCY/50-316 AC A0A0C2YLJ1.1
#=GS W4JZ95_HETIT/34-316 AC W4JZ95.1
#=GS A0A0K6FWJ6_9AGAM/162-449 AC A0A0K6FWJ6.1
#=GS A0A813E875_POLGL/49-309 AC A0A813E875.1
#=GS F0YBB4_AURAN/723-1010 AC F0YBB4.1
#=GS A0A1H1NTI5_9BACT/29-308 AC A0A1H1NTI5.1
#=GS A0A562JKQ8_9FIRM/9-289 AC A0A562JKQ8.1
#=GS A0A662XY04_NOTX5/205-390 AC A0A662XY04.1
#=GS A0A0D0AZK5_9AGAR/109-394 AC A0A0D0AZK5.1
#=GS A0A6G8PVR8_9ACTN/34-313 AC A0A6G8PVR8.1
#=GS V2X840_MONRO/102-386 AC V2X840.1
#=GS A0A662XNE1_NOTX5/205-390 AC A0A662XNE1.1
#=GS M9M514_PSEA3/84-367 AC M9M514.1
#=GS A0A9P6HKT4_9AGAM/30-305 AC A0A9P6HKT4.1
#=GS A0A8H6ZMZ6_PLEOS/80-366 AC A0A8H6ZMZ6.1
#=GS B2ZYD4_9CAUD/45-336 AC B2ZYD4.1
#=GS A0A6G6XTN6_9CAUD/28-366 AC A0A6G6XTN6.1
#=GS A0AAD5X1T8_9FUNG/78-173 AC A0AAD5X1T8.1
#=GS A0A1Q9F746_SYMMI/102-364 AC A0A1Q9F746.1
#=GS A0A543KSG1_9MICO/8-289 AC A0A543KSG1.1
#=GS A0A9E7DT47_9CAUD/42-332 AC A0A9E7DT47.1
#=GS A0A1L2C957_9CAUD/1-283 AC A0A1L2C957.1
#=GS A0A8S0XHG5_CYCAE/112-397 AC A0A8S0XHG5.1
#=GS A0AAD3TPW4_9TREE/230-531 AC A0AAD3TPW4.1
#=GS A0A1Q9DCP9_SYMMI/81-153 AC A0A1Q9DCP9.1
#=GS A0A8I2YW91_9AGAM/1-143 AC A0A8I2YW91.1
#=GS A0A8H6WVZ6_9AGAR/111-384 AC A0A8H6WVZ6.1
#=GS A0A812WPT2_SYMPI/1183-1437 AC A0A812WPT2.1
#=GS A0A926XEZ0_9CYAN/54-335 AC A0A926XEZ0.1
#=GS A0A0C3EKA6_9AGAM/44-323 AC A0A0C3EKA6.1
#=GS A0A401UD37_9BACT/28-307 AC A0A401UD37.1
#=GS A0A166F5D7_9AGAM/52-337 AC A0A166F5D7.1
#=GS A0A345YJM1_9SPHN/9-288 AC A0A345YJM1.1
#=GS A0A5C3L8Q1_COPMA/177-499 AC A0A5C3L8Q1.1
#=GS A0A0D0E8R8_9AGAM/6-285 AC A0A0D0E8R8.1
#=GS A0A327KQQ4_9HYPH/30-311 AC A0A327KQQ4.1
#=GS A0A8H6Z9C3_9AGAR/81-371 AC A0A8H6Z9C3.1
#=GS A0A9W6WTB4_9STRA/5-168 AC A0A9W6WTB4.1
#=GS A0A916Q568_9CYAN/46-327 AC A0A916Q568.1
#=GS A0AAD5M0T3_PYTIN/169-442 AC A0AAD5M0T3.1
#=GS A0A9W4SEG4_9GLOM/76-277 AC A0A9W4SEG4.1
#=GS A0AAF0Y9K0_9TREE/93-391 AC A0AAF0Y9K0.1
#=GS A0A7S5QVJ9_9CAUD/40-324 AC A0A7S5QVJ9.1
#=GS A0A977XSR3_9CAUD/42-336 AC A0A977XSR3.1
#=GS A0AAE0G6M0_9CHLO/10-266 AC A0AAE0G6M0.1
#=GS Q13ZS4_PARXL/31-310 AC Q13ZS4.1
#=GS A0A448Z8S8_9STRA/177-418 AC A0A448Z8S8.1
#=GS A0A812HS62_9DINO/3-231 AC A0A812HS62.1
#=GS A0A2N9JF68_9ACTN/14-290 AC A0A2N9JF68.1
#=GS A0A1H7RZN2_9PROT/17-298 AC A0A1H7RZN2.1
#=GS A0A1J8QUD7_9AGAM/46-324 AC A0A1J8QUD7.1
#=GS C8XUN9_9CAUD/28-366 AC C8XUN9.1
#=GS A0A812QV69_9DINO/95-167 AC A0A812QV69.1
#=GS A0A0D3JRB3_EMIH1/25-97 AC A0A0D3JRB3.1
#=GS A0A2A9N7X8_9AGAR/5-268 AC A0A2A9N7X8.1
#=GS A0A0N7CEU5_9CAUD/27-366 AC A0A0N7CEU5.1
#=GS A0AAD6XMW5_9AGAR/79-368 AC A0AAD6XMW5.1
#=GS A0A515KFT5_9BRAD/1-269 AC A0A515KFT5.1
#=GS A0A0G4FE47_VITBC/198-306 AC A0A0G4FE47.1
#=GS A0A9P7FHG6_9AGAM/46-322 AC A0A9P7FHG6.1
#=GS A0AAD5SU84_9FUNG/628-916 AC A0AAD5SU84.1
#=GS A0AAD6YLK0_9AGAR/117-416 AC A0AAD6YLK0.1
#=GS A0A0D3K900_EMIH1/1-84 AC A0A0D3K900.1
#=GS A0A2T8HH12_9SPHI/14-292 AC A0A2T8HH12.1
#=GS J4GL27_9APHY/253-358 AC J4GL27.1
#=GS K7YIT3_9CAUD/28-365 AC K7YIT3.1
#=GS A0A0S7C557_9BACT/6-288 AC A0A0S7C557.1
#=GS A0A5E3X2S8_9AGAM/55-344 AC A0A5E3X2S8.1
#=GS A0AAD2Q361_9AGAR/1-165 AC A0AAD2Q361.1
#=GS A0A0C3NX44_PHLG1/59-341 AC A0A0C3NX44.1
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A0A917P897_9ACTN/9-286 ............................................................................TPVFDTYWRFAAARQKVYEAR..L.......AG.GAG.......P..........FTD..D......P.......ILQ.RHR..FT..NCFRAADRVSQDLIG........GV...............I..Y.....R....G.....E..Q.......A..........W..E........E.............VF....F.R..TLLFKI..FN.KTS.............TWR......LL......NG..AL.G.....E....V.R..-WD...AY.................DY.RA.F....DR.V.LSQ..A..F...A.A......G.........Q..RL..Y....SAA...YIV.PP........PQF....................................................G..EER.......KHQNH.....................LRLLE.MMM.................KAD.A.........PQ.RVLSA..P.T..LQGAYQVLLG...FP..AI..GP..........FLA......................YQFVID.L................N.Y...........A......AA.....M......P......F.............SE.................M.D..FV..........VPGPGARDGIR.KCF.GP-..................................AAD.GIE.A.DAI.R...YMADT.......QDEHF.ARL..GLA...FTGL......................-R..GRPLQLIDCQ....NL.FCEVDKYARVAHPDIA-g..........................................
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A0A1B7NG63_9AGAM/82-360 ............................................................................TPVFDTFWRFAAERHAITEKR..L.......KD.VPA.......P..........WTD..D......P.......TLQ.RYP..FC..NTYRVLDRVSQYLIA........EV...............I..Q.....K....G.....S..Q.......A..........S..T........E.............LV....F.R..ILLFST..FT.SIN.............TYE......TM......RD..EM.S.....P....L.-..TWS...TY.................KR.AN.Y....ER.I.LRR..L..Y...D.D......R.........V..SI..Y....TGA...YQK.PA........PNL....................................................G..FAE.......NFMNH.....................LALIE.VLM.................RD-.L.........PE.KCEEA..E.Y..IADVFEWLCT...FK..SM..GD..........FTA......................YQLVLN.L................S.Y...........S......SV.....L......N......F.............SD.................Y.D..FV..........VVGLGSRRGLQ.RCF.KGQ..................................IPR.AYE.V.DII.R...WMQLT.......QPDHF.SRL..NLK...FKGL......................GL.kARPMMLCDIE....HT.LCEIDKYVRK-------lgtpsh.....................................
A0A7W9ALF2_9SPHN/14-294 ............................................................................TPVYDLYWRFATERQAIFMRR..L.......RG.EAA.......P..........WTY..D......P.......IFQ.RHR..FT..NAYRASDRVSQYLIR........EV...............I..Y.....N....Pa...hP..D.......I..........A..I........E.............TV....F.R..ILLFKL..FN.KVE.............TWN......ML......ER..EL.G.....P....P.S..-WQ...SF.................DI.ER.Y....AK.V.LGD..A..I...D.A......G.........R..RI..Y....SPA...YIM.PP........VSL....................................................G..RGG......pKHVGH.....................LKLID.LIL.................RSD.F.........VA.RLQQS..R.S..LDEVFGLLKA...FP..SL..GD..........FLA......................FQLAID.L................N.Y...........S......MV.....I......N......H.............DE.................A.D..FV..........VAGPGARDGLA.KTF.VD-..................................AAG.VDP.V.DLI.R...LMRDR.......QQAEF.DRL..DLA...FEDL......................-W..GRPLQLIDCQ....NL.FCEISKYTRVSHPDIM-g..........................................
A0A8H7XMN5_PSICU/131-419 ...........................................................................t-VAFDTFWRFAAERKAIDDRR..R.......AG.QSP.......P..........FTE..D......K.......ILR.DYF..FC..NTYRVLDKLSQYLIK........EV...............I..E.....K....G.....S..Q.......D..........P..E........E.............VV....F.R..VLLFNS..FT.RIE.............TWE......LL......DR..EL.G.....P....L.-..TWA...TY.................DR.DA.Y....MV.V.LAA..A..S...E.S......G.........A..KL..Y....TGA...FIK.PA........PHF....................................................G..YAH.......NYANH.....................LCLLE.AFM.................INQ.L.........HA.RLRAA..P.Y..LANVYEYIIA...FP..SM..GA..........FST......................YQLILS.L................S.Y...........T......KV.....L......N......F.............HP.................G.D..LV..........VSGPGSESGLN.KLF.GARamar..........................graqMGD.EFE.A.EVI.R...YLAAS.......QAYHF.QRL..GLE...FSGL......................GP.kRLPMTVVDIE....HT.LCEVDKYCRVAHPQLKG...........................................
A0AAD4C7N9_BOLED/49-328 ............................................................................TQAFDTFWRWAGERHAIDEKR..R.......AG.LPS.......P..........WST..D......P.......ILA.SNK..FC..NAFRVLDRVSQYIVA........EV...............I..E.....K....G.....P..Q.......R..........R..E........E.............VT....F.R..VLLFST..YT.SIR.............TYE......TL......RK..NI.Q.....P....F.-..TWQ...AY.................KR.AN.Y....ER.V.LRD..L..Y...N.K......G.........T..AI..Y....TGA...YQK.PA........PEL....................................................G..FAE.......NFMNH.....................LAFLE.VLM.................RE-.L.........PA.QLRDA..K.Y..LADIFEYLLT...YK..SM..GD..........FTA......................YQLVLN.L................S.Y...........S......DV.....I......H......F.............CE.................H.D..FV..........VIGLGSRRGLQ.RCF.RDA..................................IPR.SVE.V.DIV.R...WMQIT.......QHEHF.DRL..GIK...FNGL......................GP.nGLPMMLCDIE....HA.LCELDKYIRQCTKK---spg........................................
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A0A8J2SA89_9STRA/569-863 .......................................................................sdltm-----RFLDMLRARDSIRIQK..A.......AG.APW.......P..........WSG..D......D.......VLN.CHK..FT..NVKREHDRVTAWLRA........HW...............T..E.....P....H.....A.dA.......D..........A..A........T.............VL....F.N..CGVFRT..FG.TVA.............FAE......AL......--..--.G.....W....T.H..SLD...EW.................DA.AK.A....RA.A.AVA..C..W...R.G......G.........R..HA..F....TRA...YCR.PR........FNAerr.............................................rgdaG..--Arp..pvdVYDGA.....................IRILA.AL-.................RGE.C.........HN.VMDRG..G.S..WRAVCTRLRR...VA..GF..GGs........gFMA......................KEVLHDaM................G.W...........A......SVr...aL......V......R.............DA.................G.D..WT..........PPGPGARRGLN.RLH.GRAldlg..........................alapADS.PGE.A.RFI.-...-----.......-----.KEM..GLL...LGALrds...............drafCS..SLELDIHDVQ....FQ.LCEYDKYCRAA------gegrg......................................
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A0A5E3WQK0_9AGAM/66-348 ........................................................................sevv-----DLLYFVTERHRIFRER..L.......EG.KPA.......P..........WTK..D......V.......LLQ.QRH..FT..NVFRVLDRCSQYCLS........HV...............I..R.....E....G.....P..A.......V..........F..K........E.............QV....F.R..VVAYSIlgFN.-PV.............TYG......YL......EK..TF.G.....S....P.L..LLE...SY.................DE.HA.W....TR.A.LSS..I..N...F.S......-.........-..-I..G....RGA...YQI.PA........PTVd.................................................qiG..EGT.......YCARL.....................VRLVS.LMV.................KSE.V.........DL.ALEGC..K.H..LRDLHIIISS...YP..SM..TA..........FLG......................YQVVLN.L................N.M...........I......PA.....L......S......C.............PE.................D.-..WA..........QPGPGAVKGLR.AIF.GDD..................................LGT.QMM.V.PAM.E...WLRKH.......FSELA.IEA..GYP...MRQVp...................alKA.dSPGFTLCDIE....HL.LCEFHKYR---------sapsdgkg...................................
A0AA38PIU6_9AGAR/1-259 ...........................................................................r---------------------..-.......--.---.......-..........WTN..D......K.......VLR.TKF..FC..NTYRVLDKTSQFIIA........EV...............V..Q.....K....G.....S..Q.......E..........P..V........E.............IV....F.R..VFLFSI..FT.KIE.............TWQ......WL......EE..RL.G.....S....I.T..-WK...DY.................SR.ER.Y....TA.L.LAK..R..A...Q.T......-.........H..TL..Y....TGA...FQS.PG........PKW....................................................E..YQE.......TYRNH.....................LLLLE.TIM.................AND.L.........AG.KLQKF..K.T..MGDAYAYIAS...FP..SM..GD..........FKS......................YQLLLN.L................S.Y...........S......SV.....I......N......F.............SG.................N.D..FV..........IPGIGAVSGLA.KMF.GKSiee............................aarVDP.NVR.I.AVI.R...YMMET.......QQQHF.RRL..NLD...FSGL......................GP.dQLPMELADIE....HA.ICEVDKYSRKVHPHI--vd.........................................
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A0A8H5FA94_9AGAR/137-424 ...........................................................................t-IAFDTFWRVSAERKAMDDRR..R.......AG.LPA.......P..........WTN..D......P.......ILR.DYH..FC..NTFRVLDKGCQYLIT........DV...............I..Q.....K....G.....P..Q.......D..........P..T........E.............VV....F.R..VILFDL..FT.KIE.............TWE......LL......NS..SV.G.....P....L.-..TWK...SY.................DR.DR.Y....AD.V.LRC..A..K...Q.D......G.........I..AL..Y....TGA...FIK.PA........PKF....................................................R..DSD.......NFMNH.....................LYLLE.HFM.................AEL.L.........PE.RLLGA..K.Y..MDDVYEYLIS...FP..SM..GP..........FTA......................YQLMLG.L................S.Y...........T......NV.....L......N......F.............HP.................N.D..FA..........MAGPGSISGAN.KLF.GEKnmr...........................kgrvSNP.RFD.E.EVM.R...YMAEN.......QDYHF.KRL..GLN...FAGL......................GP.qKLPMSVVDIE....HM.LCEVDKYSREAHKNLKG...........................................
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A0A813B7Y0_9DINO/81-153 ........................................................................vdvm-----EFYAFMWRREGLRRRRelL.......RL.PPE.......Q..........WTH..D......T.......VMA.RIR..LT..NVKREDDRTTRVM-R........KI...............C..N.....R....Y.....-..-.......-..........-..-........-.............--....-.-..------..--.---.............---......--......--..--.-.....-....-.-..---...--.................--.--.-....--.-.---..-..-...-.-......-.........-..--..-....---...---.--........---....................................................-..---.......-----.....................-----.---.................---.-.........--.-----..-.-..----------...--..--..--..........---......................------.-................-.-...........-......--.....-......-......-.............--.................-.-..--..........-----------.---.---..................................---.---.-.---.-...-----.......-----.---..---...----......................--..----------....--.-----------------vdehpelkmlr................................
A0AAE0BAM9_9CHLO/99-218 .........................................................................dpv----ASFFDFCREREKVRQQR..E.......RG.AEP.......P..........WSD..D......P.......IFQ.NAR..FL..NVFREDDRGTKAILK........FV...............G..P.....L....V.....E.kG.......D..........L..T........A.............LV....H.G..LFFARW..CN.KQA.............TLD......AL......T-..--.-.....-....-.-..---...--.................--.--.-....--.-.---..-..-...-.-......-.........-..--..-....---...---.--........---....................................................-..---.......-----.....................-----.---.................---.-.........--.-----..-.-..----------...--..--..--..........---......................------.-................-.-...........-......--.....-......-......-.............--.................-.-..--..........-----------.---.---..................................---.---.-.---.-...-----.......-----.---..---...----......................--..----------....--.-----------------pdlllqpeklkevleslpdqpwcnvaaypve............
A0A9P5Y6Y7_9AGAR/93-379 ...........................................................................t-VVFDTFWRFAAERKAIDDRR..R.......LG.LPS.......P..........WTD..D......V.......FMR.KYA..FC..NTYRVLDKVSQYIIR........EV...............I..E.....K....G.....P..Q.......E..........P..Q........E.............VV....F.R..IALFNM..FT.KID.............TWE......LL......DN..EL.G.....P....L.-..TWE...RY.................DR.DA.Y....RK.V.LTK..A..K...K.Q......G.........M..TL..Y....TGA...FQK.PA........PHF....................................................G..FHD.......AHSNH.....................LCLLE.ILM.................EAD.L.........PR.RFSGA..R.Y..MDEVYEYLVS...FP..SM..GA..........FST......................FQLMLN.L................S.Y...........S......EV.....L......N......F.............SD.................M.D..FV..........VAGPGAHSGLT.KMF.GLSmkc............................ardRVH.GIE.I.NVI.R...WLAQH.......QDEHF.QRL..GLD...FQGL......................GP.dRLPMSLADIE....HL.LCEVDKYSRLAHPHIK-s..........................................
A0A8J2X1J6_9STRA/431-612 ........................................afaetlwdlgkpkfagsfqnqgkrlltylplrlyei---------------------..-.......--.---.......-..........---..-......-.......---.---..--..---------------........--...............-..-.....-....-.....-..-.......-..........-..-........-.............--....-.-..------..--.---.............---......--......--..--.-.....-....-.-..---...--.................--.--.-....--.-.---..-..-...-.-......-.........-..--..-....---...---.--........---....................................................-..---.......-----.....................-----.---.................-DD.V.........VA.ALRAA..R.T..WADACDALLI...LS..GV..GD..........YVG......................GQALCT.Fffgvc......kgdvsR.F...........A......PN.....L......D......A.............TT.................M.K.sFC..........LCGPGPEGVVQ.KMW.GGV.................................qLGK.SEA.V.KRL.A...WLAEN.......AEARF.QAL..GLR...FPFQqd..................adGK..RKRLTAVDLE....HA.LCYFSRYLS-AHDSL--ka.........................................
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A0A5E3XS85_9AGAM/55-339 ..........................................................................sg---IDTFLHYVIERHKAFERR..Y.......AG.KLG.......P..........WTD..D......P.......ILQ.MAR..FT..NNFRILDKDTQYILV........AV...............I..P.....G....G.....S..S.......N..........F..K........E.............CV....F.R..VLLFRL..FD.RIE.............TYE......FL......RD..EV.G.....P....L.-..TWK...GF.................NR.EA.Y....VE.A.LDR..R..V...A.A......R.........Y..SI..V....GHA...YQM.PS........PTPk.................................................tiG..GAS.......HHDRI.....................LRLLE.LMM.................LSG.F.........AD.DLSEC..Y.E..LCDMQAKIAL...YP..SM..RA..........FLG......................YQVILD.L................N.M...........I......PA.....L......M......V.............PE.................D.-..WA..........LPGPGAVSGLR.MIL.GKS..................................LRG.EHI.G.PAL.S...WMHEH.......FDELA.FAA..GYT...KKDIp...................alKP.sMPGLSIVDIE....HV.LCEFSKYVKIKSPA---syn........................................
A0A284RI27_ARMOS/101-388 ...........................................................................t-KGFNIFWYWCAERKLIDDRR..R.......TG.LPV.......P..........WTD..D......A.......ILR.DNF..FC..NTFRVLDQVSQFIIK........EV...............I..E.....K....G.....P..S.......E..........P..R........E.............IL....F.R..VLLFNM..FT.RPA.............TWE......YL......EK..EL.G.....P....L.-..TWK...SY.................DQ.GK.Y....FS.V.LSK..A..K...K.R......G.........M..KL..Y....TGA...FQK.PA........PIF....................................................G..LGD.......NFKNH.....................LALLE.VWM................tRDQ.L.........LD.HINKA..Y.Y..LADVFEFIAS...FP..GM..AD..........FTG......................YQLLLN.L................G.Y...........T......EL.....L......Q......F.............SG.................M.D..FV..........VPGLGAQSGLV.KLF.GGSlkk............................arvNVP.GIE.V.DII.E...WMTKH.......QKQHF.QRL..GLQ...CPVL......................GR.dKLTMELADVE....HA.ICEVDKYLRMSHPSLKG...........................................
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