KEGG   Perognathus longimembris pacificus (Pacific pocket mouse): 125351954
Entry
125351954         CDS       T08928                                 
Symbol
Pik3ca
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
plop  Perognathus longimembris pacificus (Pacific pocket mouse)
Pathway
plop00562  Inositol phosphate metabolism
plop01100  Metabolic pathways
plop01521  EGFR tyrosine kinase inhibitor resistance
plop01522  Endocrine resistance
plop01524  Platinum drug resistance
plop04012  ErbB signaling pathway
plop04014  Ras signaling pathway
plop04015  Rap1 signaling pathway
plop04024  cAMP signaling pathway
plop04062  Chemokine signaling pathway
plop04066  HIF-1 signaling pathway
plop04068  FoxO signaling pathway
plop04070  Phosphatidylinositol signaling system
plop04071  Sphingolipid signaling pathway
plop04072  Phospholipase D signaling pathway
plop04081  Hormone signaling
plop04140  Autophagy - animal
plop04145  Phagocytosis
plop04150  mTOR signaling pathway
plop04151  PI3K-Akt signaling pathway
plop04152  AMPK signaling pathway
plop04210  Apoptosis
plop04211  Longevity regulating pathway
plop04213  Longevity regulating pathway - multiple species
plop04218  Cellular senescence
plop04360  Axon guidance
plop04370  VEGF signaling pathway
plop04380  Osteoclast differentiation
plop04510  Focal adhesion
plop04517  IgSF CAM signaling
plop04518  Integrin signaling
plop04550  Signaling pathways regulating pluripotency of stem cells
plop04611  Platelet activation
plop04613  Neutrophil extracellular trap formation
plop04620  Toll-like receptor signaling pathway
plop04625  C-type lectin receptor signaling pathway
plop04630  JAK-STAT signaling pathway
plop04650  Natural killer cell mediated cytotoxicity
plop04660  T cell receptor signaling pathway
plop04662  B cell receptor signaling pathway
plop04664  Fc epsilon RI signaling pathway
plop04666  Fc gamma R-mediated phagosome formation
plop04668  TNF signaling pathway
plop04670  Leukocyte transendothelial migration
plop04722  Neurotrophin signaling pathway
plop04725  Cholinergic synapse
plop04750  Inflammatory mediator regulation of TRP channels
plop04810  Regulation of actin cytoskeleton
plop04910  Insulin signaling pathway
plop04914  Progesterone-mediated oocyte maturation
plop04915  Estrogen signaling pathway
plop04917  Prolactin signaling pathway
plop04919  Thyroid hormone signaling pathway
plop04923  Regulation of lipolysis in adipocytes
plop04926  Relaxin signaling pathway
plop04929  GnRH secretion
plop04930  Type II diabetes mellitus
plop04931  Insulin resistance
plop04932  Non-alcoholic fatty liver disease
plop04933  AGE-RAGE signaling pathway in diabetic complications
plop04935  Growth hormone synthesis, secretion and action
plop04960  Aldosterone-regulated sodium reabsorption
plop04973  Carbohydrate digestion and absorption
plop05010  Alzheimer disease
plop05017  Spinocerebellar ataxia
plop05020  Prion disease
plop05100  Bacterial invasion of epithelial cells
plop05132  Salmonella infection
plop05135  Yersinia infection
plop05142  Chagas disease
plop05146  Amoebiasis
plop05160  Hepatitis C
plop05161  Hepatitis B
plop05162  Measles
plop05163  Human cytomegalovirus infection
plop05164  Influenza A
plop05165  Human papillomavirus infection
plop05166  Human T-cell leukemia virus 1 infection
plop05167  Kaposi sarcoma-associated herpesvirus infection
plop05168  Herpes simplex virus 1 infection
plop05169  Epstein-Barr virus infection
plop05170  Human immunodeficiency virus 1 infection
plop05171  Coronavirus disease
plop05200  Pathways in cancer
plop05203  Viral carcinogenesis
plop05205  Proteoglycans in cancer
plop05206  MicroRNAs in cancer
plop05207  Chemical carcinogenesis - receptor activation
plop05208  Chemical carcinogenesis - reactive oxygen species
plop05210  Colorectal cancer
plop05211  Renal cell carcinoma
plop05212  Pancreatic cancer
plop05213  Endometrial cancer
plop05214  Glioma
plop05215  Prostate cancer
plop05218  Melanoma
plop05220  Chronic myeloid leukemia
plop05221  Acute myeloid leukemia
plop05222  Small cell lung cancer
plop05223  Non-small cell lung cancer
plop05224  Breast cancer
plop05225  Hepatocellular carcinoma
plop05226  Gastric cancer
plop05230  Central carbon metabolism in cancer
plop05231  Choline metabolism in cancer
plop05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
plop05415  Diabetic cardiomyopathy
plop05417  Lipid and atherosclerosis
plop05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:plop00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    125351954 (Pik3ca)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    125351954 (Pik3ca)
   04014 Ras signaling pathway
    125351954 (Pik3ca)
   04015 Rap1 signaling pathway
    125351954 (Pik3ca)
   04370 VEGF signaling pathway
    125351954 (Pik3ca)
   04630 JAK-STAT signaling pathway
    125351954 (Pik3ca)
   04668 TNF signaling pathway
    125351954 (Pik3ca)
   04066 HIF-1 signaling pathway
    125351954 (Pik3ca)
   04068 FoxO signaling pathway
    125351954 (Pik3ca)
   04070 Phosphatidylinositol signaling system
    125351954 (Pik3ca)
   04072 Phospholipase D signaling pathway
    125351954 (Pik3ca)
   04071 Sphingolipid signaling pathway
    125351954 (Pik3ca)
   04024 cAMP signaling pathway
    125351954 (Pik3ca)
   04151 PI3K-Akt signaling pathway
    125351954 (Pik3ca)
   04152 AMPK signaling pathway
    125351954 (Pik3ca)
   04150 mTOR signaling pathway
    125351954 (Pik3ca)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    125351954 (Pik3ca)
   04517 IgSF CAM signaling
    125351954 (Pik3ca)
   04518 Integrin signaling
    125351954 (Pik3ca)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    125351954 (Pik3ca)
   04140 Autophagy - animal
    125351954 (Pik3ca)
  09143 Cell growth and death
   04210 Apoptosis
    125351954 (Pik3ca)
   04218 Cellular senescence
    125351954 (Pik3ca)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    125351954 (Pik3ca)
   04550 Signaling pathways regulating pluripotency of stem cells
    125351954 (Pik3ca)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    125351954 (Pik3ca)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    125351954 (Pik3ca)
   04613 Neutrophil extracellular trap formation
    125351954 (Pik3ca)
   04620 Toll-like receptor signaling pathway
    125351954 (Pik3ca)
   04625 C-type lectin receptor signaling pathway
    125351954 (Pik3ca)
   04650 Natural killer cell mediated cytotoxicity
    125351954 (Pik3ca)
   04660 T cell receptor signaling pathway
    125351954 (Pik3ca)
   04662 B cell receptor signaling pathway
    125351954 (Pik3ca)
   04664 Fc epsilon RI signaling pathway
    125351954 (Pik3ca)
   04666 Fc gamma R-mediated phagosome formation
    125351954 (Pik3ca)
   04670 Leukocyte transendothelial migration
    125351954 (Pik3ca)
   04062 Chemokine signaling pathway
    125351954 (Pik3ca)
  09152 Endocrine system
   04910 Insulin signaling pathway
    125351954 (Pik3ca)
   04923 Regulation of lipolysis in adipocytes
    125351954 (Pik3ca)
   04929 GnRH secretion
    125351954 (Pik3ca)
   04915 Estrogen signaling pathway
    125351954 (Pik3ca)
   04914 Progesterone-mediated oocyte maturation
    125351954 (Pik3ca)
   04917 Prolactin signaling pathway
    125351954 (Pik3ca)
   04926 Relaxin signaling pathway
    125351954 (Pik3ca)
   04935 Growth hormone synthesis, secretion and action
    125351954 (Pik3ca)
   04919 Thyroid hormone signaling pathway
    125351954 (Pik3ca)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    125351954 (Pik3ca)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    125351954 (Pik3ca)
  09156 Nervous system
   04725 Cholinergic synapse
    125351954 (Pik3ca)
   04722 Neurotrophin signaling pathway
    125351954 (Pik3ca)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    125351954 (Pik3ca)
  09158 Development and regeneration
   04360 Axon guidance
    125351954 (Pik3ca)
   04380 Osteoclast differentiation
    125351954 (Pik3ca)
  09149 Aging
   04211 Longevity regulating pathway
    125351954 (Pik3ca)
   04213 Longevity regulating pathway - multiple species
    125351954 (Pik3ca)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    125351954 (Pik3ca)
   05206 MicroRNAs in cancer
    125351954 (Pik3ca)
   05205 Proteoglycans in cancer
    125351954 (Pik3ca)
   05207 Chemical carcinogenesis - receptor activation
    125351954 (Pik3ca)
   05208 Chemical carcinogenesis - reactive oxygen species
    125351954 (Pik3ca)
   05203 Viral carcinogenesis
    125351954 (Pik3ca)
   05230 Central carbon metabolism in cancer
    125351954 (Pik3ca)
   05231 Choline metabolism in cancer
    125351954 (Pik3ca)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    125351954 (Pik3ca)
  09162 Cancer: specific types
   05210 Colorectal cancer
    125351954 (Pik3ca)
   05212 Pancreatic cancer
    125351954 (Pik3ca)
   05225 Hepatocellular carcinoma
    125351954 (Pik3ca)
   05226 Gastric cancer
    125351954 (Pik3ca)
   05214 Glioma
    125351954 (Pik3ca)
   05221 Acute myeloid leukemia
    125351954 (Pik3ca)
   05220 Chronic myeloid leukemia
    125351954 (Pik3ca)
   05218 Melanoma
    125351954 (Pik3ca)
   05211 Renal cell carcinoma
    125351954 (Pik3ca)
   05215 Prostate cancer
    125351954 (Pik3ca)
   05213 Endometrial cancer
    125351954 (Pik3ca)
   05224 Breast cancer
    125351954 (Pik3ca)
   05222 Small cell lung cancer
    125351954 (Pik3ca)
   05223 Non-small cell lung cancer
    125351954 (Pik3ca)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    125351954 (Pik3ca)
   05170 Human immunodeficiency virus 1 infection
    125351954 (Pik3ca)
   05161 Hepatitis B
    125351954 (Pik3ca)
   05160 Hepatitis C
    125351954 (Pik3ca)
   05171 Coronavirus disease
    125351954 (Pik3ca)
   05164 Influenza A
    125351954 (Pik3ca)
   05162 Measles
    125351954 (Pik3ca)
   05168 Herpes simplex virus 1 infection
    125351954 (Pik3ca)
   05163 Human cytomegalovirus infection
    125351954 (Pik3ca)
   05167 Kaposi sarcoma-associated herpesvirus infection
    125351954 (Pik3ca)
   05169 Epstein-Barr virus infection
    125351954 (Pik3ca)
   05165 Human papillomavirus infection
    125351954 (Pik3ca)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    125351954 (Pik3ca)
   05135 Yersinia infection
    125351954 (Pik3ca)
   05100 Bacterial invasion of epithelial cells
    125351954 (Pik3ca)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    125351954 (Pik3ca)
   05142 Chagas disease
    125351954 (Pik3ca)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    125351954 (Pik3ca)
   05017 Spinocerebellar ataxia
    125351954 (Pik3ca)
   05020 Prion disease
    125351954 (Pik3ca)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    125351954 (Pik3ca)
   05418 Fluid shear stress and atherosclerosis
    125351954 (Pik3ca)
   05415 Diabetic cardiomyopathy
    125351954 (Pik3ca)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    125351954 (Pik3ca)
   04932 Non-alcoholic fatty liver disease
    125351954 (Pik3ca)
   04931 Insulin resistance
    125351954 (Pik3ca)
   04933 AGE-RAGE signaling pathway in diabetic complications
    125351954 (Pik3ca)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    125351954 (Pik3ca)
   01524 Platinum drug resistance
    125351954 (Pik3ca)
   01522 Endocrine resistance
    125351954 (Pik3ca)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:plop04131]
    125351954 (Pik3ca)
Enzymes [BR:plop01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     125351954 (Pik3ca)
Membrane trafficking [BR:plop04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    125351954 (Pik3ca)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1
Other DBs
NCBI-GeneID: 125351954
NCBI-ProteinID: XP_048203038
Position
5:complement(67541779..67610289)
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLVTIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFV
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRAFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRQPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccacgaccatcatcaggtgaactgtggggcatccatttgatgcccccaagaatc
ctagtagaatgtttactacccaatggaatgatagtgactttagaatgcctccgtgaggct
acattagtaactataaagcatgaactatttaaggaagcaagaaaataccctctccatcaa
cttcttcaagatgaatcttcttacatttttgtaagtgttactcaagaagcagaaagggaa
gaattttttgatgaaacaagaagactttgtgaccttcggcttttccaaccctttttaaaa
gtaattgaaccagtaggcaatcgtgaagaaaagatcctcaatcgagaaatcggttttgtt
attggcatgccagtgtgtgaatttgatatggttaaagacccggaagtacaggacttccga
agaaacattctgaatgtttgtaaagaagctgtggatctcagagatctcaattcacctcac
agtagagcaatgtatgtttatcccccaaatgtggaatcttcaccagaattgccaaagcac
atatataataaattagataaaggacaaataatagtagtgatttgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaaccatgactgtgtacctgaacaagtg
attgctgaagcaatccggaaaaaaactcgaagtatgttgctgtcctcagaacaactaaaa
ctctgtgttttagaatatcagggcaagtatattttaaaagtgtgtggctgtgatgaatac
ttcctagaaaagtacccactgagtcagtacaagtatataagaagttgtataatgcttggg
aggatgcctaatttgatgctgatggctaaagaaagcctttactctcagctgccaatggac
tgttttacaatgccatcttactctagacgcatttccacagctacaccttatatgaatgga
gaaacatctacaaaatccctttgggttataaatagtgcactcagaataaaaattctttgt
gcaacttatgtaaatgtaaatattcgagacattgataagatatatgttcggactggtatc
taccatggaggtgaacccttatgtgacaatgtgaacactcaaagagtaccttgttccaat
cccaggtggaatgaatggctgaattatgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgctctgttaaaggccgaaagggtgctaaagaggagcactgt
ccattggcctggggaaacataaacttgttcgattacactgatacccttgtatctggaaaa
atggctttgaatctttggccagtgcctcatggactagaagatttactgaaccctattggt
gttactgggtcaaatccaaataaagaaactccatgcttggagttggagtttgattggttc
agcagtgtggtgaagtttccagatatgtcagtgattgaagagcatgccaattggtctgtg
tctcgagaagcagggtttagttactcccatgcaggcctgagtaacagattagctagagat
aatgaattacgagagaacgataaagaacaacttcgagcaatttgtacacgggatccgcta
tctgaaatcactgagcaagagaaagatttcctttggagccacagacactattgtgtaacc
attcctgaaattctacccaaattgcttctgtcagttaaatggaattctagagatgaagta
gctcagatgtactgcttagtaaaagattggcctccaatcaaaccagaacaggctatggag
cttttggactgtaattacccagatcctatggttcgagcttttgctgttcggtgcttggaa
aagtatttaacagatgataaactttctcagtacttaattcagctagtacaggttctaaaa
tatgagcaatatttggacaatctgcttgtgagatttttactcaagaaagcattgacaaat
caaaggattggacactttttcttttggcatttaaaatctgaaatgcacaacaaaacagtt
agtcagaggtttggcctacttttggagtcctattgtcgtgcctgtgggatgtatttgaag
cacctgaataggcaagtcgaagctatggaaaaactcattaacttaactgacattctcaaa
caggagaagaaggatgaaacacaaaaggtacagatgaagtttttagttgaacaaatgagg
caaccagatttcatggatgctctgcagggcttcctctcacctctaaaccctgctcatcaa
ctaggaaacctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaatccagatatcatgtcagagttactgtttcagaacaatgagatcatc
tttaaaaatggagatgatttgcgacaagatatgctaacacttcaaattattcgcattatg
gaaaatatctggcaaaatcagggtcttgatcttagaatgttaccttatggttgtctgtca
attggtgactgtgtaggcctcattgaagtggtgagaaattctcacaccatcatgcaaatt
cagtgcaaaggtggcctaaaaggtgccctacagttcaacagccacacactgcatcaatgg
ctcaaagataaaaacaaaggagaaatatatgatgcagccattgacctatttacacgctca
tgtgctggatattgtgttgctactttcattttgggaattggagatcgtcacaacagtaac
attatggtgaaagatgatggacagctctttcatatagattttgggcactttttggatcac
aagaagaaaaagtttggttataaacgagaacgtgtaccatttgttttgacacaagatttc
ttgatagtgattagtaaaggagcccaagagtgcacaaagaccagagaatttgagaggttt
caggagatgtgttacaaggcttatctagctattcggcagcatgctaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactgcagtcttttgatgacattgca
tatattcgaaagaccttagccttagataaaactgaacaagaggctttggaatatttcatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatctttcac
acaattaaacaacatgcattgaactga

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (2)   
   RefSeq(pep) (2)   
DNA sequence (2)   
   RefSeq(nuc) (2)   
Protein domain (7)   
   Pfam (7)   
All databases (13)   

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