KEGG   Spermophilus citellus (European ground squirrel): 308648329
Entry
308648329         CDS       T11988                                 
Symbol
PLCB2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform 1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
scil  Spermophilus citellus (European ground squirrel)
Pathway
scil00562  Inositol phosphate metabolism
scil01100  Metabolic pathways
scil04015  Rap1 signaling pathway
scil04020  Calcium signaling pathway
scil04022  cGMP-PKG signaling pathway
scil04062  Chemokine signaling pathway
scil04070  Phosphatidylinositol signaling system
scil04071  Sphingolipid signaling pathway
scil04072  Phospholipase D signaling pathway
scil04081  Hormone signaling
scil04082  Neuroactive ligand signaling
scil04261  Adrenergic signaling in cardiomyocytes
scil04270  Vascular smooth muscle contraction
scil04310  Wnt signaling pathway
scil04371  Apelin signaling pathway
scil04540  Gap junction
scil04611  Platelet activation
scil04613  Neutrophil extracellular trap formation
scil04621  NOD-like receptor signaling pathway
scil04713  Circadian entrainment
scil04720  Long-term potentiation
scil04723  Retrograde endocannabinoid signaling
scil04724  Glutamatergic synapse
scil04725  Cholinergic synapse
scil04726  Serotonergic synapse
scil04728  Dopaminergic synapse
scil04730  Long-term depression
scil04742  Taste transduction
scil04750  Inflammatory mediator regulation of TRP channels
scil04911  Insulin secretion
scil04912  GnRH signaling pathway
scil04915  Estrogen signaling pathway
scil04916  Melanogenesis
scil04918  Thyroid hormone synthesis
scil04919  Thyroid hormone signaling pathway
scil04921  Oxytocin signaling pathway
scil04922  Glucagon signaling pathway
scil04924  Renin secretion
scil04925  Aldosterone synthesis and secretion
scil04926  Relaxin signaling pathway
scil04927  Cortisol synthesis and secretion
scil04928  Parathyroid hormone synthesis, secretion and action
scil04929  GnRH secretion
scil04933  AGE-RAGE signaling pathway in diabetic complications
scil04934  Cushing syndrome
scil04935  Growth hormone synthesis, secretion and action
scil04961  Endocrine and other factor-regulated calcium reabsorption
scil04970  Salivary secretion
scil04971  Gastric acid secretion
scil04972  Pancreatic secretion
scil04973  Carbohydrate digestion and absorption
scil05010  Alzheimer disease
scil05016  Huntington disease
scil05017  Spinocerebellar ataxia
scil05022  Pathways of neurodegeneration - multiple diseases
scil05142  Chagas disease
scil05143  African trypanosomiasis
scil05146  Amoebiasis
scil05163  Human cytomegalovirus infection
scil05200  Pathways in cancer
scil05415  Diabetic cardiomyopathy
scil05417  Lipid and atherosclerosis
Module
scil_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:scil00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    308648329 (PLCB2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    308648329 (PLCB2)
   04310 Wnt signaling pathway
    308648329 (PLCB2)
   04371 Apelin signaling pathway
    308648329 (PLCB2)
   04020 Calcium signaling pathway
    308648329 (PLCB2)
   04070 Phosphatidylinositol signaling system
    308648329 (PLCB2)
   04072 Phospholipase D signaling pathway
    308648329 (PLCB2)
   04071 Sphingolipid signaling pathway
    308648329 (PLCB2)
   04022 cGMP-PKG signaling pathway
    308648329 (PLCB2)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    308648329 (PLCB2)
   04081 Hormone signaling
    308648329 (PLCB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    308648329 (PLCB2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    308648329 (PLCB2)
   04613 Neutrophil extracellular trap formation
    308648329 (PLCB2)
   04621 NOD-like receptor signaling pathway
    308648329 (PLCB2)
   04062 Chemokine signaling pathway
    308648329 (PLCB2)
  09152 Endocrine system
   04911 Insulin secretion
    308648329 (PLCB2)
   04922 Glucagon signaling pathway
    308648329 (PLCB2)
   04929 GnRH secretion
    308648329 (PLCB2)
   04912 GnRH signaling pathway
    308648329 (PLCB2)
   04915 Estrogen signaling pathway
    308648329 (PLCB2)
   04921 Oxytocin signaling pathway
    308648329 (PLCB2)
   04926 Relaxin signaling pathway
    308648329 (PLCB2)
   04935 Growth hormone synthesis, secretion and action
    308648329 (PLCB2)
   04918 Thyroid hormone synthesis
    308648329 (PLCB2)
   04919 Thyroid hormone signaling pathway
    308648329 (PLCB2)
   04928 Parathyroid hormone synthesis, secretion and action
    308648329 (PLCB2)
   04916 Melanogenesis
    308648329 (PLCB2)
   04924 Renin secretion
    308648329 (PLCB2)
   04925 Aldosterone synthesis and secretion
    308648329 (PLCB2)
   04927 Cortisol synthesis and secretion
    308648329 (PLCB2)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    308648329 (PLCB2)
   04270 Vascular smooth muscle contraction
    308648329 (PLCB2)
  09154 Digestive system
   04970 Salivary secretion
    308648329 (PLCB2)
   04971 Gastric acid secretion
    308648329 (PLCB2)
   04972 Pancreatic secretion
    308648329 (PLCB2)
   04973 Carbohydrate digestion and absorption
    308648329 (PLCB2)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    308648329 (PLCB2)
  09156 Nervous system
   04724 Glutamatergic synapse
    308648329 (PLCB2)
   04725 Cholinergic synapse
    308648329 (PLCB2)
   04728 Dopaminergic synapse
    308648329 (PLCB2)
   04726 Serotonergic synapse
    308648329 (PLCB2)
   04720 Long-term potentiation
    308648329 (PLCB2)
   04730 Long-term depression
    308648329 (PLCB2)
   04723 Retrograde endocannabinoid signaling
    308648329 (PLCB2)
  09157 Sensory system
   04742 Taste transduction
    308648329 (PLCB2)
   04750 Inflammatory mediator regulation of TRP channels
    308648329 (PLCB2)
  09159 Environmental adaptation
   04713 Circadian entrainment
    308648329 (PLCB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    308648329 (PLCB2)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    308648329 (PLCB2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    308648329 (PLCB2)
   05142 Chagas disease
    308648329 (PLCB2)
   05143 African trypanosomiasis
    308648329 (PLCB2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    308648329 (PLCB2)
   05016 Huntington disease
    308648329 (PLCB2)
   05017 Spinocerebellar ataxia
    308648329 (PLCB2)
   05022 Pathways of neurodegeneration - multiple diseases
    308648329 (PLCB2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    308648329 (PLCB2)
   05415 Diabetic cardiomyopathy
    308648329 (PLCB2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    308648329 (PLCB2)
   04934 Cushing syndrome
    308648329 (PLCB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:scil04131]
    308648329 (PLCB2)
Enzymes [BR:scil01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     308648329 (PLCB2)
Membrane trafficking [BR:scil04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    308648329 (PLCB2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    308648329 (PLCB2)
SSDB
Motif
Pfam: PLC-beta_C PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 Spike_torovirin
Other DBs
NCBI-GeneID: 308648329
NCBI-ProteinID: XP_081149072
Position
4:138522846..138542263
AA seq 1182 aa
MSLLNPVLLPPKVKAYLSQGERFIKWDDETAVASPVILRVDPKGYYLYWTYQSKEIEFLD
ITSIRDTRFGKFAKIPKSQKLRDVFNMDFPDNHFLLKTLTVVSGPDMVDLTFHNFVSYKE
NVGKDWAEDVLALAKHPLTTNAPRSTFLDKILVKLKMQLTPEGKIPVKNFFQMFPADRKR
VEAALSACHLAKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEH
LTKFINQKQRDSRLNSLLFPPARPEQVQGLIDKYEPSGINVQRGQLSPEGMVWFLCGPEN
SVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDC
WKGKPPDEEPIITHGFTMTTDILFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKM
AEYCRTMFGDMLLTEPLEKFPLKPGIPLPSPEDLRGKILIKNKKNQFSGSAAPSKEPSGE
AEGNGLPRAPVGEDTVCAGEEGSELEEEEVEVEEEEESGSLDEEEMKKMQSDEGTAGLEV
TAYEEMSSLVNYIQPTKFISFEFSAQKNRSYVISSFTELKAYELLSKASVQFVDYNKRQM
SRIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEF
MRRLDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRT
KLSPSPNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHL
CMHSESNMPLTMPALFIFLEMKDYVPDTWADLTVALANPIKFFNAHDKKSMKLKEAMGGV
PEKPFSSISPVAHQVNGASSAPASNGSAAATARAREEAPKEAVEPQTTSPEELRELKGIV
KLQRRHEKELRELERRGARRWEELLQRGAAQLAELGLPSTCSKLRPGKGSRKKRTLPCEE
TGGAARGESTEDADSRVRELKDRLEQELQQQGEEQYLCILKRKEQHVAEQMAKMMELARE
KHAAELKTLKENSEIDTKEMKKKLEAKRLERIQAMTKAASDKMAQERLKREINNSHIQEV
VQTIKQMTDTLERHQEKLEEKQAACLEQIQDMEKRFKQEALAEYEARMKGLEAEVKESVR
ACLRACIPSEAEDKPERVCEASKEPCGQDPLTTMADIQESRL
NT seq 3549 nt   +upstreamnt  +downstreamnt
atgtctctgctgaaccctgtcctgctgccccccaaggtgaaggcctatctgagccaaggg
gagcgcttcatcaaatgggacgatgaaactgcagtagcctccccagttatcctccgtgtg
gatcccaagggctattacttgtactggacctatcagagtaaggagatcgagtttctggat
atcactagcatccgggacacccgctttgggaagtttgccaagattcccaagagccagaag
ctccgggatgtcttcaacatggactttccagataaccacttcttgctgaagacactcaca
gtggtgtccggccctgacatggtggacctcaccttccacaactttgtatcctacaaggag
aacgtgggcaaggactgggctgaagatgtactagctctggccaagcacccgttgacaacc
aacgccccccgcagcaccttcctggacaagatcctggtgaagctcaagatgcaactgacc
cctgaagggaagattcctgtgaagaattttttccagatgtttcctgctgaccgcaagcgg
gtggaagctgctctcagtgcctgtcacctggcaaaggggaagaatgatgctatcaatcct
gaggacttcccagaatctgtctacaagagttttctcatgagcctctgtcctcgaccagaa
atagacgagatcttcacttcctaccatgctaaggccaaaccctacatgaccaaggagcac
ctgaccaaattcatcaaccagaaacagcgtgactctcggctcaactccttgctgttccca
ccagcgagacctgaacaggtgcagggcctcatcgacaaatatgaacccagtggcatcaac
gtgcagaggggccagctgtcacctgagggcatggtctggtttctctgtgggccagagaac
agtgtgctggcccaggacaagctgctgctccaccatgacatgacgcagcctctcaatcat
tacttcatcaactcctcacacaacacctacctgacagccggccagttctcaggcctttcc
tcggctgagatgtaccgccaggtgctgctgtctggctgccgctgtgtggagctggactgc
tggaaggggaagccccctgatgaggagcccattattacccatggcttcaccatgaccaca
gacatcttgttcaaggaagctattgaagcaattgcagaaagtgcctttaagacctctccc
tatcccgtcatcctgtcatttgaaaaccatgtggactcaccccgccaacaggctaagatg
gctgagtactgcaggacgatgtttggggatatgctgctcacagagcccttggaaaaattc
ccactgaaaccaggcatccctctgcccagtcctgaggacctccggggtaagatcctcatc
aagaataagaaaaaccagttttctggttcagcagcccccagcaaggagcctagtggggag
gctgagggcaatggcctgcccagggccccagtgggcgaggacacagtgtgtgctggtgag
gaagggtctgagctggaggaggaggaggtggaagtggaagaggaagaggagtcgggaagc
ctggatgaagaagagatgaagaagatgcagtcagatgagggtactgcaggcctggaggtg
acggcttatgaagagatgtccagcctagttaattacatccagcccaccaagttcatctct
ttcgagttctctgcccagaagaaccgaagttatgtcatctcctccttcacggagctcaag
gcttatgaactgctctccaaggcctccgtgcagtttgtggactacaacaagcgccagatg
agtcgcatttaccccaagggcactcgcatggactcctccaactacatgccccagatgttc
tggaatgctggatgccagatggttgccctcaacttccagacgatggacctgcccatgcag
cagaacatggcactgttcgagttcaacgggcagagtggctacctcctcaagcatgagttc
atgcgccgactggacaagcagttcaatcccttctcggtggaccgaattgatgtggtggta
gccaccaccctttctattacggtcatctctgggcagttcctgtcagaacgcagtgtgcgc
acctatgtggaagtggaattgtttggtcttccaggggaccccaagaggcgctatcgcacc
aagctgtcacccagtcccaactccatcaatcctgtgtggaaagaggagccctttgttttt
gagaagatcttaatgcctgagctggcttccctcagggtggctgtgatggaggaaggcaat
aaatttctcggccaccgcatcatccccatcaacgccctgaattctggatatcaccatctg
tgcatgcacagtgagagcaacatgcccctcaccatgcctgcgctgtttatcttcctggag
atgaaggactatgtacctgacacttgggcagatctcaccgttgcccttgccaaccccatc
aagttcttcaatgcccatgataagaagtctatgaagctcaaggaggccatgggaggtgtg
cctgagaagcccttctcatccataagtccagttgctcaccaagtaaatggagcatcatct
gccccagcaagcaacgggtcagcagcagccacggccagggccagggaggaggcccccaaa
gaagctgtggagccgcagaccactagccccgaggagctgcgcgagctgaagggcatcgtg
aagctgcagcggcggcacgagaaggagcttcgggagctggagcggcgaggcgcgcggcgc
tgggaggagctgctgcagcgcggtgcggcgcagctggccgagctcgggctgcccagcact
tgcagcaagctccgcccgggaaagggctcccgcaagaagaggaccctgccctgcgaggag
actggtggggctgcccggggtgagagcactgaggacgcagactcacgtgtgcgggaactg
aaggacaggctggagcaggaactacaacagcagggcgaggaacagtacctgtgcattctg
aaacgcaaggagcagcatgtggctgagcaaatggctaaaatgatggagctggccagagag
aaacacgctgcagagctgaagaccctcaaggagaactcagagattgacaccaaagagatg
aagaaaaagctggaggccaagaggctagagagaatccaggccatgaccaaagctgcctct
gacaagatggcccaggagaggctgaagagagagattaacaactcccacatccaggaagtg
gtgcagaccatcaagcagatgaccgataccctggagcggcaccaggaaaagctggaggaa
aagcaggcagcctgcttggaacagatccaggacatggaaaagcggttcaagcaagaggca
ttggcggagtatgaggccaggatgaagggcctggaggctgaggtgaaggagtcggtgagg
gcctgcctcagggcctgcatcccctctgaggctgaggacaagcctgagagagtctgtgaa
gcctccaaggagccatgtggccaggacccactcacaaccatggcagacatccaggaaagc
cgcctctga

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (2)   
   RefSeq(pep) (2)   
DNA sequence (3)   
   RefSeq(nuc) (3)   
Protein domain (8)   
   Pfam (8)   
All databases (15)   

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