KEGG   Sciurus vulgaris (Eurasian red squirrel): 306671108
Entry
306671108         CDS       T11892                                 
Symbol
PIK3CA, ACX6B4_033540
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 1
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
svul  Sciurus vulgaris (Eurasian red squirrel)
Pathway
svul00562  Inositol phosphate metabolism
svul01100  Metabolic pathways
svul01521  EGFR tyrosine kinase inhibitor resistance
svul01522  Endocrine resistance
svul01524  Platinum drug resistance
svul04012  ErbB signaling pathway
svul04014  Ras signaling pathway
svul04015  Rap1 signaling pathway
svul04024  cAMP signaling pathway
svul04062  Chemokine signaling pathway
svul04066  HIF-1 signaling pathway
svul04068  FoxO signaling pathway
svul04070  Phosphatidylinositol signaling system
svul04071  Sphingolipid signaling pathway
svul04072  Phospholipase D signaling pathway
svul04081  Hormone signaling
svul04140  Autophagy - animal
svul04145  Phagocytosis
svul04150  mTOR signaling pathway
svul04151  PI3K-Akt signaling pathway
svul04152  AMPK signaling pathway
svul04210  Apoptosis
svul04211  Longevity regulating pathway
svul04213  Longevity regulating pathway - multiple species
svul04218  Cellular senescence
svul04360  Axon guidance
svul04370  VEGF signaling pathway
svul04380  Osteoclast differentiation
svul04510  Focal adhesion
svul04517  IgSF CAM signaling
svul04518  Integrin signaling
svul04550  Signaling pathways regulating pluripotency of stem cells
svul04611  Platelet activation
svul04613  Neutrophil extracellular trap formation
svul04620  Toll-like receptor signaling pathway
svul04625  C-type lectin receptor signaling pathway
svul04630  JAK-STAT signaling pathway
svul04650  Natural killer cell mediated cytotoxicity
svul04660  T cell receptor signaling pathway
svul04662  B cell receptor signaling pathway
svul04664  Fc epsilon RI signaling pathway
svul04666  Fc gamma R-mediated phagosome formation
svul04668  TNF signaling pathway
svul04670  Leukocyte transendothelial migration
svul04722  Neurotrophin signaling pathway
svul04725  Cholinergic synapse
svul04750  Inflammatory mediator regulation of TRP channels
svul04810  Regulation of actin cytoskeleton
svul04910  Insulin signaling pathway
svul04914  Progesterone-mediated oocyte maturation
svul04915  Estrogen signaling pathway
svul04917  Prolactin signaling pathway
svul04919  Thyroid hormone signaling pathway
svul04923  Regulation of lipolysis in adipocytes
svul04926  Relaxin signaling pathway
svul04929  GnRH secretion
svul04930  Type II diabetes mellitus
svul04931  Insulin resistance
svul04932  Non-alcoholic fatty liver disease
svul04933  AGE-RAGE signaling pathway in diabetic complications
svul04935  Growth hormone synthesis, secretion and action
svul04960  Aldosterone-regulated sodium reabsorption
svul04973  Carbohydrate digestion and absorption
svul05010  Alzheimer disease
svul05017  Spinocerebellar ataxia
svul05020  Prion disease
svul05100  Bacterial invasion of epithelial cells
svul05132  Salmonella infection
svul05135  Yersinia infection
svul05142  Chagas disease
svul05146  Amoebiasis
svul05160  Hepatitis C
svul05161  Hepatitis B
svul05162  Measles
svul05163  Human cytomegalovirus infection
svul05164  Influenza A
svul05165  Human papillomavirus infection
svul05166  Human T-cell leukemia virus 1 infection
svul05167  Kaposi sarcoma-associated herpesvirus infection
svul05168  Herpes simplex virus 1 infection
svul05169  Epstein-Barr virus infection
svul05170  Human immunodeficiency virus 1 infection
svul05171  Coronavirus disease
svul05200  Pathways in cancer
svul05203  Viral carcinogenesis
svul05205  Proteoglycans in cancer
svul05206  MicroRNAs in cancer
svul05207  Chemical carcinogenesis - receptor activation
svul05208  Chemical carcinogenesis - reactive oxygen species
svul05210  Colorectal cancer
svul05211  Renal cell carcinoma
svul05212  Pancreatic cancer
svul05213  Endometrial cancer
svul05214  Glioma
svul05215  Prostate cancer
svul05218  Melanoma
svul05220  Chronic myeloid leukemia
svul05221  Acute myeloid leukemia
svul05222  Small cell lung cancer
svul05223  Non-small cell lung cancer
svul05224  Breast cancer
svul05225  Hepatocellular carcinoma
svul05226  Gastric cancer
svul05230  Central carbon metabolism in cancer
svul05231  Choline metabolism in cancer
svul05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
svul05415  Diabetic cardiomyopathy
svul05417  Lipid and atherosclerosis
svul05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:svul00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    306671108 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    306671108 (PIK3CA)
   04014 Ras signaling pathway
    306671108 (PIK3CA)
   04015 Rap1 signaling pathway
    306671108 (PIK3CA)
   04370 VEGF signaling pathway
    306671108 (PIK3CA)
   04630 JAK-STAT signaling pathway
    306671108 (PIK3CA)
   04668 TNF signaling pathway
    306671108 (PIK3CA)
   04066 HIF-1 signaling pathway
    306671108 (PIK3CA)
   04068 FoxO signaling pathway
    306671108 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    306671108 (PIK3CA)
   04072 Phospholipase D signaling pathway
    306671108 (PIK3CA)
   04071 Sphingolipid signaling pathway
    306671108 (PIK3CA)
   04024 cAMP signaling pathway
    306671108 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    306671108 (PIK3CA)
   04152 AMPK signaling pathway
    306671108 (PIK3CA)
   04150 mTOR signaling pathway
    306671108 (PIK3CA)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    306671108 (PIK3CA)
   04517 IgSF CAM signaling
    306671108 (PIK3CA)
   04518 Integrin signaling
    306671108 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    306671108 (PIK3CA)
   04140 Autophagy - animal
    306671108 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    306671108 (PIK3CA)
   04218 Cellular senescence
    306671108 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    306671108 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    306671108 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    306671108 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    306671108 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    306671108 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    306671108 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    306671108 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    306671108 (PIK3CA)
   04660 T cell receptor signaling pathway
    306671108 (PIK3CA)
   04662 B cell receptor signaling pathway
    306671108 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    306671108 (PIK3CA)
   04666 Fc gamma R-mediated phagosome formation
    306671108 (PIK3CA)
   04670 Leukocyte transendothelial migration
    306671108 (PIK3CA)
   04062 Chemokine signaling pathway
    306671108 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    306671108 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    306671108 (PIK3CA)
   04929 GnRH secretion
    306671108 (PIK3CA)
   04915 Estrogen signaling pathway
    306671108 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    306671108 (PIK3CA)
   04917 Prolactin signaling pathway
    306671108 (PIK3CA)
   04926 Relaxin signaling pathway
    306671108 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    306671108 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    306671108 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    306671108 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    306671108 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    306671108 (PIK3CA)
   04722 Neurotrophin signaling pathway
    306671108 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    306671108 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    306671108 (PIK3CA)
   04380 Osteoclast differentiation
    306671108 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    306671108 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    306671108 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    306671108 (PIK3CA)
   05206 MicroRNAs in cancer
    306671108 (PIK3CA)
   05205 Proteoglycans in cancer
    306671108 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    306671108 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    306671108 (PIK3CA)
   05203 Viral carcinogenesis
    306671108 (PIK3CA)
   05230 Central carbon metabolism in cancer
    306671108 (PIK3CA)
   05231 Choline metabolism in cancer
    306671108 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    306671108 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    306671108 (PIK3CA)
   05212 Pancreatic cancer
    306671108 (PIK3CA)
   05225 Hepatocellular carcinoma
    306671108 (PIK3CA)
   05226 Gastric cancer
    306671108 (PIK3CA)
   05214 Glioma
    306671108 (PIK3CA)
   05221 Acute myeloid leukemia
    306671108 (PIK3CA)
   05220 Chronic myeloid leukemia
    306671108 (PIK3CA)
   05218 Melanoma
    306671108 (PIK3CA)
   05211 Renal cell carcinoma
    306671108 (PIK3CA)
   05215 Prostate cancer
    306671108 (PIK3CA)
   05213 Endometrial cancer
    306671108 (PIK3CA)
   05224 Breast cancer
    306671108 (PIK3CA)
   05222 Small cell lung cancer
    306671108 (PIK3CA)
   05223 Non-small cell lung cancer
    306671108 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    306671108 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    306671108 (PIK3CA)
   05161 Hepatitis B
    306671108 (PIK3CA)
   05160 Hepatitis C
    306671108 (PIK3CA)
   05171 Coronavirus disease
    306671108 (PIK3CA)
   05164 Influenza A
    306671108 (PIK3CA)
   05162 Measles
    306671108 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    306671108 (PIK3CA)
   05163 Human cytomegalovirus infection
    306671108 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    306671108 (PIK3CA)
   05169 Epstein-Barr virus infection
    306671108 (PIK3CA)
   05165 Human papillomavirus infection
    306671108 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    306671108 (PIK3CA)
   05135 Yersinia infection
    306671108 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    306671108 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    306671108 (PIK3CA)
   05142 Chagas disease
    306671108 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    306671108 (PIK3CA)
   05017 Spinocerebellar ataxia
    306671108 (PIK3CA)
   05020 Prion disease
    306671108 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    306671108 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    306671108 (PIK3CA)
   05415 Diabetic cardiomyopathy
    306671108 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    306671108 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    306671108 (PIK3CA)
   04931 Insulin resistance
    306671108 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    306671108 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    306671108 (PIK3CA)
   01524 Platinum drug resistance
    306671108 (PIK3CA)
   01522 Endocrine resistance
    306671108 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:svul04131]
    306671108 (PIK3CA)
Enzymes [BR:svul01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     306671108 (PIK3CA)
Membrane trafficking [BR:svul04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    306671108 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Sll1247_N
Other DBs
NCBI-GeneID: 306671108
NCBI-ProteinID: XP_079012471
Position
10:complement(93984763..94065829)
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFV
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRQPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccacgaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgactttagaatgcctccgtgaggct
acattaataactataaagcatgaactatttaaagaagcaagaaaataccctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaggcagaaagggaa
gaattctttgatgaaacaagacgactttgtgaccttcgactttttcaaccctttttaaaa
gtaatcgaaccagtaggcaaccgcgaagaaaagatcctgaatcgagaaattggttttgtt
atcggtatgccagtgtgtgaatttgatatggttaaagatccagaagtacaggactttcgg
agaaatattctgaatgtttgtaaagaagctgtggatcttagggatctcaattcacctcat
agtagagcaatgtatgtctatcctccaaatgtggagtcttcaccagaactgccaaagcac
atatataataaattagataaaggacaaataatagtggtgatttgggtaatagtttctcca
aataatgacaagcagaagtatactctaaaaatcaaccatgactgtgtgccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgctatcctctgagcaactaaaa
ctctgtgttttagaatatcagggcaaatacattttgaaagtatgtggatgtgatgaatac
ttcctagaaaaatatcctctgagtcaatataagtacataagaagctgtataatgcttgga
aggatgcccaatttgatgctgatggctaaagaaagcctttactctcaactgccaatggac
tgttttacaatgccatcttattctagacgcatctccacagctacaccatatatgaatgga
gaaacatctacaaaatccctttgggttataaatagtgcactcagaataaaaattctttgt
gcaacctatgtaaatgtaaatattcgagacattgataagatttatgttcgaacaggtatc
taccatggaggagaacctttatgcgacaatgtgaacactcagagagttccttgttccaat
cccaggtggaatgaatggctgaattatgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgctctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcctggggaaatataaacttgtttgattacaccgataccttagtatctggaaaa
atggctttgaatctttggccagtacctcatggattagaagatctgttgaaccctattggt
gttactgggtcaaatccaaataaagaaacaccgtgcttagagttggagtttgattggttc
agcagtgtggtcaaatttccagatatgtcagtgattgaagaacatgccaattggtctgta
tcccgagaagcaggatttagttattcccatgcaggactgagtaacagactagctagagat
aatgaattaagagaaaatgacaaagaacagcttcgagcaatatgtacacgagatcctcta
tctgaaatcactgaacaagagaaagattttctgtggagccacagacactattgtgtaact
atccccgaaattctacccaaattgcttctgtctgttaaatggaattctagagatgaagta
gcccagatgtactgcttagtaaaagattggcctccaatcaagcctgaacaggcaatggag
cttctggactgtaattacccggatcctatggttcgaggttttgctgttcgatgcttagaa
aaatatttaacagacgacaaactttctcagtacctaattcagctagtacaggtcctaaaa
tatgagcaatatttggataacctgcttgtgagatttttgctcaagaaagcattgacaaat
caaaggattgggcactttttcttttggcacttaaaatctgagatgcacaataaaacagtt
agtcagaggtttggcctgcttttggagtcctactgtcgtgcttgtgggatgtatttgaag
cacctgaataggcaagttgaggctatggaaaagctcattaacttaactgacattctcaaa
caggaaaagaaggatgaaacacaaaaggtacagatgaagtttttagtggagcaaatgagg
cagccagatttcatggatgctctccaaggctttctgtctcctttaaaccctgctcatcaa
ctaggaaatcttaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaactgggagaacccagacatcatgtcggagttactgtttcagaacaatgagatcatc
tttaaaaatggagatgatttacggcaagatatgctaacacttcaaattattcgcattatg
gaaaacatctggcaaaatcaaggtcttgatcttcgaatgttaccttatggttgtttatca
attggtgactgtgtaggacttattgaggtggtaagaaattctcacactatcatgcagatt
cagtgcaaaggtggcctgaaaggcgcactgcagttcaacagccacacgctacatcagtgg
ctcaaagacaagaacaaaggagaaatatatgatgcagccatagacctgttcacacgatcg
tgtgctggatattgtgtggctaccttcattttgggaattggagatcgtcacaatagtaac
atcatggtgaaagatgatggacaactgtttcatatagattttggacactttttggatcac
aagaagaaaaaatttggttataaacgagaacgcgtaccctttgttttgacacaagatttc
ttaatagtgatcagtaaaggagctcaagaatgcacaaaaaccagagaatttgagaggttt
caggagatgtgttacaaggcttatctagctattcggcagcacgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgacattgca
tatattcgaaagaccctagccttagataaaactgagcaagaggctttggaatatttcatg
aaacaaatgaatgatgcacaccatggtggctggacaacaaaaatggattggatcttccac
acaattaagcagcatgcattgaactga

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (2)   
   RefSeq(pep) (2)   
DNA sequence (2)   
   RefSeq(nuc) (2)   
Protein domain (8)   
   Pfam (8)   
All databases (14)   

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