KEGG   Theropithecus gelada (gelada): 112625914
Entry
112625914         CDS       T08041                                 
Symbol
PIK3R1
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
tge  Theropithecus gelada (gelada)
Pathway
tge01521  EGFR tyrosine kinase inhibitor resistance
tge01522  Endocrine resistance
tge01524  Platinum drug resistance
tge04012  ErbB signaling pathway
tge04014  Ras signaling pathway
tge04015  Rap1 signaling pathway
tge04024  cAMP signaling pathway
tge04062  Chemokine signaling pathway
tge04066  HIF-1 signaling pathway
tge04068  FoxO signaling pathway
tge04070  Phosphatidylinositol signaling system
tge04071  Sphingolipid signaling pathway
tge04072  Phospholipase D signaling pathway
tge04081  Hormone signaling
tge04140  Autophagy - animal
tge04145  Phagocytosis
tge04150  mTOR signaling pathway
tge04151  PI3K-Akt signaling pathway
tge04152  AMPK signaling pathway
tge04210  Apoptosis
tge04211  Longevity regulating pathway
tge04213  Longevity regulating pathway - multiple species
tge04218  Cellular senescence
tge04360  Axon guidance
tge04370  VEGF signaling pathway
tge04380  Osteoclast differentiation
tge04510  Focal adhesion
tge04517  IgSF CAM signaling
tge04518  Integrin signaling
tge04550  Signaling pathways regulating pluripotency of stem cells
tge04611  Platelet activation
tge04613  Neutrophil extracellular trap formation
tge04620  Toll-like receptor signaling pathway
tge04625  C-type lectin receptor signaling pathway
tge04630  JAK-STAT signaling pathway
tge04650  Natural killer cell mediated cytotoxicity
tge04660  T cell receptor signaling pathway
tge04662  B cell receptor signaling pathway
tge04664  Fc epsilon RI signaling pathway
tge04666  Fc gamma R-mediated phagosome formation
tge04668  TNF signaling pathway
tge04670  Leukocyte transendothelial migration
tge04722  Neurotrophin signaling pathway
tge04725  Cholinergic synapse
tge04750  Inflammatory mediator regulation of TRP channels
tge04810  Regulation of actin cytoskeleton
tge04910  Insulin signaling pathway
tge04914  Progesterone-mediated oocyte maturation
tge04915  Estrogen signaling pathway
tge04917  Prolactin signaling pathway
tge04919  Thyroid hormone signaling pathway
tge04923  Regulation of lipolysis in adipocytes
tge04926  Relaxin signaling pathway
tge04929  GnRH secretion
tge04930  Type II diabetes mellitus
tge04931  Insulin resistance
tge04932  Non-alcoholic fatty liver disease
tge04933  AGE-RAGE signaling pathway in diabetic complications
tge04935  Growth hormone synthesis, secretion and action
tge04960  Aldosterone-regulated sodium reabsorption
tge04973  Carbohydrate digestion and absorption
tge05010  Alzheimer disease
tge05017  Spinocerebellar ataxia
tge05020  Prion disease
tge05100  Bacterial invasion of epithelial cells
tge05135  Yersinia infection
tge05142  Chagas disease
tge05146  Amoebiasis
tge05160  Hepatitis C
tge05161  Hepatitis B
tge05162  Measles
tge05163  Human cytomegalovirus infection
tge05164  Influenza A
tge05165  Human papillomavirus infection
tge05166  Human T-cell leukemia virus 1 infection
tge05167  Kaposi sarcoma-associated herpesvirus infection
tge05168  Herpes simplex virus 1 infection
tge05169  Epstein-Barr virus infection
tge05170  Human immunodeficiency virus 1 infection
tge05171  Coronavirus disease
tge05200  Pathways in cancer
tge05203  Viral carcinogenesis
tge05205  Proteoglycans in cancer
tge05206  MicroRNAs in cancer
tge05207  Chemical carcinogenesis - receptor activation
tge05208  Chemical carcinogenesis - reactive oxygen species
tge05210  Colorectal cancer
tge05211  Renal cell carcinoma
tge05212  Pancreatic cancer
tge05213  Endometrial cancer
tge05214  Glioma
tge05215  Prostate cancer
tge05218  Melanoma
tge05220  Chronic myeloid leukemia
tge05221  Acute myeloid leukemia
tge05222  Small cell lung cancer
tge05223  Non-small cell lung cancer
tge05224  Breast cancer
tge05225  Hepatocellular carcinoma
tge05226  Gastric cancer
tge05230  Central carbon metabolism in cancer
tge05231  Choline metabolism in cancer
tge05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
tge05415  Diabetic cardiomyopathy
tge05417  Lipid and atherosclerosis
tge05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:tge00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    112625914 (PIK3R1)
   04014 Ras signaling pathway
    112625914 (PIK3R1)
   04015 Rap1 signaling pathway
    112625914 (PIK3R1)
   04370 VEGF signaling pathway
    112625914 (PIK3R1)
   04630 JAK-STAT signaling pathway
    112625914 (PIK3R1)
   04668 TNF signaling pathway
    112625914 (PIK3R1)
   04066 HIF-1 signaling pathway
    112625914 (PIK3R1)
   04068 FoxO signaling pathway
    112625914 (PIK3R1)
   04070 Phosphatidylinositol signaling system
    112625914 (PIK3R1)
   04072 Phospholipase D signaling pathway
    112625914 (PIK3R1)
   04071 Sphingolipid signaling pathway
    112625914 (PIK3R1)
   04024 cAMP signaling pathway
    112625914 (PIK3R1)
   04151 PI3K-Akt signaling pathway
    112625914 (PIK3R1)
   04152 AMPK signaling pathway
    112625914 (PIK3R1)
   04150 mTOR signaling pathway
    112625914 (PIK3R1)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    112625914 (PIK3R1)
   04517 IgSF CAM signaling
    112625914 (PIK3R1)
   04518 Integrin signaling
    112625914 (PIK3R1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    112625914 (PIK3R1)
   04140 Autophagy - animal
    112625914 (PIK3R1)
  09143 Cell growth and death
   04210 Apoptosis
    112625914 (PIK3R1)
   04218 Cellular senescence
    112625914 (PIK3R1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    112625914 (PIK3R1)
   04550 Signaling pathways regulating pluripotency of stem cells
    112625914 (PIK3R1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    112625914 (PIK3R1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    112625914 (PIK3R1)
   04613 Neutrophil extracellular trap formation
    112625914 (PIK3R1)
   04620 Toll-like receptor signaling pathway
    112625914 (PIK3R1)
   04625 C-type lectin receptor signaling pathway
    112625914 (PIK3R1)
   04650 Natural killer cell mediated cytotoxicity
    112625914 (PIK3R1)
   04660 T cell receptor signaling pathway
    112625914 (PIK3R1)
   04662 B cell receptor signaling pathway
    112625914 (PIK3R1)
   04664 Fc epsilon RI signaling pathway
    112625914 (PIK3R1)
   04666 Fc gamma R-mediated phagosome formation
    112625914 (PIK3R1)
   04670 Leukocyte transendothelial migration
    112625914 (PIK3R1)
   04062 Chemokine signaling pathway
    112625914 (PIK3R1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    112625914 (PIK3R1)
   04923 Regulation of lipolysis in adipocytes
    112625914 (PIK3R1)
   04929 GnRH secretion
    112625914 (PIK3R1)
   04915 Estrogen signaling pathway
    112625914 (PIK3R1)
   04914 Progesterone-mediated oocyte maturation
    112625914 (PIK3R1)
   04917 Prolactin signaling pathway
    112625914 (PIK3R1)
   04926 Relaxin signaling pathway
    112625914 (PIK3R1)
   04935 Growth hormone synthesis, secretion and action
    112625914 (PIK3R1)
   04919 Thyroid hormone signaling pathway
    112625914 (PIK3R1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    112625914 (PIK3R1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    112625914 (PIK3R1)
  09156 Nervous system
   04725 Cholinergic synapse
    112625914 (PIK3R1)
   04722 Neurotrophin signaling pathway
    112625914 (PIK3R1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    112625914 (PIK3R1)
  09158 Development and regeneration
   04360 Axon guidance
    112625914 (PIK3R1)
   04380 Osteoclast differentiation
    112625914 (PIK3R1)
  09149 Aging
   04211 Longevity regulating pathway
    112625914 (PIK3R1)
   04213 Longevity regulating pathway - multiple species
    112625914 (PIK3R1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    112625914 (PIK3R1)
   05206 MicroRNAs in cancer
    112625914 (PIK3R1)
   05205 Proteoglycans in cancer
    112625914 (PIK3R1)
   05207 Chemical carcinogenesis - receptor activation
    112625914 (PIK3R1)
   05208 Chemical carcinogenesis - reactive oxygen species
    112625914 (PIK3R1)
   05203 Viral carcinogenesis
    112625914 (PIK3R1)
   05230 Central carbon metabolism in cancer
    112625914 (PIK3R1)
   05231 Choline metabolism in cancer
    112625914 (PIK3R1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    112625914 (PIK3R1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    112625914 (PIK3R1)
   05212 Pancreatic cancer
    112625914 (PIK3R1)
   05225 Hepatocellular carcinoma
    112625914 (PIK3R1)
   05226 Gastric cancer
    112625914 (PIK3R1)
   05214 Glioma
    112625914 (PIK3R1)
   05221 Acute myeloid leukemia
    112625914 (PIK3R1)
   05220 Chronic myeloid leukemia
    112625914 (PIK3R1)
   05218 Melanoma
    112625914 (PIK3R1)
   05211 Renal cell carcinoma
    112625914 (PIK3R1)
   05215 Prostate cancer
    112625914 (PIK3R1)
   05213 Endometrial cancer
    112625914 (PIK3R1)
   05224 Breast cancer
    112625914 (PIK3R1)
   05222 Small cell lung cancer
    112625914 (PIK3R1)
   05223 Non-small cell lung cancer
    112625914 (PIK3R1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    112625914 (PIK3R1)
   05170 Human immunodeficiency virus 1 infection
    112625914 (PIK3R1)
   05161 Hepatitis B
    112625914 (PIK3R1)
   05160 Hepatitis C
    112625914 (PIK3R1)
   05171 Coronavirus disease
    112625914 (PIK3R1)
   05164 Influenza A
    112625914 (PIK3R1)
   05162 Measles
    112625914 (PIK3R1)
   05168 Herpes simplex virus 1 infection
    112625914 (PIK3R1)
   05163 Human cytomegalovirus infection
    112625914 (PIK3R1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    112625914 (PIK3R1)
   05169 Epstein-Barr virus infection
    112625914 (PIK3R1)
   05165 Human papillomavirus infection
    112625914 (PIK3R1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    112625914 (PIK3R1)
   05100 Bacterial invasion of epithelial cells
    112625914 (PIK3R1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    112625914 (PIK3R1)
   05142 Chagas disease
    112625914 (PIK3R1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    112625914 (PIK3R1)
   05017 Spinocerebellar ataxia
    112625914 (PIK3R1)
   05020 Prion disease
    112625914 (PIK3R1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    112625914 (PIK3R1)
   05418 Fluid shear stress and atherosclerosis
    112625914 (PIK3R1)
   05415 Diabetic cardiomyopathy
    112625914 (PIK3R1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    112625914 (PIK3R1)
   04932 Non-alcoholic fatty liver disease
    112625914 (PIK3R1)
   04931 Insulin resistance
    112625914 (PIK3R1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    112625914 (PIK3R1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    112625914 (PIK3R1)
   01524 Platinum drug resistance
    112625914 (PIK3R1)
   01522 Endocrine resistance
    112625914 (PIK3R1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:tge04131]
    112625914 (PIK3R1)
Membrane trafficking [BR:tge04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    112625914 (PIK3R1)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH2_1 SH3_1 SH3_2 CEP135_TSGA10_CC Laminin_I SH3_9 ODF2_C DicA_C FANCI_S2 Exonuc_VII_L
Other DBs
NCBI-GeneID: 112625914
NCBI-ProteinID: XP_025243216
Ensembl: ENSTGEG00000017937
UniProt: A0A8D2FJR0
Position
6:65416784..65501903
AA seq 724 aa
MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEEIGWLNGYN
ETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKTEADVEQQALTLPDLAE
QFAPPDVAPPLLIKLVEAIEKKGLECSTLYRTQSSGNLAELRQLLDCDTASVDLEMIDVH
ILADAFKRYLLDLPNPVIPAAVYSEMISLAQEVQSSEEYIQLLKKLIRSPSIPHQYWLTL
QYLLKHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLIKVIEILISTEWNE
RQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDA
STKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKL
DVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMK
RTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIID
SRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN
ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACS
VVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA
QQRR
NT seq 2175 nt   +upstreamnt  +downstreamnt
atgagtgctgaggggtaccagtacagagcgctgtatgattataaaaaggaaagagaagaa
gatattgacttgcacttgggtgacatattgactgtgaataaagggtccttagtagctctt
ggattcagtgatggacaggaagccaggcctgaagaaattggctggttaaatggctataat
gaaaccacaggggaaaggggggactttccgggaacttatgtagaatatattggaaggaaa
aaaatctcgcctcccacgccaaagccccggccgcctcggcctcttcctgttgcaccaggt
tcttcgaaaactgaagcagatgttgaacaacaagctttgactctcccggatcttgcagag
cagtttgcccctcctgacgttgccccgcctcttcttatcaagctcgtggaagccattgaa
aagaaaggtctggaatgttcaactctatacagaacacagagctccggcaacctggcggaa
ttacgacagcttcttgattgtgatacagcctctgtggacttggaaatgatcgatgtgcac
attttggccgacgctttcaaacgctatctcctggacttaccaaatcctgtcattccagca
gccgtttacagtgaaatgatttctttagctcaagaagtacaaagctccgaagaatatatt
cagctactgaagaagcttattaggtcgcctagcatacctcatcagtattggcttacgctt
cagtatttgttaaaacatttcttcaagctctctcaaacctccagcaaaaatctgttgaat
gcaagagtactctctgaaattttcagccctatgcttttcagattctcagcagccagctct
gataatacggaaaacctcataaaagttatagaaattttaatctcaactgaatggaatgaa
cgacagcctgcaccagcactgcctcctaaaccaccaaaacccactactgtagccaacaac
ggtatgaataacaatatgtccttacaagatgctgaatggtactggggagatatctcgagg
gaagaagtgaatgaaaaacttcgagatacagcagatgggacctttttggtacgagatgcg
tctactaaaatgcatggtgattatactcttacactaaggaaagggggaaataacaaatta
atcaaaatatttcatcgagatgggaaatatggcttctctgacccattaaccttcaattct
gtggttgaattaataaaccactaccggaatgaatctctagctcagtataatcccaagctg
gatgtgaaattactttatccagtatccaaataccaacaggatcaagttgtcaaagaagat
aatattgaagctgtagggaaaaaattacatgaatataacactcagtttcaagaaaaaagt
agagaatatgatagattatatgaagaatatacccgtacatcccaggaaatccaaatgaaa
aggacagctattgaagcatttaatgaaaccataaaaatatttgaagaacagtgccagacc
caggagcgctacagcaaagaatacatagaaaagtttaaacgtgagggcaatgagaaagaa
atacaaaggattatgcataattatgataagttgaagtctcgaatcagtgaaattattgac
agtagaagaagattggaagaagacttgaagaagcaggcagctgagtatcgagaaattgac
aaacgtatgaacagcattaaaccagaccttatccagctgagaaagacgagagaccaatac
ttgatgtggttgactcaaaaaggtgttcggcaaaagaagttgaacgagtggttgggcaat
gaaaacactgaagaccaatattcgctggtggaagatgatgaagatttaccccatcatgat
gagaagacgtggaatgttggaagcagcaaccgaaacaaagccgaaaacctgttgcgaggg
aagcgagatggcacttttcttgtccgggagagcagtaaacagggctgctacgcctgctct
gtagtggtggacggcgaagtaaagcattgtgtcataaacaaaacagcgactggctatggc
tttgccgagccctataacttgtacagctctctgaaagaactggtgctacattaccaacac
acctccctcgtgcagcacaacgactccctcaatgtcacactagcctacccagtatatgca
cagcagaggcgatga

  All links  
Gene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
Protein sequence (4)   
   UniProt (1)   
   RefSeq(pep) (3)   
DNA sequence (3)   
   RefSeq(nuc) (3)   
Protein domain (13)   
   Pfam (13)   
All databases (23)   

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