KEGG   Trichosurus vulpecula (common brushtail): 118843532
Entry
118843532         CDS       T10126                                 
Symbol
PLCG2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
  KO
K05859  phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Organism
tvp  Trichosurus vulpecula (common brushtail)
Pathway
tvp00562  Inositol phosphate metabolism
tvp01100  Metabolic pathways
tvp01521  EGFR tyrosine kinase inhibitor resistance
tvp04012  ErbB signaling pathway
tvp04014  Ras signaling pathway
tvp04020  Calcium signaling pathway
tvp04062  Chemokine signaling pathway
tvp04064  NF-kappa B signaling pathway
tvp04066  HIF-1 signaling pathway
tvp04070  Phosphatidylinositol signaling system
tvp04072  Phospholipase D signaling pathway
tvp04360  Axon guidance
tvp04370  VEGF signaling pathway
tvp04380  Osteoclast differentiation
tvp04611  Platelet activation
tvp04613  Neutrophil extracellular trap formation
tvp04625  C-type lectin receptor signaling pathway
tvp04650  Natural killer cell mediated cytotoxicity
tvp04662  B cell receptor signaling pathway
tvp04664  Fc epsilon RI signaling pathway
tvp04666  Fc gamma R-mediated phagocytosis
tvp04670  Leukocyte transendothelial migration
tvp04722  Neurotrophin signaling pathway
tvp04750  Inflammatory mediator regulation of TRP channels
tvp04919  Thyroid hormone signaling pathway
tvp04933  AGE-RAGE signaling pathway in diabetic complications
tvp04935  Growth hormone synthesis, secretion and action
tvp05167  Kaposi sarcoma-associated herpesvirus infection
tvp05169  Epstein-Barr virus infection
tvp05170  Human immunodeficiency virus 1 infection
tvp05171  Coronavirus disease - COVID-19
tvp05200  Pathways in cancer
tvp05205  Proteoglycans in cancer
tvp05206  MicroRNAs in cancer
tvp05214  Glioma
tvp05223  Non-small cell lung cancer
tvp05225  Hepatocellular carcinoma
Module
tvp_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:tvp00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    118843532 (PLCG2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    118843532 (PLCG2)
   04014 Ras signaling pathway
    118843532 (PLCG2)
   04370 VEGF signaling pathway
    118843532 (PLCG2)
   04064 NF-kappa B signaling pathway
    118843532 (PLCG2)
   04066 HIF-1 signaling pathway
    118843532 (PLCG2)
   04020 Calcium signaling pathway
    118843532 (PLCG2)
   04070 Phosphatidylinositol signaling system
    118843532 (PLCG2)
   04072 Phospholipase D signaling pathway
    118843532 (PLCG2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    118843532 (PLCG2)
   04613 Neutrophil extracellular trap formation
    118843532 (PLCG2)
   04625 C-type lectin receptor signaling pathway
    118843532 (PLCG2)
   04650 Natural killer cell mediated cytotoxicity
    118843532 (PLCG2)
   04662 B cell receptor signaling pathway
    118843532 (PLCG2)
   04664 Fc epsilon RI signaling pathway
    118843532 (PLCG2)
   04666 Fc gamma R-mediated phagocytosis
    118843532 (PLCG2)
   04670 Leukocyte transendothelial migration
    118843532 (PLCG2)
   04062 Chemokine signaling pathway
    118843532 (PLCG2)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    118843532 (PLCG2)
   04919 Thyroid hormone signaling pathway
    118843532 (PLCG2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    118843532 (PLCG2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    118843532 (PLCG2)
  09158 Development and regeneration
   04360 Axon guidance
    118843532 (PLCG2)
   04380 Osteoclast differentiation
    118843532 (PLCG2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    118843532 (PLCG2)
   05206 MicroRNAs in cancer
    118843532 (PLCG2)
   05205 Proteoglycans in cancer
    118843532 (PLCG2)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    118843532 (PLCG2)
   05214 Glioma
    118843532 (PLCG2)
   05223 Non-small cell lung cancer
    118843532 (PLCG2)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    118843532 (PLCG2)
   05171 Coronavirus disease - COVID-19
    118843532 (PLCG2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    118843532 (PLCG2)
   05169 Epstein-Barr virus infection
    118843532 (PLCG2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    118843532 (PLCG2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    118843532 (PLCG2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:tvp04131]
    118843532 (PLCG2)
Enzymes [BR:tvp01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     118843532 (PLCG2)
Membrane trafficking [BR:tvp04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    118843532 (PLCG2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    118843532 (PLCG2)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 SH3_1 C2 SH3_9 PH EF-hand_PLCG1 PH_12 SH2_1 SH3_2 PH_14 EF-hand_like GDPD
Other DBs
NCBI-GeneID: 118843532
NCBI-ProteinID: XP_036607097
Position
3:225707870..225882611
AA seq 1264 aa
MTTKINLDMLPEYEKSQIKRTLELGTVMTLFSLKKSNPERRTVQVITETRQVAWSKTADK
IEGFLDLMEIKEIRPGKNSKDFERGKASRQKEDCCFTIFYGTQFVLNTLSLAADSKEDAT
KWLCGLTILHQEAQSASTPAIIESWLRKQIYSVDQTRKNSISFRELKTILPLVNYKVSSA
KFLKDKFLEIGAYKDELSFEQFHLFYKKMMFEQQKSILDEFKKDSSVFILGNTDRPDASA
VHLHDFQRFLLHEQQEIWAQDLSKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSKENS
IWDDKYDSVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSTESYIRCLRMGCRCIELDC
WDGPDGKPIIYHGWTRTTKIKFDDVVHAIRDHAFVSSQFPVILSIEEHCCVEQQRHMARV
FKEVFGDLLLTKPTEASADQLPSPAQLKEKIVIKHKKLGPRGDVDINIEDKKEEKKQQGE
LYMWDSIDQKWYRHYCAIADEKLSFSDVIEQNAEEDSVKDVSQTDLHFGEKWFHKRMEKR
TSAEKLLQEYCAETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTPEGGAMKYY
LTDNLMFNSIYDLIQHYREAHLRCAEFELRLTDPVPNPNPHESKAWYYDSLSRGEAEDML
MRIPRDGAFLIRKREGGDAYAITFRAKGKVKHCRINKDGHHFVLGTSAYFESLVELVSYY
EKHALYRKMRLRYPVTPELLERYNTERDINSLYDVRMYVDPSEINPSTPQRTVKALYDYK
AKRGDELSFCRGALIHNVSKEPGGWWKGDYGGRIQQYFPSNYVEDISTVDFEELEKQIIE
DNPLGSLCRGILDLNTYNVVKVPQGKNQKPFVFILEPKKPNDPPIEFATDKVEELFEWYQ
SIREITWKNATVETNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVET
KADSIVRQKPIDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYM
QLNHALFALNGRTGYVLQPESMRNENYDPTPPESQRKILMTLTVKVLGARHLPKLGRSIA
CPFIEVEICGTEYDNNKFKTTVVNDNGLSPVWASTQEKVTFEIYDPNLAFLRFVVYEEDM
FSDPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSCR
QLRRRQEELNNQLFLYDTHQNLRNANRDALVNEFNVNENQLQLYQEKCNRRLREKRVSNS
KFYS
NT seq 3795 nt   +upstreamnt  +downstreamnt
atgaccaccaagatcaacttagacatgcttcctgaatatgagaaaagtcagatcaagcgg
accctggaactaggaactgtcatgaccctgtttagcctcaagaaatctaaccctgagagg
aggacagtccaggtcatcacggagaccaggcaggtggcctggagcaagacggctgacaag
atcgaaggattcttggacttaatggagataaaggaaatccgcccagggaaaaactcaaag
gactttgaacgtgggaaagccagtcgccagaaagaagattgctgctttaccatattttat
ggcacccagtttgtcctcaacactctgagtttagcagcggactccaaggaagatgctact
aaatggctttgtggcttgacaattttgcaccaagaagcccagagtgcctcgacgccagct
attattgagagctggctaagaaagcaaatttattctgtagatcaaactcggaaaaatagt
atcagcttcagagaactgaagaccattcttcccttagtaaactacaaagttagcagtgcc
aagttcctgaaagacaaattcctggaaataggtgcctacaaggatgaactcagctttgaa
cagttccacctattctacaaaaagatgatgtttgagcaacagaaatcaattcttgatgag
ttcaaaaaagattcgtctgtgtttattctgggaaatacagaccggccagatgcatctgcc
gttcacctgcatgacttccagaggtttctgctgcacgaacagcaggaaatatgggcacag
gatctaagtaaagtaagagagcggatgacaaaatttatagatgacacgatgagagaaaca
gctgagccgttcctgtttgtcgatgagttcctcacttacctgttttcaaaagaaaacagc
atttgggatgataaatatgattctgttgacatgcaagacatgaataatcccttgtctcat
tactggatttcttcatctcataacacgtacctcactggggaccaacttcgaagtgaatct
tctactgaatcatacattcgatgtcttcgaatgggttgccggtgtatagagttggattgc
tgggatgggcctgatgggaagccaatcatctatcatggctggacgcgaacgacgaaaatc
aagtttgatgatgtggtgcatgccatcagagaccatgcttttgtctcctcacagttccct
gtgatcctctccattgaagagcactgctgtgtagaacagcagcgtcatatggccagggtg
tttaaggaagtgtttggggacctcctccttacaaagcccactgaagccagtgccgaccag
ctgccgtcccctgcccagctgaaagaaaagattgtcatcaagcacaagaagctgggtccc
agaggagatgtggacatcaacattgaagacaagaaggaagaaaaaaaacagcaaggggaa
ttgtacatgtgggatagcattgatcagaagtggtatcgccactattgtgccatagctgat
gagaagctgtccttcagtgatgttatagagcagaatgcggaggaggattcagtaaaggat
gtgtcacagactgacttgcatttcggtgagaagtggtttcataagaggatggagaagagg
acaagtgctgagaaactgctacaggaatactgtgctgaaactgggggcaaggatgggacc
ttcttggtccgtgaaagtgagactttccccaatgactacacgctgtccttctggagatca
ggcagagtccagcactgtcgaatacggtcgactcctgagggaggggccatgaagtattat
ttgactgacaacctcatgttcaacagcatctatgacttgattcaacactaccgagaagcc
cacctgagatgtgcagaatttgagcttcgtctgacagacccagtgcccaaccccaatcct
catgaatcaaaagcttggtactatgatagcctgagcagaggagaagctgaagacatgttg
atgagaattccccgagacggagccttcctgattaggaaaagagaagggggagatgcatac
gccattactttcagagccaaggggaaagtgaaacattgccggattaacaaagacggtcac
cactttgtgctggggacgtctgcttactttgaaagtttggtggaattggtcagctactat
gaaaagcatgcgctctacaggaaaatgagactgcgctaccccgtgactccagagctgctg
gaacgttacaacacggaaagggacataaattcactctatgatgtcaggatgtatgtggat
cccagtgaaattaacccctcaacgccccagagaaccgtgaaggctttgtatgactacaaa
gccaagcgtggggatgagctcagcttctgtcggggggccctcatccacaatgtctccaag
gagcctggtggctggtggaagggtgattatggaggaaggattcagcaatatttcccatct
aattatgtggaggacatatcaacagttgattttgaagagctggaaaaacagattattgaa
gataaccctttaggatctctgtgcagaggaatcttggatcttaacacctataatgttgtg
aaagtaccacagggaaaaaaccagaagccatttgtcttcatcctggaaccgaagaaaccc
aatgatcctcccatagagtttgcgactgacaaagtggaagagctctttgagtggtaccag
agcatcagggaaatcacctggaagaatgcgacagtggagaccaacatgaagtattgggag
aagaatcaatcgattgctatagaactgtccgacttagtcgtctactgtaagccaacgagt
aaaaccaaggataatttagaaaatcctgatttcagagaaattcgctctttcgtggagacc
aaggctgacagcatcgttaggcagaagccaattgatctcttgaagtacaatcaaaaggga
ctgactcgggtctacccaaaaggtcaaagggtggactcatcaaattatgatccttttcga
ctttggctttgtggctctcagatggtcgctctgaatttccagacagcagataaatatatg
cagctgaatcatgctttatttgcactcaatggacggactggctatgtcctgcagcctgaa
agcatgaggaatgaaaactatgatccaacacccccggaatcacaaaggaagatcctgatg
accttgacggtgaaggtcctgggggcccgccatctacccaagcttggccgaagcattgcc
tgtccatttatagaggtggaaatttgtgggaccgagtatgataataacaaattcaagacg
actgtagtgaatgataatggcctgagtccagtctgggcgtctactcaggaaaaagtgaca
tttgaaatttatgacccaaatctcgcatttctacgttttgttgtttatgaggaggatatg
ttcagcgatcccaactttctggcacatgccacttatcccattaaaggaatcaaatcaggg
tttagatcagttcctcttaaaaacggttacagtgaagatatcgaactggcctccctcctg
gttttctgtgagatgcgtcctgtcttggaaagtgaagaagagctctattcttcctgtcgc
cagcttcgaagacggcaagaggagctgaataaccaactcttcttgtatgacactcatcag
aacttacgtaatgccaacagagatgccctggtgaatgaattcaacgtcaatgaaaatcag
ttgcagctgtatcaggaaaaatgcaaccggagattaagggagaagagagtcagtaacagc
aaattctactcctag

  All links  
Gene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (15)   
   Pfam (15)   
All databases (19)   

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