ID A0A087TLY4_STEMI Unreviewed; 2347 AA.
AC A0A087TLY4;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 02-APR-2025, entry version 60.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
DE Flags: Fragment;
GN ORFNames=X975_02723 {ECO:0000313|EMBL:KFM66123.1};
OS Stegodyphus mimosarum (African social velvet spider).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC Araneomorphae; Entelegynae; Eresoidea; Eresidae; Stegodyphus.
OX NCBI_TaxID=407821 {ECO:0000313|EMBL:KFM66123.1, ECO:0000313|Proteomes:UP000054359};
RN [1] {ECO:0000313|EMBL:KFM66123.1, ECO:0000313|Proteomes:UP000054359}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bechsgaard J.;
RT "Genome sequencing of Stegodyphus mimosarum.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC PRP16 sub-subfamily. {ECO:0000256|ARBA:ARBA00038040}.
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DR EMBL; KK115830; KFM66123.1; -; Genomic_DNA.
DR STRING; 407821.A0A087TLY4; -.
DR EnsemblMetazoa; KFM66123; KFM66123; X975_02723.
DR OMA; KEWEAFP; -.
DR OrthoDB; 10009520at2759; -.
DR Proteomes; UP000054359; Unassembled WGS sequence.
DR GO; GO:0034458; F:3'-5' RNA helicase activity; IEA:TreeGrafter.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:TreeGrafter.
DR GO; GO:0004540; F:RNA nuclease activity; IEA:InterPro.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0060255; P:regulation of macromolecule metabolic process; IEA:UniProtKB-ARBA.
DR CDD; cd20335; BRcat_RBR; 1.
DR CDD; cd17917; DEXHc_RHA-like; 1.
DR CDD; cd10910; PIN_limkain_b1_N_like; 1.
DR CDD; cd00590; RRM_SF; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 1.20.120.1750; -; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C-like.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR056245; KH_DEAH11/12.
DR InterPro; IPR021139; NYN.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR044066; TRIAD_supradom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF91; PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF01485; IBR; 1.
DR Pfam; PF22191; IBR_1; 1.
DR Pfam; PF24471; KH_DEAH11; 1.
DR Pfam; PF01936; NYN; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00647; IBR; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF57850; RING/U-box; 3.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51873; TRIAD; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054359};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 917..1080
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1109..1284
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 2138..2346
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51873"
FT DOMAIN 2142..2186
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 363..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 684..703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..11
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..34
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..73
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..392
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 393..404
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 684..694
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 2347
FT /evidence="ECO:0000313|EMBL:KFM66123.1"
SQ SEQUENCE 2347 AA; 265559 MW; 93642ACB5A463F95 CRC64;
MNSGKSGKKY YAKPTKSNGS TQGKKDQPQK KKSGDVQGKC NQSQKKKQPQ PTVSGEFRCE
NFTHTGKPES NLSYHGKHGG KKQSNSSNEK EIYNKEMHYR SSPGLLFQRD GKLDQDRHHS
LLSFSTGFQS SNQNSQQFPS AHFHGAHHQK TQNLVKSISP LKHNVNEKQK MTHPSHSGNY
SKFHGIHNSM PAQVRVFHGN YEYGSSQPTN PQKNSHPIKQ NISSHQNFKP PSVRNISSSI
TVSNVRNGLP CFRGNTKPSH YNSQILSSVR AEKHINDFRM SSNLNKFTSV SNTVTSKQFP
LKNPVFKFKS SKVVKPENKA KQTHKKKKRV KKVNFWKDTK NSNIGVTPLL SFQRISENSS
LDWTSVKSKE SDDDDDNASI SHKSSDGSNV SDIETDGTSS DESEFSIVSS VKDSEIGSCK
SDFMPLNASQ TEKFVIVCWD IENCSLPSTK SAVDFVKHVR NKFYDGRTET QFIVACDVSN
LNDALVKDLD EASVTIIHKS SRSKNAADQK LMIILMDFQN THRRSDSAVV LISGDSDFAS
YLSDMRYKHH IYVNLICKKN AKTSLISAAD RVVFFEDFIK DVAERSREED TQFFINVSNL
PKQMNKKQIK KYLTEKITGI KGRVKILNES LAIICFPDLC AREKAVSRLS SCILGDCKLQ
ITCSEGILEG NKLGAVNKND NKIKLPDSKR KSSEKVNSSL DDNSGKGGTL YVYVSERFGD
VEYWKNELGK LWNISDLALN WDGNSEEGFF MVNFKSLSKA QKAKKKLLKK QMKDPMAPKF
LKLVKHDELG FNTFCVNALD NMQDLNKKKI NDYICMVEKK KDYFLNKHQE EVSKLKKSPI
PQVPGAKEVL SEKLNEMNEQ KVTFLNFTSE IINKLNKADI CSENLEHCLD DILREYSREC
NCFSSALPIY AKKNTILKKI KKHQVTIIRA ETGSGKSTQL TQYVWGEQIL SKHGVIMCTQ
PRKIAAISLA KYVSSQVGCS LGDIVGYEVG MSTKKSNKTA ILYVTDFTML KMVINNEIEN
ASCIIVDEAH ERTVYTDLLL GMLKSYLKAK PSLKLVITSA TIDTSIFRDY FNVTDDAVLH
VSGRIYPVED IWCNEDVSLG WDFFQKTVDT VHDILNTEKE PGDILAFLTT PAETEKAVDA
LNKKVKDENY NHKIKILQLH GKLDVQEQQK IFERIPVGMR KVVFSTNCAE TSVTIPGIRY
VVDCGMVKES QYDSVRNMSI LCVGFVSRSS AEQRRGRAGR TQVGKCFRLY SKKNYDNMAE
GNVPEILRVN LGQALLKLMQ MGVKNPVQFD FVQSPSEESL KLAMKQLTHL GAVNETDLSL
TALGRQMSYL PVEPRLSFLV LKGVDSNIGF EAVSLASLIT VSRSIFFRNS ENKNEADKKK
MRFCQNESDF LTYLDVYKEW FSVPKVSKSK WCVLNCINAQ SMRTVHNLVN ELILILTKEI
NLKIPAKFND DLHHEELLKI IFYSFSENIC VFSGHVRYGY RSTKIPGELM IHPSSSLSTF
GNWRPQFLVY DTILKTNMTY LINISPITKD MILEAIKLHV LKINLEALES LHLRNLCISP
IGKTVLLREI IGKNGVHRKF LENKLKVLVG SDSVILDVDI SKGEVKIFAP EPKFEIIESV
ICPIIEKAKE TLAIEEKEFC LLENSELTGI VSTGAEIKDV VIPGEFRDLK VTVNNNDSIQ
TIVEKLQICG TISTVREWKN YFKITFQSPV HAKQALNMFR NEQSFSLQSI IKTAVSDNRR
CMYRVVVSYM RRPCTGEAFV SFESDAFLPL ISNSVCNRSI TYRNMPIRCS ISKKSQDLRF
SGLPCDTNRE EFETLVKSLM PDDIKLTKCI IVRKKVYESS QDELEIVKQG LISKFGAFTP
KDKLHIDLKK PSPKDFTWNA FIFFENMYDG ENAVNMLKNR ICYSYPGFKM KPCLQTTLFC
KTEIFSAVKE QIDDALKYFK DTSDSDKTLD ITAVPKDSST VKIQITSNNV SDATDARRAI
QNILYGDQIK CAGNPVLERL FLEDSLAYIR KISKDKLNCF VDANKYRKVI SIFGNASVCN
LIKLKVNSFL SAIAENSVRE ISLLPKHGRV GVIKELFKRY GSNLENLVET SGVSGIDVNL
YKHKLTVKGT ESSVFKCLEL VEEVVKELGN SDDDDGDDDE VCALCYDKIL NEFYRLEYCG
HAYCKTCILH LFENSSDFPL SCVGCKAPTV LADLYWATKQ VQQLEKIVLK KSLDFFIKNR
DDIGYCPSPD CPMIYRVAKD GKTLFECPVC SNVICTNCGD LYHYGMSCSL YQCSKHDDDY
SLKVWMLADE ANRKLCPSCS SPIEKNEGCN HMTCWKCRAH MCWLCLQVFP SAGLVYNHQA
ICPKRKV
//
