ID A0A093HLH3_STRCA Unreviewed; 995 AA.
AC A0A093HLH3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 28-JAN-2026, entry version 40.
DE RecName: Full=Exosome RNA helicase MTR4 {ECO:0000256|ARBA:ARBA00069430};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
DE AltName: Full=Superkiller viralicidic activity 2-like 2 {ECO:0000256|ARBA:ARBA00082023};
DE AltName: Full=TRAMP-like complex helicase {ECO:0000256|ARBA:ARBA00077324};
DE Flags: Fragment;
GN ORFNames=N308_07262 {ECO:0000313|EMBL:KFV83498.1};
OS Struthio camelus australis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Palaeognathae; Struthioniformes; Struthionidae;
OC Struthio.
OX NCBI_TaxID=441894 {ECO:0000313|EMBL:KFV83498.1, ECO:0000313|Proteomes:UP000053584};
RN [1] {ECO:0000313|EMBL:KFV83498.1, ECO:0000313|Proteomes:UP000053584}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N308 {ECO:0000313|EMBL:KFV83498.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + phosphate + H(+); Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00049390};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066;
CC Evidence={ECO:0000256|ARBA:ARBA00049390};
CC -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
CC Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}. Nucleus,
CC nucleoplasm {ECO:0000256|ARBA:ARBA00004642}.
CC -!- SIMILARITY: Belongs to the helicase family. SKI2 subfamily.
CC {ECO:0000256|ARBA:ARBA00010140}.
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DR EMBL; KL206556; KFV83498.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A093HLH3; -.
DR STRING; 441894.ENSSCUP00000016157; -.
DR Proteomes; UP000053584; Unassembled WGS sequence.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0006974; P:DNA damage response; IEA:UniProtKB-KW.
DR GO; GO:0000460; P:maturation of 5.8S rRNA; IEA:TreeGrafter.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0006401; P:RNA catabolic process; IEA:InterPro.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR CDD; cd18024; DEXHc_Mtr4-like; 1.
DR CDD; cd13154; KOW_Mtr4; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR FunFam; 3.40.50.300:FF:000083; ATP-dependent RNA helicase DOB1; 1.
DR FunFam; 3.40.50.300:FF:000141; ATP-dependent RNA helicase DOB1; 1.
DR FunFam; 2.40.30.300:FF:000001; Mtr4 exosome RNA helicase; 1.
DR FunFam; 1.10.3380.30:FF:000002; superkiller viralicidic activity 2-like 2; 1.
DR FunFam; 1.10.3380.30:FF:000004; Superkiller viralicidic activity 2-like 2; 1.
DR Gene3D; 1.10.3380.30; -; 2.
DR Gene3D; 2.40.30.300; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR025696; Beta-barrel_MTR4.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C-like.
DR InterPro; IPR048392; MTR4-like_stalk.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR050699; RNA-DNA_Helicase.
DR InterPro; IPR016438; SKI2-like.
DR InterPro; IPR012961; Ski2/MTR4_C.
DR PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR PANTHER; PTHR12131:SF7; EXOSOME RNA HELICASE MTR4; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF08148; DSHCT; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21408; MTR4-like_stalk; 1.
DR Pfam; PF13234; MTR4_beta-barrel; 1.
DR PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01142; DSHCT; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000053584};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552};
KW Spliceosome {ECO:0000256|ARBA:ARBA00022728};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 101..257
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 358..530
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 778..805
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFV83498.1"
FT NON_TER 995
FT /evidence="ECO:0000313|EMBL:KFV83498.1"
SQ SEQUENCE 995 AA; 112691 MW; D0840D07ED8D7027 CRC64;
KRSEEKSSVV AAGKSKREVE VNSTEDAVLG KKPKLEDVVS EDVNLADLMP QVKVQAVETV
EGCTHEVALP TDEDFTGLKP RTGKAAKEYP FILDAFQREA ILCVDNNQSV LVSAHTSAGK
TVCAEYAIAL ALREKQRVIF TSPIKALSNQ KYREMYEEFQ DVGLMTGDVT INPTASCLVM
TTEILRSMLY RGSEVMREVA WVIFDEIHYM RDSERGVVWE ETIILLPDNV HYVFLSATIP
NARQFAEWIC HLHKQPCHVI YTDYRPTPLQ HYIFPAGGDG LHLVVDENGD FREDNFNTAM
QVLRDAGDLA KGDQKGRKGG TKGPSNVFKI VKMIMERNFQ PVIIFSFSKK DCEAYALQMT
KLDFNTDEEK KMVEEVFNNA IDCLSDEDKK LPQVEHVLPL LKRGIGIHHG GLLPILKETI
EILFSEGLIK ALFATETFAM GINMPARTVL FTSACKFDGK DFRWISSGEY IQMSGRAGRR
GMDDRGIVIL MVDEKMSPTI GKQLLKGSAD PLNSAFHLTY NMVLNLLRVE EINPEYMLEK
SFYQFQHYRA IPGVVEKVNK LEEQYNKIAI PNEENVVIYY KIRQQLAKLG KEIEEYVHKP
KYCLPFLQPG RLVKVKNEDD DFGWGVVVNF SKKSNVKPNS GELDPLYVVE VLLHCSKESL
KNSATEAAKP ARPEEKGEMQ VVPVLVHLLS AISSVRLYIP KDLRPIDNRQ SVLKSIQEVQ
KRFPDGVPLL DPIDDMGIKD QGLKKVIQKV EAFEHRMYSH PLHNDPNLET VYKLCERKAQ
IAMDIKAAKR ELKKAKTVLQ MDELKCRKRV LRRLGFATSS DVIEMKGRVA CEISSADELL
LTEMMFNGLF NDLSAEQATA LLSCFVFQEN SSEMPKLTEQ LAGPLRQMQE CAKRIAKVSA
EAKLEIDEEN YLNSFRPNLM DVVYTWANGA NFAHICKMTD VFEGSIIRCM RRLEELLRQM
CQAAKAIGNT ELENKFAEGI TKIKRDIVFA ASLYL
//
