ID A0A1S3N2A5_SALSA Unreviewed; 561 AA.
AC A0A1S3N2A5;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 28-JAN-2026, entry version 38.
DE SubName: Full=Suppressor of cytokine signaling 5b {ECO:0000313|RefSeq:XP_014009618.1};
GN Name=socs5b {ECO:0000313|RefSeq:XP_014009618.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP001652741, ECO:0000313|RefSeq:XP_014009618.1};
RN [1] {ECO:0000313|RefSeq:XP_014009618.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR RefSeq; XP_014009618.1; XM_014154143.2.
DR AlphaFoldDB; A0A1S3N2A5; -.
DR STRING; 8030.ENSSSAP00000080852; -.
DR PaxDb; 8030-ENSSSAP00000080852; -.
DR GeneID; 106576765; -.
DR KEGG; sasa:106576765; -.
DR CTD; 559639; -.
DR OrthoDB; 8820570at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP001652741; Chromosome ssa18.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP001652741};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 405..500
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 495..544
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 96..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 561 AA; 61891 MW; ED1B47CCE75B3F60 CRC64;
MEKVGKMWSN LRSRCQTLFH SDGAGPSTEN SVVEVDGMHC VVDLERGGNS GEAQASRASS
LSRSLLPLPM VTGGRRHNCV SDIPQIVEIT IDSKDHEDAR GGRGGVPVAR RDSYSRHAPW
GGKKKHSCST KTQSSMDTDR RSGRARGAAG RRERRYGVSS IQEMGDSGSG GCSLSARSLR
QRLSDTVGLC LPLPRRRSRS SKTPTISKRK IHLTELMLET CPFPQGSDLA NKWHLIKQHT
APVSPHSSTA LLDAFDTAHP SPEDEEERLR ERRRLSIEEG VDPPPNAQIH TLEALAQGSS
LYKLGPKMAP GIAEASGEAR GAVACCSGGG VSVQVLGGAT AQLADCDSEE DSTTLCLQAL
RPKQRHASGD GNLSRNQPGP WKVHTQIDYI HCLVPDLLQI TALPCYWGVM DRYEAEALLD
GRPEGTFLLR DSAQEDYLFS VSFRRYNRSL HARIEQWNHN FSFDAHDPCV FHSSTVTGLL
EHYKDPSACM FFEPLLTAPL HRAFPFGLQH LARAAICPRT TYDGIGGLPL PPALQDFLKE
YHYKQKVRVR WLEREPPLKI K
//
