ID   A0A2Y9RCI0_TRIMA        Unreviewed;       537 AA.
AC   A0A2Y9RCI0;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   28-JAN-2026, entry version 35.
DE   SubName: Full=Suppressor of cytokine signaling 5 {ECO:0000313|RefSeq:XP_004369548.1, ECO:0000313|RefSeq:XP_023591191.1};
GN   Name=SOCS5 {ECO:0000313|RefSeq:XP_004369548.1,
GN   ECO:0000313|RefSeq:XP_023591191.1, ECO:0000313|RefSeq:XP_023591201.1};
OS   Trichechus manatus latirostris (Florida manatee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus.
OX   NCBI_TaxID=127582 {ECO:0000313|Proteomes:UP000248480, ECO:0000313|RefSeq:XP_023591191.1};
RN   [1] {ECO:0000313|RefSeq:XP_004369548.1, ECO:0000313|RefSeq:XP_023591191.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (APR-2025) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_004369548.1; XM_004369491.3.
DR   RefSeq; XP_023591191.1; XM_023735423.1.
DR   RefSeq; XP_023591201.1; XM_023735433.1.
DR   AlphaFoldDB; A0A2Y9RCI0; -.
DR   STRING; 127582.A0A2Y9RCI0; -.
DR   GeneID; 101348056; -.
DR   KEGG; tmu:101348056; -.
DR   CTD; 9655; -.
DR   OrthoDB; 8820570at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000248480; Unplaced.
DR   GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR   GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR   GO; GO:0007259; P:cell surface receptor signaling pathway via JAK-STAT; IEA:InterPro.
DR   GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR   GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   CDD; cd03739; SOCS_SOCS5; 1.
DR   FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR022252; SOCS4/SOCS5_dom.
DR   InterPro; IPR037343; SOCS5_SOCS.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR036036; SOCS_box-like_dom_sf.
DR   PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF12610; SOCS; 1.
DR   Pfam; PF07525; SOCS_box; 1.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00253; SOCS; 1.
DR   SMART; SM00969; SOCS_box; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   SUPFAM; SSF158235; SOCS box-like; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS50225; SOCS; 1.
PE   4: Predicted;
KW   Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248480};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191};
KW   Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          382..477
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          472..521
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000259|PROSITE:PS50225"
FT   REGION          103..175
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        159..170
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   537 AA;  61199 MW;  0A729694E0B7E0A3 CRC64;
     MDKVGKMWNN FKYRCQNLFS HEGGSRSENV GMNSSRCLSV KERNTSIGDP APQQQSSPLR
     ENVALHLGLS SSKNSSRRSQ NCAAEIPQIV EISIEKENDP CVTTPGTRLA RRDSYSRHAP
     WGGKKKHSCS TKTQSSLDTE KKFGRTRSGL QRRERRYGVS SVHDMDSVSS RTVGSRSLRQ
     RLQDTVGLCF PMRTYSKQSK PLFSNKRKIH LSELMLEKCP FPAGSDLAQK WHLIKQHTAP
     VSPHSTFFDT FDPSLVSTED EEDRLRERRR LSIEEGVDPP PNAQIHTFEA TAQVNPLYKL
     GPKLAPGMTE ISGDSSAVPQ ASCDSEEDTT TLCLQSRRQK QRQVSGDSHA HVSRQGAWKV
     HTQIDYIHCL VPDLLQITGN PCYWGVMDRY EAEALLEGKP EGTFLLRDSA QEDYLFSVSF
     RRYNRSLHAR IEQWNHNFSF DAHDPCVFHS STVTGLLEHY KDPSSCMFFE PLLTISLNRT
     FPFSLQYICR AVICRCTTYD GIDGLPLPSM LQDFLKEYHY KQKVRVRWLE REPVKAK
//