ID A0A453B2E8_AEGTS Unreviewed; 1786 AA.
AC A0A453B2E8;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 18-JUN-2025, entry version 30.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
OS Aegilops tauschii subsp. strangulata (Goatgrass).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Aegilops.
OX NCBI_TaxID=200361 {ECO:0000313|EnsemblPlants:AET2Gv20341000.5, ECO:0000313|Proteomes:UP000015105};
RN [1] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=25035499; DOI=10.1126/science.1250092;
RG International Wheat Genome Sequencing Consortium,;
RA Marcussen T., Sandve S.R., Heier L., Spannagl M., Pfeifer M.,
RA Jakobsen K.S., Wulff B.B., Steuernagel B., Mayer K.F., Olsen O.A.;
RT "Ancient hybridizations among the ancestral genomes of bread wheat.";
RL Science 345:1250092-1250092(2014).
RN [2] {ECO:0000313|Proteomes:UP000015105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|Proteomes:UP000015105};
RX PubMed=29158546; DOI=10.1038/s41477-017-0067-8;
RA Zhao G., Zou C., Li K., Wang K., Li T., Gao L., Zhang X., Wang H., Yang Z.,
RA Liu X., Jiang W., Mao L., Kong X., Jiao Y., Jia J.;
RT "The Aegilops tauschii genome reveals multiple impacts of transposons.";
RL Nat. Plants 3:946-955(2017).
RN [3] {ECO:0000313|EnsemblPlants:AET2Gv20341000.5}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|EnsemblPlants:AET2Gv20341000.5};
RX PubMed=29143815;
RA Luo M.C., Gu Y.Q., Puiu D., Wang H., Twardziok S.O., Deal K.R., Huo N.,
RA Zhu T., Wang L., Wang Y., McGuire P.E., Liu S., Long H., Ramasamy R.K.,
RA Rodriguez J.C., Van S.L., Yuan L., Wang Z., Xia Z., Xiao L., Anderson O.D.,
RA Ouyang S., Liang Y., Zimin A.V., Pertea G., Qi P., Bennetzen J.L., Dai X.,
RA Dawson M.W., Muller H.G., Kugler K., Rivarola-Duarte L., Spannagl M.,
RA Mayer K.F.X., Lu F.H., Bevan M.W., Leroy P., Li P., You F.M., Sun Q.,
RA Liu Z., Lyons E., Wicker T., Salzberg S.L., Devos K.M., Dvorak J.;
RT "Genome sequence of the progenitor of the wheat D genome Aegilops
RT tauschii.";
RL Nature 551:498-502(2017).
RN [4] {ECO:0000313|EnsemblPlants:AET2Gv20341000.5}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (MAR-2019) to UniProtKB.
RN [5] {ECO:0000313|EnsemblPlants:AET2Gv20341000.5}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. AL8/78 {ECO:0000313|EnsemblPlants:AET2Gv20341000.5};
RX PubMed=34515796;
RA Wang L., Zhu T., Rodriguez J.C., Deal K.R., Dubcovsky J., McGuire P.E.,
RA Lux T., Spannagl M., Mayer K.F.X., Baldrich P., Meyers B.C., Huo N.,
RA Gu Y.Q., Zhou H., Devos K.M., Bennetzen J.L., Unver T., Budak H.,
RA Gulick P.J., Galiba G., Kalapos B., Nelson D.R., Li P., You F.M., Luo M.C.,
RA Dvorak J.;
RT "Aegilops tauschii genome assembly Aet v5.0 features greater sequence
RT contiguity and improved annotation.";
RL G3 (Bethesda) 0:0-0(2021).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + phosphate + H(+); Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00047984};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC {ECO:0000256|ARBA:ARBA00008792}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EnsemblPlants; AET2Gv20341000.5; AET2Gv20341000.5; AET2Gv20341000.
DR Gramene; AET2Gv20341000.5; AET2Gv20341000.5; AET2Gv20341000.
DR Proteomes; UP000015105; Chromosome 2D.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:TreeGrafter.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR CDD; cd20335; BRcat_RBR; 1.
DR CDD; cd17917; DEXHc_RHA-like; 1.
DR CDD; cd22585; Rcat_RBR_DEAH12-like; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR FunFam; 1.20.120.1750:FF:000020; ATP-dependent RNA helicase DEAH12 chloroplastic; 1.
DR FunFam; 3.30.40.10:FF:000485; ATP-dependent RNA helicase DEAH12 chloroplastic; 1.
DR FunFam; 3.40.50.300:FF:001279; ATP-dependent RNA helicase DEAH12 chloroplastic; 1.
DR FunFam; 3.40.50.300:FF:002114; ATP-dependent RNA helicase DEAH12 chloroplastic; 1.
DR FunFam; 1.20.120.1080:FF:000033; RBR-type E3 ubiquitin transferase; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 1.20.120.1750; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C-like.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR056245; KH_DEAH11/12.
DR InterPro; IPR056246; KH_DEAH11/12_1st.
DR InterPro; IPR056247; KH_DEAH11/12_2nd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR056248; RBD_DEAH11/12.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR056244; RRM_DEAH11/12.
DR InterPro; IPR044066; TRIAD_supradom.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF81; ATP-DEPENDENT RNA HELICASE DEAH11, CHLOROPLASTIC-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF01485; IBR; 1.
DR Pfam; PF22191; IBR_1; 1.
DR Pfam; PF24471; KH_DEAH11; 1.
DR Pfam; PF24638; KH_DEAH11_1st; 1.
DR Pfam; PF24641; KH_DEAH11_2nd; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR Pfam; PF24475; RBD_DEAH11; 1.
DR Pfam; PF24637; RRM_DEAH11; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00647; IBR; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF57850; RING/U-box; 3.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51873; TRIAD; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000015105};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 303..467
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 506..672
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1570..1778
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51873"
FT DOMAIN 1574..1616
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..22
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..42
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..61
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1786 AA; 200391 MW; F29CDDCE35C626B8 CRC64;
SRRCRCRHLA SPDAPPPPPP ILPRRSTAPP CLSRRASAAS MRQSNHCRPF RPPDWGSPPP
HCRPHHQQSH RQPQSAPRFA VILFRAGPNI STPTATEIDA LVADLPSPPP DNLSVFSSGR
DAARLLFRFL PAAAAAAREL WSLRLEGLHL LTPYLPNAAL AAHAFPLIAS LFASHASRLL
DTDLVSRSAA RSAELAASIQ SLEHRLRSRN SVRDFDQLHL QKKTLEAEKD LVDAKIAEYK
ASMSSIRRAM LRGTDDEEEE GVDVFGIGER EDVDFARLHM MMLRECRRLN EGLPIYAYRR
KILNHIFNNQ VMILIGETGS GKSTQLVQFL ADSGLAANGS IVCTQPRKIA ATSLARRVDE
ESNGCYEDNF VLSYSTFLNS QDLNSKIIFC TDSCLLHHCM NDTGLDGISY IIVDEAHERS
LNTDLLLALI KKKLLDRLDL HLIIMSATAD ADKLADYFYG CQTFHVKGRN FPVEINYVPD
VSVEASSNAV PNSMCDACAT ASYVNDVVRM VSIIHKNEEE GAVLAFLTSQ LEVEWACENF
SDASAVVLPM HGKLSHVEQS RVFKSYPGKR KIIFCTNMAE TSLTIKEVKY VVDSGLAKES
RFVPSSGLNV LKVNWISQSS ANQRAGRAGR TGAGKCYRLY SEADFSMMDV HQEPEIRKVH
LGTAVLRILA LGVKDARKFE FVDAPNPEAI SMAVKNLEQL GAVKHRLNCF ELTDTGRYLV
KLGIEPRLGK IMLDCFDVGL RKEGVVLAAV MANSSSIFCR VGTDEEKHKA DLQKVRLCHR
DGDLFTLLAV YKKWEDGHDN RNMWCWQNSI NAKTMRRCQE TISELENCLK HELNIIIPSY
WRWNPEAPTV HDKDLKRIIL SSLTGNLAMF LGHERFGYQV ISTGQVVNLH PSSSLLNYGI
KPEWVVFTEI LSVPNQYLVC VTAVDHDALY TIHPVSFIQH LEEQKLQIKV ISGLGTNLLR
RFCGKYGQNQ QKIISRLKED CRDDRITVEI NFQNNEVVLF ATEQNMEKVF CTVNSALKCE
GKILRNECLE RNLFPGRPGS SPIALFGSGA EIKHLELGGR YLTVEVLHQN AHDIDDKELI
FLVDSIVSGV ANFHKSTGSF RIASDGIKWG KFTFLKPENA EDAVSKLNGI EFNGSSLKLV
PVCTSDNRGL PFPAVRAKLC WPRRYSSGRA LVTCASGEAE FVVNDCFALG IGGRYIKCRV
STKYENCVFA EGIPMHVTEP ELYDAFRSTT ARRILNIRLL RVKGNAIASP SVSTCEEELV
REISPFMPNK SFPGQNFRVE VFPPEENDSL TRATITFDGS LHREAARALD HLEGHFLPCC
QPWQIIQCNH VFHSTLSCPV RVYNVISQEV ASLLESFQSQ KGVSYNFEKT ENGIFRLKLT
ANATKTIADL RRPLEILMKG KTINHPDLTL SAVQLLLSRD GVAHLKSIEQ ETGTYIMYDR
QSLNIKVFGH QEQMAAAEVK LVHALRQLLE KKPLEICLRG HNLPPDLMKK TVENFGVDLE
GFNKEMPEIK VELHQHRHLL KVWGSKEDKR RVERMIFELA SFKHSSLVQL ASENVGGKED
NQRVDYSEPS EDACPICLCE IEDPFRLESC GHMFCLACLM DQCESAMKSH DGFPICCLKT
GCKEPLLVVD LKHLLSNEKL EDLFRASLRA FVASRAGMYR FCPTPDCQSI YQVAAPDAET
KPFSCGACYV EICTKCHFEY HPFISCEAYK EYKEDPDSTL LEWRKGKANV KSCPSCGYTI
EKADGCNHVE CRCGSHICWV CLENFRSSEE CYGHLRSVHQ SFVDIV
//
