ID A0A5B9W944_9BACT Unreviewed; 515 AA.
AC A0A5B9W944;
DT 13-NOV-2019, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2019, sequence version 1.
DT 02-APR-2025, entry version 18.
DE SubName: Full=Nucleoside permease NupX {ECO:0000313|EMBL:QEH36719.1};
GN Name=nupX {ECO:0000313|EMBL:QEH36719.1};
GN ORFNames=OJF2_53040 {ECO:0000313|EMBL:QEH36719.1};
OS Aquisphaera giovannonii.
OC Bacteria; Pseudomonadati; Planctomycetota; Planctomycetia; Isosphaerales;
OC Isosphaeraceae; Aquisphaera.
OX NCBI_TaxID=406548 {ECO:0000313|EMBL:QEH36719.1, ECO:0000313|Proteomes:UP000324233};
RN [1] {ECO:0000313|EMBL:QEH36719.1, ECO:0000313|Proteomes:UP000324233}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OJF2 {ECO:0000313|EMBL:QEH36719.1,
RC ECO:0000313|Proteomes:UP000324233};
RA Wiegand S., Jogler M., Boedeker C., Pinto D., Vollmers J., Rivas-Marin E.,
RA Kohn T., Peeters S.H., Heuer A., Rast P., Oberbeckmann S., Bunk B.,
RA Jeske O., Meyerdierks A., Storesund J.E., Kallscheuer N., Luecker S.,
RA Lage O.M., Pohl T., Merkel B.J., Hornburger P., Mueller R.-W., Bruemmer F.,
RA Labrenz M., Spormann A.M., Op den Camp H., Overmann J., Amann R.,
RA Jetten M.S.M., Mascher T., Medema M.H., Devos D.P., Kaster A.-K.,
RA Ovreas L., Rohde M., Galperin M.Y., Jogler C.;
RT "Deep-cultivation of Planctomycetes and their phenomic and genomic
RT characterization uncovers novel biology.";
RL Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- SIMILARITY: Belongs to the concentrative nucleoside transporter (CNT)
CC (TC 2.A.41) family. {ECO:0000256|ARBA:ARBA00009033}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP042997; QEH36719.1; -; Genomic_DNA.
DR RefSeq; WP_210420182.1; NZ_CP042997.1.
DR AlphaFoldDB; A0A5B9W944; -.
DR KEGG; agv:OJF2_53040; -.
DR Proteomes; UP000324233; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005337; F:nucleoside transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015293; F:symporter activity; IEA:TreeGrafter.
DR InterPro; IPR008276; C_nuclsd_transpt.
DR InterPro; IPR011657; CNT_C_dom.
DR InterPro; IPR002668; CNT_N_dom.
DR InterPro; IPR011642; Gate_dom.
DR PANTHER; PTHR10590; SODIUM/NUCLEOSIDE COTRANSPORTER; 1.
DR PANTHER; PTHR10590:SF4; SOLUTE CARRIER FAMILY 28 MEMBER 3; 1.
DR Pfam; PF07670; Gate; 1.
DR Pfam; PF07662; Nucleos_tra2_C; 1.
DR Pfam; PF01773; Nucleos_tra2_N; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000324233};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 35..54
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 120..136
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 148..167
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 209..230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 239..265
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 285..307
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 370..390
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 457..482
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 494..514
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 124..196
FT /note="Concentrative nucleoside transporter N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01773"
FT DOMAIN 210..307
FT /note="Nucleoside transporter/FeoB GTPase Gate"
FT /evidence="ECO:0000259|Pfam:PF07670"
FT DOMAIN 313..512
FT /note="Concentrative nucleoside transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07662"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 57..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..78
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 515 AA; 54695 MW; D304AC16772ED2D3 CRC64;
MRRIRLTLTD PRRTNRDPGT SPAGARPRVC RPWRVGLLLL ALYQVYAPAI AVAAQGAEDG
PPTGSAASTG TAATRPGRPG VTVEPGPAEV RREYRLKVGS WTTRFSLPES IDLADVMDRA
RGVLGMLAIV GVAVFLSEDR RAISRRIVFW GLTLQCAFAV LVLRVPAGIR AMRAAGGAVE
SVLACAMEGA EFVFGKALVA PDGPAGFVFA FRVLPTVIFV AALFAALYYL HVMQWIVRLF
AVVMAWFMGT SGAESLNVAA SLFLGQTEAP LTIRPYLARL TRSELLTVMT SGMAHVSGGI
MAVYFGYGVE PRHIITAVIM TAPGTILLSK LLLPETGKPE TLGHTRPSSE VEDANILDAV
ARGTRDGLTL ALNIAAMLIA ILGLIALINL GLGQVGMSLQ KILGWLLAPV AYLLGVPWED
CREIGGLLGT RTVLNEVIAF KELGAVKGSL YARSFDIASF ALCGFANFSS IGIQLGGIGA
LVPDRRRDLA ELGWRALLAG TMANFLSACI AGILL
//
