ID   A0A6J0GYZ1_9PASS        Unreviewed;       537 AA.
AC   A0A6J0GYZ1;
DT   07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT   07-OCT-2020, sequence version 1.
DT   28-JAN-2026, entry version 25.
DE   SubName: Full=Suppressor of cytokine signaling 5 {ECO:0000313|RefSeq:XP_017667215.1, ECO:0000313|RefSeq:XP_017667216.1};
GN   Name=SOCS5 {ECO:0000313|RefSeq:XP_017667215.1,
GN   ECO:0000313|RefSeq:XP_017667216.1, ECO:0000313|RefSeq:XP_017667217.1};
OS   Lepidothrix coronata (blue-crowned manakin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC   Passeriformes; Pipridae; Lepidothrix.
OX   NCBI_TaxID=321398 {ECO:0000313|Proteomes:UP000504624, ECO:0000313|RefSeq:XP_017667217.1};
RN   [1] {ECO:0000313|RefSeq:XP_017667215.1, ECO:0000313|RefSeq:XP_017667216.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (APR-2025) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
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DR   RefSeq; XP_017667215.1; XM_017811726.1.
DR   RefSeq; XP_017667216.1; XM_017811727.1.
DR   RefSeq; XP_017667217.1; XM_017811728.1.
DR   AlphaFoldDB; A0A6J0GYZ1; -.
DR   GeneID; 108495721; -.
DR   CTD; 9655; -.
DR   OrthoDB; 8820570at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000504624; Unplaced.
DR   GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR   GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR   GO; GO:0007259; P:cell surface receptor signaling pathway via JAK-STAT; IEA:InterPro.
DR   GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR   GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   CDD; cd03739; SOCS_SOCS5; 1.
DR   FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR022252; SOCS4/SOCS5_dom.
DR   InterPro; IPR037343; SOCS5_SOCS.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR036036; SOCS_box-like_dom_sf.
DR   PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF12610; SOCS; 1.
DR   Pfam; PF07525; SOCS_box; 1.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00253; SOCS; 1.
DR   SMART; SM00969; SOCS_box; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   SUPFAM; SSF158235; SOCS box-like; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS50225; SOCS; 1.
PE   4: Predicted;
KW   Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW   Reference proteome {ECO:0000313|Proteomes:UP000504624};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191};
KW   Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          382..477
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          472..521
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000259|PROSITE:PS50225"
FT   REGION          117..160
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   537 AA;  61483 MW;  0F290F2615083D47 CRC64;
     MDKVGKMWNN FKYRCQNLFS HEGGSQNENI IVNSSNCSSA KEKAIQVTDL TQQQPPSSPL
     RENIALQLGL SPSKNSARRN QNCVTEIPQI VEISIEKEND SCVTTGARLA RRDSYSRHAP
     WGGKKKHSCS TKTQSSLDTE KRFGRTRSGL QRRERRYGVS SVHDMDAVSS RTVGSRSLRQ
     RLQDTVGLCF PMRTYSKQSK PLFSNKRKIH LSELMLEKCP FPAGSDLAQK WHLIKQHTAP
     VSPHSTFFDT FDPSLVSTED EEDRLRERRR LSIEEGVDPP PNAQIHTFEA TAQVNPLYKL
     GPKLAPGMTE LTGDKTITPP GNCDSEEDTT TLCLQSRRQK QRQMSGESHG HISRQGAWKV
     HTQIDYIHCL VPDLLQITGN PCYWGVMDRY EAEALLEGKP EGTFLLRDSA QEDYLFSVSF
     RRYNRSLHAR IEQWNHNFSF DAHDPCVFHS STVTGLLEHY KDPSSCMFFE PLLTVSLNRT
     FPFSLQYICR AVICRCTTYD GIDDLPLPSM LQDFLKEYHY KQKVRVRWLE REPIKTK
//