ID A0A6J1U4Y4_9SAUR Unreviewed; 437 AA.
AC A0A6J1U4Y4;
DT 07-OCT-2020, integrated into UniProtKB/TrEMBL.
DT 07-OCT-2020, sequence version 1.
DT 28-JAN-2026, entry version 23.
DE SubName: Full=Suppressor of cytokine signaling 4 {ECO:0000313|RefSeq:XP_026526021.1, ECO:0000313|RefSeq:XP_026526022.1};
GN Name=SOCS4 {ECO:0000313|RefSeq:XP_026526021.1,
GN ECO:0000313|RefSeq:XP_026526022.1, ECO:0000313|RefSeq:XP_026526023.1};
OS Notechis scutatus (mainland tiger snake).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Hydrophiinae; Notechis.
OX NCBI_TaxID=8663 {ECO:0000313|Proteomes:UP000504612, ECO:0000313|RefSeq:XP_026526022.1};
RN [1] {ECO:0000313|RefSeq:XP_026526021.1, ECO:0000313|RefSeq:XP_026526022.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (APR-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR RefSeq; XP_026526021.1; XM_026670236.1.
DR RefSeq; XP_026526022.1; XM_026670237.1.
DR RefSeq; XP_026526023.1; XM_026670238.1.
DR AlphaFoldDB; A0A6J1U4Y4; -.
DR GeneID; 113413735; -.
DR KEGG; nss:113413735; -.
DR CTD; 122809; -.
DR GeneTree; ENSGT00940000161456; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000504612; Unplaced.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd10385; SH2_SOCS4; 1.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR035864; SOCS4_SH2.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF21; SUPPRESSOR OF CYTOKINE SIGNALING 4; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000504612};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 283..378
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 373..422
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 182..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 437 AA; 50215 MW; 540FD7593DF184BD CRC64;
MAENKERKPK NADVRPKTSR SRSADRKDGY VWSGKKLSWI KKNENSSNAA MANASGIPTL
SLRNQERKQS CSSAEMELEH VCGHRFLSRS FKQKLQDAMG QCFPIKSCST RHSSRLSPKR
KIHISELMLD KCPFPPRSEL AFRWHLIKQH TAPVRQKSES WLSMGSSKGE RKDEELREIE
MADEPDSGVL QESSGIENAS YPCDPQEESA LGGKQLKSSR EESDMDSDDE VVTLCTSSRK
RNKPQWEIED DLLQLQMPLR YHTQIDYVHC LVPDLLQINN NPCYWGVMDK YAAEALLDGK
PEGTFLLRDS AQEDYLFSVS FRRYSRSLHA RIEQWNHNFS FDAHDPCVFH SPDITGLLEH
YKDPSSCMFF EPLLSTPLHR TFPFSLQHLC RTVICNSTTY DGINALPVPP SVKLYLKEYH
YKSKVRVLRV DVPDQHA
//
