ID A0A7L1NSV7_RHICY Unreviewed; 531 AA.
AC A0A7L1NSV7;
DT 07-APR-2021, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 1.
DT 28-JAN-2026, entry version 19.
DE RecName: Full=Exosome RNA helicase MTR4 {ECO:0000256|ARBA:ARBA00069430};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
DE AltName: Full=Superkiller viralicidic activity 2-like 2 {ECO:0000256|ARBA:ARBA00082023};
DE AltName: Full=TRAMP-like complex helicase {ECO:0000256|ARBA:ARBA00077324};
DE Flags: Fragment;
GN Name=Mtrex {ECO:0000313|EMBL:NXO02709.1};
GN ORFNames=RHICYA_R07501 {ECO:0000313|EMBL:NXO02709.1};
OS Rhinopomastus cyanomelas (Common scimitarbill).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Coraciimorphae;
OC Bucerotiformes; Rhinopomastidae; Rhinopomastus.
OX NCBI_TaxID=113115 {ECO:0000313|EMBL:NXO02709.1, ECO:0000313|Proteomes:UP000565785};
RN [1] {ECO:0000313|EMBL:NXO02709.1, ECO:0000313|Proteomes:UP000565785}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B10K-DU-002-35 {ECO:0000313|EMBL:NXO02709.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:NXO02709.1};
RA Zhang G.;
RT "Bird 10,000 Genomes (B10K) Project - Family phase.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + phosphate + H(+); Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00049390};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066;
CC Evidence={ECO:0000256|ARBA:ARBA00049390};
CC -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
CC Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}. Nucleus,
CC nucleoplasm {ECO:0000256|ARBA:ARBA00004642}.
CC -!- SIMILARITY: Belongs to the helicase family. SKI2 subfamily.
CC {ECO:0000256|ARBA:ARBA00010140}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:NXO02709.1}.
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DR EMBL; VXBP01008658; NXO02709.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A7L1NSV7; -.
DR OrthoDB; 64767at2759; -.
DR Proteomes; UP000565785; Unassembled WGS sequence.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0006974; P:DNA damage response; IEA:UniProtKB-KW.
DR GO; GO:0000460; P:maturation of 5.8S rRNA; IEA:TreeGrafter.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR CDD; cd13154; KOW_Mtr4; 1.
DR FunFam; 2.40.30.300:FF:000001; Mtr4 exosome RNA helicase; 1.
DR FunFam; 1.10.3380.30:FF:000002; superkiller viralicidic activity 2-like 2; 1.
DR FunFam; 1.10.3380.30:FF:000004; Superkiller viralicidic activity 2-like 2; 1.
DR Gene3D; 1.10.3380.30; -; 2.
DR Gene3D; 2.40.30.300; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR025696; Beta-barrel_MTR4.
DR InterPro; IPR048392; MTR4-like_stalk.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR050699; RNA-DNA_Helicase.
DR InterPro; IPR012961; Ski2/MTR4_C.
DR PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR PANTHER; PTHR12131:SF7; EXOSOME RNA HELICASE MTR4; 1.
DR Pfam; PF08148; DSHCT; 1.
DR Pfam; PF21408; MTR4-like_stalk; 1.
DR Pfam; PF13234; MTR4_beta-barrel; 1.
DR SMART; SM01142; DSHCT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:NXO02709.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000565785};
KW Spliceosome {ECO:0000256|ARBA:ARBA00022728};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 354..531
FT /note="ATP-dependent RNA helicase Ski2/MTR4 C-terminal"
FT /evidence="ECO:0000259|SMART:SM01142"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:NXO02709.1"
FT NON_TER 531
FT /evidence="ECO:0000313|EMBL:NXO02709.1"
SQ SEQUENCE 531 AA; 60510 MW; CAF4F145ADD207FE CRC64;
ISSGEYIQMS GRAGRRGMDD RGIVILMVDE KMSPTVGKQL LKGSADPLNS AFHLTYNMVL
NLLRVEEINP EYMLEKSFYQ FQHYRTIPEI VERVNNLEGQ YNKIVIPNEE NVVIYYKIRQ
QLAKLAKEIE EYIHKPKYCL PFLQPGRLVK VKNEGDDFGW GVVVNFSKKS NVKPNSGELD
PLYVVEVLLH CSKESLKNSA TEAAKPARPD EKGEMQVVPV LVHLLSAISS VRLYIPKDLR
PIDNRQSVLK SIQEVQKRFP DGVPLLDPID DMGIKDQGLK KVIQKVEAFE HRMYSHPLHN
DPNLETVYRL CEKKAQIAVD IKVAKRELKK ARTVLQMDEL KCRKRVLRRL GFATSSDVIE
MKGRVACEIS SADELLLTEM MFNGLFNDLT AEQATALLSC FVFQENSSEM PKLTEQLAGP
LRQMQECAKR IAKVSAEAKL EIDEENYLNS FKPNLMDVVY TWANGANFAH ICKMTDVFEG
SIIRCMRRLE ELLRQMCQAA KAIGNTELEN KFAEGITKIK RDIVFAASLY L
//
